Gang Wu

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi request reprint Direct detection of potassium cations bound to G-quadruplex structures by solid-state 39K NMR at 19.6 T
    Gang Wu
    Department of Chemistry, Queen s University, Kingston, Ontario, Canada K7L 3N6
    J Am Chem Soc 125:7182-3. 2003
  2. doi request reprint Integrative analyses of posttranscriptional regulation in the yeast Saccharomyces cerevisiae using transcriptomic and proteomic data
    Gang Wu
    Department of Molecular Micriobiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Curr Microbiol 57:18-22. 2008
  3. ncbi request reprint The Synthetic Gene Designer: a flexible web platform to explore sequence manipulation for heterologous expression
    Gang Wu
    Department of Biological Sciences, University of Maryland at Baltimore County, 21250, USA
    Protein Expr Purif 47:441-5. 2006
  4. ncbi request reprint Simplified gene synthesis: a one-step approach to PCR-based gene construction
    Gang Wu
    Applied Molecular Biology Laboratory, Department of Biological Sciences, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA
    J Biotechnol 124:496-503. 2006
  5. ncbi request reprint The effects of differential gene expression on coding sequence features: analysis by one-way ANOVA
    Gang Wu
    Department of Biological Sciences, University of Maryland at Baltimore County, Baltimore, MD 21250, USA
    Biochem Biophys Res Commun 358:1108-13. 2007
  6. pmc SGDB: a database of synthetic genes re-designed for optimizing protein over-expression
    Gang Wu
    Department of Biological Sciences, University of Maryland at Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21229, USA
    Nucleic Acids Res 35:D76-9. 2007
  7. ncbi request reprint Relation between mRNA expression and sequence information in Desulfovibrio vulgaris: combinatorial contributions of upstream regulatory motifs and coding sequence features to variations in mRNA abundance
    Gang Wu
    Department of Biological Sciences, University of Maryland at Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA
    Biochem Biophys Res Commun 344:114-21. 2006
  8. pmc Identification of molecular pathway aberrations in uterine serous carcinoma by genome-wide analyses
    Elisabetta Kuhn
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    J Natl Cancer Inst 104:1503-13. 2012
  9. ncbi request reprint Analysis of myostatin gene structure, expression and function in zebrafish
    Cheng Xu
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore, MD 21202, USA
    J Exp Biol 206:4067-79. 2003
  10. pmc Amplification of the ch19p13.2 NACC1 locus in ovarian high-grade serous carcinoma
    Ie Ming Shih
    Departments of Pathology, Oncology and Gynecology Obstetrics, Johns Hopkins Medical Institutions, 1550 Orleans Street, Baltimore, MD 21231, USA
    Mod Pathol 24:638-45. 2011

Collaborators

  • Lei Nie
  • Jinghui Zhang
  • Weiwen Zhang
  • Tian Li Wang
  • Kentaro Nakayama
  • Ie Ming Shih
  • Yue Wang
  • Lei Song
  • Blazej Bulka
  • Shao Jun Du
  • Xiu Feng Wan
  • Johannes C Scholten
  • L Li
  • Guohui Lin
  • Dong Xu
  • Alan Wong
  • Yuhua Wu
  • Ramsey Ida
  • Wuwei Zeng
  • Iwona Pawlikowska
  • Hong Xue
  • Baosheng Chen
  • Elisabetta Kuhn
  • Le Shen
  • Xuewei Zhu
  • Ling Xiao
  • Changming Lu
  • Daniel G Lee
  • Guotao Sun
  • Xiaomeng Wu
  • Jiang Chen
  • Yi Li
  • Cheng Xu
  • Michael Edmonson
  • Stan Pounds
  • Tanja Gruber
  • Zhifa Liu
  • Robert J Kurman
  • Douglas A Levine
  • Bin Guan
  • Patricia Shaw
  • Kuan Tin Kuo
  • Lei Wei
  • Ren Chin Wu
  • Xiguo Yuan
  • Richard B S Roden
  • Blaise Clarke
  • Narciso Olvera
  • Zhimin Yan
  • Yining Huang
  • Maude Saucier
  • Sachiko Miyata
  • Lenard T Diggins
  • Guoping Li
  • Rhonda L Feinbaum
  • Raju Kucherlapati
  • Kate Montgomery
  • Frederick M Ausubel
  • George Grills
  • Jianxin He
  • Nan Bi
  • Laurence G Rahme
  • Lisa Friedman
  • Nicole T Liberati
  • Eric D├ęziel
  • Jonathan M Urbach
  • Youming Zhang
  • Peter P Nawroth
  • David M Stern
  • Michael Kasper
  • Michael Morcos
  • Baoshen Chen
  • Stephan Schiekofer
  • Tobias Heck
  • Angelika Bierhaus
  • Ling Bai
  • Martin Andrassy
  • Katsumi Nakagawa
  • Thomas Luther
  • Andreas Hamann
  • Lea Spindler
  • Per M Humpert
  • Yi M Bao
  • Yong W Zhong
  • Joachim Schiemann
  • Chun H Wei
  • Zhen S Kang
  • Richard S Nelson
  • Zhang L Chen
  • Peng Mao

Detail Information

Publications33

  1. ncbi request reprint Direct detection of potassium cations bound to G-quadruplex structures by solid-state 39K NMR at 19.6 T
    Gang Wu
    Department of Chemistry, Queen s University, Kingston, Ontario, Canada K7L 3N6
    J Am Chem Soc 125:7182-3. 2003
    ..Solid-state 39K NMR spectra for hydrated K salts of adenosine 2'-monophosphate and adenosine 5'-diphosphate are also reported...
  2. doi request reprint Integrative analyses of posttranscriptional regulation in the yeast Saccharomyces cerevisiae using transcriptomic and proteomic data
    Gang Wu
    Department of Molecular Micriobiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Curr Microbiol 57:18-22. 2008
    ..Taken together, all posttranscriptional biological properties contributed to 33.15% of the total variation of mRNA-protein correlation...
  3. ncbi request reprint The Synthetic Gene Designer: a flexible web platform to explore sequence manipulation for heterologous expression
    Gang Wu
    Department of Biological Sciences, University of Maryland at Baltimore County, 21250, USA
    Protein Expr Purif 47:441-5. 2006
    ..The Synthetic Gene Designer, together with on-line tutorials and the forum, is available at ...
  4. ncbi request reprint Simplified gene synthesis: a one-step approach to PCR-based gene construction
    Gang Wu
    Applied Molecular Biology Laboratory, Department of Biological Sciences, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA
    J Biotechnol 124:496-503. 2006
    ..Overall, the simplified gene synthesis provides an easier and more efficient approach to gene synthesis, providing a further step towards the future goal of generalized automation for this process...
  5. ncbi request reprint The effects of differential gene expression on coding sequence features: analysis by one-way ANOVA
    Gang Wu
    Department of Biological Sciences, University of Maryland at Baltimore County, Baltimore, MD 21250, USA
    Biochem Biophys Res Commun 358:1108-13. 2007
    ..This analysis also demonstrates that one-way ANOVA is a powerful and simple method to explore the influence of gene expression on CDS features...
  6. pmc SGDB: a database of synthetic genes re-designed for optimizing protein over-expression
    Gang Wu
    Department of Biological Sciences, University of Maryland at Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21229, USA
    Nucleic Acids Res 35:D76-9. 2007
    ..evolvingcode.net/codon/sgdb/aligner.php, and discuss questions, findings and related information on an associated e-forum at http://www.evolvingcode.net/forum/viewforum.php?f=27...
  7. ncbi request reprint Relation between mRNA expression and sequence information in Desulfovibrio vulgaris: combinatorial contributions of upstream regulatory motifs and coding sequence features to variations in mRNA abundance
    Gang Wu
    Department of Biological Sciences, University of Maryland at Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA
    Biochem Biophys Res Commun 344:114-21. 2006
    ..This result demonstrates that upstream regulatory motifs and coding sequence information contribute to the overall mRNA expression in a combinatorial rather than an additive manner...
  8. pmc Identification of molecular pathway aberrations in uterine serous carcinoma by genome-wide analyses
    Elisabetta Kuhn
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    J Natl Cancer Inst 104:1503-13. 2012
    ..However, the molecular pathogenesis of uterine serous carcinoma is largely unknown. We analyzed the genomes of uterine serous carcinoma samples to better understand the molecular genetic characteristics of this cancer...
  9. ncbi request reprint Analysis of myostatin gene structure, expression and function in zebrafish
    Cheng Xu
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore, MD 21202, USA
    J Exp Biol 206:4067-79. 2003
    ..Together, these data demonstrate that Myostatin plays an inhibitory role in hyperplastic muscle growth in zebrafish...
  10. pmc Amplification of the ch19p13.2 NACC1 locus in ovarian high-grade serous carcinoma
    Ie Ming Shih
    Departments of Pathology, Oncology and Gynecology Obstetrics, Johns Hopkins Medical Institutions, 1550 Orleans Street, Baltimore, MD 21231, USA
    Mod Pathol 24:638-45. 2011
    ..005). In summary, our data suggest that amplification at the ch19p13.2 NACC1 locus, leading to NAC1 overexpression, is one of the molecular genetic alterations associated with early tumor recurrence in ovarian cancer...
  11. ncbi request reprint Predicted highly expressed genes in Nocardia farcinica and the implication for its primary metabolism and nocardial virulence
    Gang Wu
    Department of Biological Sciences, University of Maryland, Baltimore County, Baltimore, MD 21250, USA
    Antonie Van Leeuwenhoek 89:135-46. 2006
    ..The results provided the first estimates of global gene expression patterns in N. farcinica, which will be useful in guiding experimental design for further investigations...
  12. pmc The most informative spacing test effectively discovers biologically relevant outliers or multiple modes in expression
    Iwona Pawlikowska
    Departments of Biostatistics, St Jude Children s Research Hospital, Memphis, TN, USA, Institue of Mathematics, University of Silesia, Katowice, Poland, Department of Computational Biology and Department of Oncology, St Jude Children s Research Hospital, Memphis, TN, USA
    Bioinformatics 30:1400-8. 2014
    ..MIST was also effective at identifying features related to gender or molecular subtype in an example application involving 157 adult cases of acute myeloid leukemia...
  13. pmc Optimal encoding rules for synthetic genes: the need for a community effort
    Gang Wu
    Mol Syst Biol 3:134. 2007
  14. ncbi request reprint Event-specific qualitative and quantitative PCR methods for the detection of genetically modified rapeseed Oxy-235
    Gang Wu
    Oilcrops Research Institute, Chinese Academy of Agricultural Sciences, No 2 Xudong 2nd Road, Wuhan, 430062, China
    Transgenic Res 17:851-62. 2008
    ..The real-time PCR systems so established were examined with two mixed rapeseed samples with known Oxy-235 contents and found to obtain the expected results...
  15. doi request reprint Direct NMR detection of alkali metal ions bound to G-quadruplex DNA
    Ramsey Ida
    Department of Chemistry, Queen s University, 90 Bader Lane, Kingston, Ontario, Canada K7L 3N6
    J Am Chem Soc 130:3590-602. 2008
    ..Our results strongly suggest that multinuclear NMR is a viable technique for studying ion binding to G-quadruplex DNA...
  16. doi request reprint Secreted human apolipoprotein(a) kringle IV-10 and kringle V inhibit angiogenesis and xenografted tumor growth
    Le Shen
    Department of Biochemistry and Molecular Biology, National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing 100005, PR China
    Biol Chem 389:135-41. 2008
    ..01) against the control tumor cells. From these results, we conclude that human apolipoprotein(a) carboxyl-terminal kringle IV-10-kringle V fusion protein is an effective inhibitor of angiogenesis and angiogenesis-dependent tumor growth...
  17. ncbi request reprint Zero erucic acid trait of rapeseed (Brassica napus L.) results from a deletion of four base pairs in the fatty acid elongase 1 gene
    Gang Wu
    Oilcrops Research Institute, Chinese Academy of Agricultural Sciences, Hubei, 430062, People s Republic of China
    Theor Appl Genet 116:491-9. 2008
    ..The four base pair deletion proved to be a mutation responsible for the low erucic acid trait in rapeseed and independent from the point mutation reported by Han et al. (Plant Mol Biol 46:229-239, 2001)...
  18. doi request reprint A solid-state 23Na NMR study of monovalent cation binding to double-stranded DNA at low relative humidity
    Alan Wong
    Department of Chemistry, Queen s University, 90 Bader Lane, Kingston, Ontario, K7L 3N6, Canada
    Magn Reson Chem 46:308-15. 2008
    ..The reported experimental results on relative ion-binding affinity for the DNA backbone may be used for testing theoretical treatment of cation-phosphate interactions in DNA...
  19. ncbi request reprint Phylogenetic analysis using complete signature information of whole genomes and clustered Neighbour-Joining method
    Xiaomeng Wu
    Bioinformatics Research Group, Department of Computing Science, University of Alberta Edmonton, Alberta, Canada
    Int J Bioinform Res Appl 2:219-48. 2006
    ..The final phylogenies were built by an improved clustered Neighbour-Joining method. The generated phylogenetic trees are highly consistent with taxonomy hierarchy and previous studies, with some biologically interesting disagreements...
  20. ncbi request reprint Event-specific qualitative and quantitative PCR detection methods for transgenic rapeseed hybrids MS1xRF1 and MS1xRF2
    Yuhua Wu
    Institute of Oil Crops Research, Chinese Academy of Agricultural Sciences, No 2 Xudong 2nd Road, Wuhan, 430062, China
    J Agric Food Chem 55:8380-9. 2007
    ....
  21. ncbi request reprint Event-specific qualitative and quantitative polymerase chain reaction methods for detection of genetically modified rapeseed Ms8xRf3 based on the right border junctions
    Gang Wu
    Oilcrops Research Institute, Chinese Academy of Agricultural Sciences, No 2 Xudong 2nd Rd, Wuhan 430062, People s Republic of China
    J AOAC Int 91:143-51. 2008
    ..5 initial template copies for the Ms8 event and 50 copies for the Rf3 event. Quantitiative detection methods were established, with the absolute quantification limit being approximately 25 initial template copies...
  22. ncbi request reprint Cloning of fatty acid elongase1 gene and molecular identification of A and C genome in Brassica species
    Yuhua Wu
    Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, Wuhan, China
    Sci China C Life Sci 50:343-9. 2007
    ..rapa from B. oleracea and between the A and C genome of B. napus. In addition, the FAE1 genes could be used as marker genes to detect the pollen flow of B. napus, thus providing an alternative method for risk assessment of gene flow...
  23. ncbi request reprint Cloning and characterization of cholesteryl ester transfer transfer protein isolated from the tree shrew
    Wuwei Zeng
    Department of Biochemistry and Molecular Biology, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100005, China
    Chin Med J (Engl) 116:928-31. 2003
    ..To obtain the nucleotide sequence and deduced amino acid sequence of cholesteryl ester transfer protein (CETP) cDNA from the tree shrew (Tupaia glis)...
  24. ncbi request reprint [Analysis of lecithin-cholesterol acyltransferase cDNA and protein sequence from tree shrew]
    Jian Zhang
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, CAMS, PUMC, Beijing 100005, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 24:149-55. 2002
    ..To acquire cDNA sequence of lecithin-cholesterol acyltransferase (LCAT) from tree shrew and analyze the sequence structure...
  25. ncbi request reprint Glycogen phosphorylase sequences from the amitochondriate protists, Trichomonas vaginalis, Mastigamoeba balamuthi, Entamoeba histolytica and Giardia intestinalis
    Gang Wu
    The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    J Eukaryot Microbiol 50:366-72. 2003
    ..Protist phosphorylases, as their prokaryotic and plant counterparts, are probably not regulated by phosphorylation...
  26. pmc Rice dwarf phytoreovirus segment S6-encoded nonstructural protein has a cell-to-cell movement function
    Yi Li
    Peking Yale Joint Center for Plant Molecular Genetics and Agrobiotechnology, The National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing 100871, China
    J Virol 78:5382-9. 2004
    ..S6 thus encodes a protein with characteristics identical to those of other viral proteins required for the cell-to-cell movement of their genome and therefore is likely required for the cell-to-cell movement of RDV...
  27. ncbi request reprint Disodium guanosine 5'-monophosphate self-associates into nanoscale cylinders at pH 8: a combined diffusion NMR spectroscopy and dynamic light scattering study
    Alan Wong
    Department of Chemistry, Queen s University, 90 Queen s Crescent, Kingston, Ontario, Canada K7L 3N6
    J Am Chem Soc 127:6990-8. 2005
    ..We observed a linear relationship between the axial ratio of the 5'-GMP cylinders and the Na(2)(5'-GMP) concentration for both types of 5'-GMP aggregates, which suggests a common stacking mechanism for monomers and G-quartets...
  28. ncbi request reprint Tissue factor as a link between wounding and tissue repair
    Jiang Chen
    University of Heidelberg, Department of Medicine I, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Diabetes 54:2143-54. 2005
    ..These data establish TF expression as an important link between the early inflammatory response to cutaneous wounding and reparative processes...
  29. ncbi request reprint Direct NMR detection of the "invisible" alkali metal cations tightly bound to G-quadruplex structures
    Alan Wong
    Department of Chemistry, Queen s University, Kingston, Ont, Canada K7L 3N6
    Biochem Biophys Res Commun 337:363-6. 2005
    ..Our finding that it is possible to directly observe these alkali metal cations by NMR spectroscopy provides a new tool for studying cation binding affinity and dynamics in G-quadruplex DNA...
  30. ncbi request reprint Identification of lipid binding and lipoprotein lipase activation domains of human apoAV
    Guotao Sun
    Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China
    Chem Phys Lipids 143:22-8. 2006
    ..While, the LPL activation function of apoAV remarkably impaired after deletion of residues 192-238. These findings suggested that the domain (192-238) is absolutely necessary for apoAV in lipid binding and lipoprotein lipase activation...
  31. pmc Genomic analysis reveals that Pseudomonas aeruginosa virulence is combinatorial
    Daniel G Lee
    Department of Molecular Biology, Massachusetts General Hospital, Cambridge Street, Boston, Massachusetts 02114, USA
    Genome Biol 7:R90. 2006
    ..We therefore sequenced a highly virulent strain of P. aeruginosa, PA14, and compared it with a previously sequenced (and less pathogenic) strain, PAO1, to identify novel virulence genes...
  32. ncbi request reprint Evolution of the syntrophic interaction between Desulfovibrio vulgaris and Methanosarcina barkeri: Involvement of an ancient horizontal gene transfer
    Johannes C Scholten
    Microbiology Department, Pacific Northwest National Laboratory, Richland, WA 99352, USA
    Biochem Biophys Res Commun 352:48-54. 2007
    ..vulgaris. This report provides novel insights into the origin and evolution of bacterial genes linked to the lifestyle change of D. vulgaris from a syntrophic to a sulfate-reducing lifestyle...
  33. ncbi request reprint Quartet-based phylogeny reconstruction with answer set programming
    Gang Wu
    Department of Computing Science, University of Alberta, Edmonton, Canada
    IEEE/ACM Trans Comput Biol Bioinform 4:139-52. 2007
    ..The experimental results on a number of simulated data sets suggest that the new representation, combined with answer set programming, presents a unique perspective to the MQC problem...