Marcel Wuthrich

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. ncbi Requisite elements in vaccine immunity to Blastomyces dermatitidis: plasticity uncovers vaccine potential in immune-deficient hosts
    Marcel Wuthrich
    Department of Pediatrics, University of Wisconsin Medical School, Madison, WI 53792, USA
    J Immunol 169:6969-76. 2002
  2. ncbi A C-terminal EGF-like domain governs BAD1 localization to the yeast surface and fungal adherence to phagocytes, but is dispensable in immune modulation and pathogenicity of Blastomyces dermatitidis
    Tristan Brandhorst
    Department of Pediatrics, University of Wisconsin Medical School, 600 Highland Ave, K4 434, Madison, WI 53792, USA
    Mol Microbiol 48:53-65. 2003
  3. pmc Vaccine immunity to pathogenic fungi overcomes the requirement for CD4 help in exogenous antigen presentation to CD8+ T cells: implications for vaccine development in immune-deficient hosts
    Marcel Wuthrich
    Department of Pediatrics, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madison, WI 53792, USA
    J Exp Med 197:1405-16. 2003
  4. pmc Interleukin 1 enhances vaccine-induced antifungal T-helper 17 cells and resistance against Blastomyces dermatitidis infection
    Marcel Wuthrich
    Department of Pediatrics, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madison, WI 53706, USA
    J Infect Dis 208:1175-82. 2013
  5. pmc Fungi subvert vaccine T cell priming at the respiratory mucosa by preventing chemokine-induced influx of inflammatory monocytes
    Marcel Wuthrich
    Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Immunity 36:680-92. 2012
  6. pmc Adaptive immunity to fungi
    Marcel Wuthrich
    Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792, USA
    Annu Rev Immunol 30:115-48. 2012
  7. pmc V beta1+ J beta1.1+/V alpha2+ J alpha49+ CD4+ T cells mediate resistance against infection with Blastomyces dermatitidis
    Marcel Wuthrich
    Department of Pediatrics, University of Wisconsin Medical School, University of Wisconsin Hospitals and Clinics, Madison, WI 53792, USA
    Infect Immun 75:193-200. 2007
  8. ncbi Analysis of non-adhesive pathogenic mechanisms of BAD1 on Blastomyces dermatitidis
    Marcel Wuthrich
    Department of Pediatrics, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madison, WI 53792, USA
    Med Mycol 44:41-9. 2006
  9. ncbi Differential requirements of T cell subsets for CD40 costimulation in immunity to Blastomyces dermatitidis
    Marcel Wuthrich
    Department of Pediatrics, University Hospital and Clinics, University of Wisconsin Medical School, 600 Highland Avenue, Madison, WI 53792, USA
    J Immunol 176:5538-47. 2006
  10. pmc CD28 is required for optimal induction, but not maintenance, of vaccine-induced immunity to Blastomyces dermatitidis
    Marcel Wuthrich
    University of Wisconsin Hospitals and Clinics, 600 Highland Ave, K4 444, Madison, WI 53792, USA
    Infect Immun 73:7436-41. 2005

Collaborators

Detail Information

Publications28

  1. ncbi Requisite elements in vaccine immunity to Blastomyces dermatitidis: plasticity uncovers vaccine potential in immune-deficient hosts
    Marcel Wuthrich
    Department of Pediatrics, University of Wisconsin Medical School, Madison, WI 53792, USA
    J Immunol 169:6969-76. 2002
    ....
  2. ncbi A C-terminal EGF-like domain governs BAD1 localization to the yeast surface and fungal adherence to phagocytes, but is dispensable in immune modulation and pathogenicity of Blastomyces dermatitidis
    Tristan Brandhorst
    Department of Pediatrics, University of Wisconsin Medical School, 600 Highland Ave, K4 434, Madison, WI 53792, USA
    Mol Microbiol 48:53-65. 2003
    ..They also demonstrate that the requirements for host cell binding and immune modulation by BAD1 can be dissociated from one another, and that the former is unexpectedly dispensable in the requisite role of BAD1 in pathogenesis...
  3. pmc Vaccine immunity to pathogenic fungi overcomes the requirement for CD4 help in exogenous antigen presentation to CD8+ T cells: implications for vaccine development in immune-deficient hosts
    Marcel Wuthrich
    Department of Pediatrics, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madison, WI 53792, USA
    J Exp Med 197:1405-16. 2003
    ....
  4. pmc Interleukin 1 enhances vaccine-induced antifungal T-helper 17 cells and resistance against Blastomyces dermatitidis infection
    Marcel Wuthrich
    Department of Pediatrics, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madison, WI 53706, USA
    J Infect Dis 208:1175-82. 2013
    ....
  5. pmc Fungi subvert vaccine T cell priming at the respiratory mucosa by preventing chemokine-induced influx of inflammatory monocytes
    Marcel Wuthrich
    Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Immunity 36:680-92. 2012
    ..Mucosal vaccination against fungi and perhaps other respiratory pathogens may require manipulation of host MMPs in order to alter chemokine signals needed to recruit Ly6C(hi) monocytes and prime T cells at the respiratory mucosa...
  6. pmc Adaptive immunity to fungi
    Marcel Wuthrich
    Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792, USA
    Annu Rev Immunol 30:115-48. 2012
    ..Also emphasized is how the latter deploy effector and regulatory mechanisms that eliminate these nasty invaders while also constraining collateral damage to vital tissue...
  7. pmc V beta1+ J beta1.1+/V alpha2+ J alpha49+ CD4+ T cells mediate resistance against infection with Blastomyces dermatitidis
    Marcel Wuthrich
    Department of Pediatrics, University of Wisconsin Medical School, University of Wisconsin Hospitals and Clinics, Madison, WI 53792, USA
    Infect Immun 75:193-200. 2007
    ..Thus, the outgrowth of protective T-cell clones against immunodominant antigens of B. dermatitidis is biased by a combination of the TCR repertoire and Th1 cytokine production...
  8. ncbi Analysis of non-adhesive pathogenic mechanisms of BAD1 on Blastomyces dermatitidis
    Marcel Wuthrich
    Department of Pediatrics, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madison, WI 53792, USA
    Med Mycol 44:41-9. 2006
    ..dermatitidis by also deviating host adaptive immunity, and leukocyte responses...
  9. ncbi Differential requirements of T cell subsets for CD40 costimulation in immunity to Blastomyces dermatitidis
    Marcel Wuthrich
    Department of Pediatrics, University Hospital and Clinics, University of Wisconsin Medical School, 600 Highland Avenue, Madison, WI 53792, USA
    J Immunol 176:5538-47. 2006
    ..Despite the plasticity of T cell subsets in vaccine immunity, in absence of CD40/CD40L interaction, CD4(+) cells may impede the priming of CD8(+) cells at the cost of host survival against a lethal infectious disease...
  10. pmc CD28 is required for optimal induction, but not maintenance, of vaccine-induced immunity to Blastomyces dermatitidis
    Marcel Wuthrich
    University of Wisconsin Hospitals and Clinics, 600 Highland Ave, K4 444, Madison, WI 53792, USA
    Infect Immun 73:7436-41. 2005
    ..Our findings suggest that CD28 is required for the induction of optimal, protective T-cell responses to B. dermatitidis infection but may be dispensable for the maintenance of T-cell memory...
  11. ncbi IL-12 is required for induction but not maintenance of protective, memory responses to Blastomyces dermatitidis: implications for vaccine development in immune-deficient hosts
    Marcel Wuthrich
    Department of Pediatrics, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madison, WI 53792, USA
    J Immunol 175:5288-97. 2005
    ..In conclusion, these studies demonstrate that once CD4 and CD8 cells have acquired a protective T1 phenotype they no longer require the presence of IL-12 to maintain antifungal protective memory...
  12. pmc Limited model antigen expression by transgenic fungi induces disparate fates during differentiation of adoptively transferred T cell receptor transgenic CD4+ T cells: robust activation and proliferation with weak effector function during recall
    Marcel Wuthrich
    Department of Pediatrics, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madison, Wisconsin, USA
    Infect Immun 80:787-97. 2012
    ..However, the limited availability of model Ag expressed by Tg fungi during T cell priming blunts the downstream generation of effector and memory T cells...
  13. pmc A TCR transgenic mouse reactive with multiple systemic dimorphic fungi
    Marcel Wuthrich
    Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, University of Wisconsin Madison, Madison, WI 53792, USA
    J Immunol 187:1421-31. 2011
    ....
  14. pmc Vaccine-induced protection against 3 systemic mycoses endemic to North America requires Th17 cells in mice
    Marcel Wuthrich
    Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706, USA
    J Clin Invest 121:554-68. 2011
    ..These data suggest that human vaccines against systemic fungal infections should be designed to induce Th17 cells if they are to be effective...
  15. pmc Safety, tolerability, and immunogenicity of a recombinant, genetically engineered, live-attenuated vaccine against canine blastomycosis
    Marcel Wuthrich
    Department of Pediatrics, University of Wisconsin Madison, Madison, WI 53706, USA
    Clin Vaccine Immunol 18:783-9. 2011
    ..Thus, the live-attenuated vaccine against blastomycosis studied here proved safe, well tolerated, and immunogenic in dogs and merits further studies of vaccine efficacy...
  16. pmc C-type lectin receptors differentially induce th17 cells and vaccine immunity to the endemic mycosis of north america
    Huafeng Wang
    Department of Pediatrics, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madison, WI 53792
    J Immunol 192:1107-19. 2014
    ..Our work provides new insight into innate immune mechanisms that drive vaccine immunity and Th17 cells. ..
  17. pmc Tc17 cells mediate vaccine immunity against lethal fungal pneumonia in immune deficient hosts lacking CD4+ T cells
    Som Gowda Nanjappa
    The Department of Pediatrics, School of Medicine and Public Health, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS Pathog 8:e1002771. 2012
    ..Our work has implications for designing vaccines against fungal infections in immune suppressed patients...
  18. ncbi Global control of dimorphism and virulence in fungi
    Julie C Nemecek
    Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madison, WI 53792, USA
    Science 312:583-8. 2006
    ..This global regulator shapes how dimorphic fungal pathogens adapt to the mammalian host, which has broad implications for treating and preventing systemic fungal disease...
  19. pmc Dynamic interplay among monocyte-derived, dermal, and resident lymph node dendritic cells during the generation of vaccine immunity to fungi
    Karen Ersland
    Cell and Molecular Pathology Graduate Training Program, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Cell Host Microbe 7:474-87. 2010
    ..Our work reveals the dynamic interplay among distinct DC subsets that prime naive CD4 T cells after yeast are injected in the skin and discloses the cellular elements underlying vaccine-induced immunity to fungi...
  20. pmc Structure and function of a fungal adhesin that binds heparin and mimics thrombospondin-1 by blocking T cell activation and effector function
    T Tristan Brandhorst
    Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America
    PLoS Pathog 9:e1003464. 2013
    ..The tandem repeats of BAD-1 thus confer pathogenicity, harbor motifs that bind heparin, and suppress T-cell activation via a CD47-dependent mechanism, mimicking mammalian TSP-1. ..
  21. ncbi Exploiting type 3 complement receptor for TNF-alpha suppression, immune evasion, and progressive pulmonary fungal infection
    T Tristan Brandhorst
    Department of Pediatrics, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madison, WI 53792, USA
    J Immunol 173:7444-53. 2004
    ..BAD1 of B. dermatitidis thus co-opts normal host cell physiology by exploiting CR3 to subdue TNF-alpha production and foster pathogen survival...
  22. pmc Discordant influence of Blastomyces dermatitidis yeast-phase-specific gene BYS1 on morphogenesis and virulence
    Theerapong Krajaejun
    Departments of Pediatrics, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin 53706, USA
    Infect Immun 78:2522-8. 2010
    ..Thus, although silencing of BYS1 alters morphology at 37 degrees C, it does not appear to impair the pathogenicity of B. dermatitidis...
  23. ncbi BAD1, an essential virulence factor of Blastomyces dermatitidis, suppresses host TNF-alpha production through TGF-beta-dependent and -independent mechanisms
    Beatriz Finkel-Jimenez
    Departments of Pediatrics, Internal Medicine, and Medical Microbiology and Immunology, and Comprehensive Cancer Center, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madison, WI 53792
    J Immunol 168:5746-55. 2002
    ..Thus, BAD1 of B. dermatitidis induces suppression of TNF-alpha and progressive infection by both TGF-beta-dependent and -independent mechanisms...
  24. pmc Indirect regulation of CD4 T-cell responses by tumor necrosis factor receptors in an acute viral infection
    Anju Singh
    Department of Pathobiological Sciences, University of Wisconsin Madison, 2015 Linden Drive, Madison, WI 53706, USA
    J Virol 81:6502-12. 2007
    ..In summary, our findings suggest that TNFRs down regulate CD4 T-cell responses during an acute LCMV infection by a non-T-cell autonomous mechanism...
  25. pmc Isolation of Blastomyces dermatitidis yeast from lung tissue during murine infection for in vivo transcriptional profiling
    Amber J Marty
    Department of Medicine, School of Medicine and Public Health, University of Wisconsin Madison, 1550 Linden Drive, Microbial Sciences Building, Room 4335A, Madison, WI 53706, USA
    Fungal Genet Biol 56:1-8. 2013
    ..In conclusion, we have developed a technique that recovers the majority of yeast causing pulmonary infection and yields high-quality fungal RNA with minimal contamination by mammalian RNA. ..
  26. pmc Protective antifungal memory CD8(+) T cells are maintained in the absence of CD4(+) T cell help and cognate antigen in mice
    Som G Nanjappa
    Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706, USA
    J Clin Invest 122:987-99. 2012
    ..This has implications for the development of novel antifungal vaccine strategies effective in immunocompromised patients...
  27. pmc Chitin elicits CCL2 from airway epithelial cells and induces CCR2-dependent innate allergic inflammation in the lung
    Rene M Roy
    Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    J Immunol 189:2545-52. 2012
    ..Thus, airway epithelial cells secrete CCL2 in response to chitin and CCR2 signaling mediates chitin-induced alternative activation of macrophages and allergic inflammation in vivo...
  28. ncbi Detection and measurement of two-component systems that control dimorphism and virulence in fungi
    Julie C Nemecek
    Department of Pediatrics, University of Wisconsin Madison School of Medicine and Public Health, Madison, Wisconsin, USA
    Methods Enzymol 422:465-87. 2007
    ..This chapter describes our approach to the identification and analysis of this global regulator...