Research Topics
Genomes and Genes | Tim WrightSummaryAffiliation: University of North Carolina Country: USA Publications
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Publications
The role of amelogenin during enamel-crystallite growth and organization in vivoJ Tim Wright
Department of Pediatric Dentistry, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599, USA
Eur J Oral Sci 119:65-9. 2011..We conclude that amelogenin is essential for the development of normal crystallite size...- The molecular etiologies and associated phenotypes of amelogenesis imperfectaJ Timothy Wright
Department of Pediatric Dentistry, School of Dentistry, The University of North Carolina, Chapel Hill, North Carolina 27599, USA
Am J Med Genet A 140:2547-55. 2006..Our current knowledge of the known mutations and associated phenotypes of the different AI subtypes are reviewed... 
The molecular control of and clinical variations in root formationTim Wright
Department of Pediatric Dentistry, University of North Carolina School of Dentistry, Chapel Hill, NC 27599, USA
Cells Tissues Organs 186:86-93. 2007..The purpose of this study was to review our knowledge regarding developmental defects of root formation, the molecular mechanisms involved, and the impact of root variants on clinical dentistry...- Human enamel phenotype associated with amelogenesis imperfecta and a kallikrein-4 (g.2142G>A) proteinase mutationJ Tim Wright
Department of Pediatric Dentistry, UNC Chapel Hill, NC 27599, USA
Eur J Oral Sci 114:13-7; discussion 39-41, 379. 2006..Collectively, these studies suggest that the KLK-4 proteinase is essential for the final crystallite growth of enamel but is not critical for crystallite orientation, prism formation or enamel thickness... - Human and mouse enamel phenotypes resulting from mutation or altered expression of AMEL, ENAM, MMP20 and KLK4J Timothy Wright
Department of Pediatric Dentistry, University of North Carolina, Chapel Hill, NC 27599, USA
Cells Tissues Organs 189:224-9. 2009..Mice lacking expression of the currently known genes associated with the human AI conditions provide useful models for understanding the pathogenesis of these conditions... - Phenotypic variation in FAM83H-associated amelogenesis imperfectaJ T Wright
Dept of Pediatric Dentistry, School of Dentistry, CB 7450 Brauer Hall, UNC Chapel Hill, NC 27599, USA
J Dent Res 88:356-60. 2009..This investigation shows that unique phenotypes are associated with specific FAM83H mutations... - Relationship of phenotype and genotype in X-linked amelogenesis imperfectaJ T Wright
Department of Pediatric Dentistry, School of Dentistry, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Connect Tissue Res 44:72-8. 2003..The phenotype-genotype correlations in this study suggest there are important functional domains of the amelogenin molecule that are critical for the development of normal enamel structure, composition, and thickness... 
Classifying ectodermal dysplasias: Incorporating the molecular basis and pathways (Workshop II)J Timothy Wright
Department of Pediatric Dentistry, School of Dentistry, The University of North Carolina, Chapel Hill, NC 27599, USA
Am J Med Genet A 149:2062-7. 2009....- Amelogenesis imperfecta: genotype-phenotype studies in 71 familiesJ Timothy Wright
Department of Pediatric Dentistry, School of Dentistry, The University of North Carolina, Chapel Hill, NC, USA
Cells Tissues Organs 194:279-83. 2011..g. exon deletion) or they could have promoter sequence mutations not evaluated in this study. However, the results suggest that there remain new AI causative genes to be identified... - Normal formation and development defects of the human dentitionJ T Wright
Department of Pediatric Dentistry, School of Dentistry, University of North Carolina, Chapel Hill, USA
Pediatr Clin North Am 47:975-1000. 2000..Despite the severity of some developmental defects of the dentition, the ability to diagnose and manage these conditions, in most cases, allows children the benefit of optimal oral health... - The etch-bleach-seal technique for managing stained enamel defects in young permanent incisorsJ Timothy Wright
Department of Pediatric Dentistry, School of Dentistry, University of North Carolina, Chapel Hill, USA
Pediatr Dent 24:249-52. 2002..Young permanent incisors with yellow-brown intrinsic discolorations can often be treated by a simple and conservative bleaching protocol using sodium hypochlorite... - The genome projects: implications for dental practice and educationJ T Wright
Department of Pediatric Dentistry, School of Dentistry, University of North Carolina, Chapel Hill 27599, USA
J Dent Educ 66:659-71. 2002..Oral health care practitioners will increasingly require knowledge of human genetics and the application of new molecular-based diagnostic and therapeutic technologies... - Oral manifestations in the epidermolysis bullosa spectrumJ Timothy Wright
Department of Pediatric Dentistry, School of Dentistry, Brauer Hall 7450, The University of North Carolina, Chapel Hill, NC 27599 7450, USA
Dermatol Clin 28:159-64. 2010..In this article, the major oral manifestations are reviewed for different EB subtypes and are related to the causative genetic mutations and gene expression... - Increased bone density associated with DLX3 mutation in the tricho-dento-osseous syndromeRyan J Haldeman
Department of Pediatric Dentistry, School of Dentistry Brauer Hall CB, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7450, USA
Bone 35:988-97. 2004.... - DLX3 c.561_562delCT mutation causes attenuated phenotype of tricho-dento-osseous syndromeJ Timothy Wright
Department of Pediatric Dentistry, The University of North, Chapel Hill, North Carolina 27599
Am J Med Genet A 146:343-9. 2008.... - Food sugar substitutes: a brief review for dental cliniciansMichael W Roberts
Department of Pediatric Dentistry, University of North Carolina School of Dentistry, Chapel Hill 27599 7450, USA
J Clin Pediatr Dent 27:1-4. 2002..However, there are several other non-caloric sweeteners being commonly used in other countries. A review of these sweeteners is provided with information on a promising new agent that has not yet gained FDA approval... - Primary failure of eruption and PTH1R: the importance of a genetic diagnosis for orthodontic treatment planningSylvia A Frazier-Bowers
Department of Orthodontics, University of North Carolina, Chapel Hill, NC, USA
Am J Orthod Dentofacial Orthop 137:160.e1-7; discussion 160-1. 2010..The objective of our study was to investigate how genetic analysis can be used with clinical diagnostic information for improved orthodontic management of PFE... - mRNA expression and phenotype of odontogenic tumours in the v-Ha-ras transgenic mouseA P Dodds
Department Pediatric Dentistry, UNC School of Dentistry, University of North Carolina at Chapel Hill, Manning Drive, Chapel Hill, NC 27599, USA
Arch Oral Biol 48:843-50. 2003..The Tg.AC transgenic mouse carrying the v-Ha-ras oncogene has been found to spontaneously develop ameloblastoma-like tumours (35% by 1 year of age) that are rare in the wild type FVB background strain... - Characterization and mRNA expression in an unusual odontogenic lesion in a patient with tricho-dento-osseous syndromeA P Dodds
Dept Pediatric Dentistry, School of Dentistry, The University of North Carolina at Chapel Hill, 27599 7455, USA
Histol Histopathol 18:849-54. 2003..This study evaluated the histology and mRNA expression of an unusual odontogenic lesion in a patient with a confirmed history of tricho-dento-osseous syndrome... - Cloning human enamelin cDNA, chromosomal localization, and analysis of expression during tooth developmentC C Hu
University of Texas Health Science Center at San Antonio, School of Dentistry, Department of Pediatric Dentistry, 78284 7888, USA
J Dent Res 79:912-9. 2000..These findings will facilitate the search for specific mutations in the enamelin gene in kindreds suffering from amelogenesis imperfecta... - Craniofacial morphology of the tricho-dento-osseous syndromeK Kula
Department of Pediatric Dentistry, University of North Carolina Dental School, Chapel Hill 27599 7450, USA
Clin Genet 50:446-54. 1996..The major TDO craniofacial features involve the cranial base, mandibular body length, absence of visible pneumatized mastoids, frontal sinuses and diploe, and thicker cranial bone... - Structural and compositional alteration of tooth enamel in hereditary epidermolysis bullosaJ T Wright
Department of Pediatric Dentistry, School of Dentistry, University of North Carolina at Chapel Hill 27599 7450, USA
Connect Tissue Res 34:271-9. 1996..The marked enamel hypoplasia in this EB type suggests that laminin-5 plays an important role in the secretory phase of enamel development... - A costs analysis of dental treatment for ectodermal dysplasiaSean Murdock
School of Dentistry, University of North Carolina, Chapel Hill 27599-7450, USA
J Am Dent Assoc 136:1273-6. 2005..CONCLUSIONS: Dental treatment for ED had a marked financial impact on patients and their families and varied depending on the type and duration of treatment... - Abnormal enamel development in a cystic fibrosis transgenic mouse modelJ T Wright
Department of Pediatric Dentistry, School of Dentistry, University of North Carolina at Chapel Hill 27599 7450, USA
J Dent Res 75:966-73. 1996..Although further investigation is required to determine the mechanism leading to abnormal enamel formation, the CF mouse provides a potentially useful animal model for investigating aberrant enamel development... - Variation in dental and skeletal open bite malocclusion in humans with amelogenesis imperfectaDarren B Ravassipour
Department of Orthodontics, School of Dentistry, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA
Arch Oral Biol 50:611-23. 2005..The pathophysiological relationship between AI associated enamel defects and open bite malocclusion remains unknown... - Altered pH regulation during enamel development in the cystic fibrosis mouse incisorW Sui
Department of Pediatric Dentistry, Brauer Hall CB 7450, School of Dentistry, University of North Carolina, Chapel Hill 27599 7450, USA
J Dent Res 82:388-92. 2003..These results indicate that CFTR plays a role in pH regulation during enamel development and that a reduced pH results in a lack of calcium influx during enamel maturation and hypomineralization of the CF incisor enamel... - WNT5A expression in ameloblastoma and its roles in regulating enamel epithelium tumorigenic behaviorsWaleerat Sukarawan
North Carolina Oral Health Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7454, USA
Am J Pathol 176:461-71. 2010..Taken together, our data indicate that WNT5A signaling is important in modulating tumorigenic behaviors of enamel epithelium cells in ameloblastomas... - Remineralization potential of a fluoridated carbamide peroxide whitening gelJason Gladwell
Dental Research Center; Pediatric Dentistry, University of North Carolina, School of Dentistry, Chapel Hill, NC 27599-7450, USA
J Esthet Restor Dent 18:206-12; discussion 212-3. 2006..CLINICAL SIGNIFICANCE: Therapuetic quantities of fluoride can impact remineralization properties of commercially available tooth whitening gels without altering whitening properties... - Regulation of pH During AmelogenesisRodrigo S Lacruz
School of Dentistry, Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA 90033, USA
Calcif Tissue Int 86:91-103. 2010.... - The psychosocial impact of developmental dental defects in people with hereditary amelogenesis imperfectaKristina D Coffield
Department of Pediatric Dentistry, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599-7450, USA
J Am Dent Assoc 136:620-30. 2005..The authors' study shows that AI has marked psychosocial effects, which suggests that dental treatment could be medically necessary and has far-reaching implications for the affected person's overall health... - Clinical evaluation of and parental satisfaction with resin-faced stainless steel crownsC Roberts
Department of Pediatric Dentistry, School of Dentistry, University of North Carolina, Chapel Hill, NC, USA
Pediatr Dent 23:28-31. 2001..CONCLUSIONS: While parental satisfaction with treatment of anterior primary dentition caries with prefabricated resin-faced stainless steel crowns is excellent, the high failure rate of the resin facings is problematic... - A developmental comparison of matrix metalloproteinase-20 and amelogenin null mouse enamelJohn D Bartlett
Department of Cytokine Biology, Forsyth Institute, Boston, MA 02115, USA
Eur J Oral Sci 114:18-23; discussion 39-41, 379. 2006..Both genes are essential for the generation of full-thickness enamel containing the characteristic decussating prism pattern... - Diagnosis and treatment of molar incisor hypomineralizationKavita Mathu-Muju
Division of Dental Public Health, University of Kentucky College of Dentistry, Lexington, Kentucky, USA
Compend Contin Educ Dent 27:604-10; quiz 611. 2006..Usually, severely affected molars are extremely hypersensitive, prone to rapid caries development, and can be difficult to manage in young patients. The purpose of this article is to review approaches to diagnosing and treating MIH... - Phenotypic diversity and revision of the nomenclature for autosomal recessive amelogenesis imperfectaMohamad Nusier
Department of Biochemistry and Molecular Biology, Jordan University of Science and Technology, School of Medicine, Irbid, Jordan
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 97:220-30. 2004..Therefore, we propose a revised nomenclature permitting both classification of all ARAI clinical forms and inclusion of anticipated molecular-based nomenclature, such as now exists for some X-linked and autosomal dominant AI subtypes... - Exclusion of candidate genes in two families with autosomal dominant hypocalcified amelogenesis imperfectaP Suzanne Hart
Department of Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh PA 15261, USA
Eur J Oral Sci 111:326-31. 2003.... - The use of animal models to explore amelogenin variants in amelogenesis imperfectaCarolyn W Gibson
Department of Anatomy and Cell Biology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Cells Tissues Organs 181:196-201. 2005..Future studies are expected to answer remaining questions concerning structure/function relationships among these 'enamel proteins'... - Analysis of craniofacial development in children with hypohidrotic ectodermal dysplasiaEuphemia LaRee Johnson
Private Pediatric Dentistry Practice, Rocky Mount, North Carolina, USA
Am J Med Genet 112:327-34. 2002.... - Cloning of rat amelotin and localization of the protein to the basal lamina of maturation stage ameloblasts and junctional epitheliumPierre Moffatt
Laboratory for the Study of Calcified Tissues and Biomaterials, Faculte de Medecine Dentaire, Universite de Montreal, P O Box 6128, Station Centre Ville, Montreal, QC, Canada H3C 3J7
Biochem J 399:37-46. 2006..Intense Amtn protein expression was also detected in the internal basal lamina of junctional epithelium in molars. The peculiar and unique cellular localization of Amtn suggests a role in cell adhesion... - Clinical success and parental satisfaction with anterior preveneered primary stainless steel crownsPurvi V Shah
University of North Carolina School of Dentistry, The University of North Carolina at Chapel Hill, NC, USA
Pediatr Dent 26:391-5. 2004..CONCLUSIONS: Kinder Krown prefabricated resin-faced SSCs showed a low failure rate, and the parental satisfaction with treatment was positive... - Partial rescue of the amelogenin null dental enamel phenotypeYong Li
Department of Anatomy and Cell Biology, University of Pennsylvania School of Dental Medicine, 240 S 40th Street, Philadelphia, PA 19104 6030, USA
J Biol Chem 283:15056-62. 2008..Rescue was not observed in the molars from the TgP70TKO mice. It was concluded that a single amelogenin protein was able to significantly rescue the KO phenotype and that one amino acid change abrogated this function during development... - Enamel defects and ameloblast-specific expression in Enam knock-out/lacz knock-in miceJan C C Hu
Department of Orthodontics and Pediatric Dentistry and Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, Michigan 48108, USA
J Biol Chem 283:10858-71. 2008..These results demonstrate ameloblast-specific expression of enamelin and reveal that enamelin is essential for proper enamel matrix organization and mineralization... - Junctional epidermolysis bullosa associated with hypoplastic enamel and pervasive failure of tooth eruption: Oral rehabilitation with use of an overdentureJohn K Brooks
Department of Diagnostic Sciences and Pathology, University of Maryland Dental School, Baltimore, Maryland 21201 1586, USA
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 105:e24-8. 2008..The use of this prosthesis has provided an economical, nonsurgical treatment option when oral soft tissue permits and with relative ease of construction...
Research Grants
- Phenotype and Gene Expression in Odontogenic TumorsJohn Wright; Fiscal Year: 2007..Gene data will be placed on our web site in a timely fashion for data sharing. These studies will provide the first detailed mutational and gene profile studies of human odontogenic tumors. ..
- MODIFYING GENE DETERMINANTS OF TOOTH AND BONE PHENOTYPESJohn Wright; Fiscal Year: 2007..abstract_text> ..
- THE GENOTYPE AND PHENOTYPE AMELOGENESIS IMPERFECTAJohn Wright; Fiscal Year: 2004..Knowledge of the molecular determinants of morphogenesis and tissue formation will allow novel and more effective treatments and more accurate diagnosis of the diverse hereditary conditions affecting teeth. ..
- Phenotype and Gene Expression in Odontogenic TumorsJOHN T WRIGHT; Fiscal Year: 2010..Gene data will be placed on our web site in a timely fashion for data sharing. These studies will provide the first detailed mutational and gene profile studies of human odontogenic tumors. ..