J C Wu
Affiliation: University of California
- The effect of sleep deprivation on cerebral glucose metabolic rate in normal humans assessed with positron emission tomographyJ C Wu
University of California, Irvine
Sleep 14:155-62. 1991....
- A PET study of the pathophysiology of negative symptoms in schizophrenia. Positron emission tomographySteven G Potkin
Department of Psychiatry and Human Behavior, University of California, Irvine 92697 3960, USA
Am J Psychiatry 159:227-37. 2002....
- Molecular imaging of embryonic stem cell misbehavior and suicide gene ablationFeng Cao
The Department of Radiology and Bio X Program, Stanford University School of Medicine, Stanford, California 94305 5344, USA
Cloning Stem Cells 9:107-17. 2007....
- Sleep deprivation PET correlations of Hamilton symptom improvement ratings with changes in relative glucose metabolism in patients with depressionJoseph C Wu
UC Irvine Department of Psychiatry and Human Behavior, Irvine, California 92697 3960, United States
J Affect Disord 107:181-6. 2008..In addition, we also studied the effect of concomitant antidepressant medication in conjunction with sleep depression...
- Rapid and sustained antidepressant response with sleep deprivation and chronotherapy in bipolar disorderJoseph C Wu
Department of Psychiatry and Human Behavior, University of California at Irvine School of Medicine, Room 109, Irvine Hall, Irvine, CA 92697 3960, USA
Biol Psychiatry 66:298-301. 2009..This study evaluates the combined efficacy of three established circadian-related treatments (SD, bright light [BL]), sleep phase advance [SPA]) as adjunctive treatment to lithium and antidepressants...
- Frontal lobe metabolic decreases with sleep deprivation not totally reversed by recovery sleepJoseph C Wu
UC Irvine Department of Psychiatry and Human Behavior, Irvine, CA, USA
Neuropsychopharmacology 31:2783-92. 2006..Recovery sleep was found to have only a partial restorative effect on frontal lobe function with minimal reversal of subcortical deficits. Sleep may be especially important for maintenance of frontal lobe activity...
- Prediction of antidepressant effects of sleep deprivation by metabolic rates in the ventral anterior cingulate and medial prefrontal cortexJ Wu
Department of Psychiatry and Human Behavior, College of Medicine, University of California, Irvine 92717, USA
Am J Psychiatry 156:1149-58. 1999..The authors extend their earlier work in a larger group of patients and explore additional brain areas with statistical probability mapping...
- Clinical neurochemical implications of sleep deprivation's effects on the anterior cingulate of depressed respondersJ C Wu
Department of Psychiatry, University of California, Irvine 92717, USA
Neuropsychopharmacology 25:S74-8. 2001..The neurochemical implications of these findings are explored. Possible dopaminergic and serotonergic mechanisms are discussed...
- Effects of amoxapine and imipramine on evoked potentials in the Continuous Performance Test in patients with affective disorderM S Buchsbaum
Department of Psychiatry, University of California, Irvine
Neuropsychobiology 20:15-22. 1988..CPT performance was significantly better on amoxapine than placebo...
- Brain metabolic and clinical effects of rivastigmine in Alzheimer's diseaseS G Potkin
Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92627 3960, USA
Int J Neuropsychopharmacol 4:223-30. 2001..Rivastigmine prevented the expected deterioration in clinical status and dramatically increased brain metabolic activity in a majority of patients...
- The relationship of respiratory and cardiovascular hospital admissions to the southern California wildfires of 2003R J Delfino
Epidemiology Department, School of Medicine, University of California Irvine, 100 Theory Drive, Irvine, CA 92617 7555, USA
Occup Environ Med 66:189-97. 2009..The relationship of cardiorespiratory hospital admissions (n = 40 856) to wildfire-related particulate matter (PM(2.5)) during catastrophic wildfires in southern California in October 2003 was evaluated...
- Sleep deprivation as a model experimental antidepressant treatment: findings from functional brain imagingJ C Gillin
Department of Psychiatry, UCSD and VA San Diego Healthcare System 116a, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
Depress Anxiety 14:37-49. 2001..Finally, a SPECT study using a radioactively labeled D2 receptor antagonist suggests that the antidepressant benefits of sleep deprivation are correlated with endogenous release of dopamine...
- D1 receptor alleles predict PET metabolic correlates of clinical response to clozapineS G Potkin
Department of Psychiatry and Human Behavior, University of Caliornia, Irvine 92697 3960, USA
Mol Psychiatry 8:109-13. 2003..05). In this preliminary study, brain metabolic and clinical response to clozapine are related to the D1 receptor genotype...
- Neural correlates of STN DBS-induced cognitive variability in Parkinson diseaseM C Campbell
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, United States
Neuropsychologia 46:3162-9. 2008..The purpose of this study was to determine the neural correlates of STN DBS-induced variability in cognitive performance...
- Positron emission tomography with deoxyglucose-F18 imaging of sleepM S Buchsbaum
Neuroscience PET Laboratory, Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
Neuropsychopharmacology 25:S50-6. 2001..Compared with REM sleep, nonREM sleep was associated with significantly lower metabolic rates in the temporal and occipital regions, as well as the thalamus...
- Localized and lateralized cerebral glucose metabolism associated with eye movements during REM sleep and wakefulness: a positron emission tomography (PET) studyC C Hong
Department of Psychiatry, University of California, San Diego, La Jolla 92093-0603, USA
Sleep 18:570-80. 1995..Our data also suggest right hemispheric specialization in saccadic eye movement control and reciprocal inhibition in the contralateral homologous area during higher cortical functioning...
- Expression of the human integrin beta6 subunit in alveolar type II cells and bronchiolar epithelial cells reverses lung inflammation in beta6 knockout miceX Huang
Lung Biology Center, and the Department of Medicine, University of California, San Francisco, USA
Am J Respir Cell Mol Biol 19:636-42. 1998....
- Brightening depressionAnna Wirz-Justice
Science 303:467-9. 2004
- Positron emission tomography imaging of conditional gene activation in the heartGwendolen Y Chang
The Molecular Imaging Program at Stanford MIPS and Department of Radiology, Stanford University, Palo Alto, CA, USA
J Mol Cell Cardiol 43:18-26. 2007..With further development and validation, PET imaging will likely play an important role in the noninvasive, repetitive, and quantitative measurement of conditional gene activation in the future...
- Reporter gene imaging following percutaneous delivery in swine moving toward clinical applicationsMartin Rodriguez-Porcel
J Am Coll Cardiol 51:595-7. 2008
- Imaging of VEGF receptor in a rat myocardial infarction model using PETMartin Rodriguez-Porcel
Molecular Imaging Program at Stanford, Department of Radiology, Division of Nuclear Medicine, Stanford University, Stanford, CA 94305 5427, USA
J Nucl Med 49:667-73. 2008..We have developed a PET tracer (64Cu-DOTA-VEGF121 [DOTA is 1,4,7,10-tetraazadodecane-N,N',N'',N'''-tetraacetic acid]) to image VEGF receptor (VEGFR) expression after MI in the living subject...
- Can radionuclide imaging predict future response to stem cell therapy?Joseph C Wu
J Nucl Cardiol 15:308-10. 2008
- Intracellular and extracellular targets of molecular imaging in the myocardiumHyung J Chun
Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305 5344, USA
Nat Clin Pract Cardiovasc Med 5:S33-41. 2008..Further development of these imaging targets may lead to improved characterization of disease processes and guide provision of individualized therapies...
- Noninvasive radionuclide imaging of cardiac gene therapy: progress and potentialAsimina Hiona
Department of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, CA 94305 5344, USA
Nat Clin Pract Cardiovasc Med 5:S87-95. 2008..We discuss limitations of current methods for analyzing gene transfer and describe how reporter gene imaging works...
- Clinical hurdles for the transplantation of cardiomyocytes derived from human embryonic stem cells: role of molecular imagingRutger Jan Swijnenburg
Molecular Imaging Program at Stanford, Department of Radiology, Stanford University, Stanford, California, USA
Curr Opin Biotechnol 18:38-45. 2007..Therefore, molecular imaging is expected to play an increasing role in characterizing the biology and physiology of hESC-derived cardiac cells in living subjects...
- Positron emission tomography imaging of cardiac reporter gene expression in living ratsJoseph C Wu
Crump Institute for Molecular Imaging, UCLA School of Medicine, Los Angeles, Calif 90095-1770, USA
Circulation 106:180-3. 2002..The presence of [18F]-FHBG uptake is confirmed by gamma counting and the presence of HSV1-sr39TK protein by thymidine kinase enzyme assay. Cardiac reporter gene imaging by PET may eventually be applied toward human gene therapy studies...
- Positron-emission tomography reporter gene expression imaging in rat myocardiumMasayuki Inubushi
Department of Molecular and Medical Pharmacology, The Crump Institute for Molecular Imaging, University of California, Los Angeles 90095-1735, USA
Circulation 107:326-32. 2003..Cardiac PET reporter gene imaging offers the potential of monitoring the expression of therapeutic genes in cardiac gene therapy...
- Molecular imaging of cardiac cell transplantation in living animals using optical bioluminescence and positron emission tomographyJoseph C Wu
Department of Molecular and Medical Pharmacology and Crump Institute for Molecular Imaging, UCLA School of Medicine, Los Angeles, Calif, USA
Circulation 108:1302-5. 2003..With further development, molecular imaging studies should add critical insights into cardiac cell transplantation biology...
- Molecular imaging of the kinetics of vascular endothelial growth factor gene expression in ischemic myocardiumJoseph C Wu
Department of Molecular and Medical Pharmacology, the Crump Institute of Molecular Imaging, UCLA School of Medicine, Los Angeles, Calif, USA
Circulation 110:685-91. 2004..The principles demonstrated here can be used to evaluate other therapeutic genes of interest in animal models before future clinical trials are initiated...
- Human gene therapy and imaging: cardiologyJoseph C Wu
Department of Medicine, Division of Cardiology, Stanford University School of Medicine, Edwards Building, Room R354, Stanford, CA 94305 5344, USA
Eur J Nucl Med Mol Imaging 32:S346-57. 2005....
- Imaging chemically modified adenovirus for targeting tumors expressing integrin alphavbeta3 in living mice with mutant herpes simplex virus type 1 thymidine kinase PET reporter geneZhengming Xiong
Molecular Imaging Program at Stanford, MIPS, Department of Radiology, Stanford University School of Medicine, California 94305 5484, USA
J Nucl Med 47:130-9. 2006....
- In vivo visualization of embryonic stem cell survival, proliferation, and migration after cardiac deliveryFeng Cao
Department of Radiology, Bio-X Program, Stanford University School of Medicine, Stanford, CA 94305-5344, USA
Circulation 113:1005-14. 2006..This versatile imaging platform should have broad applications for basic research and clinical studies on stem cell therapy...
- 18F-labeled bombesin analogs for targeting GRP receptor-expressing prostate cancerXianzhong Zhang
Molecular Imaging Program at Stanford (MIPS, Department of Radiology and Bio-X Program, Stanford University School of Medicine, Stanford, California 94305-5484, USA
J Nucl Med 47:492-501. 2006..CONCLUSION: This study demonstrates that 18F-FB-[Lys3]BBN and PET are suitable for detecting GRPR-positive prostate cancer in vivo...
- Molecular imaging of cardiac stem cell transplantationAhmad Y Sheikh
Department of Medicine, Division of Cardiology and Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Edwards Building, Room R-354, Stanford, CA 94305-5324, USA
Curr Cardiol Rep 8:147-54. 2006..This article provides a focused overview of clinical stem cell therapy for the heart, followed by a discussion of how novel molecular imaging techniques are presently being applied to monitor cell therapy...
- Transcriptional profiling of reporter genes used for molecular imaging of embryonic stem cell transplantationJoseph C Wu
Division of Cardiology, Department of Medicine, Stanford University School of Medicine, Stanford, USA
Physiol Genomics 25:29-38. 2006..Taken together, this is the first study to analyze in detail the effects of reporter genes on molecular imaging of ES cells...