WOODRING ERIK WRIGHT

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint Cellular senescence as a tumor-protection mechanism: the essential role of counting
    W E Wright
    Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9039, USA
    Curr Opin Genet Dev 11:98-103. 2001
  2. ncbi request reprint Historical claims and current interpretations of replicative aging
    Woodring E Wright
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9039, USA
    Nat Biotechnol 20:682-8. 2002
  3. pmc Quantitative telomeric overhang determination using a double-strand specific nuclease
    Yong Zhao
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Nucleic Acids Res 36:e14. 2008
  4. pmc Immortalized pathological human myoblasts: towards a universal tool for the study of neuromuscular disorders
    Kamel Mamchaoui
    Thérapie des maladies du muscle strié, Institut de Myologie, UM76, UPMC Universite Paris 6, Paris, France
    Skelet Muscle 1:34. 2011
  5. ncbi request reprint Telomere biology in aging and cancer
    Woodring E Wright
    Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Building K2 206, MC 9039, Dallas, TX 75235, USA
    J Am Geriatr Soc 53:S292-4. 2005
  6. ncbi request reprint Inexpensive low-oxygen incubators
    Woodring E Wright
    Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9039, USA
    Nat Protoc 1:2088-90. 2006
  7. pmc Establishment of clonal myogenic cell lines from severely affected dystrophic muscles - CDK4 maintains the myogenic population
    Guido Stadler
    Department of Cell Biology, UT Southwestern Medical Center at Dallas, Dallas, TX, USA
    Skelet Muscle 1:12. 2011
  8. ncbi request reprint p16(INK4a) inactivation is not required to immortalize human mammary epithelial cells
    Brittney Shea Herbert
    Department of Cell Biology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas, TX 75390 9039, USA
    Oncogene 21:7897-900. 2002
  9. pmc Telomere length regulates ISG15 expression in human cells
    Zhenjun Lou
    Department of Cell Biology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Aging (Albany NY) 1:608-21. 2009
  10. ncbi request reprint Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins
    Ruben D Ramirez
    Hamon Center for Therapeutic Oncology Research and Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Cancer Res 64:9027-34. 2004

Research Grants

  1. GENE EXPRESSION IN AGING AND DEVELOPMENT
    WOODRING ERIK WRIGHT; Fiscal Year: 2010
  2. GENE EXPRESSION IN AGING AND DEVELOPMENT
    Woodring Wright; Fiscal Year: 2002
  3. GENE EXPRESSION IN AGING AND DEVELOPMENT
    Woodring Wright; Fiscal Year: 2003
  4. MECHANISMS OF CELLULAR IMMORTALIZATION
    Woodring Wright; Fiscal Year: 2004
  5. GENE EXPRESSION IN AGING AND DEVELOPMENT
    Woodring Wright; Fiscal Year: 2006
  6. GENE EXPRESSION IN AGING AND DEVELOPMENT
    Woodring Wright; Fiscal Year: 2007
  7. MECHANISMS OF CELLULAR IMMORTALIZATION
    Woodring Wright; Fiscal Year: 2007
  8. MECHANISMS OF CELLULAR IMMORTALIZATION
    Woodring Wright; Fiscal Year: 2009
  9. GENE EXPRESSION IN AGING AND DEVELOPMENT
    Woodring Wright; Fiscal Year: 2009
  10. MECHANISMS OF CELLULAR IMMORTALIZATION
    WOODRING ERIK WRIGHT; Fiscal Year: 2010

Collaborators

Detail Information

Publications64

  1. ncbi request reprint Cellular senescence as a tumor-protection mechanism: the essential role of counting
    W E Wright
    Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9039, USA
    Curr Opin Genet Dev 11:98-103. 2001
    ....
  2. ncbi request reprint Historical claims and current interpretations of replicative aging
    Woodring E Wright
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9039, USA
    Nat Biotechnol 20:682-8. 2002
    ..Although the presence of telomere shortening provides strong circumstantial evidence that replicative aging is occurring in vivo, thus far there is only very limited direct evidence for actual physiological effects of replicative aging...
  3. pmc Quantitative telomeric overhang determination using a double-strand specific nuclease
    Yong Zhao
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Nucleic Acids Res 36:e14. 2008
    ..We here describe the use of a double-strand specific nuclease (DSN) that entirely digests double-stranded DNA including telomeres, leaving the overhangs intact so that they can be measured...
  4. pmc Immortalized pathological human myoblasts: towards a universal tool for the study of neuromuscular disorders
    Kamel Mamchaoui
    Thérapie des maladies du muscle strié, Institut de Myologie, UM76, UPMC Universite Paris 6, Paris, France
    Skelet Muscle 1:34. 2011
    ..abstract:..
  5. ncbi request reprint Telomere biology in aging and cancer
    Woodring E Wright
    Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Building K2 206, MC 9039, Dallas, TX 75235, USA
    J Am Geriatr Soc 53:S292-4. 2005
    ..Such treatments should increase health span, but because replicative aging represents only one of many processes that may contribute to overall human aging, modest increases in life span are expected at best...
  6. ncbi request reprint Inexpensive low-oxygen incubators
    Woodring E Wright
    Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9039, USA
    Nat Protoc 1:2088-90. 2006
    ..This permits any laboratory to easily try the effects of physiological oxygen on their system without the need for dedicated incubators and substantial monetary investments...
  7. pmc Establishment of clonal myogenic cell lines from severely affected dystrophic muscles - CDK4 maintains the myogenic population
    Guido Stadler
    Department of Cell Biology, UT Southwestern Medical Center at Dallas, Dallas, TX, USA
    Skelet Muscle 1:12. 2011
    ..abstract:..
  8. ncbi request reprint p16(INK4a) inactivation is not required to immortalize human mammary epithelial cells
    Brittney Shea Herbert
    Department of Cell Biology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas, TX 75390 9039, USA
    Oncogene 21:7897-900. 2002
    ..These findings support the concept that the so-called M0 stage represents a cell culture stress-induced growth arrest and that hTERT is sufficient to immortalize HMECs when cultured under adequate conditions...
  9. pmc Telomere length regulates ISG15 expression in human cells
    Zhenjun Lou
    Department of Cell Biology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Aging (Albany NY) 1:608-21. 2009
    ..The upregulation of ISG15 with telomere shortening may contribute to chronic inflammatory states associated with human aging...
  10. ncbi request reprint Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins
    Ruben D Ramirez
    Hamon Center for Therapeutic Oncology Research and Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Cancer Res 64:9027-34. 2004
    ..These HBEC lines are a valuable new tool for studying of the pathogenesis of lung cancer...
  11. ncbi request reprint Characterization of growth and differentiation in a telomerase-immortalized human corneal epithelial cell line
    Danielle M Robertson
    Department of Ophthalmology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Invest Ophthalmol Vis Sci 46:470-8. 2005
    ..To develop and characterize a telomerase-immortalized human corneal epithelial cell line (hTCEpi) to serve as an in vitro model for studying the molecular mechanisms involved in regulating human corneal epithelial cell differentiation...
  12. ncbi request reprint Telomere biology and cellular aging in nonhuman primate cells
    Susanne Steinert
    Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9039, USA
    Exp Cell Res 272:146-52. 2002
    ..Here we show that the presence of continuous TTAGGG repeats at telomeres and rigorous control of replicative aging by telomere shortening appear to be conserved among anthropoid primates but is less effective in prosimian lemurs...
  13. ncbi request reprint Mechanism-based combination telomerase inhibition therapy
    Jerry W Shay
    University of Texas Southwestern Medical Center, Dallas, Texas 75309, USA
    Cancer Cell 7:1-2. 2005
    ..The combination of tankyrase and telomerase inhibitors may offer new opportunities for realizing the promise of telomerase inhibition therapy...
  14. ncbi request reprint Senescence and immortalization: role of telomeres and telomerase
    Jerry W Shay
    University of Texas Southwestern Medical Center at Dallas, Department of Cell Biology, 5323 Harry Hines Boulevard, Dallas, TX 75390 9039, USA
    Carcinogenesis 26:867-74. 2005
    ....
  15. pmc Human telomeres maintain their overhang length at senescence
    Weihang Chai
    Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9039, USA
    Mol Cell Biol 25:2158-68. 2005
    ..We thus conclude that a global reduction in overhang length is not the molecular signal that triggers replicative senescence...
  16. ncbi request reprint Tissue culture as a hostile environment: identifying conditions for breast cancer progression studies
    Jerry W Shay
    Department of Cell Biology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9039, USA
    Cancer Cell 12:100-1. 2007
    ..This suggests that pre-existing differences in cell culture can modulate the tumor phenotype...
  17. ncbi request reprint Effects of a novel telomerase inhibitor, GRN163L, in human breast cancer
    Ginelle C Gellert
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9039, USA
    Breast Cancer Res Treat 96:73-81. 2006
    ..These results reveal critical information regarding the effectiveness of GRN163L as a potential therapeutic agent for the treatment of human breast cancer...
  18. ncbi request reprint Use of telomerase to create bioengineered tissues
    Jerry W Shay
    Department of Cell Biology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9039, USA
    Ann N Y Acad Sci 1057:479-91. 2005
    ..The production of hTERT-engineered tissues offers the possibility of producing tissues to treat a variety of chronic diseases and age-related medical conditions that are due to telomere-based replicative senescence...
  19. ncbi request reprint Telomerase therapeutics for cancer: challenges and new directions
    Jerry W Shay
    Department of Cell Biology, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9039, USA
    Nat Rev Drug Discov 5:577-84. 2006
    ....
  20. ncbi request reprint Cellular senescence in human myoblasts is overcome by human telomerase reverse transcriptase and cyclin-dependent kinase 4: consequences in aging muscle and therapeutic strategies for muscular dystrophies
    Chun Hong Zhu
    Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9039, USA
    Aging Cell 6:515-23. 2007
    ..We demonstrate that it functions as well as young myoblasts in xenotransplant experiments in immunocompromized mice under conditions of regeneration following muscle damage...
  21. pmc Telomeres and telomerase in normal and cancer stem cells
    Jerry W Shay
    UT Southwestern Medical Center, Department of Cell Biology, Dallas, TX 75390, USA
    FEBS Lett 584:3819-25. 2010
    ....
  22. pmc Altered states of telomere deprotection and the two-stage mechanism of replicative aging
    Ying Zou
    Department of Cell Biology, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9039, USA
    Mol Cell Biol 29:2390-7. 2009
    ..M2/crisis involves both qualitative changes (a shift from TAs to TAs plus dicentric chromosomes) and quantitative changes (an increase in the number of dysfunctional telomeres)...
  23. doi request reprint Immortalized epithelial cells derived from human colon biopsies express stem cell markers and differentiate in vitro
    Andres I Roig
    Department of Cell Biology, Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Gastroenterology 138:1012-21.e1-5. 2010
    ..We sought to immortalize human colon biopsy-derived cells expressing stem cell markers and retaining multilineage epithelial differentiation capability...
  24. pmc Does a sentinel or a subset of short telomeres determine replicative senescence?
    Ying Zou
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Mol Biol Cell 15:3709-18. 2004
    ..These results demonstrate that a specific group of chromosomes with the shortest telomeres rather than either all or only one or two sentinel telomeres is responsible for the induction of replicative senescence...
  25. ncbi request reprint Human Ku70/80 associates physically with telomerase through interaction with hTERT
    Weihang Chai
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9039, USA
    J Biol Chem 277:47242-7. 2002
    ..The results presented here are the first to report that Ku associates with hTERT, and this interaction may function to regulate the access of telomerase to telomeric DNA ends...
  26. ncbi request reprint A peroxisome proliferator-activated receptor-gamma agonist and the p53 rescue drug CP-31398 inhibit the spontaneous immortalization of breast epithelial cells
    Brittney Shea Herbert
    Department of Cell Biology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9039, USA
    Cancer Res 63:1914-9. 2003
    ....
  27. ncbi request reprint Developmental differences in the immortalization of lung fibroblasts by telomerase
    Nicholas R Forsyth
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9039, USA
    Aging Cell 2:235-43. 2003
    ....
  28. ncbi request reprint Myofibroblast differentiation of normal human keratocytes and hTERT, extended-life human corneal fibroblasts
    James V Jester
    Departments of Ophthalmology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Invest Ophthalmol Vis Sci 44:1850-8. 2003
    ..The purpose of this study was to determine whether TGFbeta induces myofibroblast differentiation in cultured human keratocytes and in telomerase (hTERT)-immortalized human corneal fibroblast cell lines...
  29. ncbi request reprint Bypass of telomere-dependent replicative senescence (M1) upon overexpression of Cdk4 in normal human epithelial cells
    Ruben D Ramirez
    Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center, Dallas, TX 75390 8593, USA
    Oncogene 22:433-44. 2003
    ..These results suggest that the differentiation pathways in Cdk4-overexpressing cells remain intact...
  30. ncbi request reprint Human telomerase can immortalize Indian muntjac cells
    Ying Zou
    Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9039, USA
    Exp Cell Res 281:63-76. 2002
    ..Indian muntjac cells provide an excellent system for understanding the mechanism of replicative senescence and the role of telomerase in the elongation of individual telomeres...
  31. ncbi request reprint Telomerase: a target for cancer therapeutics
    Jerry W Shay
    The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75309, USA
    Cancer Cell 2:257-65. 2002
    ..In this review, we will discuss the challenges and the pros and cons of the most promising antitelomerase approaches currently being investigated...
  32. pmc Human telomerase and its regulation
    Yu Sheng Cong
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9039, USA
    Microbiol Mol Biol Rev 66:407-25, table of contents. 2002
    ..This review describes the currently known components of the telomerase complex and attempts to provide an update on the molecular mechanisms of human telomerase regulation...
  33. ncbi request reprint Telomerase and differentiation in multicellular organisms: turn it off, turn it on, and turn it off again
    Nicholas R Forsyth
    Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9039, USA
    Differentiation 69:188-97. 2002
    ..We will also highlight similarities, differences and misconceptions in the developing field of telomere and telomerase biology...
  34. ncbi request reprint Telomerase in cancer and aging
    Meaghan P Granger
    Department of Cell Biology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9039, USA
    Crit Rev Oncol Hematol 41:29-40. 2002
    ..The ultimate goal of telomerase research is to use our understanding to develop anti-telomerase therapies, an almost universal tumor target...
  35. ncbi request reprint Telomerase regulation: not just flipping the switch
    Dara L Aisner
    The University of Texas Southwestern Medical Center, The Department of Cell Biology, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9039, USA
    Curr Opin Genet Dev 12:80-5. 2002
    ..It is hoped that shedding light on these diverse areas of telomerase regulation will allow us to manipulate telomerase activity for therapeutic purposes...
  36. pmc Spontaneous immortalization of clinically normal colon-derived fibroblasts from a familial adenomatous polyposis patient
    Nicholas R Forsyth
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Neoplasia 6:258-65. 2004
    ....
  37. pmc The telomerase antagonist, imetelstat, efficiently targets glioblastoma tumor-initiating cells leading to decreased proliferation and tumor growth
    Calin O Marian
    Department of Cell Biology, Annette G Strauss Center for Neuro Oncology, University of Texas, Southwestern Medical Center, Dallas, Texas 75390 9039, USA
    Clin Cancer Res 16:154-63. 2010
    ..The effects of a novel human telomerase antagonist, imetelstat, on primary human glioblastoma (GBM) tumor-initiating cells were investigated in vitro and in vivo...
  38. doi request reprint CDDO-Me protects against space radiation-induced transformation of human colon epithelial cells
    Ugur Eskiocak
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9039, USA
    Radiat Res 174:27-36. 2010
    ..The utility of premalignant HCECs to test novel compounds such as CDDO-Me that can be used to protect against radiation-induced neoplastic transformation is also demonstrated...
  39. pmc Telomere biology in Metazoa
    Nuno M V Gomes
    Department of Cell Biology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9039, USA
    FEBS Lett 584:3741-51. 2010
    ..Telomerase repression among birds and many mammals suggests that, as humans, they may use replicative aging as a tumor protection mechanism...
  40. pmc Function of AP-1 in transcription of the telomerase reverse transcriptase gene (TERT) in human and mouse cells
    Masahiro Takakura
    Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9039, USA
    Mol Cell Biol 25:8037-43. 2005
    ..The species-specific function of AP-1 in TERT expression may in part help explain the difference in telomerase activity between normal human and mouse cells...
  41. pmc Homologous recombination in human telomerase-positive and ALT cells occurs with the same frequency
    Oliver E Bechter
    Department of Cell Biology, Southwestern Medical Center, The University of Texas, Dallas, Texas 75390, USA
    EMBO Rep 4:1138-43. 2003
    ..Our results indicate that the underlying defect in homologous recombination in ALT cells does not affect sequences independent of their chromosomal location but is likely to be primarily a specific telomeric defect...
  42. ncbi request reprint The establishment of telomerase-immortalized Tangier disease cell lines indicates the existence of an apolipoprotein A-I-inducible but ABCA1-independent cholesterol efflux pathway
    Michael Walter
    Department of Biochemistry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235 9038, USA
    J Biol Chem 279:20866-73. 2004
    ....
  43. ncbi request reprint Telomere-end processing the terminal nucleotides of human chromosomes
    Agnel J Sfeir
    Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Mol Cell 18:131-8. 2005
    ..In contrast, the G-terminal nucleotide was less precise than Tetrahymena and Euplotes but still had a bias that changed as a function of telomerase expression...
  44. doi request reprint The effects of telomerase inhibition on prostate tumor-initiating cells
    Calin O Marian
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Int J Cancer 127:321-31. 2010
    ..These findings suggest that telomerase inhibition therapy may be able to efficiently target the prostate TICs in addition to the bulk tumor cells, providing new opportunities for combination therapies...
  45. ncbi request reprint A reproducible laser-wounded skin equivalent model to study the effects of aging in vitro
    Melville B Vaughan
    Department of Cell Biology, UT Southwestern Medical Center, Dallas, Texas, USA
    Rejuvenation Res 7:99-110. 2004
    ..The laser-wounded skin equivalent is an adjustable, reproducible partial-thickness wound model where keratinocyte biology akin to in vivo can be studied, and will be useful to study the effects of aging on wound healing...
  46. ncbi request reprint Telomeres are double-strand DNA breaks hidden from DNA damage responses
    Jerry W Shay
    University of Texas Southwestern Medical Center, Department of Cell Biology, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Mol Cell 14:420-1. 2004
    ..In yeast and in human cells, investigators, including, and Herbig et al., published in this issue of Molecular Cell, are beginning to decipher the signaling pathways involved at the telomeres...
  47. ncbi request reprint Protein-coated poly(L-lactic acid) fibers provide a substrate for differentiation of human skeletal muscle cells
    Elizabeth M Cronin
    Joint Biomedical Engineering Program, University of Texas Southwestern Medical Center, Dallas, and University of Texas at Arlington, Arlington, USA
    J Biomed Mater Res A 69:373-81. 2004
    ..Therefore, PLLA fibers coated with ECM proteins provide a scaffold for the development of skeletal muscle tissue for tissue engineering and cell transplantation applications...
  48. ncbi request reprint Antiadhesive effects of GRN163L--an oligonucleotide N3'->P5' thio-phosphoramidate targeting telomerase
    Shalmica R Jackson
    Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Cancer Res 67:1121-9. 2007
    ....
  49. ncbi request reprint Lipid modification of GRN163, an N3'-->P5' thio-phosphoramidate oligonucleotide, enhances the potency of telomerase inhibition
    Brittney Shea Herbert
    Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9039, USA
    Oncogene 24:5262-8. 2005
    ..These results suggest that the lipid-conjugated thio-phosphoramidates could be important for improved pharmacodynamics of telomerase inhibitors in cancer therapy...
  50. ncbi request reprint Human telomeres have different overhang sizes at leading versus lagging strands
    Weihang Chai
    Department of Cell Biology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Mol Cell 21:427-35. 2006
    ..Thus, the overhangs at the leading and lagging daughter telomeres are generated differently in human cells, and telomerase may preferentially affect overhangs generated at the telomeres produced by leading-strand synthesis...
  51. ncbi request reprint Lagomorphs (rabbits, pikas and hares) do not use telomere-directed replicative aging in vitro
    Nicholas R Forsyth
    Department of Cell Biology, The University of Texas Southwestern Medical Center at Dallas, 75390 9039, USA
    Mech Ageing Dev 126:685-91. 2005
    ..Pika was unique in displaying endogenous telomerase activity throughout time in culture. These results show that it is unlikely that lagomorphs use telomere shortening and replicative senescence as a tumor protective mechanism...
  52. pmc H-ras expression in immortalized keratinocytes produces an invasive epithelium in cultured skin equivalents
    Melville B Vaughan
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 4:e7908. 2009
    ..In the present studies we sought to determine whether expression of H-ras in skin keratinocytes would affect these parameters during the establishment and maintenance of an in vitro skin equivalent...
  53. ncbi request reprint Analysis of mammalian telomere position effect
    Joseph A Baur
    Department of Cell Biology, The University of Texas Southwestern Medical Center, Dallas, TX, USA
    Methods Mol Biol 287:121-36. 2004
    ..This chapter summarizes the techniques currently in use that relate to human telomere position effect...
  54. pmc Telomere extension occurs at most chromosome ends and is uncoupled from fill-in in human cancer cells
    Yong Zhao
    Department of Cell Biology, UT Southwestern Medical Center, Dallas, TX 75390, USA
    Cell 138:463-75. 2009
    ....
  55. pmc Asynchronous replication timing of telomeres at opposite arms of mammalian chromosomes
    Ying Zou
    University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 101:12928-33. 2004
    ..The approach, which we call replicative detargeting fluorescence in situ hybridization, is widely applicable to different species and genetic loci...
  56. ncbi request reprint The frequency of homologous recombination in human ALT cells
    Oliver E Bechter
    UT Southwestern Medical Center, Dallas, Texas 75390 9039, USA
    Cell Cycle 3:547-9. 2004
    ..We conclude that the underlying recombination defect in ALT cells is restricted to telomeric sequences...
  57. ncbi request reprint Spontaneous reactivation of a silent telomeric transgene in a human cell line
    Joseph A Baur
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9039, USA
    Chromosoma 112:240-6. 2004
    ..These data imply that telomere shortening during human aging could lead to stochastic activation of subtelomeric genes...
  58. pmc The involvement of the Mre11/Rad50/Nbs1 complex in the generation of G-overhangs at human telomeres
    Weihang Chai
    Department of Cell Biology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, Texas 75390 9039, USA
    EMBO Rep 7:225-30. 2006
    ..The reduction in overhang length was not seen in telomerase-negative cells, but was observed after the expression of exogenous telomerase, which suggested that the MRN complex might be involved in the recruitment or action of telomerase...
  59. ncbi request reprint Stem cells and their derivatives can bypass the requirement of myocardin for smooth muscle gene expression
    G C Teg Pipes
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390, USA
    Dev Biol 288:502-13. 2005
    ....
  60. pmc Human diseases of telomerase dysfunction: insights into tissue aging
    Christine Kim Garcia
    McDermott Center for Human Growth and Development, Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Nucleic Acids Res 35:7406-16. 2007
    ..Understanding the biological effects of these mutations may ultimately lead to novel treatments for these patients...
  61. doi request reprint Analysis of telomeres and telomerase
    Brittney Shea Herbert
    The University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Curr Protoc Cell Biol . 2003
    ..These assays can be used to study the in vitro cellular effects of aging and cancer treatments on telomere biology and telomerase activity...
  62. ncbi request reprint Fine-tuning the chromosome ends: the last base of human telomeres
    Agnel J Sfeir
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9039, USA
    Cell Cycle 4:1467-70. 2005
    ..While the mechanism behind this phenotype is yet to be unraveled, we discuss potential models that could explain the last base specificity...
  63. pmc Modification of subtelomeric DNA
    Susanne Steinert
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9039, USA
    Mol Cell Biol 24:4571-80. 2004
    ..We show that the X-region represents a variable domain whose size changes with telomere length, and neither non-TTAGGG sequences nor cytidine methylation can adequately explain the size of the X-region...
  64. pmc SGNP: an essential Stress Granule/Nucleolar Protein potentially involved in 5.8s rRNA processing/transport
    Chun Hong Zhu
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    PLoS ONE 3:e3716. 2008
    ..In a genetic screen for factors involved in protecting human myoblasts from acute oxidative stress, we identified a gene encoding a protein we designate SGNP (Stress Granule and Nucleolar Protein)...

Research Grants39

  1. GENE EXPRESSION IN AGING AND DEVELOPMENT
    WOODRING ERIK WRIGHT; Fiscal Year: 2010
    ..Knowledge of the structure and processing of telomeres and the mechanisms by which they are maintained will provide targets for the development of new drugs to treat cancer and age-related diseases. ..
  2. GENE EXPRESSION IN AGING AND DEVELOPMENT
    Woodring Wright; Fiscal Year: 2002
    ..Knowledge gained from these studies may lead to the ability to manipulate rates of telomere shortening, with consequences both for slowing cellular senescence and enhancing the efficacy of anti-telomerase cancer therapeutics. ..
  3. GENE EXPRESSION IN AGING AND DEVELOPMENT
    Woodring Wright; Fiscal Year: 2003
    ..abstract_text> ..
  4. MECHANISMS OF CELLULAR IMMORTALIZATION
    Woodring Wright; Fiscal Year: 2004
    ..The information resulting from these studies should help define the molecular mechanisms underlying replicative senescence and its relationship to cancer. ..
  5. GENE EXPRESSION IN AGING AND DEVELOPMENT
    Woodring Wright; Fiscal Year: 2006
    ..abstract_text> ..
  6. GENE EXPRESSION IN AGING AND DEVELOPMENT
    Woodring Wright; Fiscal Year: 2007
    ..abstract_text> ..
  7. MECHANISMS OF CELLULAR IMMORTALIZATION
    Woodring Wright; Fiscal Year: 2007
    ..Insights from these studies may lead to treatments for cancer and interventions to modify cellular aging. ..
  8. MECHANISMS OF CELLULAR IMMORTALIZATION
    Woodring Wright; Fiscal Year: 2009
    ..Insights from these studies may lead to treatments for cancer and interventions to modify cellular aging. ..
  9. GENE EXPRESSION IN AGING AND DEVELOPMENT
    Woodring Wright; Fiscal Year: 2009
    ..Knowledge of the structure and processing of telomeres and the mechanisms by which they are maintained will provide targets for the development of new drugs to treat cancer and age-related diseases. ..
  10. MECHANISMS OF CELLULAR IMMORTALIZATION
    WOODRING ERIK WRIGHT; Fiscal Year: 2010
    ..Insights from these studies may lead to treatments for cancer and interventions to modify cellular aging. ..
  11. MECHANISMS OF CELLULAR IMMORTALIZATION
    Woodring Wright; Fiscal Year: 1993
  12. MECHANISMS OF CELLULAR IMMORTALIZATION
    Woodring Wright; Fiscal Year: 1999
    ..The identification of the specific molecular events controlling both M1 and M2 should permit detailed studies of their functional roles in oncogenesis and the degenerative pathologies of aging. ..
  13. GENE EXPRESSION IN AGING AND DEVELOPMENT
    Woodring Wright; Fiscal Year: 1980
    ....
  14. Manipulating telomerase alternative splicing for cancer therapy
    WOODRING ERIK WRIGHT; Fiscal Year: 2011
    ..This application explores the ability to manipulate the alternative splicing of telomerase in order to develop more effective cancer treatments. ..