CHUNG WU

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. pmc Two evolutionary histories in the genome of rice: the roles of domestication genes
    Ziwen He
    State Key Laboratory of Biocontrol and Guangdong Key Laboratory of Plant Resources, Sun Yat Sen University, Guangzhou, China
    PLoS Genet 7:e1002100. 2011
  2. pmc New microRNAs in Drosophila--birth, death and cycles of adaptive evolution
    Yang Lyu
    State Key Laboratory of Biocontrol, Key Laboratory of Gene Engineering of the Ministry of Education, School of Life Sciences, Sun Yat Sen University, Guangzhou, Guangdong, China Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat Sen University, Guangzhou, Guangdong, China Key Laboratory of Biodiversity Dynamics and Conservation of Guangdong Higher Education Institutes, Sun Yat Sen University, Guangzhou, Guangdong, China
    PLoS Genet 10:e1004096. 2014
  3. pmc Transcriptional regulation of human eosinophil RNases by an evolutionary- conserved sequence motif in primate genome
    Hsiu Yu Wang
    Institute of Molecular and Cellular Biology and Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan 30013, Republic of China
    BMC Mol Biol 8:89. 2007
  4. pmc Testing a hypothesis of unidirectional hybridization in plants: observations on Sonneratia, Bruguiera and Ligularia
    Renchao Zhou
    State Key Laboratory of Biocontrol and Key Laboratory of Gene Engineering of Ministry of Education, Sun Yat Sen University, Guangzhou 510275, PR China
    BMC Evol Biol 8:149. 2008
  5. pmc Sex, sex chromosomes and gene expression
    Xuemei Lu
    Laboratory of Disease Genomics and Individualized Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beichen West Road, Chaoyang, Beijing, China
    BMC Biol 9:30. 2011
  6. ncbi request reprint Sexual antagonism and X inactivation--the SAXI hypothesis
    Chung I Wu
    Department of Ecology and Evolution, University of Chicago, Chicago, IL 60637, USA
    Trends Genet 19:243-7. 2003
  7. pmc Evolution under canalization and the dual roles of microRNAs: a hypothesis
    Chung I Wu
    Department of Ecology and Evolution, University of Chicago, Chicago, IL 60637, USA
    Genome Res 19:734-43. 2009
  8. ncbi request reprint Comment on "Chromosomal speciation and molecular divergence-accelerated evolution in rearranged chromosomes"
    Jian Lu
    Department of Ecology and Evolution, University of Chicago, Chicago, IL 60637, USA
    Science 302:988; author reply 988. 2003
  9. ncbi request reprint Genes and speciation
    Chung I Wu
    Department of Ecology and Evolution, University of Chicago, Chicago, Illinois 60637, USA
    Nat Rev Genet 5:114-22. 2004
  10. ncbi request reprint Genomic inferences of the cis-regulatory nucleotide polymorphisms underlying gene expression differences between Drosophila melanogaster mating races
    Naoki Osada
    Division of Biomedical Research Resources, National Institute of Biomedical Innovation, Ibaraki, Osaka, Japan
    Mol Biol Evol 23:1585-91. 2006

Detail Information

Publications50

  1. pmc Two evolutionary histories in the genome of rice: the roles of domestication genes
    Ziwen He
    State Key Laboratory of Biocontrol and Guangdong Key Laboratory of Plant Resources, Sun Yat Sen University, Guangzhou, China
    PLoS Genet 7:e1002100. 2011
    ..In summary, we identified 13 additional candidate genes of domestication...
  2. pmc New microRNAs in Drosophila--birth, death and cycles of adaptive evolution
    Yang Lyu
    State Key Laboratory of Biocontrol, Key Laboratory of Gene Engineering of the Ministry of Education, School of Life Sciences, Sun Yat Sen University, Guangzhou, Guangdong, China Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat Sen University, Guangzhou, Guangdong, China Key Laboratory of Biodiversity Dynamics and Conservation of Guangdong Higher Education Institutes, Sun Yat Sen University, Guangzhou, Guangdong, China
    PLoS Genet 10:e1004096. 2014
    ..In conclusion, the selective advantages driving evolution of miRNAs are themselves evolving, and sometimes changing direction, which highlights the regulatory roles of miRNAs. ..
  3. pmc Transcriptional regulation of human eosinophil RNases by an evolutionary- conserved sequence motif in primate genome
    Hsiu Yu Wang
    Institute of Molecular and Cellular Biology and Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan 30013, Republic of China
    BMC Mol Biol 8:89. 2007
    ..Although they are generated by gene duplication event, distinct edn and ecp expression profile in various tissues have been reported...
  4. pmc Testing a hypothesis of unidirectional hybridization in plants: observations on Sonneratia, Bruguiera and Ligularia
    Renchao Zhou
    State Key Laboratory of Biocontrol and Key Laboratory of Gene Engineering of Ministry of Education, Sun Yat Sen University, Guangzhou 510275, PR China
    BMC Evol Biol 8:149. 2008
    ..We wish to test this hypothesis using data of plant hybridizations both from our own experimentation and from the literature...
  5. pmc Sex, sex chromosomes and gene expression
    Xuemei Lu
    Laboratory of Disease Genomics and Individualized Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beichen West Road, Chaoyang, Beijing, China
    BMC Biol 9:30. 2011
    ..Here, we discuss possible mechanisms underlying this bias, including sexual antagonism and dosage compensation...
  6. ncbi request reprint Sexual antagonism and X inactivation--the SAXI hypothesis
    Chung I Wu
    Department of Ecology and Evolution, University of Chicago, Chicago, IL 60637, USA
    Trends Genet 19:243-7. 2003
    ....
  7. pmc Evolution under canalization and the dual roles of microRNAs: a hypothesis
    Chung I Wu
    Department of Ecology and Evolution, University of Chicago, Chicago, IL 60637, USA
    Genome Res 19:734-43. 2009
    ..In light of the constant emergence of new miRNAs, we further discuss the relative importance of these two functions in evolution...
  8. ncbi request reprint Comment on "Chromosomal speciation and molecular divergence-accelerated evolution in rearranged chromosomes"
    Jian Lu
    Department of Ecology and Evolution, University of Chicago, Chicago, IL 60637, USA
    Science 302:988; author reply 988. 2003
  9. ncbi request reprint Genes and speciation
    Chung I Wu
    Department of Ecology and Evolution, University of Chicago, Chicago, Illinois 60637, USA
    Nat Rev Genet 5:114-22. 2004
  10. ncbi request reprint Genomic inferences of the cis-regulatory nucleotide polymorphisms underlying gene expression differences between Drosophila melanogaster mating races
    Naoki Osada
    Division of Biomedical Research Resources, National Institute of Biomedical Innovation, Ibaraki, Osaka, Japan
    Mol Biol Evol 23:1585-91. 2006
    ..Results have implications for models of gene regulatory evolution as well as experimental studies trying to identify the nucleotide sequence polymorphisms underlying gene expression differences between Drosophila strains...
  11. ncbi request reprint Ecological adaptation during incipient speciation revealed by precise gene replacement
    Anthony J Greenberg
    Department of Ecology and Evolution, The University of Chicago, Chicago, IL 60637, USA
    Science 302:1754-7. 2003
    ..We conclude that ecological adaptation likely accompanies sexual isolation between the two behavioral races of D. melanogaster...
  12. ncbi request reprint The normal function of a speciation gene, Odysseus, and its hybrid sterility effect
    Sha Sun
    Department of Ecology and Evolution, University of Chicago, Chicago, IL 60637, USA
    Science 305:81-3. 2004
    ..The implication of a weak effect of OdsH on the normal phenotype but a strong influence on hybrid male sterility is discussed in light of Haldane's rule of postmating isolation...
  13. ncbi request reprint Evolution of sexual isolation during secondary contact: genotypic versus phenotypic changes in laboratory populations
    Julie A Alipaz
    Committee on Evolutionary Biology, University of Chicago, Chicago, Illinois 60637, USA
    Am Nat 165:420-8. 2005
    ..The genome appears to be "fine grained," with adjacent loci having different evolutionary dynamics and genealogical histories...
  14. pmc Statistical tests for detecting positive selection by utilizing high-frequency variants
    Kai Zeng
    State Key Laboratory of Biocontrol, Ministry of Education, Sun Yat Sen University, Guangzhou, China
    Genetics 174:1431-9. 2006
    ..We thus propose a joint test, referred to as the DH test. Simulations indicate that DH is indeed sensitive primarily to directional selection and no other driving forces...
  15. ncbi request reprint Comparisons of site- and haplotype-frequency methods for detecting positive selection
    Kai Zeng
    State Key Laboratory of Biocontrol and Key Laboratory of Gene Engineering of the Ministry of Education, Sun Yat Sen University, Guangzhou, China
    Mol Biol Evol 24:1562-74. 2007
    ..In the companion paper (Zeng K, Shi S, Wu C-I, in preparation), we use the EW test to devise 2 compound tests, which are more powerful in detecting positive selection than DH, but are also relatively insensitive to demography...
  16. ncbi request reprint Proper control of genetic background with precise allele substitution: a comment on Coyne and Elwyn
    Anthony J Greenberg
    Department of Ecology and Evolution, University of Chicago, Illinois 60637, USA
    Evolution 60:623-5; discussion 626-7. 2006
    ..Their experiments are thus not meaningful replications of our previous ones. We discuss ways of circumventing this problem in studies involving induced mutations in single genes...
  17. ncbi request reprint Proceedings of the SMBE Tri-National Young Investigators' Workshop 2005. Molecular genetics of natural populations
    Anthony J Greenberg
    Department of Ecology and Evolution, The University of Chicago, IL, USA
    Mol Biol Evol 23:883-6. 2006
    ..Molecular genetic manipulation, DNA polymorphism analysis, and field studies then have to be integrated to provide fresh insights into the mechanisms of evolutionary change...
  18. ncbi request reprint Adaptive loss of an old duplicated gene during incipient speciation
    Anthony J Greenberg
    Department of Ecology and Evolution, The University of Chicago, USA
    Mol Biol Evol 23:401-10. 2006
    ..Taken together with previous molecular genetic evidence, our results suggest that ds2 is one of the genes responsible for adaptive divergence of the Z and M races of D. melanogaster...
  19. ncbi request reprint Compound tests for the detection of hitchhiking under positive selection
    Kai Zeng
    State Key Laboratory of Biocontrol and Key Laboratory of Gene Engineering of the Ministry of Education, Sun Yat Sen University, Guangzhou, China
    Mol Biol Evol 24:1898-908. 2007
    ..Furthermore, the DHEW test, similar to DH, is also relatively insensitive to background selection and demography. The HEW test, on the other hand, tends to be somewhat less conservative than DH and DHEW in some cases...
  20. ncbi request reprint Testing the neutral theory of molecular evolution with genomic data from Drosophila
    Justin C Fay
    Committee on Genetics, University of Chicago, Chicago, Illinois 60637, USA
    Nature 415:1024-6. 2002
    ..A higher A/S ratio of divergence than of polymorphism is also observed in other species, which suggests a rate of adaptive evolution that is far higher than permitted by the neutral theory of molecular evolution...
  21. ncbi request reprint Inference of positive and negative selection on the 5' regulatory regions of Drosophila genes
    Michael H Kohn
    Department of Ecology and Evolution, The University of Chicago, USA
    Mol Biol Evol 21:374-83. 2004
    ....
  22. pmc Adaptive genic evolution in the Drosophila genomes
    Joshua A Shapiro
    Department of Ecology and Evolution, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 104:2271-6. 2007
    ..Finally, we discuss the theories and data pertaining to the interpretation of adaptive evolution in genomic studies...
  23. pmc Adaptive evolution of newly emerged micro-RNA genes in Drosophila
    Jian Lu
    Department of Ecology and Evolution, University of Chicago, USA
    Mol Biol Evol 25:929-38. 2008
    ..melanogaster is indicative of hitchhiking under positive selection. Thus, a large number of adaptive changes over a long period of time may be essential for the evolution of newly emerged miRNA genes...
  24. ncbi request reprint Evolution of sexual isolation in laboratory populations: fitness differences between mating types and the associated hybrid incompatibilities
    Julie A Alipaz
    Committee on Evolutionary Biology, University of Chicago, Chicago, Illinois 60637, USA
    Am Nat 165:429-38. 2005
    ..These fitness effects suggest that multiple mechanisms of postmating isolation have evolved concurrently with the divergence in behavior...
  25. ncbi request reprint The birth and death of microRNA genes in Drosophila
    Jian Lu
    Department of Ecology and Evolution, University of Chicago, 1101 East 57th Street, Chicago, Illinois 60637, USA
    Nat Genet 40:351-5. 2008
    ..The estimated net gain of long-lived miRNA genes, which is not strongly affected by either the depth or the breadth (number of tissues) of sequencing, is 0.3 genes per Myr in Drosophila...
  26. ncbi request reprint A universal evolutionary index for amino acid changes
    Hua Tang
    Department of Ecology and Evolution, University of Chicago, Chicago, IL, USA
    Mol Biol Evol 21:1548-56. 2004
    ..The codon-based, empirically determined EI (i.e., U*R) makes much better predictions on protein evolution than do previous methods...
  27. pmc Weak selection revealed by the whole-genome comparison of the X chromosome and autosomes of human and chimpanzee
    Jian Lu
    Department of Ecology and Evolution, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 102:4063-7. 2005
    ..However, X-linked nonsynonymous substitutions are approximately 30% more frequent than autosomal ones, suggesting the fixation of advantageous mutations that are recessive...
  28. pmc A mutation in the promoter of desaturase 2 is correlated with sexual isolation between Drosophila behavioral races
    Shu Fang
    Department of Ecology and Evolution, The University of Chicago, Illinois 60637, USA
    Genetics 162:781-4. 2002
    ..These two behavioral races appear to be at the incipient stage of speciation. The desaturase 2 mutation may be one of the many loci underlying the behavioral differences between the two races...
  29. pmc Inferring the mode of speciation from genomic data: a study of the great apes
    Naoki Osada
    Department of Ecology and Evolution, University of Chicago, Chicago, Illinois 60637, USA
    Genetics 169:259-64. 2005
    ..Because the analysis should be generally applicable, collecting DNA sequence data from many genomic regions between closely related species should help to settle the debate over the prevalence of the allopatric mode of speciation...
  30. pmc Detecting novel low-abundant transcripts in Drosophila
    Sanggyu Lee
    Department of Medicine, University of Chicago, IL 60637, USA
    RNA 11:939-46. 2005
    ..Our study reveals the presence of a significant number of novel low-abundant transcripts in Drosophila, and highlights the need to isolate these novel low-abundant transcripts for further biological studies...
  31. ncbi request reprint A case for conservation
    Chung I Wu
    Department of Ecology and Evolution, University of Chicago, Chicago, IL 60637, USA
    Nature 428:213-4. 2004
  32. ncbi request reprint A new method for estimating nonsynonymous substitutions and its applications to detecting positive selection
    Hua Tang
    Department of Ecology and Evolution, University of Chicago, USA
    Mol Biol Evol 23:372-9. 2006
    ..Many genes with Ka/Ks > 0.5 can now be shown to have Kh/Ks > 1 and to have evolved adaptively, at least for the high-exchangeability group of amino acid changes...
  33. ncbi request reprint Decoupled differentiation of gene expression and coding sequence among Drosophila populations
    Michael H Kohn
    Department of Ecology and Evolutionary Biology, Rice University, Houston, TX 77005, USA
    Genes Genet Syst 83:265-73. 2008
    ..Our contrasts between genetic differentiation of populations in expression and sequences revealed that even when genotype and phenotype can be connected the sources of variation that are the target of selection remain to be identified...
  34. ncbi request reprint Evolution of genes and genomes on the Drosophila phylogeny
    Andrew G Clark
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Nature 450:203-18. 2007
    ..These may prove to underlie differences in the ecology and behaviour of these diverse species...
  35. pmc Precision and high-resolution mapping of quantitative trait loci by use of recurrent selection, backcross or intercross schemes
    Z W Luo
    School of Biosciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, England
    Genetics 161:915-29. 2002
    ....
  36. ncbi request reprint Molecular evolution of functional genes on the mammalian Y chromosome
    Gerald J Wyckoff
    Mol Biol Evol 19:1633-6. 2002
  37. pmc Complex genetic interactions underlying expression differences between Drosophila races: analysis of chromosome substitutions
    Hurng Yi Wang
    Graduate Institute of Clinical Medicine, National Taiwan University, 7 Chung Shan South Road, Taipei 100, Taiwan
    Proc Natl Acad Sci U S A 105:6362-7. 2008
    ..Between Drosophila racial groups, trans regulation of expression difference is extensive, and cis regulation often evolves in conjunction with trans effects...
  38. pmc Poly A- transcripts expressed in HeLa cells
    Qingfa Wu
    Center for Functional Genomics, Division of Medical Genetics, Department of Medicine, ENH Research Institute, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America
    PLoS ONE 3:e2803. 2008
    ..Most transcripts identified so far are poly A+ transcripts, whereas the poly A- transcripts remain largely unknown...
  39. ncbi request reprint Rapidly evolving genes in human. I. The glycophorins and their possible role in evading malaria parasites
    Hurng Yi Wang
    Department of Biology, National Taiwan Normal University, Taipei, Taiwan
    Mol Biol Evol 20:1795-804. 2003
    ..The support for the evasion hypothesis is still indirect, but, unlike other hypotheses, it can be tested specifically and systematically...
  40. ncbi request reprint Molecular criteria for determining new hybrid species--an application to the Sonneratia hybrids
    Renchao Zhou
    State Key Laboratory of Biocontrol and Key Laboratory of Gene Engineering of the Ministry of Education, Zhongshan University, Guangzhou 510275, People s Republic of China
    Mol Phylogenet Evol 35:595-601. 2005
    ..Thus, S. x gulngai and S. x hainanensis are not true hybrid species. The segregation patterns of molecular markers should be heeded in interpreting the existence of hybrid species...
  41. pmc Cross-host evolution of severe acute respiratory syndrome coronavirus in palm civet and human
    Huai Dong Song
    State Key Laboratory for Medical Genomics Pôle Sino Français de Recherche en Sciences du Vivant et Génomique, Ruijin Hospital Affiliated to Shanghai Second Medical University, 197 Rui Jin Road II, Shanghai 200025, China
    Proc Natl Acad Sci U S A 102:2430-5. 2005
    ....
  42. pmc An ancient balanced polymorphism in a regulatory region of human major histocompatibility complex is retained in Chinese minorities but lost worldwide
    Xiaoyi Liu
    State Key Laboratory for Biocontrol, Department of Biochemistry, Key Laboratory of Genetic Engineering of the Ministry of Education, College of Life Sciences, Sun Yat Sen Zhongshan University, Guangzhou, China
    Am J Hum Genet 78:393-400. 2006
    ..As suspected, some ancient balanced polymorphisms, lost in major populations, still exist in isolated ethnicities. These isolated populations may thus contribute disproportionately to the total diversity of modern humans...
  43. pmc Gene duplication and speciation in Drosophila: evidence from the Odysseus locus
    Chau Ti Ting
    Department of Life Science, National Tsing Hua University, Hsinchu 300, Taiwan
    Proc Natl Acad Sci U S A 101:12232-5. 2004
    ..We suggest that duplicated genes that have yet to evolve a stable function at the time of speciation may be candidates for "speciation genes," which is broadly defined as genes that contribute to differential adaptation between species...
  44. pmc Genomic variation in rice: genesis of highly polymorphic linkage blocks during domestication
    Tian Tang
    State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat Sen Zhongshan University, Guangzhou, People s Republic of China
    PLoS Genet 2:e199. 2006
    ..If true, these high divergence regions of the genome would be enriched for loci that contribute to the enormous range of phenotypic variation observed among domesticated breeds...
  45. pmc Adaptive evolution in humans revealed by the negative correlation between the polymorphism and fixation phases of evolution
    Jun Gojobori
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 104:3907-12. 2007
    ..These patterns suggest that negative and positive selection operate more effectively on the same set of amino acid changes and that approximately 10-13% of amino acid substitutions between humans and chimpanzee may be adaptive...
  46. ncbi request reprint Population genetics of speciation in nonmodel organisms: I. Ancestral polymorphism in mangroves
    Renchao Zhou
    State Key Laboratory of Biocontrol and Key Laboratory of Gene Engineering of the Ministry of Education, Sun Yat Sen University, Guangzhou, China
    Mol Biol Evol 24:2746-54. 2007
    ..This population structure would give rise to high level of polymorphism across species range. This approach of studying the speciation history by genomic means should be applicable to nonmodel organisms...
  47. ncbi request reprint Sequence divergence, functional constraint, and selection in protein evolution
    Justin C Fay
    Department of Genome Sciences, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Annu Rev Genomics Hum Genet 4:213-35. 2003
    ..We relate these studies to our understanding of the neutral theory and adaptive evolution...
  48. pmc Genetic complexity underlying hybrid male sterility in Drosophila
    Kyoichi Sawamura
    Drosophila Genetic Resource Center, Kyoto Institute of Technology, Kyoto 616 8354, Japan
    Genetics 166:789-96. 2004
    ..Such an epistatic view, even in the less-related species, suggests that the genetic complexity is special to hybrid male sterility...
  49. pmc Rate of evolution in brain-expressed genes in humans and other primates
    Hurng Yi Wang
    Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan
    PLoS Biol 5:e13. 2007
    ..Possible explanations and hypotheses are discussed...
  50. ncbi request reprint Substitution rate and structural divergence of 5'UTR evolution: comparative analysis between human and cynomolgus monkey cDNAs
    Naoki Osada
    Division of Genetic Resources, National Institute of Infectious Diseases, Tokyo, Japan
    Mol Biol Evol 22:1976-82. 2005
    ..The results imply that positive selection increased K5UTR and structural alteration rate of a certain fraction of genes as well as Ka. We found that both positive and negative selection can act on the 5'UTR sequences...

Research Grants18

  1. Analysis of Speciation by Complex Trait Mapping
    CHUNG WU; Fiscal Year: 2003
    ..In the final phase, we will carry out association studies between 30 natural isolates and the candidate genes from each mapped region. ..
  2. MOLECULAR EVOLUTION OF A HOMEODOMAIN GENE OF SPECIATION
    CHUNG WU; Fiscal Year: 1999
    ..4) To study the molecular evolution and population genetics of Ods: This will be the first DNA sequence analysis of a gene that plays a key role in reproductive isolation. ..
  3. MicroRNA evolution and species divergence in Drosophila
    Chung I Wu; Fiscal Year: 2009
    ..A survey of the scope of microRNA repertoire and their rise and fall through evolution will be useful for understanding their roles in regulating the normal and aberrant phenotypes in human populations. ..
  4. MicroRNA evolution and species divergence in Drosophila
    Chung I Wu; Fiscal Year: 2009
    ..A survey of the scope of microRNA repertoire and their rise and fall through evolution will be useful for understanding their roles in regulating the normal and aberrant phenotypes in human populations. ..
  5. Transcriptional and genic basis of incipient speciation
    Chung I Wu; Fiscal Year: 2007
    ..We expect to identify a number of candidate "speciation genes,* and will carry out precise gene replacement (Rong and Golic 2000; Greenberg et al. 2003) to confirm their effects on the mating behavior. ..
  6. Transcriptional and genic basis of incipient speciation
    CHUNG WU; Fiscal Year: 2006
    ..We expect to identify a number of candidate "speciation genes,* and will carry out precise gene replacement (Rong and Golic 2000; Greenberg et al. 2003) to confirm their effects on the mating behavior. ..
  7. Evolution of a New Gene and Speciation
    Chung I Wu; Fiscal Year: 2006
    ..3. Evolution of the "abnormal" function of 0ds: 0ds-induced hybrid sterility is considered the "abnormal" function. By transgenic experiments, we will address the genetic mechanism by which 0ds sterilizes hybrid males. ..
  8. Transcriptional and genic basis of incipient speciation
    CHUNG WU; Fiscal Year: 2005
    ..We expect to identify a number of candidate "speciation genes,* and will carry out precise gene replacement (Rong and Golic 2000; Greenberg et al. 2003) to confirm their effects on the mating behavior. ..
  9. Analysis of Speciation by Complex Trait Mapping
    CHUNG WU; Fiscal Year: 2004
    ..In the final phase, we will carry out association studies between 30 natural isolates and the candidate genes from each mapped region. ..
  10. Evolution of a New Gene and Speciation
    CHUNG WU; Fiscal Year: 2003
    ..3. Evolution of the "abnormal" function of 0ds: 0ds-induced hybrid sterility is considered the "abnormal" function. By transgenic experiments, we will address the genetic mechanism by which 0ds sterilizes hybrid males. ..
  11. Analysis of Speciation by Complex Trait Mapping
    CHUNG WU; Fiscal Year: 2002
    ..In the final phase, we will carry out association studies between 30 natural isolates and the candidate genes from each mapped region. ..
  12. Analysis of Speciation by Complex Trait Mapping
    CHUNG WU; Fiscal Year: 2001
    ..In the final phase, we will carry out association studies between 30 natural isolates and the candidate genes from each mapped region. ..
  13. MOLECULAR EVOLUTION OF A HOMEODOMAIN GENE OF SPECIATION
    CHUNG WU; Fiscal Year: 2000
    ..4) To study the molecular evolution and population genetics of Ods: This will be the first DNA sequence analysis of a gene that plays a key role in reproductive isolation. ..
  14. MicroRNA evolution and species divergence in Drosophila
    Chung I Wu; Fiscal Year: 2010
    ..A survey of the scope of microRNA repertoire and their rise and fall through evolution will be useful for understanding their roles in regulating the normal and aberrant phenotypes in human populations. ..