TODD WYATT

Summary

Affiliation: University of Nebraska Medical Center
Country: USA

Publications

  1. pmc Asymmetric dimethylarginine blocks nitric oxide-mediated alcohol-stimulated cilia beating
    T A Wyatt
    VA Nebraska Western Iowa Health Care System Research Service, Department of Veterans Affairs Medical Center, 4101 Woolworth Avenue, Omaha, NE 68105, USA Department of Environmental, Agricultural, and Occupational Health, College of Public Health, University of Nebraska Medical Center, Omaha, NE 68198, USA Pulmonary, Critical Care, Sleep and Allergy Division, Department of Internal Medicine, 985300 Nebraska Medical Center, Omaha, NE 68198 5300, USA
    Mediators Inflamm 2013:592892. 2013
  2. pmc Non-typeable Haemophilus influenzae decreases cilia beating via protein kinase Cε
    KRISTINA L BAILEY
    Department of Epidemiology, College of Public Health, University of Nebraska Medical Center, Omaha, NE 68198 5910, USA
    Respir Res 13:49. 2012
  3. pmc Co-exposure to cigarette smoke and alcohol decreases airway epithelial cell cilia beating in a protein kinase Cε-dependent manner
    Todd A Wyatt
    VA Nebraska Western Iowa Health Care System Research Service, Department of Veterans Affairs Medical Center, Omaha, Nebraska, USA
    Am J Pathol 181:431-40. 2012
  4. pmc Malondialdehyde-acetaldehyde-adducted protein inhalation causes lung injury
    Todd A Wyatt
    Research Service, Veteran Affairs Nebraska Western Iowa Health Care System, Omaha, NE 68105, USA
    Alcohol 46:51-9. 2012
  5. ncbi request reprint Malondialdehyde-acetaldehyde adducts decrease bronchial epithelial wound repair
    Todd A Wyatt
    Research Service, Department of Veterans Affairs Medical Center, 4101 Woolworth Avenue, Omaha, NE 68105, USA
    Alcohol 36:31-40. 2005
  6. ncbi request reprint Both cAMP and cGMP are required for maximal ciliary beat stimulation in a cell-free model of bovine ciliary axonemes
    Todd A Wyatt
    Research Service, Department of Veterans Affairs Medical Center, Omaha, Nebraska, USA
    Am J Physiol Lung Cell Mol Physiol 288:L546-51. 2005
  7. pmc Desensitization of PKA-stimulated ciliary beat frequency in an ethanol-fed rat model of cigarette smoke exposure
    Todd A Wyatt
    Department of Internal Medicine, Pulmonary, Critical Care, and Sleep Medicine Section, University of Nebraska Medical Center, Omaha, Nebraska 68198 5300, USA
    Alcohol Clin Exp Res 28:998-1004. 2004
  8. pmc Ethanol stimulates ciliary beating by dual cyclic nucleotide kinase activation in bovine bronchial epithelial cells
    Todd A Wyatt
    Research Service, Department of Veterans Affairs Medical Center, Omaha, Nebraska 68198, USA
    Am J Pathol 163:1157-66. 2003
  9. ncbi request reprint Protein kinase C activation is required for cigarette smoke-enhanced C5a-mediated release of interleukin-8 in human bronchial epithelial cells
    T A Wyatt
    Research Service, Department of Veterans Affairs Medical Center, Omaha, Nebraska, USA
    Am J Respir Cell Mol Biol 21:283-8. 1999
  10. ncbi request reprint Relaxin stimulates bronchial epithelial cell PKA activation, migration, and ciliary beating
    T A Wyatt
    Research Service, Department of Veterans Affairs Medical Center, Omaha, NE 68105, USA
    Exp Biol Med (Maywood) 227:1047-53. 2002

Research Grants

  1. Airway Injury Caused by MAA Adducts
    Todd A Wyatt; Fiscal Year: 2010
  2. Airway Injury Caused by MAA Adducts
    TODD WYATT; Fiscal Year: 2009

Collaborators

Detail Information

Publications53

  1. pmc Asymmetric dimethylarginine blocks nitric oxide-mediated alcohol-stimulated cilia beating
    T A Wyatt
    VA Nebraska Western Iowa Health Care System Research Service, Department of Veterans Affairs Medical Center, 4101 Woolworth Avenue, Omaha, NE 68105, USA Department of Environmental, Agricultural, and Occupational Health, College of Public Health, University of Nebraska Medical Center, Omaha, NE 68198, USA Pulmonary, Critical Care, Sleep and Allergy Division, Department of Internal Medicine, 985300 Nebraska Medical Center, Omaha, NE 68198 5300, USA
    Mediators Inflamm 2013:592892. 2013
    ..Alcohol-stimulated increases in lung slice PKA and CBF were temporally enhanced in the DDAH mice versus control mice...
  2. pmc Non-typeable Haemophilus influenzae decreases cilia beating via protein kinase Cε
    KRISTINA L BAILEY
    Department of Epidemiology, College of Public Health, University of Nebraska Medical Center, Omaha, NE 68198 5910, USA
    Respir Res 13:49. 2012
    ..The subsequent auto-downregulation of PKCε or the direct inhibition of PKCε leads to the specific detachment of the ciliated cells...
  3. pmc Co-exposure to cigarette smoke and alcohol decreases airway epithelial cell cilia beating in a protein kinase Cε-dependent manner
    Todd A Wyatt
    VA Nebraska Western Iowa Health Care System Research Service, Department of Veterans Affairs Medical Center, Omaha, Nebraska, USA
    Am J Pathol 181:431-40. 2012
    ..No decreases in CBF were observed in PKCε knockout mice co-exposed to smoke and alcohol. These data identify PKCε as a key regulator of cilia slowing in response to combined smoke and alcohol-induced lung injury...
  4. pmc Malondialdehyde-acetaldehyde-adducted protein inhalation causes lung injury
    Todd A Wyatt
    Research Service, Veteran Affairs Nebraska Western Iowa Health Care System, Omaha, NE 68105, USA
    Alcohol 46:51-9. 2012
    ..These data further implicate MAA-adduct formation as a potential mechanism for smoke- and alcohol-induced lung injury...
  5. ncbi request reprint Malondialdehyde-acetaldehyde adducts decrease bronchial epithelial wound repair
    Todd A Wyatt
    Research Service, Department of Veterans Affairs Medical Center, 4101 Woolworth Avenue, Omaha, NE 68105, USA
    Alcohol 36:31-40. 2005
    ..Scavenger receptor-mediated activation of PKC alpha may function to reduce wound healing under conditions of alcohol and cigarette smoke exposure where malondialdehyde-acetaldehyde adducts may be present...
  6. ncbi request reprint Both cAMP and cGMP are required for maximal ciliary beat stimulation in a cell-free model of bovine ciliary axonemes
    Todd A Wyatt
    Research Service, Department of Veterans Affairs Medical Center, Omaha, Nebraska, USA
    Am J Physiol Lung Cell Mol Physiol 288:L546-51. 2005
    ..However, the cyclic nucleotides did not stimulate CBF in the absence of ATP. Therefore, the combination of cAMP and cGMP augments ATP-driven CBF increases at the level of isolated axoneme...
  7. pmc Desensitization of PKA-stimulated ciliary beat frequency in an ethanol-fed rat model of cigarette smoke exposure
    Todd A Wyatt
    Department of Internal Medicine, Pulmonary, Critical Care, and Sleep Medicine Section, University of Nebraska Medical Center, Omaha, Nebraska 68198 5300, USA
    Alcohol Clin Exp Res 28:998-1004. 2004
    ..We hypothesized that a similar ethanol-mediated desensitization of CBF would occur in vivo...
  8. pmc Ethanol stimulates ciliary beating by dual cyclic nucleotide kinase activation in bovine bronchial epithelial cells
    Todd A Wyatt
    Research Service, Department of Veterans Affairs Medical Center, Omaha, Nebraska 68198, USA
    Am J Pathol 163:1157-66. 2003
    ..8-pCPT-cGMPS, an antagonist analogue to cGMP, blocked EtOH-stimulated PKA activity increases. These data support that EtOH-stimulated increases in CBF require the dual activation of both PKA (via cAMP) and PKG (via NO)...
  9. ncbi request reprint Protein kinase C activation is required for cigarette smoke-enhanced C5a-mediated release of interleukin-8 in human bronchial epithelial cells
    T A Wyatt
    Research Service, Department of Veterans Affairs Medical Center, Omaha, Nebraska, USA
    Am J Respir Cell Mol Biol 21:283-8. 1999
    ..These results suggest that PKC activation by CSE alone does not result in IL-8 release, but that CSE-stimulated PKC activation is required for C5a-mediated IL-8 release from HBECs...
  10. ncbi request reprint Relaxin stimulates bronchial epithelial cell PKA activation, migration, and ciliary beating
    T A Wyatt
    Research Service, Department of Veterans Affairs Medical Center, Omaha, NE 68105, USA
    Exp Biol Med (Maywood) 227:1047-53. 2002
    ..These data suggest that relaxin augments epithelial repair by increasing airway cell migration and CBF via PKA-dependent mechanisms...
  11. ncbi request reprint Acetaldehyde-stimulated PKC activity in airway epithelial cells treated with smoke extract from normal and smokeless cigarettes
    T A Wyatt
    Veterans Affairs Medical Center Research Services and Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 5300, USA
    Proc Soc Exp Biol Med 225:91-7. 2000
    ..These results suggest that volatile components such as acetaldehyde in cigarette smoke may inhibit ciliary motility via a PKC-dependent mechanism...
  12. ncbi request reprint Chronic ethanol downregulates PKA activation and ciliary beating in bovine bronchial epithelial cells
    T A Wyatt
    Research Service, Department of Veterans Affairs Medical Center, Omaha, Nebraska 68105, USA
    Am J Physiol Lung Cell Mol Physiol 281:L575-81. 2001
    ..EtOH desensitizes BBEC to PKA-activating agents, suggesting that EtOH rapidly stimulates, whereas long-term EtOH downregulates, CBF via PKA in BBEC...
  13. pmc Exposure to hog barn dust alters airway epithelial ciliary beating
    T A Wyatt
    Dept of Internal Medicine, Pulmonary, Critical Care, Sleep and Allergy Section, University of Nebraska Medical Center, Omaha, NE 68198 5300, USA
    Eur Respir J 31:1249-55. 2008
    ..These data demonstrate that hog barn dust can alter normal stimulation of cilia, suggesting a mechanism for the abrogation of stimulated increases in mucociliary clearance in response to inhaled dust exposure...
  14. ncbi request reprint Malondialdehyde-acetaldehyde-adducted bovine serum albumin activates protein kinase C and stimulates interleukin-8 release in bovine bronchial epithelial cells
    T A Wyatt
    Research Service, Department of Veterans Affairs Medical Center, 4101 Woolworth Avenue, Omaha, NE 68105, USA
    Alcohol 25:159-66. 2001
    ....
  15. pmc Sequential activation of protein kinase C isoforms by organic dust is mediated by tumor necrosis factor
    Todd A Wyatt
    Department of Internal Medicine, Pulmonary, Critical Care, Sleep and Allergy Section, University of Nebraska Medical Center, 985300 Nebraska Medical Center, Omaha, NE 68198 5300, USA
    Am J Respir Cell Mol Biol 42:706-15. 2010
    ..These results suggest a temporal ordering of events responsible for the release of cytokines, which initiate and exacerbate inflammatory events in the airways of people exposed to agricultural dust...
  16. pmc Effects of cigarette smoke and alcohol on ciliated tracheal epithelium and inflammatory cell recruitment
    Margaret K Elliott
    University of Nebraska Medical Center, 985300 Nebraska Medical Center, Omaha, NE 68198 5300, USA
    Am J Respir Cell Mol Biol 36:452-9. 2007
    ....
  17. ncbi request reprint Nitric oxide-dependent cilia regulatory enzyme localization in bovine bronchial epithelial cells
    Sarah L Stout
    Pulmonary, Critical Care, Sleep and Allergy Medicine, Dept of Internal Medicine, University of Nebraska Medical Center 985300, Omaha, NE 68198 5300, USA
    J Histochem Cytochem 55:433-42. 2007
    ..Our findings suggest that these enzymes are sequestered close to their points of action into a discrete ciliary metabolon, enabling targeted phosphorylation and efficient upregulation of ciliary beating...
  18. pmc Inhibition of protein kinase C epsilon causes ciliated bovine bronchial cell detachment
    Rebecca E Slager
    Pulmonary, Critical Care and Sleep Medicine Section, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 5300, USA
    Exp Lung Res 32:349-62. 2006
    ..The results of this study support a possible novel PKCepsilon-mediated signaling pathway through which ciliated cell attachment is maintained...
  19. ncbi request reprint Feedlot dust stimulation of interleukin-6 and -8 requires protein kinase Cepsilon in human bronchial epithelial cells
    Todd A Wyatt
    Pulmonary and Critical Care Medicine Section, Department of Internal Medicine, Omaha, NE, USA
    Am J Physiol Lung Cell Mol Physiol 293:L1163-70. 2007
    ..These data support the hypothesis that FLDE exposure stimulates bronchial epithelial IL-8 and IL-6 release via a PKCepsilon-dependent pathway...
  20. pmc Smoke exposure exacerbates an ethanol-induced defect in mucociliary clearance of Streptococcus pneumoniae
    Elizabeth A Vander Top
    Veterans Affairs Medical Center, Omaha, Nebraska 68105, USA
    Alcohol Clin Exp Res 29:882-7. 2005
    ..Both cigarette smoke and ethanol (EtOH) exposure alter ciliary beating and protein kinase activity in the respiratory mucosa in vitro, but their effects on bacterial clearance in the intact animal have not been determined...
  21. ncbi request reprint Hog barn dust slows airway epithelial cell migration in vitro through a PKCalpha-dependent mechanism
    Rebecca E Slager
    Department of Internal Medicine, Pulmonary and Critical Care Medicine Section, University of Nebraska Medical Center, Omaha, NE 68198 5300, USA
    Am J Physiol Lung Cell Mol Physiol 293:L1469-74. 2007
    ..These results suggest that the PKCalpha isoform is an important regulator of cell migration in response to agricultural dust exposure...
  22. ncbi request reprint Ethanol increases phosphodiesterase 4 activity in bovine bronchial epithelial cells
    Mary A Forgèt
    Pulmonary and Critical Care Medicine Section, Department of Internal Medicine, University of Nebraska Medical Center, 985300 Nebraska Medical Center, Omaha, NE 68198 5300, USA
    Alcohol 31:31-8. 2003
    ..Other compensatory mechanisms however, may be responsible for the down-regulation of PKA, which occurs after chronic epithelial exposure (>/=6 h) to ethanol...
  23. pmc Differential in vivo effects of whole cigarette smoke exposure versus cigarette smoke extract on mouse ciliated tracheal epithelium
    Margaret K Elliott
    Pulmonary, Critical Care and Sleep Medicine Section, University of Nebraska Medical Center, Omaha, Nebraska 68198 5300, USA
    Exp Lung Res 32:99-118. 2006
    ..CSE exposure induced inflammatory cell bronchiolitis. These data indicate that CSE exposure has differential effects on the lungs and tracheal epithelium compared to CS exposure...
  24. ncbi request reprint Protein kinase C-alpha mediates cigarette smoke extract- and complement factor 5a-stimulated interleukin-8 release in human bronchial epithelial cells
    Ravindra Kashyap
    Pulmonary and Critical Care Medicine Section, Department of Internal Medicine, University of Nebraska Medical Center, Omaha 68198 5300, USA
    J Investig Med 50:46-53. 2002
    ..We hypothesized that PKC activation by alternative PKC activators will also mediate C5a-stimulated IL-8 release in HBEC...
  25. pmc Alcohol functionally upregulates Toll-like receptor 2 in airway epithelial cells
    KRISTINA L BAILEY
    Department of Internal Medicine, Pulmonary, Critical Care, Sleep and Allergy Section, University of Nebraska Medical Center, Omaha, Nebraska 68198 5815, USA
    Alcohol Clin Exp Res 33:499-504. 2009
    ..Little is known about why this phenomenon is observed. We hypothesized that alcohol may modulate Toll-like receptor 2 (TLR2), which regulates inflammation caused by gram-positive bacteria...
  26. pmc Ethanol attenuates contraction of primary cultured rat airway smooth muscle cells
    Peter J Oldenburg
    Department of Internal Medicine, Pulmonary, Critical Care, Sleep, and Allergy Division, University of Nebraska Medical Center, Omaha, Nebraska 68198 5910, USA
    Am J Respir Cell Mol Biol 43:539-45. 2010
    ..In addition, it appears that this effect is the result of activation of the cGMP/PKG kinase pathway. These findings implicate a direct effect of ethanol on airway smooth muscle cells as the basis for in vivo ethanol effects...
  27. ncbi request reprint Adenosine promotion of cellular migration in bronchial epithelial cells is mediated by the activation of cyclic adenosine monophosphate-dependent protein kinase A
    Diane S Allen-Gipson
    Department of Internal Medicine, Nebraska Medical Center, Omaha, NE 68198 5815, USA
    J Investig Med 55:378-85. 2007
    ..These data suggest that adenosine activation of A(2A)AR augments epithelial repair by increasing airway cellular migration by PKA-dependent mechanisms...
  28. pmc Alcohol stimulates ciliary motility of isolated airway axonemes through a nitric oxide, cyclase, and cyclic nucleotide-dependent kinase mechanism
    Joseph H Sisson
    Department of Internal Medicine, University of Nebraska Medical Center, Pulmonary, Critical Care, Sleep and Allergy Section, Omaha, Nebraska 68198 5300, USA
    Alcohol Clin Exp Res 33:610-6. 2009
    ....
  29. pmc Intranasal organic dust exposure-induced airway adaptation response marked by persistent lung inflammation and pathology in mice
    Jill A Poole
    Pulmonary, Critical Care, Sleep, and Allergy Section, Univ of Nebraska Medical Center, 985300 The Nebraska Medical Center, Omaha, NE 68198 5300, USA
    Am J Physiol Lung Cell Mol Physiol 296:L1085-95. 2009
    ..Collectively, intranasal exposure to DE results in significant lung inflammatory and pathological responses marked by a modulated innate immune response to single and repetitive dust exposures that is associated with PKC activity...
  30. ncbi request reprint Activation of protein kinase A accelerates bovine bronchial epithelial cell migration
    John R Spurzem
    Department of Veterans Affairs Medical Center, Omaha, Nebraska 68105, USA
    Am J Physiol Lung Cell Mol Physiol 282:L1108-16. 2002
    ..Augmentation of PKA activity reduced the levels of active Rho and the formation of focal adhesions. These studies suggest that PKA activation modulates Rho activity, migration mechanisms, and thus bronchial epithelial repair mechanisms...
  31. pmc Ethanol blocks adenosine uptake via inhibiting the nucleoside transport system in bronchial epithelial cells
    Diane S Allen-Gipson
    Department of Internal Medicine, Pulmonary, Critical Care, Sleep and Allergy Section, 985815 Nebraska Medical Center, Omaha, NE 68198 5815, USA
    Alcohol Clin Exp Res 33:791-8. 2009
    ..Taken together, we hypothesized that ethanol impairs adenosine uptake via the nucleoside transport system...
  32. pmc Alcohol up-regulates TLR2 through a NO/cGMP dependent pathway
    KRISTINA L BAILEY
    Pulmonary, Critical Care, Sleep and Allergy Section, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Alcohol Clin Exp Res 34:51-6. 2010
    ..We have previously shown that alcohol up-regulates TLR2 in the airway epithelium. However, the mechanism of alcohol-mediated up-regulation of TLR2 has not been identified...
  33. ncbi request reprint Inhibition of human airway smooth muscle cell proliferation by beta 2-adrenergic receptors and cAMP is PKA independent: evidence for EPAC involvement
    Karen M Kassel
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5800, USA
    Am J Physiol Lung Cell Mol Physiol 294:L131-8. 2008
    ....
  34. ncbi request reprint Effect of malondialdehyde-acetaldehyde-protein adducts on the protein kinase C-dependent secretion of urokinase-type plasminogen activator in hepatic stellate cells
    Kusum K Kharbanda
    Department of Veterans Affairs Medical Center, VA Alcohol Research Center, 4101 Woolworth Avenue, Omaha, NE 68105, USA
    Biochem Pharmacol 63:553-62. 2002
    ..These results indicate that MAA adducts via a PKC-mediated pathway may regulate plasmin-mediated matrix degradation in the liver, thereby contributing to the progression of hepatic fibrosis...
  35. ncbi request reprint Cigarette smoke extract increases C5a receptor expression in human bronchial epithelial cells
    Diane S Allen-Gipson
    Pulmonary, Critical Care, and Sleep Medicine Section, Department of Internal Medicine, University of Nebraska Medical Center, 985815 Nebraska Medical Center, Omaha, NE 68198 5815, USA
    J Pharmacol Exp Ther 314:476-82. 2005
    ..The data also indicate that PKC-alpha may play an important role in modulating C5aR binding...
  36. ncbi request reprint Alcohol intake is associated with altered pulmonary function
    Joseph H Sisson
    Pulmonary and Critical Medicine Section, Internal Medicine Department, University of Nebraska Medical Center, Omaha, NE 68198 5300, USA
    Alcohol 36:19-30. 2005
    ..Our analyses indicate that alcohol consumption, even at very modest intake levels, is associated with less lung restriction...
  37. ncbi request reprint Repeat organic dust exposure-induced monocyte inflammation is associated with protein kinase C activity
    Jill A Poole
    Pulmonary, Critical Care, Sleep and Allergy Section, Department of Internal Medicine, University of Nebraska Medical Center, 985300 The Nebraska Medical Center, Omaha, NE 68198 5300, USA
    J Allergy Clin Immunol 120:366-73. 2007
    ..Organic dust exposure results in an inflammatory response that attenuates over time, but repetitive exposures can result in chronic respiratory diseases. Mechanisms underlying this modulated response are not clear...
  38. pmc RACK1, a PKC targeting protein, is exclusively localized to basal airway epithelial cells
    Rebecca E Slager
    Department of Internal Medicine, Pulmonary and Critical Care Medicine Section, University of Nebraska Medical Center, 985300 Nebraska Medical Center, Omaha, NE 68198 5300, USA
    J Histochem Cytochem 56:7-14. 2008
    ..These results suggest that PKCepsilon signaling in the basal airway cell may involve RACK1; however, PKCepsilon regulation in ciliated cells uses RACK1-independent pathways...
  39. ncbi request reprint Transforming growth factor-beta induces contraction of activated hepatic stellate cells
    Kusum K Kharbanda
    Department of Veterans Affairs Medical Center, VA Alcohol Research Center, 4101 Woolworth Avenue, Omaha, NE 68105, USA
    J Hepatol 41:60-6. 2004
    ..Recognizing the prominent roles that hepatic stellate cells (HSCs) and TGF-beta play in portal hypertension and fibrogenesis, respectively, we sought to evaluate the effect of TGF-beta on the contractility of activated HSCs...
  40. ncbi request reprint Smoke and C5a induce airway epithelial intercellular adhesion molecule-1 and cell adhesion
    Anthony A Floreani
    Division of Pulmonary and Critical Care Medicine, School of Allied Health Professions, University of Nebraska Medical Center Nebraska Health Systems, Omaha, NE 68198 5300, USA
    Am J Respir Cell Mol Biol 29:472-82. 2003
    ..Our results may help explain the initiation and propagation of inflammatory events in vivo induced by chronic airway exposure to cigarette smoke...
  41. pmc Association of chronic alcohol consumption and increased susceptibility to and pathogenic effects of pulmonary infection with respiratory syncytial virus in mice
    Thomas R Jerrells
    Department of Pathology and Microbiology, University of Nebraska Medical Center, 986495 Nebraska Medical Center, Omaha, Nebraska 68198 6495, USA
    Alcohol 41:357-69. 2007
    ..Infection of mice that had consumed alcohol chronically was more severe in terms of increased proinflammatory cytokine production, inflammation, and a failure to clear the virus from the lungs...
  42. ncbi request reprint Ethanol treatment reduces bovine bronchial epithelial cell migration
    John R Spurzem
    Department of Internal Medicine, Omaha Veterans Affairs Medical Center, Omaha, Nebraska 68198 5300, USA
    Alcohol Clin Exp Res 29:485-92. 2005
    ..We hypothesize that chronic ethanol exposure down-regulates the adenosine 3':5'-cyclic monophosphate signaling cascade in airway epithelial cells, resulting in decreased epithelial cell migration and repair...
  43. pmc Prostaglandin F2alpha represses IGF-I-stimulated IRS1/phosphatidylinositol-3-kinase/AKT signaling in the corpus luteum: role of ERK and P70 ribosomal S6 kinase
    Edward Arvisais
    Omaha Veterans Affairs Medical Center, Omaha, Nebraska 68105, USA
    Mol Endocrinol 24:632-43. 2010
    ..It seems likely that the rapid changes in phosphorylation events are among the early events that mediate PGF2alpha-induced corpus luteum regression...
  44. pmc Direct involvement of the isotype-specific C-terminus of beta tubulin in ciliary beating
    Julia Vent
    Department of Biomedical Sciences, Creighton University, Omaha, Nebraska 68178, USA
    J Cell Sci 118:4333-41. 2005
    ....
  45. pmc Convergence of 3',5'-cyclic adenosine 5'-monophosphate/protein kinase A and glycogen synthase kinase-3beta/beta-catenin signaling in corpus luteum progesterone synthesis
    Lynn Roy
    Department of Obstetrics and Gynecology, Olson Center for Women s Health, 3255 Nebraska Medical Center, Omaha, Nebraska 68198, USA
    Endocrinology 150:5036-45. 2009
    ..Collectively these data suggest that cAMP/PKA regulation of GSK3beta/beta-catenin signaling may contribute to the acute increase in progesterone production in response to LH...
  46. ncbi request reprint Bronchodilator responsiveness in swine veterinarians
    Jill A Poole
    Department of Medicine, University of Nebraska Medical Center, Omaha 68198 5300, USA
    J Agromedicine 12:49-54. 2007
    ..The present study reassessed the prevalence of respiratory complaints and pulmonary function abnormalities in swine veterinarians and sought to characterize their response to bronchodilators...
  47. pmc Long-term cigarette smoke exposure in a mouse model of ciliated epithelial cell function
    Samantha M Simet
    Pulmonary, Critical Care, Sleep, and Allergy Division, Department of Internal Medicine, University of Nebraska Medical Center, 985910 Nebraska Medical Center, Omaha, NE 68198 5910, USA
    Am J Respir Cell Mol Biol 43:635-40. 2010
    ..In parallel with the slowing of CBF, significant PKC activation from cytosol to the membrane of tracheal epithelial cells was detected in mice exposed to smoke for 6-12 months...
  48. ncbi request reprint Tumor necrosis factor-alpha hyper-responsiveness to endotoxin in whole blood is associated with chronic bronchitis in farmers
    G Patrick Lambert
    Department of Exercise Science and Athletic Training, Creighton University, Omaha, NE 68178, USA
    J Agromedicine 10:39-44. 2005
    ....
  49. pmc Exercise training during diabetes attenuates cardiac ryanodine receptor dysregulation
    Chun Hong Shao
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA
    J Appl Physiol (1985) 106:1280-92. 2009
    ..These data are the first to show that ExT during diabetes normalizes RyR2 function and Ca(2+) release from the sarcoplasmic reticulum, providing insights into mechanisms by which ExT during diabetes improves cardiac function...
  50. pmc PKCdelta mediates thrombin-augmented fibroblast-mediated collagen gel contraction
    Qiuhong Fang
    Beijing Shijitan Hospital, Peking University, Beijing, China
    Biochem Biophys Res Commun 369:1199-203. 2008
    ..These results suggest that thrombin contributes to the tissue remodeling in inflammatory airways and lung diseases at least partially through both PKCdelta and PKCepsilon signaling...
  51. pmc Maternal alcohol ingestion reduces surfactant protein A expression by preterm fetal lung epithelia
    Tatjana Lazic
    Department of Veterinary Pathology, 2740 College of Veterinary Medicine, Iowa State University, Ames, IA 50011 1250, USA
    Alcohol 41:347-55. 2007
    ..These alterations may underlie increased susceptibility of preterm infants, exposed to ethanol in utero, to RSV and other microbial agents...
  52. ncbi request reprint PGD(2) modulates fibroblast-mediated native collagen gel contraction
    Tadashi Kohyama
    Department of Respiratory Medicine, University of Tokyo, Tokyo, Japan
    Am J Respir Cell Mol Biol 27:375-81. 2002
    ....
  53. pmc Primary ciliary dyskinesia in mice lacking the novel ciliary protein Pcdp1
    Lance Lee
    Department of Pathology, Enders 1116, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
    Mol Cell Biol 28:949-57. 2008
    ..This study demonstrates that Pcdp1 plays an important role in ciliary and flagellar biogenesis and motility, making the nm1054 mutant a useful model for studying the molecular genetics and pathogenesis of PCD...

Research Grants4

  1. Airway Injury Caused by MAA Adducts
    Todd A Wyatt; Fiscal Year: 2010
    ....
  2. Airway Injury Caused by MAA Adducts
    TODD WYATT; Fiscal Year: 2009
    ....