Hsiao Ming Wu

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi In vivo quantitation of glucose metabolism in mice using small-animal PET and a microfluidic device
    Hsiao Ming Wu
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095 6948, USA
    J Nucl Med 48:837-45. 2007
  2. ncbi Measurement of the global lumped constant for 2-deoxy-2-[18F]fluoro-D-glucose in normal human brain using [15O]water and 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography imaging. A method with validation based on multiple methodologies
    Hsiao Ming Wu
    Department of Molecular and Medical Pharmacology, UCLA DOE Center for Molecular Medicine, Los Angeles, CA 90095, USA
    Mol Imaging Biol 5:32-41. 2003
  3. ncbi Selective metabolic reduction in gray matter acutely following human traumatic brain injury
    Hsiao Ming Wu
    Department of Molecular and Medical Pharmacology, UCLA Brain Injury Research Center, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Neurotrauma 21:149-61. 2004
  4. ncbi Acute changes in regional cerebral (18)F-FDG kinetics in patients with traumatic brain injury
    Naoya Hattori
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095 6948, USA
    J Nucl Med 45:775-83. 2004
  5. ncbi Correlation of regional metabolic rates of glucose with glasgow coma scale after traumatic brain injury
    Naoya Hattori
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Nucl Med 44:1709-16. 2003
  6. ncbi Subcortical white matter metabolic changes remote from focal hemorrhagic lesions suggest diffuse injury after human traumatic brain injury
    Hsiao Ming Wu
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095 6901, USA
    Neurosurgery 55:1306-15; discussio 1316-7. 2004
  7. ncbi Accuracy of a method using short inhalation of (15)O-O(2) for measuring cerebral oxygen extraction fraction with PET in healthy humans
    Naoya Hattori
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Nucl Med 45:765-70. 2004
  8. ncbi Investigation of a new input function validation approach for dynamic mouse microPET studies
    Sung Cheng Huang
    Department of Molecular and Medical Pharmacology, UCLA David Geffen School of Medicine University of California Los Angeles, Los Angeles, CA, USA
    Mol Imaging Biol 6:34-46. 2004
  9. ncbi Metabolic crisis without brain ischemia is common after traumatic brain injury: a combined microdialysis and positron emission tomography study
    Paul Vespa
    1David Geffen School of Medicine at UCLA, UCLA Medical Center, University of California, Los Angeles, 90095, USA
    J Cereb Blood Flow Metab 25:763-74. 2005
  10. ncbi Noninvasive measurement of cardiovascular function in mice with high-temporal-resolution small-animal PET
    Michael C Kreissl
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, California, USA
    J Nucl Med 47:974-80. 2006

Detail Information

Publications19

  1. ncbi In vivo quantitation of glucose metabolism in mice using small-animal PET and a microfluidic device
    Hsiao Ming Wu
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095 6948, USA
    J Nucl Med 48:837-45. 2007
    ..Difficulties associated with the conventional blood-sampling procedure need to be overcome to facilitate the full use of this technique in mice...
  2. ncbi Measurement of the global lumped constant for 2-deoxy-2-[18F]fluoro-D-glucose in normal human brain using [15O]water and 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography imaging. A method with validation based on multiple methodologies
    Hsiao Ming Wu
    Department of Molecular and Medical Pharmacology, UCLA DOE Center for Molecular Medicine, Los Angeles, CA 90095, USA
    Mol Imaging Biol 5:32-41. 2003
    ....
  3. ncbi Selective metabolic reduction in gray matter acutely following human traumatic brain injury
    Hsiao Ming Wu
    Department of Molecular and Medical Pharmacology, UCLA Brain Injury Research Center, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Neurotrauma 21:149-61. 2004
    ..There was a selective CMRglc reduction in cortical GM following TBI. The pathophysiological basis for the reduction in GM-to-WM CMRglc ratio seen on FDG-PET imaging following TBI remains to be determined...
  4. ncbi Acute changes in regional cerebral (18)F-FDG kinetics in patients with traumatic brain injury
    Naoya Hattori
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095 6948, USA
    J Nucl Med 45:775-83. 2004
    ..The purpose of this study was to characterize contusional, pericontusional, and remote regions of TBI by estimating glucose transporter and hexokinase activities on the basis of (18)F-FDG kinetic modeling...
  5. ncbi Correlation of regional metabolic rates of glucose with glasgow coma scale after traumatic brain injury
    Naoya Hattori
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Nucl Med 44:1709-16. 2003
    ..Therefore, thalamic and brain stem CMRglc may have a closer correlation than does the cerebral cortex with depth of coma after TBI...
  6. ncbi Subcortical white matter metabolic changes remote from focal hemorrhagic lesions suggest diffuse injury after human traumatic brain injury
    Hsiao Ming Wu
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095 6901, USA
    Neurosurgery 55:1306-15; discussio 1316-7. 2004
    ..The objective was to determine the nature, extent, and degree of metabolic abnormalities in subcortical brain regions remote from hemorrhagic lesions...
  7. ncbi Accuracy of a method using short inhalation of (15)O-O(2) for measuring cerebral oxygen extraction fraction with PET in healthy humans
    Naoya Hattori
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Nucl Med 45:765-70. 2004
    ..The purpose of this study was to test the accuracy of the short-inhalation technique for estimating OEF in healthy human volunteers...
  8. ncbi Investigation of a new input function validation approach for dynamic mouse microPET studies
    Sung Cheng Huang
    Department of Molecular and Medical Pharmacology, UCLA David Geffen School of Medicine University of California Los Angeles, Los Angeles, CA, USA
    Mol Imaging Biol 6:34-46. 2004
    ..We introduced the theoretical basis and used computer simulations to show the capability of a new approach that requires only a small number of blood samples per mouse but uses multiple animals...
  9. ncbi Metabolic crisis without brain ischemia is common after traumatic brain injury: a combined microdialysis and positron emission tomography study
    Paul Vespa
    1David Geffen School of Medicine at UCLA, UCLA Medical Center, University of California, Los Angeles, 90095, USA
    J Cereb Blood Flow Metab 25:763-74. 2005
    ..001), but not with OEF or CvO(2). Traumatic brain injury leads to a state of persistent metabolic crisis as reflected by abnormal cerebral microdialysis LPR that is not related to ischemia...
  10. ncbi Noninvasive measurement of cardiovascular function in mice with high-temporal-resolution small-animal PET
    Michael C Kreissl
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, California, USA
    J Nucl Med 47:974-80. 2006
    ..The aim of this study was to explore the feasibility of determining parameters of cardiovascular function in mice noninvasively by high-temporal-resolution imaging with a dedicated small-animal PET system...
  11. pmc Quantification of cerebral glucose metabolic rate in mice using 18F-FDG and small-animal PET
    Amy S Yu
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California 90095 6948, USA
    J Nucl Med 50:966-73. 2009
    ..The feasibility of using the image-derived liver time-activity curve as a surrogate input function in various quantification methods was also evaluated...
  12. pmc Redefining the pericontusional penumbra following traumatic brain injury: evidence of deteriorating metabolic derangements based on positron emission tomography
    Hsiao Ming Wu
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095 7039, USA
    J Neurotrauma 30:352-60. 2013
    ..68) with time after injury. A large proportion (%area: 22-76%) of pericontusional hypodense GM tissue had CMRO2 values less than 35 μmol/100 g/min, with this percentage increased with time after injury...
  13. pmc An internet-based "kinetic imaging system" (KIS) for MicroPET
    Sung Cheng Huang
    Department of Molecular and Medical Pharmacology, UCLA David Geffen School of Medicine, University of California in Los Angeles, CA 90095, USA
    Mol Imaging Biol 7:330-41. 2005
    ..KIS is designed for biology/pharmaceutical scientists to make learning and applying tracer kinetics fun and easy...
  14. pmc Influence of dietary state and insulin on myocardial, skeletal muscle and brain [F]-fluorodeoxyglucose kinetics in mice
    Michael C Kreissl
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    EJNMMI Res 1:8. 2011
    ..We evaluated the effect of insulin stimulation and dietary changes on myocardial, skeletal muscle and brain [(18)F]-fluorodeoxyglucose (FDG) kinetics and uptake in vivo in intact mice...
  15. ncbi Semiautomated analysis of small-animal PET data
    Adam L Kesner
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California 90095 6942, USA
    J Nucl Med 47:1181-6. 2006
    ..The objective of the work reported here was to develop and test automated methods to calculate biodistribution of PET tracers using small-animal PET images...
  16. ncbi Imaging beta-amyloid fibrils in Alzheimer's disease: a critical analysis through simulation of amyloid fibril polymerization
    Kooresh Shoghi-Jadid
    Department of Biomathematics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1766, USA
    Nucl Med Biol 32:337-51. 2005
    ....
  17. pmc Estimation of the 18F-FDG input function in mice by use of dynamic small-animal PET and minimal blood sample data
    Gregory Z Ferl
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, California 90095 6948, USA
    J Nucl Med 48:2037-45. 2007
    ..We sought to develop a method for plasma time-activity curve estimation based on a model of tracer kinetics in blood, muscle, and liver...
  18. ncbi Differential cerebral metabolic changes with paroxetine treatment of obsessive-compulsive disorder vs major depression
    Sanjaya Saxena
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, 300 UCLA Medical Plaza, Room 2229, Los Angeles, CA 90095, USA
    Arch Gen Psychiatry 59:250-61. 2002
    ....
  19. pmc Titration of variant HSV1-tk gene expression to determine the sensitivity of 18F-FHBG PET imaging in a prostate tumor
    Mai Johnson
    Department of Molecular, Cellular and Integrative Physiology, UCLA, Los Angeles, CA, USA
    J Nucl Med 50:757-64. 2009
    ..Addressing this question could determine the sensitivity of vector-mediated sr39tk PET in cancer-targeting strategies...

Research Grants1

  1. Small Animal In vivo quantification of cerebral glucose metabolic rate
    Christine Wu; Fiscal Year: 2008
    ..Upon completion of this project a new imaging tool will be available to researchers to study brain function under physiologically stable conditions with minimal radiation exposure. ..