Terry Wright

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc Chemokine gene expression during Pneumocystis carinii-driven pulmonary inflammation
    T W Wright
    Departments of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Infect Immun 67:3452-60. 1999
  2. pmc Immune-mediated inflammation directly impairs pulmonary function, contributing to the pathogenesis of Pneumocystis carinii pneumonia
    T W Wright
    Department of Pediatrics, Department of Microbiology University of Rochester School of Medicine, Rochester, New York 14642, USA
    J Clin Invest 104:1307-17. 1999
  3. pmc Pulmonary inflammation disrupts surfactant function during Pneumocystis carinii pneumonia
    T W Wright
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Infect Immun 69:758-64. 2001
  4. ncbi request reprint Pneumocystis stimulates MCP-1 production by alveolar epithelial cells through a JNK-dependent mechanism
    Jing Wang
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Am J Physiol Lung Cell Mol Physiol 292:L1495-505. 2007
  5. pmc Pneumocystis carinii activates the NF-kappaB signaling pathway in alveolar epithelial cells
    Jing Wang
    Department of Pediatrics, P O Box 850, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, USA
    Infect Immun 73:2766-77. 2005
  6. pmc Anti-CD3 antibody decreases inflammation and improves outcome in a murine model of Pneumocystis pneumonia
    Samir P Bhagwat
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Immunol 184:497-502. 2010
  7. pmc Parenchymal cell TNF receptors contribute to inflammatory cell recruitment and respiratory failure in Pneumocystis carinii-induced pneumonia
    Gloria S Pryhuber
    Department of Pediatrics, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Immunol 181:1409-19. 2008
  8. pmc Mixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cells
    Emily A Desmet
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Virology 400:224-32. 2010
  9. pmc Sensitized CD8+ T cells fail to control organism burden but accelerate the onset of lung injury during Pneumocystis carinii pneumonia
    Francis Gigliotti
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 690, Rochester, NY 14642, USA
    Infect Immun 74:6310-6. 2006
  10. ncbi request reprint Contribution of T cell subsets to the pathophysiology of Pneumocystis-related immunorestitution disease
    Samir P Bhagwat
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 291:L1256-66. 2006

Collaborators

Detail Information

Publications23

  1. pmc Chemokine gene expression during Pneumocystis carinii-driven pulmonary inflammation
    T W Wright
    Departments of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Infect Immun 67:3452-60. 1999
    ..carinii infection. Thus, these observations indicate that chemokines play a role in the focal targeting of inflammatory cell recruitment to sites of P. carinii infection after the passive transfer of lymphocytes to the host...
  2. pmc Immune-mediated inflammation directly impairs pulmonary function, contributing to the pathogenesis of Pneumocystis carinii pneumonia
    T W Wright
    Department of Pediatrics, Department of Microbiology University of Rochester School of Medicine, Rochester, New York 14642, USA
    J Clin Invest 104:1307-17. 1999
    ..carinii directly impairs pulmonary function and contributes to the pathogenesis of PCP. Furthermore, CD8(+) T cells likely contribute to the respiratory compromise observed during PCP...
  3. pmc Pulmonary inflammation disrupts surfactant function during Pneumocystis carinii pneumonia
    T W Wright
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Infect Immun 69:758-64. 2001
    ..carinii. Moreover, CD8(+) lymphocytes are involved in the mechanism leading to surfactant dysfunction...
  4. ncbi request reprint Pneumocystis stimulates MCP-1 production by alveolar epithelial cells through a JNK-dependent mechanism
    Jing Wang
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Am J Physiol Lung Cell Mol Physiol 292:L1495-505. 2007
    ..carinii-stimulated AECs. These data demonstrate that AECs respond to P. carinii in a proinflammatory manner that may contribute to the generation of immune-mediated lung injury...
  5. pmc Pneumocystis carinii activates the NF-kappaB signaling pathway in alveolar epithelial cells
    Jing Wang
    Department of Pediatrics, P O Box 850, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, USA
    Infect Immun 73:2766-77. 2005
    ..Given the global regulatory functions of the NF-kappaB family, these findings suggest that Pneumocystis directly alters AEC gene expression in a manner that promotes pulmonary immune and inflammatory responses...
  6. pmc Anti-CD3 antibody decreases inflammation and improves outcome in a murine model of Pneumocystis pneumonia
    Samir P Bhagwat
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Immunol 184:497-502. 2010
    ..Thus, the anti-human CD3 monoclonal Ab OKT3, which is already in clinical use, has the potential to be developed as an adjunctive therapy for PcP...
  7. pmc Parenchymal cell TNF receptors contribute to inflammatory cell recruitment and respiratory failure in Pneumocystis carinii-induced pneumonia
    Gloria S Pryhuber
    Department of Pediatrics, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Immunol 181:1409-19. 2008
    ..This study supports a key role of parenchymal cell TNFRs in lung injury induced by Pc and a potential protective effect of receptors on radiosensitive, bone marrow-derived cells...
  8. pmc Mixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cells
    Emily A Desmet
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Virology 400:224-32. 2010
    ..These findings support a role for MLK3 in viral production during influenza infection...
  9. pmc Sensitized CD8+ T cells fail to control organism burden but accelerate the onset of lung injury during Pneumocystis carinii pneumonia
    Francis Gigliotti
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 690, Rochester, NY 14642, USA
    Infect Immun 74:6310-6. 2006
    ..Thus, in the absence of CD4+ T cells, CD8+ T cells are a key contributor to the inflammatory lung injury associated with PCP. However, we were unable to demonstrate an in vivo effect of these cells on the course of P. carinii infection...
  10. ncbi request reprint Contribution of T cell subsets to the pathophysiology of Pneumocystis-related immunorestitution disease
    Samir P Bhagwat
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 291:L1256-66. 2006
    ..In the absence of CD4(+) cells, CD8(+) T cells produced a nonprotective, pathological immune response. These data suggest that the interplay of CD4(+) and CD8(+) T cells affects the ultimate outcome of PcP-related IRD...
  11. ncbi request reprint Type II epithelial cells are critical target for hyperoxia-mediated impairment of postnatal lung development
    Min Yee
    Department of Pediatrics, Box 850, University of Rochester, School of Medicine and Dentistry, 601 Elmwood Ave, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 291:L1101-11. 2006
    ..These data suggest that perinatal hyperoxia adversely affects alveolar development by disrupting the proper timing of type II cell proliferation and differentiation into type I cells...
  12. ncbi request reprint Immunopathogenesis of Pneumocystis carinii pneumonia
    Francis Gigliotti
    University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 690, Rochester, NY 14642, USA
    Expert Rev Mol Med 7:1-16. 2005
    ..carinii determines the ultimate outcome of PCP. A better understanding of the pathophysiology of PCP should lead to the development of improved therapies for the treatment of PCP...
  13. pmc Passive intranasal monoclonal antibody prophylaxis against murine Pneumocystis carinii pneumonia
    Francis Gigliotti
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Infect Immun 70:1069-74. 2002
    ..An IgG1 switch variant of one of the IgM monoclonal antibodies was also protective. These experiments provide a model for exploring the utility of this approach in protecting at-risk patients from infection with P. carinii...
  14. doi request reprint Murine mechanical ventilation stimulates alveolar epithelial cell proliferation
    Patricia Rose Chess
    Departments of Pediatrics and Biomedical Engineering, University of Rochester, Rochester, New York 14642, USA patricia
    Exp Lung Res 36:331-41. 2010
    ..Ventilation did not increase apoptosis in alveolar type II cells, as measured by TUNEL staining. Ventilation at low tidal volumes leads to a mild inflammatory response and alveolar epithelial cell proliferation...
  15. pmc Complement and Fc function are required for optimal antibody prophylaxis against Pneumocystis carinii pneumonia
    Jesse Wells
    University of Rochester School of Medicine and Dentistry, Department of Pediatrics, Box 690, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Infect Immun 74:390-3. 2006
    ..The necessity of complement for optimal PCP prophylaxis by MAb 4F11(G1) suggests that complement may play a role in antibody-mediated protection against development of PCP...
  16. ncbi request reprint Inhibition of surfactant activity by Pneumocystis carinii organisms and components in vitro
    Zhengdong Wang
    Dept of Pediatrics, Box 850, Univ of Rochester School of Medicine, 601 Elmwood Ave, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 288:L1124-31. 2005
    ....
  17. ncbi request reprint TNF receptor signaling contributes to chemokine secretion, inflammation, and respiratory deficits during Pneumocystis pneumonia
    Terry W Wright
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Immunol 172:2511-21. 2004
    ....
  18. pmc Active immunization against Pneumocystis carinii with a recombinant P. carinii antigen
    Jesse Wells
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Box 690, 601 Elmwood Ave, Rochester, NY 14642, USA
    Infect Immun 74:2446-8. 2006
    ..Compared to mice immunized with thioredoxin alone, mice immunized with A12-thioredoxin had significantly reduced lung P. carinii burdens after CD4+ T-cell depletion and challenge with P. carinii...
  19. pmc Normal remodeling of the oxygen-injured lung requires the cyclin-dependent kinase inhibitor p21(Cip1/WAF1/Sdi1)
    Rhonda J Staversky
    Department of Pediatrics, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14642, USA
    Am J Pathol 161:1383-93. 2002
    ..This observation has important implications for therapeutic strategies designed to attenuate long-term chronic lung disease after oxidant injury...
  20. pmc Activity of Hoechst 33258 against Pneumocystis carinii f. sp. muris, Candida albicans, and Candida dubliniensis
    Matthew D Disney
    Department of Chemistry, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14642, USA
    Antimicrob Agents Chemother 49:1326-30. 2005
    ....
  21. ncbi request reprint Pneumocystis carinii infection sensitizes lung to radiation-induced injury after syngeneic marrow transplantation: role of CD4+ T cells
    Lauren Bruckner
    Division of Hematology Oncology Bone Marrow Transplant, Department of Pediatrics, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 290:L1087-96. 2006
    ..carinii alone or undepleted P. carinii/TBI mice. Together, these results indicate that P. carinii infection can sensitize the lung to subsequent TBI-mediated lung injury via a process dependent on non-alloreactive CD4(+) T cells...
  22. pmc p21Cip1 protection against hyperoxia requires Bcl-XL and is uncoupled from its ability to suppress growth
    Peter F Vitiello
    Department of Environmental Medicine, Box 850, The University of Rochester, 601 Elmwood Ave, Rochester, NY 14642, USA
    Am J Pathol 168:1838-47. 2006
    ..Taken together, these data show that p21-mediated cytoprotection against hyperoxia involves regulation of Bcl-XL and is uncoupled from its ability to inhibit proliferation...
  23. pmc Neither neutrophils nor reactive oxygen species contribute to tissue damage during Pneumocystis pneumonia in mice
    Steve D Swain
    Department of Veterinary Molecular Biology, Montana State University, Bozeman, Montana 59717, USA
    Infect Immun 72:5722-32. 2004
    ..We also show that there is no difference in Pneumocystis burdens between wild-type and knockout mice, which supports the idea that neutrophils do not have a major role in the clearance of this organism...

Research Grants11

  1. Chemokine regulation of immune cell recruitment
    Terry Wright; Fiscal Year: 2009
    ..Thereforethe proposed studies are designed to increase our understanding of the mechanisms leading to PcP-related lung injury with the hope of identifying specific therapeutic targets. ..
  2. Chemokine regulation of immune cell recruitment during Pneumocystis pneumonia
    Terry Wright; Fiscal Year: 2007
    ..Therefore the proposed studies are designed to increase our understanding of the mechanisms leading to PcP-related lung injury with the hope of identifying specific therapeutic targets. ..
  3. P CARINII-EPITHELIAL INTERACTIONS MEDIATE INFLAMMATION
    Terry Wright; Fiscal Year: 2003
    ..The goal of this proposal is to understand the inflammatory response to P. carinii so that strategies may be developed to circumvent the lung injury that results from the host response to P. carinii. ..
  4. Chemokine regulation of immune cell recruitment
    Terry W Wright; Fiscal Year: 2010
    ..Thereforethe proposed studies are designed to increase our understanding of the mechanisms leading to PcP-related lung injury with the hope of identifying specific therapeutic targets. ..