W E Wright

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Normal human chromosomes have long G-rich telomeric overhangs at one end
    W E Wright
    Department of Cell Biology and Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75235 9039 USA
    Genes Dev 11:2801-9. 1997
  2. ncbi request reprint Normal human telomeres are not late replicating
    W E Wright
    Department of Cell Biology and Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75235, USA
    Exp Cell Res 251:492-9. 1999
  3. pmc Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions
    R D Ramirez
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9039, USA
    Genes Dev 15:398-403. 2001
  4. ncbi request reprint Telomere position effect in human cells
    J A Baur
    Department of Cell Biology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390-9039, USA
    Science 292:2075-7. 2001
  5. ncbi request reprint Telomerase and cancer
    J W Shay
    The University of Texas Southwestern Medical Center, Department of Cell Biology, 5323 Harry Hines Boulevard, Dallas, TX 75390 9039, USA
    Hum Mol Genet 10:677-85. 2001
  6. pmc The La antigen associates with the human telomerase ribonucleoprotein and influences telomere length in vivo
    L P Ford
    The University of Texas Southwestern Medical Center, The Department of Cell Biology, Dallas 75390-9039, USA
    RNA 7:1068-75. 2001
  7. ncbi request reprint Effects of chemopreventive and antitelomerase agents on the spontaneous immortalization of breast epithelial cells
    B S Herbert
    Department of Cell Biology, The University of Texas Southwestern Medical Center, Dallas, TX 75390-9039, USA
    J Natl Cancer Inst 93:39-45. 2001
  8. ncbi request reprint Cellular senescence as a tumor-protection mechanism: the essential role of counting
    W E Wright
    Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9039, USA
    Curr Opin Genet Dev 11:98-103. 2001
  9. ncbi request reprint Hayflick, his limit, and cellular ageing
    J W Shay
    University of Texas Southwestern Medical Center at Dallas, Department of Cell Biology, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9039, USA
    Nat Rev Mol Cell Biol 1:72-6. 2000
  10. pmc Is telomerase a viable target in cancer?
    C M Buseman
    The University of Texas Southwestern Medical Center, Department of Cell Biology, Dallas, TX 75390 9039, USA
    Mutat Res 730:90-7. 2012

Collaborators

Detail Information

Publications22

  1. pmc Normal human chromosomes have long G-rich telomeric overhangs at one end
    W E Wright
    Department of Cell Biology and Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75235 9039 USA
    Genes Dev 11:2801-9. 1997
    ..Our results do not exclude the possibility that nuclease processing events following leading strand synthesis result in short overhangs on one end...
  2. ncbi request reprint Normal human telomeres are not late replicating
    W E Wright
    Department of Cell Biology and Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75235, USA
    Exp Cell Res 251:492-9. 1999
    ..Therefore, the timings of replication and processing of human telomeres are very different from those of yeast...
  3. pmc Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions
    R D Ramirez
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9039, USA
    Genes Dev 15:398-403. 2001
    ..These results do not support a telomere-independent mechanism of replicative aging...
  4. ncbi request reprint Telomere position effect in human cells
    J A Baur
    Department of Cell Biology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390-9039, USA
    Science 292:2075-7. 2001
    ..The dependence of TPE on telomere length provides a mechanism for the modification of gene expression throughout the replicative life-span of human cells...
  5. ncbi request reprint Telomerase and cancer
    J W Shay
    The University of Texas Southwestern Medical Center, Department of Cell Biology, 5323 Harry Hines Boulevard, Dallas, TX 75390 9039, USA
    Hum Mol Genet 10:677-85. 2001
    ..This review covers recent advances in the field including the use of telomerase in cancer diagnostics and an overview of anti-telomerase cancer therapeutic approaches...
  6. pmc The La antigen associates with the human telomerase ribonucleoprotein and influences telomere length in vivo
    L P Ford
    The University of Texas Southwestern Medical Center, The Department of Cell Biology, Dallas 75390-9039, USA
    RNA 7:1068-75. 2001
    ..Our results demonstrate that La can associate with telomerase and its expression level can influence telomere homeostasis in vivo...
  7. ncbi request reprint Effects of chemopreventive and antitelomerase agents on the spontaneous immortalization of breast epithelial cells
    B S Herbert
    Department of Cell Biology, The University of Texas Southwestern Medical Center, Dallas, TX 75390-9039, USA
    J Natl Cancer Inst 93:39-45. 2001
    ..The results also suggest that the telomerase ribonucleoprotein complex may be an important molecular target for breast cancer prevention...
  8. ncbi request reprint Cellular senescence as a tumor-protection mechanism: the essential role of counting
    W E Wright
    Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9039, USA
    Curr Opin Genet Dev 11:98-103. 2001
    ....
  9. ncbi request reprint Hayflick, his limit, and cellular ageing
    J W Shay
    University of Texas Southwestern Medical Center at Dallas, Department of Cell Biology, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9039, USA
    Nat Rev Mol Cell Biol 1:72-6. 2000
    ....
  10. pmc Is telomerase a viable target in cancer?
    C M Buseman
    The University of Texas Southwestern Medical Center, Department of Cell Biology, Dallas, TX 75390 9039, USA
    Mutat Res 730:90-7. 2012
    ..A frank and balanced assessment of the current state of telomerase inhibitors with caveats and potential limitations will be included...
  11. ncbi request reprint Telomeres and telomerase: implications for cancer and aging
    J W Shay
    The University of Texas Southwestern Medical Center, Department of Cell Biology, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9039, USA
    Radiat Res 155:188-193. 2001
    ..Thus telomerase may also be a promising target for cancer therapy...
  12. pmc Characterisation of telomerase immortalised normal human oesophageal squamous cells
    C P Morales
    Department of Veterans Affairs Medical Center, Dallas, Texas, USA
    Gut 52:327-33. 2003
    ..We have used telomerase technology to establish normal human oesophageal cell lines...
  13. ncbi request reprint Ageing and cancer: the telomere and telomerase connection
    J W Shay
    University of Texas Southwestern Medical Center at Dallas, Department of Cell Biology, 5323 Harry Hines Boulevard, Dallas, TX 75390-9039, USA
    Novartis Found Symp 235:116-25; discussion 125-9, 146-9. 2001
    ..This indicates that telomerase-induced telomere length manipulations may have utility for tissue engineering and for dissecting the molecular mechanisms underlying genetic diseases including cancer...
  14. ncbi request reprint Hallmarks of telomeres in ageing research
    J W Shay
    University of Texas Southwestern Medical Center, Department of Cell Biology, Dallas, TX 75390 9039, USA
    J Pathol 211:114-23. 2007
    ..This indicates that telomerase-induced telomere length manipulations may have utility for tissue engineering and for dissecting the molecular mechanisms underlying genetic diseases, including cancer...
  15. ncbi request reprint Telomerase can inhibit the recombination-based pathway of telomere maintenance in human cells
    L P Ford
    Department of Cell Biology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390-9039, USA
    J Biol Chem 276:32198-203. 2001
    ....
  16. doi request reprint Aneuploid human colonic epithelial cells are sensitive to AICAR-induced growth inhibition through EGFR degradation
    P Ly
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Oncogene 32:3139-46. 2013
    ..Our data collectively support the pharmacological compound AICAR as a novel inhibitor of EGFR protein abundance and as a potential anticancer agent for aneuploidy-driven colorectal cancer. ..
  17. ncbi request reprint Monoclonal antimyogenin antibodies define epitopes outside the bHLH domain where binding interferes with protein-protein and protein-DNA interactions
    W E Wright
    University of Texas Southwestern Medical Center, Department of Cell Biology and Neuroscience, Dallas 75235, USA
    Dev Genet 19:131-8. 1996
    ..The binding of one antibody to its epitope did not appear to affect the myogenin/E12 interaction but nonetheless interfered with the binding of the complex to DNA, suggesting that this epitope lies near to a surface occupied by DNA...
  18. pmc Quantitation of telomerase components and hTERT mRNA splicing patterns in immortal human cells
    X Yi
    Department of Cell Biology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390-9039, USA
    Nucleic Acids Res 29:4818-25. 2001
    ..We also found that most telomerase-positive cell lines only contain a few molecules of potentially functional hTERT mRNA, and there is a correlation between telomerase activity and the levels of both hTR and hTERT +alpha+beta mRNA...
  19. ncbi request reprint Telomerase immortalization of human myometrial cells
    Jennifer Condon
    Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9032, USA
    Biol Reprod 67:506-14. 2002
    ..The expression of various smooth muscle/myometrium cell markers suggests that these cells may be an appropriate model system to study certain aspects of human myometrial function...
  20. ncbi request reprint Complexes containing the retinoblastoma gene product recognize different DNA motifs related to the E2F binding site
    M M Ouellette
    Department of Cell Biology and Neuroscience, University of Texas Southwestern Medical Center, Dallas 75235 9039
    Oncogene 7:1075-81. 1992
    ..Screening these sequences against a DNA database identified their presence in non-coding regions of many oncogenes, growth factor genes and in the RB gene itself...
  21. pmc Functional requirement of p23 and Hsp90 in telomerase complexes
    S E Holt
    Department of Cell Biology and Neuroscience, University of Texas UT Southwestern Medical Center, Dallas, Texas 75235 USA
    Genes Dev 13:817-26. 1999
    ..Consistent with in vitro results, inhibition of Hsp90 function in cells blocks assembly of active telomerase. To our knowledge, p23 and Hsp90 are the first telomerase-associated proteins demonstrated to contribute to telomerase activity...
  22. pmc Cyclic amplification and selection of targets for multicomponent complexes: myogenin interacts with factors recognizing binding sites for basic helix-loop-helix, nuclear factor 1, myocyte-specific enhancer-binding factor 2, and COMP1 factor
    W D Funk
    Department of Cell Biology and Neuroscience, University of Texas Southwestern Medical Center, Dallas 75235
    Proc Natl Acad Sci U S A 89:9484-8. 1992
    ....