Gary Wu

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi High-level expression of I kappa B-beta in the surface epithelium of the colon: in vitro evidence for an immunomodulatory role
    G D Wu
    Department of Internal Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104 6144, USA
    J Leukoc Biol 66:1049-56. 1999
  2. ncbi Sampling and pyrosequencing methods for characterizing bacterial communities in the human gut using 16S sequence tags
    Gary D Wu
    Division of Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6076 USA
    BMC Microbiol 10:206. 2010
  3. ncbi Linking long-term dietary patterns with gut microbial enterotypes
    Gary D Wu
    Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 334:105-8. 2011
  4. ncbi Evidence for epigenetic mechanisms that silence both basal and immune-stimulated transcription of the IL-8 gene
    X Wen
    Division of Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 166:7290-9. 2001
  5. ncbi Activation of RegIIIbeta/gamma and interferon gamma expression in the intestinal tract of SCID mice: an innate response to bacterial colonisation of the gut
    S A Keilbaugh
    Division of Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia, USA
    Gut 54:623-9. 2005
  6. ncbi A family of tissue-specific resistin-like molecules
    C M Steppan
    Division of Endocrinology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 98:502-6. 2001
  7. ncbi Nuclear hormone receptors and intestinal inflammation
    Gary D Wu
    Gastroenterology 133:1068. 2007
  8. ncbi Rosiglitazone for active ulcerative colitis: a randomized placebo-controlled trial
    James D Lewis
    Division of Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Gastroenterology 134:688-95. 2008

Research Grants

  1. IMMUNE MODULATION BY INTESTINAL CELL DIFFERENTIATION
    Gary Wu; Fiscal Year: 2004
  2. IMMUNE MODULATION BY INTESTINAL CELL DIFFERENTIATION
    Gary Wu; Fiscal Year: 2009
  3. EPITHELIAL GENE TRANSCRIPTION IN INTESTINAL PATHOLOGY
    Gary Wu; Fiscal Year: 2002
  4. IMMUNE MODULATION BY INTESTINAL CELL DIFFERENTIATION
    Gary Wu; Fiscal Year: 1999
  5. Regulation of Host Nitrogen Balance by the Gut Microbiome
    Gary D Wu; Fiscal Year: 2010

Collaborators

Detail Information

Publications8

  1. ncbi High-level expression of I kappa B-beta in the surface epithelium of the colon: in vitro evidence for an immunomodulatory role
    G D Wu
    Department of Internal Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104 6144, USA
    J Leukoc Biol 66:1049-56. 1999
    ..Therefore, the expression of IkappaB-beta in the differentiated surface epithelium of the colon may help these cells act as an immunological barrier to prevent activation of the mucosal immune system...
  2. ncbi Sampling and pyrosequencing methods for characterizing bacterial communities in the human gut using 16S sequence tags
    Gary D Wu
    Division of Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6076 USA
    BMC Microbiol 10:206. 2010
    ....
  3. ncbi Linking long-term dietary patterns with gut microbial enterotypes
    Gary D Wu
    Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 334:105-8. 2011
    ..Thus, alternative enterotype states are associated with long-term diet...
  4. ncbi Evidence for epigenetic mechanisms that silence both basal and immune-stimulated transcription of the IL-8 gene
    X Wen
    Division of Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 166:7290-9. 2001
    ..Epigenetic silencing of cytokine gene transcription through distant genomic elements is an important level of gene regulation that may be relevant to the pathogenesis of immunologic disease states...
  5. ncbi Activation of RegIIIbeta/gamma and interferon gamma expression in the intestinal tract of SCID mice: an innate response to bacterial colonisation of the gut
    S A Keilbaugh
    Division of Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia, USA
    Gut 54:623-9. 2005
    ..These innate immune responses may play a role in the pathogenesis of colitis in SCID adoptive transfer models in mice and possibly in patients with IBD...
  6. ncbi A family of tissue-specific resistin-like molecules
    C M Steppan
    Division of Endocrinology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 98:502-6. 2001
    ..Resistin and the RELMs share a cysteine composition and other signature features. Thus, the RELMs together with resistin comprise a class of tissue-specific signaling molecules...
  7. ncbi Nuclear hormone receptors and intestinal inflammation
    Gary D Wu
    Gastroenterology 133:1068. 2007
  8. ncbi Rosiglitazone for active ulcerative colitis: a randomized placebo-controlled trial
    James D Lewis
    Division of Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Gastroenterology 134:688-95. 2008
    ..Thiazolidinedione ligands for the gamma subtype of peroxisome proliferator-activated receptors (PPARgamma), widely used to treat type 2 diabetes mellitus, have been proposed as novel therapies for ulcerative colitis (UC)...

Research Grants20

  1. IMMUNE MODULATION BY INTESTINAL CELL DIFFERENTIATION
    Gary Wu; Fiscal Year: 2004
    ..Ultimately, the studies described in this grant proposal may provide novel insights into mechanisms by which nuclear hormone receptors and their ligands modulate the intestinal inflammatory response. ..
  2. IMMUNE MODULATION BY INTESTINAL CELL DIFFERENTIATION
    Gary Wu; Fiscal Year: 2009
    ..These studies will provide novel insights into the mechanisms by which nutrition affects metabolic and immunologic responses to intestinal parasitic infections. ..
  3. EPITHELIAL GENE TRANSCRIPTION IN INTESTINAL PATHOLOGY
    Gary Wu; Fiscal Year: 2002
    ..Ultimately, once the mechanisms by which DRA gene transcription is regulated in the normal colon have been elucidated, DRA may be a useful model with which to investigate how gene expression is altered in pathobiology. ..
  4. IMMUNE MODULATION BY INTESTINAL CELL DIFFERENTIATION
    Gary Wu; Fiscal Year: 1999
    ..Finally, to ascertain cis-acting elements by Dnase 1 footprinting, electrophoretic mobility shift assay and site directed mutagenesis in chimeric and minigene constructs of the IL-8 gene. ..
  5. Regulation of Host Nitrogen Balance by the Gut Microbiome
    Gary D Wu; Fiscal Year: 2010
    ....