Research Topics
Species | WOODRING ERIK WRIGHTSummaryAffiliation: University of Texas Southwestern Medical Center Country: USA Publications
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Publications
Cellular senescence as a tumor-protection mechanism: the essential role of countingW E Wright
Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9039, USA
Curr Opin Genet Dev 11:98-103. 2001....- Historical claims and current interpretations of replicative agingWoodring E Wright
Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9039, USA
Nat Biotechnol 20:682-8. 2002..Although the presence of telomere shortening provides strong circumstantial evidence that replicative aging is occurring in vivo, thus far there is only very limited direct evidence for actual physiological effects of replicative aging... 
Quantitative telomeric overhang determination using a double-strand specific nucleaseYong Zhao
Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Nucleic Acids Res 36:e14. 2008..We here describe the use of a double-strand specific nuclease (DSN) that entirely digests double-stranded DNA including telomeres, leaving the overhangs intact so that they can be measured...- Immortalized pathological human myoblasts: towards a universal tool for the study of neuromuscular disordersKamel Mamchaoui
Thérapie des maladies du muscle strié, Institut de Myologie, UM76, UPMC Universite Paris 6, Paris, France
Skelet Muscle 1:34. 2011..abstract:.. - Telomere biology in aging and cancerWoodring E Wright
Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Building K2 206, MC 9039, Dallas, TX 75235, USA
J Am Geriatr Soc 53:S292-4. 2005..Such treatments should increase health span, but because replicative aging represents only one of many processes that may contribute to overall human aging, modest increases in life span are expected at best... - Inexpensive low-oxygen incubatorsWoodring E Wright
Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9039, USA
Nat Protoc 1:2088-90. 2006..This permits any laboratory to easily try the effects of physiological oxygen on their system without the need for dedicated incubators and substantial monetary investments... - Establishment of clonal myogenic cell lines from severely affected dystrophic muscles - CDK4 maintains the myogenic populationGuido Stadler
Department of Cell Biology, UT Southwestern Medical Center at Dallas, Dallas, TX, USA
Skelet Muscle 1:12. 2011..abstract:.. - p16(INK4a) inactivation is not required to immortalize human mammary epithelial cellsBrittney Shea Herbert
Department of Cell Biology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas, TX 75390 9039, USA
Oncogene 21:7897-900. 2002..These findings support the concept that the so-called M0 stage represents a cell culture stress-induced growth arrest and that hTERT is sufficient to immortalize HMECs when cultured under adequate conditions... - Telomere length regulates ISG15 expression in human cellsZhenjun Lou
Department of Cell Biology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
Aging (Albany NY) 1:608-21. 2009..The upregulation of ISG15 with telomere shortening may contribute to chronic inflammatory states associated with human aging... - Immortalization of human bronchial epithelial cells in the absence of viral oncoproteinsRuben D Ramirez
Hamon Center for Therapeutic Oncology Research and Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
Cancer Res 64:9027-34. 2004..These HBEC lines are a valuable new tool for studying of the pathogenesis of lung cancer... - Characterization of growth and differentiation in a telomerase-immortalized human corneal epithelial cell lineDanielle M Robertson
Department of Ophthalmology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
Invest Ophthalmol Vis Sci 46:470-8. 2005..Further study of the hTCEpi cell line may be valuable in studying the molecular mechanisms regulating corneal epithelial cell differentiation and desquamation... - Telomere biology and cellular aging in nonhuman primate cellsSusanne Steinert
Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9039, USA
Exp Cell Res 272:146-52. 2002..Here we show that the presence of continuous TTAGGG repeats at telomeres and rigorous control of replicative aging by telomere shortening appear to be conserved among anthropoid primates but is less effective in prosimian lemurs... - Mechanism-based combination telomerase inhibition therapyJerry W Shay
University of Texas Southwestern Medical Center, Dallas, Texas 75309, USA
Cancer Cell 7:1-2. 2005..The combination of tankyrase and telomerase inhibitors may offer new opportunities for realizing the promise of telomerase inhibition therapy... - Senescence and immortalization: role of telomeres and telomeraseJerry W Shay
University of Texas Southwestern Medical Center at Dallas, Department of Cell Biology, 5323 Harry Hines Boulevard, Dallas, TX 75390 9039, USA
Carcinogenesis 26:867-74. 2005.... - Human telomeres maintain their overhang length at senescenceWeihang Chai
Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9039, USA
Mol Cell Biol 25:2158-68. 2005..We thus conclude that a global reduction in overhang length is not the molecular signal that triggers replicative senescence... - Tissue culture as a hostile environment: identifying conditions for breast cancer progression studiesJerry W Shay
Department of Cell Biology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9039, USA
Cancer Cell 12:100-1. 2007..This suggests that pre-existing differences in cell culture can modulate the tumor phenotype... - Effects of a novel telomerase inhibitor, GRN163L, in human breast cancerGinelle C Gellert
Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9039, USA
Breast Cancer Res Treat 96:73-81. 2006..These results reveal critical information regarding the effectiveness of GRN163L as a potential therapeutic agent for the treatment of human breast cancer... - Use of telomerase to create bioengineered tissuesJerry W Shay
Department of Cell Biology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9039, USA
Ann N Y Acad Sci 1057:479-91. 2005..The production of hTERT-engineered tissues offers the possibility of producing tissues to treat a variety of chronic diseases and age-related medical conditions that are due to telomere-based replicative senescence... - Telomerase therapeutics for cancer: challenges and new directionsJerry W Shay
Department of Cell Biology, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9039, USA
Nat Rev Drug Discov 5:577-84. 2006.... - Cellular senescence in human myoblasts is overcome by human telomerase reverse transcriptase and cyclin-dependent kinase 4: consequences in aging muscle and therapeutic strategies for muscular dystrophiesChun Hong Zhu
Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9039, USA
Aging Cell 6:515-23. 2007..We demonstrate that it functions as well as young myoblasts in xenotransplant experiments in immunocompromized mice under conditions of regeneration following muscle damage... - Telomeres and telomerase in normal and cancer stem cellsJerry W Shay
UT Southwestern Medical Center, Department of Cell Biology, Dallas, TX 75390, USA
FEBS Lett 584:3819-25. 2010.... - Altered states of telomere deprotection and the two-stage mechanism of replicative agingYing Zou
Department of Cell Biology, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9039, USA
Mol Cell Biol 29:2390-7. 2009..M2/crisis involves both qualitative changes (a shift from TAs to TAs plus dicentric chromosomes) and quantitative changes (an increase in the number of dysfunctional telomeres)... 
Immortalized epithelial cells derived from human colon biopsies express stem cell markers and differentiate in vitroAndres I Roig
Department of Cell Biology, Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Gastroenterology 138:1012-21.e1-5. 2010..We sought to immortalize human colon biopsy-derived cells expressing stem cell markers and retaining multilineage epithelial differentiation capability...- Does a sentinel or a subset of short telomeres determine replicative senescence?Ying Zou
Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Mol Biol Cell 15:3709-18. 2004..These results demonstrate that a specific group of chromosomes with the shortest telomeres rather than either all or only one or two sentinel telomeres is responsible for the induction of replicative senescence... - Human Ku70/80 associates physically with telomerase through interaction with hTERTWeihang Chai
Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9039, USA
J Biol Chem 277:47242-7. 2002..The results presented here are the first to report that Ku associates with hTERT, and this interaction may function to regulate the access of telomerase to telomeric DNA ends... - A peroxisome proliferator-activated receptor-gamma agonist and the p53 rescue drug CP-31398 inhibit the spontaneous immortalization of breast epithelial cellsBrittney Shea Herbert
Department of Cell Biology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9039, USA
Cancer Res 63:1914-9. 2003.... - Developmental differences in the immortalization of lung fibroblasts by telomeraseNicholas R Forsyth
Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9039, USA
Aging Cell 2:235-43. 2003.... - Myofibroblast differentiation of normal human keratocytes and hTERT, extended-life human corneal fibroblastsJames V Jester
Departments of Ophthalmology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
Invest Ophthalmol Vis Sci 44:1850-8. 2003..The purpose of this study was to determine whether TGFbeta induces myofibroblast differentiation in cultured human keratocytes and in telomerase (hTERT)-immortalized human corneal fibroblast cell lines... - Bypass of telomere-dependent replicative senescence (M1) upon overexpression of Cdk4 in normal human epithelial cellsRuben D Ramirez
Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center, Dallas, TX 75390 8593, USA
Oncogene 22:433-44. 2003..These results suggest that the differentiation pathways in Cdk4-overexpressing cells remain intact... - Human telomerase can immortalize Indian muntjac cellsYing Zou
Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9039, USA
Exp Cell Res 281:63-76. 2002..Indian muntjac cells provide an excellent system for understanding the mechanism of replicative senescence and the role of telomerase in the elongation of individual telomeres... - Telomerase: a target for cancer therapeuticsJerry W Shay
The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75309, USA
Cancer Cell 2:257-65. 2002..In this review, we will discuss the challenges and the pros and cons of the most promising antitelomerase approaches currently being investigated... - Human telomerase and its regulationYu Sheng Cong
Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9039, USA
Microbiol Mol Biol Rev 66:407-25, table of contents. 2002..This review describes the currently known components of the telomerase complex and attempts to provide an update on the molecular mechanisms of human telomerase regulation... - Telomerase and differentiation in multicellular organisms: turn it off, turn it on, and turn it off againNicholas R Forsyth
Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9039, USA
Differentiation 69:188-97. 2002..We will also highlight similarities, differences and misconceptions in the developing field of telomere and telomerase biology... - Telomerase in cancer and agingMeaghan P Granger
Department of Cell Biology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9039, USA
Crit Rev Oncol Hematol 41:29-40. 2002..The ultimate goal of telomerase research is to use our understanding to develop anti-telomerase therapies, an almost universal tumor target... - Telomerase regulation: not just flipping the switchDara L Aisner
The University of Texas Southwestern Medical Center, The Department of Cell Biology, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9039, USA
Curr Opin Genet Dev 12:80-5. 2002..It is hoped that shedding light on these diverse areas of telomerase regulation will allow us to manipulate telomerase activity for therapeutic purposes... - Spontaneous immortalization of clinically normal colon-derived fibroblasts from a familial adenomatous polyposis patientNicholas R Forsyth
Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA
Neoplasia 6:258-65. 2004.... - The telomerase antagonist, imetelstat, efficiently targets glioblastoma tumor-initiating cells leading to decreased proliferation and tumor growthCalin O Marian
Department of Cell Biology, Annette G Strauss Center for Neuro Oncology, University of Texas, Southwestern Medical Center, Dallas, Texas 75390 9039, USA
Clin Cancer Res 16:154-63. 2010..The effects of a novel human telomerase antagonist, imetelstat, on primary human glioblastoma (GBM) tumor-initiating cells were investigated in vitro and in vivo... - CDDO-Me protects against space radiation-induced transformation of human colon epithelial cellsUgur Eskiocak
Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9039, USA
Radiat Res 174:27-36. 2010..The utility of premalignant HCECs to test novel compounds such as CDDO-Me that can be used to protect against radiation-induced neoplastic transformation is also demonstrated... - Telomere biology in MetazoaNuno M V Gomes
Department of Cell Biology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9039, USA
FEBS Lett 584:3741-51. 2010..Telomerase repression among birds and many mammals suggests that, as humans, they may use replicative aging as a tumor protection mechanism... - Function of AP-1 in transcription of the telomerase reverse transcriptase gene (TERT) in human and mouse cellsMasahiro Takakura
Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9039, USA
Mol Cell Biol 25:8037-43. 2005..The species-specific function of AP-1 in TERT expression may in part help explain the difference in telomerase activity between normal human and mouse cells... - Homologous recombination in human telomerase-positive and ALT cells occurs with the same frequencyOliver E Bechter
Department of Cell Biology, Southwestern Medical Center, The University of Texas, Dallas, Texas 75390, USA
EMBO Rep 4:1138-43. 2003..Our results indicate that the underlying defect in homologous recombination in ALT cells does not affect sequences independent of their chromosomal location but is likely to be primarily a specific telomeric defect... - The establishment of telomerase-immortalized Tangier disease cell lines indicates the existence of an apolipoprotein A-I-inducible but ABCA1-independent cholesterol efflux pathwayMichael Walter
Department of Biochemistry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235 9038, USA
J Biol Chem 279:20866-73. 2004.... - Telomere-end processing the terminal nucleotides of human chromosomesAgnel J Sfeir
Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
Mol Cell 18:131-8. 2005..In contrast, the G-terminal nucleotide was less precise than Tetrahymena and Euplotes but still had a bias that changed as a function of telomerase expression... - The effects of telomerase inhibition on prostate tumor-initiating cellsCalin O Marian
Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA
Int J Cancer 127:321-31. 2010..These findings suggest that telomerase inhibition therapy may be able to efficiently target the prostate TICs in addition to the bulk tumor cells, providing new opportunities for combination therapies... - A reproducible laser-wounded skin equivalent model to study the effects of aging in vitroMelville B Vaughan
Department of Cell Biology, UT Southwestern Medical Center, Dallas, Texas, USA
Rejuvenation Res 7:99-110. 2004..The laser-wounded skin equivalent is an adjustable, reproducible partial-thickness wound model where keratinocyte biology akin to in vivo can be studied, and will be useful to study the effects of aging on wound healing... - Telomeres are double-strand DNA breaks hidden from DNA damage responsesJerry W Shay
University of Texas Southwestern Medical Center, Department of Cell Biology, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Mol Cell 14:420-1. 2004..In yeast and in human cells, investigators, including, and Herbig et al., published in this issue of Molecular Cell, are beginning to decipher the signaling pathways involved at the telomeres... - Protein-coated poly(L-lactic acid) fibers provide a substrate for differentiation of human skeletal muscle cellsElizabeth M Cronin
Joint Biomedical Engineering Program, University of Texas Southwestern Medical Center, Dallas, and University of Texas at Arlington, Arlington, USA
J Biomed Mater Res A 69:373-81. 2004..Therefore, PLLA fibers coated with ECM proteins provide a scaffold for the development of skeletal muscle tissue for tissue engineering and cell transplantation applications... - Antiadhesive effects of GRN163L--an oligonucleotide N3'->P5' thio-phosphoramidate targeting telomeraseShalmica R Jackson
Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Cancer Res 67:1121-9. 2007.... - Lipid modification of GRN163, an N3'-->P5' thio-phosphoramidate oligonucleotide, enhances the potency of telomerase inhibitionBrittney Shea Herbert
Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9039, USA
Oncogene 24:5262-8. 2005..These results suggest that the lipid-conjugated thio-phosphoramidates could be important for improved pharmacodynamics of telomerase inhibitors in cancer therapy... - Human telomeres have different overhang sizes at leading versus lagging strandsWeihang Chai
Department of Cell Biology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
Mol Cell 21:427-35. 2006..Thus, the overhangs at the leading and lagging daughter telomeres are generated differently in human cells, and telomerase may preferentially affect overhangs generated at the telomeres produced by leading-strand synthesis... - Lagomorphs (rabbits, pikas and hares) do not use telomere-directed replicative aging in vitroNicholas R Forsyth
Department of Cell Biology, The University of Texas Southwestern Medical Center at Dallas, 75390-9039, USA
Mech Ageing Dev 126:685-91. 2005..Pika was unique in displaying endogenous telomerase activity throughout time in culture. These results show that it is unlikely that lagomorphs use telomere shortening and replicative senescence as a tumor protective mechanism... - H-ras expression in immortalized keratinocytes produces an invasive epithelium in cultured skin equivalentsMelville B Vaughan
Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
PLoS ONE 4:e7908. 2009..In the present studies we sought to determine whether expression of H-ras in skin keratinocytes would affect these parameters during the establishment and maintenance of an in vitro skin equivalent... - Analysis of mammalian telomere position effectJoseph A Baur
Department of Cell Biology, The University of Texas Southwestern Medical Center, Dallas, TX, USA
Methods Mol Biol 287:121-36. 2004..This chapter summarizes the techniques currently in use that relate to human telomere position effect... - Telomere extension occurs at most chromosome ends and is uncoupled from fill-in in human cancer cellsYong Zhao
Department of Cell Biology, UT Southwestern Medical Center, Dallas, TX 75390, USA
Cell 138:463-75. 2009.... - Asynchronous replication timing of telomeres at opposite arms of mammalian chromosomesYing Zou
University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Proc Natl Acad Sci U S A 101:12928-33. 2004..The approach, which we call replicative detargeting fluorescence in situ hybridization, is widely applicable to different species and genetic loci... - The frequency of homologous recombination in human ALT cellsOliver E Bechter
UT Southwestern Medical Center, Dallas, Texas 75390-9039, USA
Cell Cycle 3:547-9. 2004..We conclude that the underlying recombination defect in ALT cells is restricted to telomeric sequences... - Spontaneous reactivation of a silent telomeric transgene in a human cell lineJoseph A Baur
Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9039, USA
Chromosoma 112:240-6. 2004..These data imply that telomere shortening during human aging could lead to stochastic activation of subtelomeric genes... - The involvement of the Mre11/Rad50/Nbs1 complex in the generation of G-overhangs at human telomeresWeihang Chai
Department of Cell Biology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, Texas 75390-9039, USA
EMBO Rep 7:225-30. 2006..The reduction in overhang length was not seen in telomerase-negative cells, but was observed after the expression of exogenous telomerase, which suggested that the MRN complex might be involved in the recruitment or action of telomerase... - Stem cells and their derivatives can bypass the requirement of myocardin for smooth muscle gene expressionG C Teg Pipes
Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390, USA
Dev Biol 288:502-13. 2005.... - Human diseases of telomerase dysfunction: insights into tissue agingChristine Kim Garcia
McDermott Center for Human Growth and Development, Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Nucleic Acids Res 35:7406-16. 2007..Understanding the biological effects of these mutations may ultimately lead to novel treatments for these patients... - Analysis of telomeres and telomeraseBrittney-Shea Herbert
The University of Texas Southwestern Medical Center, Dallas, Texas, USA
Curr Protoc Cell Biol . 2003..These assays can be used to study the in vitro cellular effects of aging and cancer treatments on telomere biology and telomerase activity... - Fine-tuning the chromosome ends: the last base of human telomeresAgnel J Sfeir
Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9039, USA
Cell Cycle 4:1467-70. 2005..While the mechanism behind this phenotype is yet to be unraveled, we discuss potential models that could explain the last base specificity... - Modification of subtelomeric DNASusanne Steinert
Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9039, USA
Mol Cell Biol 24:4571-80. 2004..We show that the X-region represents a variable domain whose size changes with telomere length, and neither non-TTAGGG sequences nor cytidine methylation can adequately explain the size of the X-region... - SGNP: an essential Stress Granule/Nucleolar Protein potentially involved in 5.8s rRNA processing/transportChun Hong Zhu
Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA
PLoS ONE 3:e3716. 2008..In a genetic screen for factors involved in protecting human myoblasts from acute oxidative stress, we identified a gene encoding a protein we designate SGNP (Stress Granule and Nucleolar Protein)...
Research Grants
- GENE EXPRESSION IN AGING AND DEVELOPMENTWOODRING ERIK WRIGHT; Fiscal Year: 2010..Knowledge of the structure and processing of telomeres and the mechanisms by which they are maintained will provide targets for the development of new drugs to treat cancer and age-related diseases. ..
- GENE EXPRESSION IN AGING AND DEVELOPMENTWoodring Wright; Fiscal Year: 2002..Knowledge gained from these studies may lead to the ability to manipulate rates of telomere shortening, with consequences both for slowing cellular senescence and enhancing the efficacy of anti-telomerase cancer therapeutics. ..
- GENE EXPRESSION IN AGING AND DEVELOPMENTWoodring Wright; Fiscal Year: 2003..abstract_text> ..
- MECHANISMS OF CELLULAR IMMORTALIZATIONWoodring Wright; Fiscal Year: 2004..The information resulting from these studies should help define the molecular mechanisms underlying replicative senescence and its relationship to cancer. ..
- GENE EXPRESSION IN AGING AND DEVELOPMENTWoodring Wright; Fiscal Year: 2006..abstract_text> ..
- GENE EXPRESSION IN AGING AND DEVELOPMENTWoodring Wright; Fiscal Year: 2007..abstract_text> ..
- MECHANISMS OF CELLULAR IMMORTALIZATIONWoodring Wright; Fiscal Year: 2007..Insights from these studies may lead to treatments for cancer and interventions to modify cellular aging. ..
- MECHANISMS OF CELLULAR IMMORTALIZATIONWoodring Wright; Fiscal Year: 2009..Insights from these studies may lead to treatments for cancer and interventions to modify cellular aging. ..
- GENE EXPRESSION IN AGING AND DEVELOPMENTWoodring Wright; Fiscal Year: 2009..Knowledge of the structure and processing of telomeres and the mechanisms by which they are maintained will provide targets for the development of new drugs to treat cancer and age-related diseases. ..
- MECHANISMS OF CELLULAR IMMORTALIZATIONWOODRING ERIK WRIGHT; Fiscal Year: 2010..Insights from these studies may lead to treatments for cancer and interventions to modify cellular aging. ..
- MECHANISMS OF CELLULAR IMMORTALIZATIONWoodring Wright; Fiscal Year: 1993
- MECHANISMS OF CELLULAR IMMORTALIZATIONWoodring Wright; Fiscal Year: 1999..The identification of the specific molecular events controlling both M1 and M2 should permit detailed studies of their functional roles in oncogenesis and the degenerative pathologies of aging. ..
- GENE EXPRESSION IN AGING AND DEVELOPMENTWoodring Wright; Fiscal Year: 1980....
- Manipulating telomerase alternative splicing for cancer therapyWOODRING ERIK WRIGHT; Fiscal Year: 2011..This application explores the ability to manipulate the alternative splicing of telomerase in order to develop more effective cancer treatments. ..