Qiuqian Wu

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi 5-azacytidine alters TGF-beta and BMP signaling and induces maturation in articular chondrocytes
    Michael J Zuscik
    Center for Musculoskeletal Research, Department of Orthopaedics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Cell Biochem 92:316-31. 2004
  2. ncbi Overexpression of Smurf2 stimulates endochondral ossification through upregulation of beta-catenin
    Qiuqian Wu
    Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, New York 14642, USA
    J Bone Miner Res 23:552-63. 2008
  3. ncbi Regulation of embryonic endochondral ossification by Smurf2
    Qiuqian Wu
    Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, New York 14642, USA
    J Orthop Res 26:704-12. 2008
  4. ncbi Smurf2 induces degradation of GSK-3beta and upregulates beta-catenin in chondrocytes: a potential mechanism for Smurf2-induced degeneration of articular cartilage
    Qiuqian Wu
    Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Exp Cell Res 315:2386-98. 2009
  5. ncbi Induction of an osteoarthritis-like phenotype and degradation of phosphorylated Smad3 by Smurf2 in transgenic mice
    Qiuqian Wu
    Department of Orthopaedics, University of Rochester Medical Center, Rochester, New York 14642, USA
    Arthritis Rheum 58:3132-44. 2008
  6. ncbi Beta-catenin, cartilage, and osteoarthritis
    Qiuqian Wu
    Department of Orthopaedics and Rehabilitation, Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Ann N Y Acad Sci 1192:344-50. 2010
  7. ncbi Activation of beta-catenin signaling in articular chondrocytes leads to osteoarthritis-like phenotype in adult beta-catenin conditional activation mice
    Mei Zhu
    Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester School of Medicine, Rochester, New York 14642, USA
    J Bone Miner Res 24:12-21. 2009
  8. ncbi Transforming growth factor-beta stimulates cyclin D1 expression through activation of beta-catenin signaling in chondrocytes
    Tian Fang Li
    Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester, New York 14642, USA
    J Biol Chem 281:21296-304. 2006
  9. ncbi Inhibition of beta-catenin signaling in articular chondrocytes results in articular cartilage destruction
    Mei Zhu
    University of Rochester, Rochester, New York 14642, USA
    Arthritis Rheum 58:2053-64. 2008

Collaborators

Detail Information

Publications9

  1. ncbi 5-azacytidine alters TGF-beta and BMP signaling and induces maturation in articular chondrocytes
    Michael J Zuscik
    Center for Musculoskeletal Research, Department of Orthopaedics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Cell Biochem 92:316-31. 2004
    ....
  2. ncbi Overexpression of Smurf2 stimulates endochondral ossification through upregulation of beta-catenin
    Qiuqian Wu
    Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, New York 14642, USA
    J Bone Miner Res 23:552-63. 2008
    ..The mechanism underlying Smurf2-mediated morphological changes during embryonic development may provide new mechanistic insights and potential targets for prevention and treatment of human osteoarthritis...
  3. ncbi Regulation of embryonic endochondral ossification by Smurf2
    Qiuqian Wu
    Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, New York 14642, USA
    J Orthop Res 26:704-12. 2008
    ....
  4. ncbi Smurf2 induces degradation of GSK-3beta and upregulates beta-catenin in chondrocytes: a potential mechanism for Smurf2-induced degeneration of articular cartilage
    Qiuqian Wu
    Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Exp Cell Res 315:2386-98. 2009
    ....
  5. ncbi Induction of an osteoarthritis-like phenotype and degradation of phosphorylated Smad3 by Smurf2 in transgenic mice
    Qiuqian Wu
    Department of Orthopaedics, University of Rochester Medical Center, Rochester, New York 14642, USA
    Arthritis Rheum 58:3132-44. 2008
    ..To determine whether Smurf2, an E3 ubiquitin ligase known to inhibit transforming growth factor beta (TGFbeta) signaling, is expressed in human osteoarthritic (OA) cartilage and can initiate OA in mice...
  6. ncbi Beta-catenin, cartilage, and osteoarthritis
    Qiuqian Wu
    Department of Orthopaedics and Rehabilitation, Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Ann N Y Acad Sci 1192:344-50. 2010
    ..These findings indicate that beta-catenin plays a central role in articular cartilage function and that activation of beta-catenin signaling may represent a pathologic mechanism for OA development...
  7. ncbi Activation of beta-catenin signaling in articular chondrocytes leads to osteoarthritis-like phenotype in adult beta-catenin conditional activation mice
    Mei Zhu
    Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester School of Medicine, Rochester, New York 14642, USA
    J Bone Miner Res 24:12-21. 2009
    ..This study provides direct and definitive evidence about the role of beta-catenin in the development of OA...
  8. ncbi Transforming growth factor-beta stimulates cyclin D1 expression through activation of beta-catenin signaling in chondrocytes
    Tian Fang Li
    Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester, New York 14642, USA
    J Biol Chem 281:21296-304. 2006
    ..These results demonstrate that TGF-beta stimulates cyclin D(1) expression at least in part through activation of beta-catenin signaling...
  9. ncbi Inhibition of beta-catenin signaling in articular chondrocytes results in articular cartilage destruction
    Mei Zhu
    University of Rochester, Rochester, New York 14642, USA
    Arthritis Rheum 58:2053-64. 2008
    ..To determine the role of beta-catenin signaling in articular chondrocyte function, we generated Col2a1-ICAT-transgenic mice to inhibit beta-catenin signaling in chondrocytes...