Tim Wright

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc The role of amelogenin during enamel-crystallite growth and organization in vivo
    J Tim Wright
    Department of Pediatric Dentistry, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599, USA
    Eur J Oral Sci 119:65-9. 2011
  2. pmc The molecular etiologies and associated phenotypes of amelogenesis imperfecta
    J Timothy Wright
    Department of Pediatric Dentistry, School of Dentistry, The University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Am J Med Genet A 140:2547-55. 2006
  3. ncbi request reprint The molecular control of and clinical variations in root formation
    Tim Wright
    Department of Pediatric Dentistry, University of North Carolina School of Dentistry, Chapel Hill, NC 27599, USA
    Cells Tissues Organs 186:86-93. 2007
  4. ncbi request reprint Human enamel phenotype associated with amelogenesis imperfecta and a kallikrein-4 (g.2142G>A) proteinase mutation
    J Tim Wright
    Department of Pediatric Dentistry, UNC Chapel Hill, NC 27599, USA
    Eur J Oral Sci 114:13-7; discussion 39-41, 379. 2006
  5. pmc Human and mouse enamel phenotypes resulting from mutation or altered expression of AMEL, ENAM, MMP20 and KLK4
    J Timothy Wright
    Department of Pediatric Dentistry, University of North Carolina, Chapel Hill, NC 27599, USA
    Cells Tissues Organs 189:224-9. 2009
  6. pmc Phenotypic variation in FAM83H-associated amelogenesis imperfecta
    J T Wright
    Dept of Pediatric Dentistry, School of Dentistry, CB 7450 Brauer Hall, UNC Chapel Hill, NC 27599, USA
    J Dent Res 88:356-60. 2009
  7. ncbi request reprint Relationship of phenotype and genotype in X-linked amelogenesis imperfecta
    J T Wright
    Department of Pediatric Dentistry, School of Dentistry, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Connect Tissue Res 44:72-8. 2003
  8. doi request reprint Classifying ectodermal dysplasias: Incorporating the molecular basis and pathways (Workshop II)
    J Timothy Wright
    Department of Pediatric Dentistry, School of Dentistry, The University of North Carolina, Chapel Hill, NC 27599, USA
    Am J Med Genet A 149:2062-7. 2009
  9. pmc Amelogenesis imperfecta: genotype-phenotype studies in 71 families
    J Timothy Wright
    Department of Pediatric Dentistry, School of Dentistry, The University of North Carolina, Chapel Hill, NC, USA
    Cells Tissues Organs 194:279-83. 2011
  10. ncbi request reprint Normal formation and development defects of the human dentition
    J T Wright
    Department of Pediatric Dentistry, School of Dentistry, University of North Carolina, Chapel Hill, USA
    Pediatr Clin North Am 47:975-1000. 2000

Collaborators

Detail Information

Publications42

  1. pmc The role of amelogenin during enamel-crystallite growth and organization in vivo
    J Tim Wright
    Department of Pediatric Dentistry, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599, USA
    Eur J Oral Sci 119:65-9. 2011
    ..We conclude that amelogenin is essential for the development of normal crystallite size...
  2. pmc The molecular etiologies and associated phenotypes of amelogenesis imperfecta
    J Timothy Wright
    Department of Pediatric Dentistry, School of Dentistry, The University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Am J Med Genet A 140:2547-55. 2006
    ..Our current knowledge of the known mutations and associated phenotypes of the different AI subtypes are reviewed...
  3. ncbi request reprint The molecular control of and clinical variations in root formation
    Tim Wright
    Department of Pediatric Dentistry, University of North Carolina School of Dentistry, Chapel Hill, NC 27599, USA
    Cells Tissues Organs 186:86-93. 2007
    ..The purpose of this study was to review our knowledge regarding developmental defects of root formation, the molecular mechanisms involved, and the impact of root variants on clinical dentistry...
  4. ncbi request reprint Human enamel phenotype associated with amelogenesis imperfecta and a kallikrein-4 (g.2142G>A) proteinase mutation
    J Tim Wright
    Department of Pediatric Dentistry, UNC Chapel Hill, NC 27599, USA
    Eur J Oral Sci 114:13-7; discussion 39-41, 379. 2006
    ..Collectively, these studies suggest that the KLK-4 proteinase is essential for the final crystallite growth of enamel but is not critical for crystallite orientation, prism formation or enamel thickness...
  5. pmc Human and mouse enamel phenotypes resulting from mutation or altered expression of AMEL, ENAM, MMP20 and KLK4
    J Timothy Wright
    Department of Pediatric Dentistry, University of North Carolina, Chapel Hill, NC 27599, USA
    Cells Tissues Organs 189:224-9. 2009
    ..Mice lacking expression of the currently known genes associated with the human AI conditions provide useful models for understanding the pathogenesis of these conditions...
  6. pmc Phenotypic variation in FAM83H-associated amelogenesis imperfecta
    J T Wright
    Dept of Pediatric Dentistry, School of Dentistry, CB 7450 Brauer Hall, UNC Chapel Hill, NC 27599, USA
    J Dent Res 88:356-60. 2009
    ..This investigation shows that unique phenotypes are associated with specific FAM83H mutations...
  7. ncbi request reprint Relationship of phenotype and genotype in X-linked amelogenesis imperfecta
    J T Wright
    Department of Pediatric Dentistry, School of Dentistry, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Connect Tissue Res 44:72-8. 2003
    ..The phenotype-genotype correlations in this study suggest there are important functional domains of the amelogenin molecule that are critical for the development of normal enamel structure, composition, and thickness...
  8. doi request reprint Classifying ectodermal dysplasias: Incorporating the molecular basis and pathways (Workshop II)
    J Timothy Wright
    Department of Pediatric Dentistry, School of Dentistry, The University of North Carolina, Chapel Hill, NC 27599, USA
    Am J Med Genet A 149:2062-7. 2009
    ....
  9. pmc Amelogenesis imperfecta: genotype-phenotype studies in 71 families
    J Timothy Wright
    Department of Pediatric Dentistry, School of Dentistry, The University of North Carolina, Chapel Hill, NC, USA
    Cells Tissues Organs 194:279-83. 2011
    ..g. exon deletion) or they could have promoter sequence mutations not evaluated in this study. However, the results suggest that there remain new AI causative genes to be identified...
  10. ncbi request reprint Normal formation and development defects of the human dentition
    J T Wright
    Department of Pediatric Dentistry, School of Dentistry, University of North Carolina, Chapel Hill, USA
    Pediatr Clin North Am 47:975-1000. 2000
    ..Despite the severity of some developmental defects of the dentition, the ability to diagnose and manage these conditions, in most cases, allows children the benefit of optimal oral health...
  11. ncbi request reprint The etch-bleach-seal technique for managing stained enamel defects in young permanent incisors
    J Timothy Wright
    Department of Pediatric Dentistry, School of Dentistry, University of North Carolina, Chapel Hill, USA
    Pediatr Dent 24:249-52. 2002
    ..Young permanent incisors with yellow-brown intrinsic discolorations can often be treated by a simple and conservative bleaching protocol using sodium hypochlorite...
  12. ncbi request reprint The genome projects: implications for dental practice and education
    J T Wright
    Department of Pediatric Dentistry, School of Dentistry, University of North Carolina, Chapel Hill 27599, USA
    J Dent Educ 66:659-71. 2002
    ..Oral health care practitioners will increasingly require knowledge of human genetics and the application of new molecular-based diagnostic and therapeutic technologies...
  13. pmc Oral manifestations in the epidermolysis bullosa spectrum
    J Timothy Wright
    Department of Pediatric Dentistry, School of Dentistry, Brauer Hall 7450, The University of North Carolina, Chapel Hill, NC 27599 7450, USA
    Dermatol Clin 28:159-64. 2010
    ..In this article, the major oral manifestations are reviewed for different EB subtypes and are related to the causative genetic mutations and gene expression...
  14. ncbi request reprint Increased bone density associated with DLX3 mutation in the tricho-dento-osseous syndrome
    Ryan J Haldeman
    Department of Pediatric Dentistry, School of Dentistry Brauer Hall CB, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7450, USA
    Bone 35:988-97. 2004
    ....
  15. doi request reprint DLX3 c.561_562delCT mutation causes attenuated phenotype of tricho-dento-osseous syndrome
    J Timothy Wright
    Department of Pediatric Dentistry, The University of North, Chapel Hill, North Carolina 27599
    Am J Med Genet A 146:343-9. 2008
    ....
  16. ncbi request reprint Food sugar substitutes: a brief review for dental clinicians
    Michael W Roberts
    Department of Pediatric Dentistry, University of North Carolina School of Dentistry, Chapel Hill 27599 7450, USA
    J Clin Pediatr Dent 27:1-4. 2002
    ..However, there are several other non-caloric sweeteners being commonly used in other countries. A review of these sweeteners is provided with information on a promising new agent that has not yet gained FDA approval...
  17. doi request reprint Primary failure of eruption and PTH1R: the importance of a genetic diagnosis for orthodontic treatment planning
    Sylvia A Frazier-Bowers
    Department of Orthodontics, University of North Carolina, Chapel Hill, NC, USA
    Am J Orthod Dentofacial Orthop 137:160.e1-7; discussion 160-1. 2010
    ..The objective of our study was to investigate how genetic analysis can be used with clinical diagnostic information for improved orthodontic management of PFE...
  18. ncbi request reprint mRNA expression and phenotype of odontogenic tumours in the v-Ha-ras transgenic mouse
    A P Dodds
    Department Pediatric Dentistry, UNC School of Dentistry, University of North Carolina at Chapel Hill, Manning Drive, Chapel Hill, NC 27599, USA
    Arch Oral Biol 48:843-50. 2003
    ..The Tg.AC transgenic mouse carrying the v-Ha-ras oncogene has been found to spontaneously develop ameloblastoma-like tumours (35% by 1 year of age) that are rare in the wild type FVB background strain...
  19. ncbi request reprint Characterization and mRNA expression in an unusual odontogenic lesion in a patient with tricho-dento-osseous syndrome
    A P Dodds
    Dept Pediatric Dentistry, School of Dentistry, The University of North Carolina at Chapel Hill, 27599 7455, USA
    Histol Histopathol 18:849-54. 2003
    ..This study evaluated the histology and mRNA expression of an unusual odontogenic lesion in a patient with a confirmed history of tricho-dento-osseous syndrome...
  20. ncbi request reprint Cloning human enamelin cDNA, chromosomal localization, and analysis of expression during tooth development
    C C Hu
    University of Texas Health Science Center at San Antonio, School of Dentistry, Department of Pediatric Dentistry, 78284 7888, USA
    J Dent Res 79:912-9. 2000
    ..These findings will facilitate the search for specific mutations in the enamelin gene in kindreds suffering from amelogenesis imperfecta...
  21. ncbi request reprint Craniofacial morphology of the tricho-dento-osseous syndrome
    K Kula
    Department of Pediatric Dentistry, University of North Carolina Dental School, Chapel Hill 27599 7450, USA
    Clin Genet 50:446-54. 1996
    ..The major TDO craniofacial features involve the cranial base, mandibular body length, absence of visible pneumatized mastoids, frontal sinuses and diploe, and thicker cranial bone...
  22. ncbi request reprint Structural and compositional alteration of tooth enamel in hereditary epidermolysis bullosa
    J T Wright
    Department of Pediatric Dentistry, School of Dentistry, University of North Carolina at Chapel Hill 27599 7450, USA
    Connect Tissue Res 34:271-9. 1996
    ..The marked enamel hypoplasia in this EB type suggests that laminin-5 plays an important role in the secretory phase of enamel development...
  23. ncbi request reprint A costs analysis of dental treatment for ectodermal dysplasia
    Sean Murdock
    School of Dentistry, University of North Carolina, Chapel Hill 27599 7450, USA
    J Am Dent Assoc 136:1273-6. 2005
    ..On the basis of anecdotal and clinical reports, the authors postulate that costs of dental treatment for this condition can have a substantial financial impact on patients and their families...
  24. ncbi request reprint Abnormal enamel development in a cystic fibrosis transgenic mouse model
    J T Wright
    Department of Pediatric Dentistry, School of Dentistry, University of North Carolina at Chapel Hill 27599 7450, USA
    J Dent Res 75:966-73. 1996
    ..Although further investigation is required to determine the mechanism leading to abnormal enamel formation, the CF mouse provides a potentially useful animal model for investigating aberrant enamel development...
  25. ncbi request reprint Variation in dental and skeletal open bite malocclusion in humans with amelogenesis imperfecta
    Darren B Ravassipour
    Department of Orthodontics, School of Dentistry, University of North Carolina Chapel Hill, Chapel Hill, NC, USA
    Arch Oral Biol 50:611-23. 2005
    ..The pathophysiological relationship between AI associated enamel defects and open bite malocclusion remains unknown...
  26. ncbi request reprint Altered pH regulation during enamel development in the cystic fibrosis mouse incisor
    W Sui
    Department of Pediatric Dentistry, Brauer Hall CB 7450, School of Dentistry, University of North Carolina, Chapel Hill 27599 7450, USA
    J Dent Res 82:388-92. 2003
    ..These results indicate that CFTR plays a role in pH regulation during enamel development and that a reduced pH results in a lack of calcium influx during enamel maturation and hypomineralization of the CF incisor enamel...
  27. pmc WNT5A expression in ameloblastoma and its roles in regulating enamel epithelium tumorigenic behaviors
    Waleerat Sukarawan
    North Carolina Oral Health Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7454, USA
    Am J Pathol 176:461-71. 2010
    ..Taken together, our data indicate that WNT5A signaling is important in modulating tumorigenic behaviors of enamel epithelium cells in ameloblastomas...
  28. ncbi request reprint Remineralization potential of a fluoridated carbamide peroxide whitening gel
    Jason Gladwell
    Dental Research Center Pediatric Dentistry, University of North Carolina, School of Dentistry, Chapel Hill, NC 27599 7450, USA
    J Esthet Restor Dent 18:206-12; discussion 212-3. 2006
    ..The aim of this project was to evaluate whether a whitening system with fluoride will remineralize previously demineralized enamel...
  29. pmc Regulation of pH During Amelogenesis
    Rodrigo S Lacruz
    School of Dentistry, Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA 90033, USA
    Calcif Tissue Int 86:91-103. 2010
    ....
  30. ncbi request reprint The psychosocial impact of developmental dental defects in people with hereditary amelogenesis imperfecta
    Kristina D Coffield
    Department of Pediatric Dentistry, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599 7450, USA
    J Am Dent Assoc 136:620-30. 2005
    ..The authors hypothesized that AI is associated with a negative psychosocial outcome...
  31. ncbi request reprint Clinical evaluation of and parental satisfaction with resin-faced stainless steel crowns
    C Roberts
    Department of Pediatric Dentistry, School of Dentistry, University of North Carolina, Chapel Hill, NC, USA
    Pediatr Dent 23:28-31. 2001
    ..CONCLUSIONS: While parental satisfaction with treatment of anterior primary dentition caries with prefabricated resin-faced stainless steel crowns is excellent, the high failure rate of the resin facings is problematic...
  32. ncbi request reprint A developmental comparison of matrix metalloproteinase-20 and amelogenin null mouse enamel
    John D Bartlett
    Department of Cytokine Biology, Forsyth Institute, Boston, MA 02115, USA
    Eur J Oral Sci 114:18-23; discussion 39-41, 379. 2006
    ..Both genes are essential for the generation of full-thickness enamel containing the characteristic decussating prism pattern...
  33. ncbi request reprint Diagnosis and treatment of molar incisor hypomineralization
    Kavita Mathu-Muju
    Division of Dental Public Health, University of Kentucky College of Dentistry, Lexington, Kentucky, USA
    Compend Contin Educ Dent 27:604-10; quiz 611. 2006
    ..Usually, severely affected molars are extremely hypersensitive, prone to rapid caries development, and can be difficult to manage in young patients. The purpose of this article is to review approaches to diagnosing and treating MIH...
  34. ncbi request reprint Phenotypic diversity and revision of the nomenclature for autosomal recessive amelogenesis imperfecta
    Mohamad Nusier
    Department of Biochemistry and Molecular Biology, Jordan University of Science and Technology, School of Medicine, Irbid, Jordan
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 97:220-30. 2004
    ..The purpose of this study was to characterize the phenotype in 9 families with autosomal recessive amelogenesis imperfecta (ARAI), and to propose a classification system allowing inclusion and delineation of diverse ARAI phenotypes...
  35. ncbi request reprint Exclusion of candidate genes in two families with autosomal dominant hypocalcified amelogenesis imperfecta
    P Suzanne Hart
    Department of Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh PA 15261, USA
    Eur J Oral Sci 111:326-31. 2003
    ....
  36. ncbi request reprint The use of animal models to explore amelogenin variants in amelogenesis imperfecta
    Carolyn W Gibson
    Department of Anatomy and Cell Biology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cells Tissues Organs 181:196-201. 2005
    ..Future studies are expected to answer remaining questions concerning structure/function relationships among these 'enamel proteins'...
  37. ncbi request reprint Analysis of craniofacial development in children with hypohidrotic ectodermal dysplasia
    Euphemia LaRee Johnson
    Private Pediatric Dentistry Practice, Rocky Mount, North Carolina, USA
    Am J Med Genet 112:327-34. 2002
    ....
  38. pmc Cloning of rat amelotin and localization of the protein to the basal lamina of maturation stage ameloblasts and junctional epithelium
    Pierre Moffatt
    Laboratory for the Study of Calcified Tissues and Biomaterials, Faculte de Medecine Dentaire, Universite de Montreal, P O Box 6128, Station Centre Ville, Montreal, QC, Canada H3C 3J7
    Biochem J 399:37-46. 2006
    ..Intense Amtn protein expression was also detected in the internal basal lamina of junctional epithelium in molars. The peculiar and unique cellular localization of Amtn suggests a role in cell adhesion...
  39. ncbi request reprint Clinical success and parental satisfaction with anterior preveneered primary stainless steel crowns
    Purvi V Shah
    University of North Carolina School of Dentistry, The University of North Carolina at Chapel Hill, NC, USA
    Pediatr Dent 26:391-5. 2004
    ....
  40. pmc Partial rescue of the amelogenin null dental enamel phenotype
    Yong Li
    Department of Anatomy and Cell Biology, University of Pennsylvania School of Dental Medicine, 240 S 40th Street, Philadelphia, PA 19104 6030, USA
    J Biol Chem 283:15056-62. 2008
    ..Rescue was not observed in the molars from the TgP70TKO mice. It was concluded that a single amelogenin protein was able to significantly rescue the KO phenotype and that one amino acid change abrogated this function during development...
  41. pmc Enamel defects and ameloblast-specific expression in Enam knock-out/lacz knock-in mice
    Jan C C Hu
    Department of Orthodontics and Pediatric Dentistry and Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, Michigan 48108, USA
    J Biol Chem 283:10858-71. 2008
    ..These results demonstrate ameloblast-specific expression of enamelin and reveal that enamelin is essential for proper enamel matrix organization and mineralization...
  42. doi request reprint Junctional epidermolysis bullosa associated with hypoplastic enamel and pervasive failure of tooth eruption: Oral rehabilitation with use of an overdenture
    John K Brooks
    Department of Diagnostic Sciences and Pathology, University of Maryland Dental School, Baltimore, Maryland 21201 1586, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 105:e24-8. 2008
    ..The use of this prosthesis has provided an economical, nonsurgical treatment option when oral soft tissue permits and with relative ease of construction...

Research Grants15

  1. Phenotype and Gene Expression in Odontogenic Tumors
    JOHN T WRIGHT; Fiscal Year: 2010
    ..Gene data will be placed on our web site in a timely fashion for data sharing. These studies will provide the first detailed mutational and gene profile studies of human odontogenic tumors. ..
  2. Phenotype and Gene Expression in Odontogenic Tumors
    John Wright; Fiscal Year: 2007
    ..Gene data will be placed on our web site in a timely fashion for data sharing. These studies will provide the first detailed mutational and gene profile studies of human odontogenic tumors. ..
  3. MODIFYING GENE DETERMINANTS OF TOOTH AND BONE PHENOTYPES
    John Wright; Fiscal Year: 2007
    ..abstract_text> ..
  4. THE GENOTYPE AND PHENOTYPE AMELOGENESIS IMPERFECTA
    John Wright; Fiscal Year: 2004
    ..Knowledge of the molecular determinants of morphogenesis and tissue formation will allow novel and more effective treatments and more accurate diagnosis of the diverse hereditary conditions affecting teeth. ..