R Wu

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. pmc Functional mapping of quantitative trait loci that interact with the hg mutation to regulate growth trajectories in mice
    Rongling Wu
    Department of Statistics, University of Florida, Gainesville 32611, USA
    Genetics 171:239-49. 2005
  2. pmc A statistical model for the identification of genes governing the incidence of cancer with age
    Kiranmoy Das
    Department of Statistics, University of Florida, Gainesville, FL 32611, USA
    Theor Biol Med Model 5:7. 2008
  3. pmc A computational model for functional mapping of genes that regulate intra-cellular circadian rhythms
    Tian Liu
    Department of Statistics, University of Florida, Gainesville, FL 32611, USA
    Theor Biol Med Model 4:5. 2007
  4. pmc A hierarchical statistical model for estimating population properties of quantitative genes
    Samuel S Wu
    Department of Statistics, University of Florida, Gainesville, FL 32611, USA
    BMC Genet 3:10. 2002
  5. pmc A joint model for nonparametric functional mapping of longitudinal trajectory and time-to-event
    Min Lin
    Department of Statistics, University of Florida, Gainesville, FL 32611, USA
    BMC Bioinformatics 7:138. 2006
  6. ncbi request reprint Functional mapping of quantitative trait loci underlying growth trajectories using a transform-both-sides logistic model
    Rongling Wu
    Department of Statistics, University of Florida, USA
    Biometrics 60:729-38. 2004
  7. ncbi request reprint Quantitative trait loci for growth trajectories in Populus
    Rongling Wu
    Department of Statistics, University of Florida, Gainesville, FL 32611, USA
    Genet Res 81:51-64. 2003
  8. ncbi request reprint Simultaneous maximum likelihood estimation of linkage and linkage phases in outcrossing species
    Rongling Wu
    Department of Statistics, University of Florida, Gainesville, Florida 32611, USA
    Theor Popul Biol 61:349-63. 2002
  9. ncbi request reprint Functional mapping for quantitative trait loci governing growth rates: a parametric model
    Rongling Wu
    Department of Statistics, University of Florida, Gainesville, Florida 32611, USA
    Physiol Genomics 14:241-9. 2003
  10. pmc A mechanistic model for genetic machinery of ontogenetic growth
    Rongling Wu
    Department of Statistics, University of Florida, Gainesville, Florida 32611, USA
    Genetics 168:2383-94. 2004

Collaborators

Detail Information

Publications93

  1. pmc Functional mapping of quantitative trait loci that interact with the hg mutation to regulate growth trajectories in mice
    Rongling Wu
    Department of Statistics, University of Florida, Gainesville 32611, USA
    Genetics 171:239-49. 2005
    ..Our model provides a powerful means for understanding the genetic architecture and regulation of growth rate and body size in mammals...
  2. pmc A statistical model for the identification of genes governing the incidence of cancer with age
    Kiranmoy Das
    Department of Statistics, University of Florida, Gainesville, FL 32611, USA
    Theor Biol Med Model 5:7. 2008
    ..Computer simulation was used to examine the statistical behavior of the model. The model can be used as a tool for explaining the epidemiological pattern of cancer incidence...
  3. pmc A computational model for functional mapping of genes that regulate intra-cellular circadian rhythms
    Tian Liu
    Department of Statistics, University of Florida, Gainesville, FL 32611, USA
    Theor Biol Med Model 4:5. 2007
    ..Genes that control circadian rhythms in organisms have been recognized, but have been difficult to detect because circadian behavior comprises periodically dynamic traits and is sensitive to environmental changes...
  4. pmc A hierarchical statistical model for estimating population properties of quantitative genes
    Samuel S Wu
    Department of Statistics, University of Florida, Gainesville, FL 32611, USA
    BMC Genet 3:10. 2002
    ..However, for many outcrossing species, such pedigrees are not available and genes also display population properties...
  5. pmc A joint model for nonparametric functional mapping of longitudinal trajectory and time-to-event
    Min Lin
    Department of Statistics, University of Florida, Gainesville, FL 32611, USA
    BMC Bioinformatics 7:138. 2006
    ..This has emerged as an important issue in genetic studies when one attempts to detect the common genes or quantitative trait loci (QTL) that govern both a longitudinal trajectory and developmental event...
  6. ncbi request reprint Functional mapping of quantitative trait loci underlying growth trajectories using a transform-both-sides logistic model
    Rongling Wu
    Department of Statistics, University of Florida, USA
    Biometrics 60:729-38. 2004
    ..The implications of our model for understanding the genetic architecture of growth are discussed...
  7. ncbi request reprint Quantitative trait loci for growth trajectories in Populus
    Rongling Wu
    Department of Statistics, University of Florida, Gainesville, FL 32611, USA
    Genet Res 81:51-64. 2003
    ..The implications of the results for breeding and silviculture are discussed...
  8. ncbi request reprint Simultaneous maximum likelihood estimation of linkage and linkage phases in outcrossing species
    Rongling Wu
    Department of Statistics, University of Florida, Gainesville, Florida 32611, USA
    Theor Popul Biol 61:349-63. 2002
    ..A numerical example is presented to demonstrate the statistical properties of the model for characterizing the linkage phase between markers...
  9. ncbi request reprint Functional mapping for quantitative trait loci governing growth rates: a parametric model
    Rongling Wu
    Department of Statistics, University of Florida, Gainesville, Florida 32611, USA
    Physiol Genomics 14:241-9. 2003
    ..The implications of the new model are discussed...
  10. pmc A mechanistic model for genetic machinery of ontogenetic growth
    Rongling Wu
    Department of Statistics, University of Florida, Gainesville, Florida 32611, USA
    Genetics 168:2383-94. 2004
    ..The estimates of QTL positions and effects from our model are broadly in agreement with those by traditional interval-mapping approaches. The implications of this model for biological and biomedical research are discussed...
  11. ncbi request reprint Modeling the genetic architecture of complex traits with molecular markers
    Rongling Wu
    Department of Statistics, University of Florida, Gainesville, FL 32611, USA
    Recent Pat Nanotechnol 1:41-9. 2007
    ..Some of the statistical methods for genetic mapping have been patented...
  12. pmc A hyperspace model to decipher the genetic architecture of developmental processes: allometry meets ontogeny
    Rongling Wu
    Department of Statistics, University of Florida, Gainesville, Florida 32611, USA
    Genetics 172:627-37. 2006
    ..We used a worked example to validate the utility of this model. The implications of this model for genetic research of evo-devo are discussed...
  13. ncbi request reprint A mixed polyploid model for linkage analysis in outcrossing tetraploids using a pseudo-test backcross design
    Rongling Wu
    Department of Statistics, University of Florida, Gainesville, Florida 32611, USA
    J Comput Biol 11:562-80. 2004
    ..We performed extensive simulation studies to demonstrate the statistical properties of our hierarchical model for linkage analysis in tetraploids. The implications of our model for polyploid linkage mapping are discussed...
  14. pmc A bivalent polyploid model for mapping quantitative trait loci in outcrossing tetraploids
    Rongling Wu
    Department of Statistics, University of Florida, Gainesville, Florida 32611, USA
    Genetics 166:581-95. 2004
    ..Simulation studies are performed to investigate the performance and robustness of our statistical method for parameter estimation. The implication and extension of the bivalent polyploid model are discussed...
  15. pmc A general framework for analyzing the genetic architecture of developmental characteristics
    Rongling Wu
    Department of Statistics, University of Florida, Gainesville, Florida 32611, USA
    Genetics 166:1541-51. 2004
    ..Using our newly developed model, we have successfully detected significant additive x additive epistatic effects on stem height growth trajectories in a forest tree...
  16. pmc Statistical methods for dissecting triploid endosperm traits using molecular markers. An autogamous model
    Rongling Wu
    Department of Statistics, University of Florida, Gainesville 32611, USA
    Genetics 162:875-92. 2002
    ..Our method will be broadly useful in mapping endosperm traits for many agriculturally important crop plants and also make it possible to study the genetic significance of double fertilization in the evolution of higher plants...
  17. ncbi request reprint A statistical model for the genetic origin of allometric scaling laws in biology
    Rongling Wu
    Department of Statistics, University of Florida, 533 McCarty Hall C, Gainesville, FL, U S A
    J Theor Biol 219:121-35. 2002
    ..The model proposed here has implications for genetic, evolutionary, biomedicinal and breeding research...
  18. pmc Joint linkage and linkage disequilibrium mapping in natural populations
    R Wu
    Department of Statistics, University of Florida, 533 McCarty Hall C, Gainesville, FL 32611, USA
    Genetics 157:899-909. 2001
    ..The strategy has great implications for constructing a dense linkage disequilibrium map that can facilitate the identification and positional cloning of the genes underlying both simple and complex traits...
  19. ncbi request reprint A maximum likelihood-based method for mining major genes affecting a quantitative character
    R Wu
    Department of Statistics, University of Florida, Gainesville 32611, USA
    Biometrics 57:764-8. 2001
    ..It is suggested that further molecular genetic research toward mapping single genes affecting aspen growth and production based on the same experimental data has a high probability of success...
  20. pmc A general polyploid model for analyzing gene segregation in outcrossing tetraploid species
    R Wu
    Department of Statistics, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, 32611, USA
    Genetics 159:869-82. 2001
    ..The implications of this model for linkage mapping, population genetic studies, and polyploid classification are discussed...
  21. pmc Joint linkage and linkage disequilibrium mapping of quantitative trait loci in natural populations
    Rongling Wu
    Department of Statistics, University of Florida, Gainesville, Florida 32611, USA
    Genetics 160:779-92. 2002
    ..The potential utility of our mapping strategy is discussed...
  22. ncbi request reprint Mapping epigenetic quantitative trait loci (QTL) altering a developmental trajectory
    Rongling Wu
    Department of Statistics, University of Florida, Gainesville 32611, USA
    Genome 45:28-33. 2002
    ..It is suggested that the activation and expression of epigenetic QTL are influenced by the developmental status of trees and the environment in which they are grown...
  23. ncbi request reprint Linkage mapping of sex-specific differences
    Rongling Wu
    Department of Statistics, University of Florida, Gainesville, FL 32611, USA
    Genet Res 79:85-96. 2002
    ..This approach will have important implications for precise gene mapping based on sex-specific linkage maps...
  24. pmc Phenotypic plasticity of fine root growth increases plant productivity in pine seedlings
    Rongling Wu
    School of Life Sciences, Zhejiang Forestry University, Lin an, Zhejiang 311300, People s Republic of China
    BMC Ecol 4:14. 2004
    ..We use two contrasting pine ecotypes, "mesic" and "xeric", to investigate the adaptive significance of such a plastic response...
  25. ncbi request reprint A logistic mixture model for characterizing genetic determinants causing differentiation in growth trajectories
    Rongling Wu
    Department of Statistics, University of Florida, Gainesville 32611, USA
    Genet Res 79:235-45. 2002
    ..The power of this model is demonstrated by an example using forest tree data, in which evidence of major genes affecting stem growth processes is successfully detected. The implications for this model and its extensions are discussed...
  26. ncbi request reprint Functional mapping - how to map and study the genetic architecture of dynamic complex traits
    Rongling Wu
    School of Forestry and Biotechnology, Zhejiang Forestry University, Lin an, Zhejiang 311300, People s Republic of China
    Nat Rev Genet 7:229-37. 2006
    ..The approach provides a useful quantitative and testable framework for assessing the interplay between gene actions or interactions and developmental changes...
  27. pmc A multivalent pairing model of linkage analysis in autotetraploids
    S S Wu
    Department of Statistics, University of Florida, Gainesville, Florida 32611, USA
    Genetics 159:1339-50. 2001
    ..Extensive simulation studies were performed to demonstrate the statistical properties of this method. The implications of the new method for understanding the genome structure and organization of polyploid species are discussed...
  28. ncbi request reprint Statistical model for characterizing epistatic control of triploid endosperm triggered by maternal and offspring QTLs
    Yuehua Cui
    Department of Statistics, University of Florida, Gainesville, FL 32611, USA
    Genet Res 86:65-75. 2005
    ..Also, the additive effect of the offspring QTLs is better estimated than the additive effect of the maternal QTLs. The implications of our model for agricultural and evolutionary genetic research are discussed...
  29. ncbi request reprint Sequencing drug response with HapMap
    M Lin
    Department of Statistics, University of Florida, Gainesville, FL 32611, USA
    Pharmacogenomics J 5:149-56. 2005
    ..This model provides a powerful tool for elucidating the genetic variants of drug response and ultimately designing personalized medications based on each patient's genetic constitution...
  30. pmc A general framework for statistical linkage analysis in multivalent tetraploids
    Rongling Wu
    Department of Statistics, University of Florida, Gainesville, 32611, USA
    Genetics 170:899-907. 2005
    ..The model will have great implications for understanding the genome structure and organization of polyploid species...
  31. ncbi request reprint Modelling epistatic effects of embryo and endosperm QTL on seed quality traits
    Yuehua Cui
    Department of Statistics, University of Florida, Gainesville, FL 32611, USA
    Genet Res 87:61-71. 2006
    ..This model will have great implications for agricultural and evolutionary genetic research...
  32. ncbi request reprint Exponential mapping of quantitative trait loci governing allometric relationships in organisms
    Chang Xing Ma
    Department of Statistics, University of Florida, 533 McCarty Hall C, Gainesville, FL 32611, USA
    J Math Biol 47:313-24. 2003
    ..It is expected that our model will have broad implications for genetic, evolutionary, biomedical and breeding research...
  33. ncbi request reprint A model for estimating joint maternal-offspring effects on seed development in autogamous plants
    Li Zhang
    Department of Statistics, University of Florida, Gainesville, Florida 32611, USA
    Physiol Genomics 19:262-9. 2004
    ..This approach will be broadly useful in mapping endosperm traits for many agriculturally important crop plants and also make it possible to study the genetic significance of double fertilization in the evolution of higher plants...
  34. doi request reprint A nonlinear mixed-effect mixture model for functional mapping of dynamic traits
    W Hou
    Department of Statistics, University of Florida, Gainesville, FL 32611, USA
    Heredity (Edinb) 101:321-8. 2008
    ..The new model can be useful for the identification of the ontogenetic patterns of QTL genetic effects during time course...
  35. pmc Theoretical basis for the identification of allelic variants that encode drug efficacy and toxicity
    Min Lin
    Department of Statistics, University of Florida, Gainesville, 32611, USA
    Genetics 170:919-28. 2005
    ..Extensive simulations are performed to investigate the statistical properties of our model. The implications of our model in pharmacogenetic and pharmacogenomic research are discussed...
  36. pmc A statistical model for estimating maternal-zygotic interactions and parent-of-origin effects of QTLs for seed development
    Yanchun Li
    School of Forestry and Biotechnology, Zhejiang Forestry University, Lin an, Zhejiang, People s Republic of China
    PLoS ONE 3:e3131. 2008
    ..The reciprocal design and a series of analytical and testing strategies proposed provide a standard procedure for genomic mapping of QTLs involved in the genetic control of complex seed development traits in flowering plants...
  37. ncbi request reprint A quantitative genetic model for analyzing species differences in outcrossing species
    R Wu
    Program in Statistical Genetics, Department of Statistics, North Carolina State University, Raleigh, North Carolina 27695 8203, USA
    Biometrics 56:1098-104. 2000
    ..We perform simulation studies and illustrate an example to demonstrate the statistical property and procedure of the method...
  38. ncbi request reprint Model for mapping imprinted quantitative trait loci in an inbred F2 design
    Yuehua Cui
    Department of Statistics, University of Florida, Gainesville, FL 32611, USA
    Genomics 87:543-51. 2006
    ..Our approach provides a standard procedure for testing the statistical significance of iQTL involved in the genetic control of complex traits...
  39. ncbi request reprint An algorithm for molecular dissection of tumor progression
    Tian Liu
    Department of Statistics, University of Florida, Gainesville, 32611, USA
    J Math Biol 50:336-54. 2005
    ..The implications of our model in gene therapy for cancer research are discussed...
  40. pmc A unified framework for mapping quantitative trait loci in bivalent tetraploids using single-dose restriction fragments: a case study from alfalfa
    Chang Xing Ma
    Department of Statistics, University of Florida, Gainesville, Florida 32611, USA
    Genome Res 12:1974-81. 2002
    ..Moreover, our results reveal significant preferential chromosome pairing at meiosis in an F1 hybrid population, which indicates the importance of reassessing the traditional view of random chromosome segregation in alfalfa...
  41. ncbi request reprint A statistical model to analyse quantitative trait locus interactions for HIV dynamics from the virus and human genomes
    Zuoheng Wang
    Department of Statistics, University of Florida, Gainesville, 32611, USA
    Stat Med 25:495-511. 2006
    ..Our model allows for the tests of a number of clinically meaningful hypotheses and provides a powerful tool for unravelling the genetic architecture of HIV-1 dynamics and therefore AIDS progression rate...
  42. pmc A haplotype-based algorithm for multilocus linkage disequilibrium mapping of quantitative trait loci with epistasis
    Xiang Yang Lou
    Department of Statistics, University of Florida, Gainesville, Florida 32611, USA
    Genetics 163:1533-48. 2003
    ..The computer program for the method proposed in this article is available at the webpage http://www.ifasstat.ufl.edu/genome/~LD...
  43. pmc Haplotyping a quantitative trait with a high-density map in experimental crosses
    Wei Hou
    Department of Epidemiology and Health Policy Research, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 2:e732. 2007
    ..However, only a small portion (< or = 1%) of the QTL detected have been characterized at the molecular level, despite the report of hundreds of thousands of QTL for different traits and populations...
  44. ncbi request reprint A non-stationary model for functional mapping of complex traits
    Wei Zhao
    Department of Statistics, University of Florida, Gainesville, FL 32611, USA
    Bioinformatics 21:2469-77. 2005
    ..Based on results from computer simulation studies, we suggest that these two models are alternative to one another and should be used simultaneously for the same dataset...
  45. ncbi request reprint A statistical model for high-resolution mapping of quantitative trait loci determining HIV dynamics
    Zuoheng Wang
    Department of Statistics, University of Florida, Gainesville, FL 32611, USA
    Stat Med 23:3033-51. 2004
    ..The implications of our model for genetic and genomic research into AIDS pathogenesis are discussed...
  46. doi request reprint Multilocus genomics of outcrossing plant populations
    Wei Hou
    Department of Epidemiology and Health Policy Research, University of Florida, Gainesville, FL 32611, USA
    Theor Popul Biol 76:68-76. 2009
    ..This multilocus model will be useful for studying the pattern and amount of genetic variation within and among populations to further infer the evolutionary history of a plant species...
  47. pmc Estimation of multilocus linkage disequilibria in diploid populations with dominant markers
    Yanchun Li
    School of Forestry and Biotechnology, Zhejiang Forestry University, Lin an, Zhejiang, People s Republic of China
    Genetics 176:1811-21. 2007
    ..This algorithm is useful for studying the pattern and amount of genetic variation within and among populations...
  48. pmc Sequencing complex diseases With HapMap
    Tian Liu
    Department of Statistics, University of Florida, Gainesville 32611, USA
    Genetics 168:503-11. 2004
    ..The implications and extensions of our model are discussed...
  49. ncbi request reprint Semiparametric functional mapping of quantitative trait loci governing long-term HIV dynamics
    Song Wu
    Department of Statistics, University of Florida, Gainesville, FL 32611, USA
    Bioinformatics 23:i569-76. 2007
    ..However, existing functional mapping cannot be used to map long-term HIV dynamics because no mathematical functions are available for later stages of HIV dynamic changes...
  50. ncbi request reprint Genetic mapping of allometric scaling laws
    Fei Long
    Department of Statistics, University of Florida, Gainesville, FL 32611, USA
    Genet Res 87:207-16. 2006
    ..This model has been validated by a real example for a mouse F2 progeny, in which two QTLs were detected on different chromosomes that determine the allometric relationship between growth rate and body weight...
  51. ncbi request reprint Identification of quantitative trait nucleotides that regulate cancer growth: a simulation approach
    Hongying Li
    Department of Statistics, University of Florida, Gainesville, FL 32611, USA
    J Theor Biol 242:426-39. 2006
    ..The proposed model provides a generic platform model for testing and detecting specific DNA sequence variants that regulates the timing of cancer emergence, growth and differentiation...
  52. ncbi request reprint A likelihood approach for mapping growth trajectories using dominant markers in a phase-unknown full-sib family
    C X Ma
    Department of Statistics, University of Florida, 533 McCarty Hall C, Gainesville, FL 32611, USA
    Theor Appl Genet 108:699-705. 2004
    ..The implications of this method for the understanding of the genetic architecture of growth using dominant markers are discussed...
  53. ncbi request reprint A bivalent polyploid model for linkage analysis in outcrossing tetraploids
    Rongling Wu
    Department of Statistics, University of Florida, Gainesville, Florida 32611, USA
    Theor Popul Biol 62:129-51. 2002
    ..The implications of this method for current genome projects in polyploid species are discussed...
  54. pmc A computational approach for functional mapping of quantitative trait loci that regulate thermal performance curves
    John Stephen Yap
    Department of Statistics, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 2:e554. 2007
    ..The model provides a conceptual platform for testing many ecologically relevant hypotheses regarding organismic adaptation within the Eco-Devo paradigm...
  55. ncbi request reprint A general model for detecting genetic determinants underlying longitudinal traits with unequally spaced measurements and nonstationary covariance structure
    Wei Hou
    Department of Statistics, University of Florida, Gainesville, FL 32611, USA
    Biostatistics 6:420-33. 2005
    ..Finally, we discuss the implications and extensions of our model for detecting QTL that affect growth trajectories...
  56. doi request reprint An algorithmic model for constructing a linkage and linkage disequilibrium map in outcrossing plant populations
    Jiahan Li
    Department of Statistics, University of Florida, Gainesville, FL 32611, USA
    Genet Res (Camb) 91:9-21. 2009
    ..By providing a number of testable hypotheses about population genetic parameters, this algorithmic model will open a broad gateway to understand the genetic structure and dynamics of an outcrossing population under natural selection...
  57. pmc A unified statistical model for functional mapping of environment-dependent genetic expression and genotype x environment interactions for ontogenetic development
    Wei Zhao
    Department of Statistics, University of Florida, Gainesville, Florida 32611, USA
    Genetics 168:1751-62. 2004
    ....
  58. ncbi request reprint Mapping genome-genome epistasis: a high-dimensional model
    Yuehua Cui
    Department of Statistics, University of Florida, Gainesville, FL 32611, USA
    Bioinformatics 21:2447-55. 2005
    ..For instance, each step in the development of seed for a higher plant is the consequence of gene interactions from the maternal, embryo and endosperm genomes...
  59. pmc A multilocus likelihood approach to joint modeling of linkage, parental diplotype and gene order in a full-sib family
    Qing Lu
    Department of Statistics, University of Florida, Gainesville, Florida 32611 USA
    BMC Genet 5:20. 2004
    ..Unlike a pedigree initiated with two inbred lines, a full-sib family derived from two outbred parents frequently has many different segregation types of markers whose linkage phases are not known prior to linkage analysis...
  60. ncbi request reprint A statistical model for functional mapping of quantitative trait loci regulating drug response
    Y Gong
    Department of Statistics, University of Florida, Gainesville, FL, USA
    Pharmacogenomics J 4:315-21. 2004
    ..Extensive simulations are performed to investigate the statistical properties of our model. The implications of our model in pharmacogenetic and pharmacogenomic research are discussed...
  61. ncbi request reprint Association between beta-adrenergic receptor polymorphisms and their G-protein-coupled receptors with body mass index and obesity in women: a report from the NHLBI-sponsored WISE study
    S G Terra
    Department of Pharmacy Practice, University of Florida College of Pharmacy, Gainesville, FL 32610, USA
    Int J Obes (Lond) 29:746-54. 2005
    ....
  62. doi request reprint A differential equation model for functional mapping of a virus-cell dynamic system
    Jiangtao Luo
    Department of Mathematics, University of Florida, Gainesville, FL 32611, USA
    J Math Biol 61:1-15. 2010
    ..With an increasing availability of genetic polymorphic data, the model will have great implications for probing the molecular genetic mechanism of virus dynamics and disease progression...
  63. pmc Nonparametric modeling of longitudinal covariance structure in functional mapping of quantitative trait loci
    John Stephen Yap
    Department of Statistics, University of Florida, Gainesville, Florida 32611, USA
    Biometrics 65:1068-77. 2009
    ..The new method will provide a useful tool for genome-wide scanning for the existence and distribution of quantitative trait loci underlying a dynamic trait important to agriculture, biology, and health sciences...
  64. pmc A statistical model for mapping morphological shape
    Guifang Fu
    Department of Statistics, Pennsylvania State University, University Park, PA 16802, USA
    Theor Biol Med Model 7:28. 2010
    ..Knowledge about the genetic mechanisms for biological shape has far-reaching implications for a range spectrum of scientific disciplines including anthropology, agriculture, developmental biology, evolution and biomedicine...
  65. doi request reprint Computing genetic imprinting expressed by haplotypes
    Yun Cheng
    Department of Statistics, University of Florida, Gainesville, FL, USA
    Methods Mol Biol 573:189-212. 2009
    ..The new model will be useful for characterizing the genetic architecture of complex quantitative traits at the nucleotide level...
  66. doi request reprint Candidate gene polymorphisms (BoIFNG, TLR4, SLC11A1) as risk factors for paratuberculosis infection in cattle
    Pablo J Pinedo
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610 0136, USA
    Prev Vet Med 91:189-96. 2009
    ....
  67. pmc Functional mapping of quantitative trait loci underlying the character process: a theoretical framework
    Chang Xing Ma
    Department of Statistics, University of Florida, Gainesville, Florida 32611, USA
    Genetics 161:1751-62. 2002
    ..The advantages of functional mapping are also discussed...
  68. ncbi request reprint Modeling sequence-sequence interactions for drug response
    Min Lin
    Department of Statistics, University of Florida, Gainesville, FL 32611, USA
    Bioinformatics 23:1251-7. 2007
    ..With the availability of large-scale, high-density single nucleotide polymorphism markers, a great challenge is how to associate haplotype structures and complex drug response through its underlying pharmacodynamic mechanisms...
  69. ncbi request reprint The extent and distribution of linkage disequilibrium in a multi-hierarchic outbred canine pedigree
    Xiang Yang Lou
    Department of Statistics, 533 McCarty Hall C, University of Florida, Gainesville, Florida 32611, USA
    Mamm Genome 14:555-64. 2003
    ..This study supports the appropriateness of linkage disequilibrium analysis to detect and map quantitative trait loci underlying complex traits in dogs...
  70. pmc A general statistical framework for mapping quantitative trait loci in nonmodel systems: issue for characterizing linkage phases
    Min Lin
    Department of Statistics, University of Florida, Gainesville, Florida 32611, USA
    Genetics 165:901-13. 2003
    ..Also, the probability of the linkage phase between this QTL and its flanking markers is estimated. The implications of our model and its extension to more general circumstances are discussed...
  71. ncbi request reprint Mechanistic mapping of ontogenetic growth based on biological principles
    Min Lin
    Department of Statistics, University of Florida, Gainesville, Florida 32611, USA
    Growth Dev Aging 69:31-7. 2005
    ..The model provides the basis for deciphering genetic relationships for growth rates and the timing of life history events for any kind of organisms...
  72. pmc A fast algorithm for functional mapping of complex traits
    Wei Zhao
    Department of Statistics, University of Florida, Gainesville, Florida 32611, USA
    Genetics 167:2133-7. 2004
    ..Moreover, because of its nonderivative nature and easy implementation with current software, the simplex algorithm enjoys an advantage over the EM algorithm in the dynamic modeling and analysis of complex traits...
  73. pmc Mapping quantitative trait Loci interactions from the maternal and offspring genomes
    Yuehua Cui
    Department of Statistics, University of Florida, Gainesville, 32611, USA
    Genetics 167:1017-26. 2004
    ..Our model provides a powerful means for studying the evolutionary significance of indirect genetic effects in any sexually reproductive organisms...
  74. doi request reprint Association between CARD15/NOD2 gene polymorphisms and paratuberculosis infection in cattle
    Pablo J Pinedo
    Department of Large Animal Clinical Sciences, University of Florida, FL, USA
    Vet Microbiol 134:346-52. 2009
    ..These data contribute to the understanding of paratuberculosis, suggest new similarities with Crohn's disease and provide new information for the control of bovine paratuberculosis...
  75. doi request reprint Score statistics for mapping quantitative trait loci
    Myron N Chang
    University of Florida, USA
    Stat Appl Genet Mol Biol 8:Article 16. 2009
    ..Therefore, the critical threshold for the score test can be used for the LR test also. A simple backcross design is used to demonstrate the application of the score test to QTL mapping...
  76. ncbi request reprint Multilocus linkage disequilibrium mapping of epistatic quantitative trait loci that regulate HIV dynamics: a simulation approach
    Song Wu
    Department of Statistics, University of Florida, Gainesville, FL 32611, U S A
    Stat Med 25:3826-49. 2006
    ..Simulation studies with different scenarios are performed to examine the statistical behaviour of the model. The genetic and statistical extensions of this mapping model to HIV/AIDS genomic research are discussed...
  77. pmc A computational model for sex-specific genetic architecture of complex traits in humans: implications for mapping pain sensitivity
    Chenguang Wang
    Department of Statistics, University of Florida, Gainesville, FL 32611 USA
    Mol Pain 4:13. 2008
    ..The model could have important implications for mapping complex trait genes and studying the detailed genetic architecture of sex-specific differences...
  78. doi request reprint A multilocus model for constructing a linkage disequilibrium map in human populations
    Qin Li
    University of Florida, USA
    Stat Appl Genet Mol Biol 8:Article 18. 2009
    ..The new strategy will provide a platform for studying the genetic control of inherited diseases in which genetic material is accurately copied before being passed onto the offspring from a parent...
  79. doi request reprint Nonparametric functional mapping of quantitative trait loci
    Jie Yang
    Genetics Institute, University of Florida, Gainesville, Florida 32611, USA
    Biometrics 65:30-9. 2009
    ..We consider two types of genetic maps: dense maps and general maps, and the power of nonparametric functional mapping is investigated through simulation studies and demonstrated by examples...
  80. doi request reprint Risk haplotype analysis for bovine paratuberculosis
    Pablo J Pinedo
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32611, USA
    Mamm Genome 20:124-9. 2009
    ..Marginally significant haplotypes were identified for the other two genes. The results obtained will provide scientific guidance about the selection and prediction of resistance types in bovines...
  81. ncbi request reprint FunMap: functional mapping of complex traits
    Chang Xing Ma
    Department of Statistics, 533 McCarty Hall C, University of Florida, Gainesville, FL 32611, USA
    Bioinformatics 20:1808-11. 2004
    ..AVAILABILITY: http://web.biostat.ufl.edu/~cma/genetics/software.html..
  82. pmc An improved genetic model generates high-resolution mapping of QTL for protein quality in maize endosperm
    Rongling Wu
    Department of Statistics, University of Florida, Gainesville, FL 32611, USA
    Proc Natl Acad Sci U S A 99:11281-6. 2002
    ..The increased resolution made possible with this approach makes identified QTL accessible to positional cloning...
  83. ncbi request reprint Thiopurine S-methyltransferase genotype predicts azathioprine-induced myelotoxicity in kidney transplant recipients
    Christine M Formea
    College of Pharmacy, Department of Nephrology, University of Florida, Gainesville, Florida, USA
    Am J Transplant 4:1810-7. 2004
    ..Prospective application of pharmacogenetic principles may assist in optimization of immunosuppressive drug therapy and minimize drug toxicities...
  84. ncbi request reprint Quantitative trait loci for hip dysplasia in a cross-breed canine pedigree
    Rory J Todhunter
    Department of Clinical Sciences, Box 32 College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    Mamm Genome 16:720-30. 2005
    ..Successful detection of QTL was due to the cross-breed pedigree, multiple-trait measurements, control of environmental background, and marked advancement in canine mapping tools...
  85. pmc Genetic mapping of developmental instability: design, model and algorithm
    Jiasheng Wu
    College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, Zhejiang 310029, People s Republic of China
    Genetics 176:1187-96. 2007
    ..A live example for poplar trees was used to map the QTL that control root length growth and its developmental instability from cuttings in water culture...
  86. ncbi request reprint A statistical model for dissecting genomic imprinting through genetic mapping
    Yuehua Cui
    Department of Statistics and Probability, Michigan State University, A 411 Wells Hall, East Lansing, MI 48824, USA
    Genetica 130:227-39. 2007
    ..Two partially maternal imprinting iQTL are identified which regulate the growth of body weight. Our approach provides a testable framework for identifying and estimating iQTL involved in the genetic control of complex traits...
  87. pmc Modeling extent and distribution of zygotic disequilibrium: implications for a multigenerational canine pedigree
    Tian Liu
    Department of Statistics, University of Florida, Gainesville, Florida 32611, USA
    Genetics 174:439-53. 2006
    ..The results from this study provide scientific guidance about the determination of the number of markers used for whole-genome association studies...
  88. ncbi request reprint Identification of quantitative trait loci that affect endoreduplication in maize endosperm
    Cintia M Coelho
    Department of Plant Sciences, Forbes Hall 303, University of Arizona, Tucson, AZ 85721, USA
    Theor Appl Genet 115:1147-62. 2007
    ..The results from this study shed light on the regulation of endoreduplication in maize endosperm and provide a marker-assisted selection strategy for potentially improving grain yield...
  89. pmc A semiparametric approach for composite functional mapping of dynamic quantitative traits
    Runqing Yang
    School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 200240, People s Republic of China
    Genetics 177:1859-70. 2007
    ..We used the new mapping approach to analyze a genetic mapping example in rice, leading to the identification of multiple QTL, some of which are linked on the same chromosome, that control the developmental trajectory of leaf age...
  90. pmc A conceptual framework for mapping quantitative trait Loci regulating ontogenetic allometry
    Hongying Li
    Department of Statistics, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 2:e1245. 2007
    ..The statistical model proposed will help to study the genetic architecture of complex phenotypes and, therefore, gain better insights into the mechanistic regulation for developmental patterns and processes in organisms...
  91. doi request reprint Nonparametric functional mapping of quantitative trait loci underlying programmed cell death
    Yuehua Cui
    Michigan State University, USA
    Stat Appl Genet Mol Biol 7:Article4. 2008
    ..The developed model provides a quantitative and testable framework for assessing the interplay between genes and the developmental PCD process, and will have great implications for elucidating the genetic architecture of the PCD process...
  92. pmc A statistical model for testing the pleiotropic control of phenotypic plasticity for a count trait
    Chang Xing Ma
    Department of Biostatistics, University at Buffalo, SUNY, Buffalo, NY 14214, USA
    Genetics 179:627-36. 2008
    ..This model will provide insights into how genomes and environments interact to determine the phenotypes of complex count traits...
  93. ncbi request reprint Functional mapping of reaction norms to multiple environmental signals
    Jiasheng Wu
    College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, Zhejiang, PR China
    Genet Res 89:27-38. 2007
    ....