Kenneth Wright

Summary

Affiliation: University of Colorado
Country: USA

Publications

  1. pmc Energy expenditure during sleep, sleep deprivation and sleep following sleep deprivation in adult humans
    Christopher M Jung
    Sleep and Chronobiology Laboratory, Department of Integrative Physiology, 1725 Pleasant Street, Clare Small 114, University of Colorado, Boulder, CO 80309 0354, USA
    J Physiol 589:235-44. 2011
  2. pmc Influence of weeks of circadian misalignment on leptin levels
    June Nguyen
    Department of Integrative Physiology, Sleep and Chronobiology Laboratory, University of Colorado, Boulder, CO, USA
    Nat Sci Sleep 2:9-18. 2010
  3. pmc Circadian and wakefulness-sleep modulation of cognition in humans
    Kenneth P Wright
    Department of Integrative Physiology, Sleep and Chronobiology Laboratory, University of Colorado, Boulder CO, USA
    Front Mol Neurosci 5:50. 2012
  4. ncbi request reprint Entrainment of the human circadian clock to the natural light-dark cycle
    Kenneth P Wright
    Sleep and Chronobiology Laboratory, Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO 80309 0354, USA
    Curr Biol 23:1554-8. 2013
  5. doi request reprint Shift work and the assessment and management of shift work disorder (SWD)
    Kenneth P Wright
    Sleep and Chronobiology Laboratory, Department of Integrative Physiology, University of Colorado at Boulder, 1725 Pleasant Street, Boulder, CO 80309, USA
    Sleep Med Rev 17:41-54. 2013
  6. ncbi request reprint Sleep and wakefulness out of phase with internal biological time impairs learning in humans
    Kenneth P Wright
    Harvard Medical School, USA
    J Cogn Neurosci 18:508-21. 2006
  7. pmc Intrinsic period and light intensity determine the phase relationship between melatonin and sleep in humans
    Kenneth P Wright
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Biol Rhythms 20:168-77. 2005
  8. ncbi request reprint Relationship between alertness, performance, and body temperature in humans
    Kenneth P Wright
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol Regul Integr Comp Physiol 283:R1370-7. 2002
  9. ncbi request reprint The influence of subjective alertness and motivation on human performance independent of circadian and homeostatic regulation
    Joseph T Hull
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Biol Rhythms 18:329-38. 2003
  10. pmc Effect of modafinil on impairments in neurobehavioral performance and learning associated with extended wakefulness and circadian misalignment
    Scott Grady
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neuropsychopharmacology 35:1910-20. 2010

Research Grants

Collaborators

Detail Information

Publications23

  1. pmc Energy expenditure during sleep, sleep deprivation and sleep following sleep deprivation in adult humans
    Christopher M Jung
    Sleep and Chronobiology Laboratory, Department of Integrative Physiology, 1725 Pleasant Street, Clare Small 114, University of Colorado, Boulder, CO 80309 0354, USA
    J Physiol 589:235-44. 2011
    ..These findings provide support for the hypothesis that sleep conserves energy and that sleep deprivation increases total daily EE in humans...
  2. pmc Influence of weeks of circadian misalignment on leptin levels
    June Nguyen
    Department of Integrative Physiology, Sleep and Chronobiology Laboratory, University of Colorado, Boulder, CO, USA
    Nat Sci Sleep 2:9-18. 2010
    ..Our findings indicate that weeks of circadian misalignment, such as that which occurs in circadian sleep disorders, alters leptin levels and therefore may have implications for appetite and energy balance...
  3. pmc Circadian and wakefulness-sleep modulation of cognition in humans
    Kenneth P Wright
    Department of Integrative Physiology, Sleep and Chronobiology Laboratory, University of Colorado, Boulder CO, USA
    Front Mol Neurosci 5:50. 2012
    ....
  4. ncbi request reprint Entrainment of the human circadian clock to the natural light-dark cycle
    Kenneth P Wright
    Sleep and Chronobiology Laboratory, Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO 80309 0354, USA
    Curr Biol 23:1554-8. 2013
    ..These findings have important implications for understanding how modern light exposure patterns contribute to late sleep schedules and may disrupt sleep and circadian clocks...
  5. doi request reprint Shift work and the assessment and management of shift work disorder (SWD)
    Kenneth P Wright
    Sleep and Chronobiology Laboratory, Department of Integrative Physiology, University of Colorado at Boulder, 1725 Pleasant Street, Boulder, CO 80309, USA
    Sleep Med Rev 17:41-54. 2013
    ....
  6. ncbi request reprint Sleep and wakefulness out of phase with internal biological time impairs learning in humans
    Kenneth P Wright
    Harvard Medical School, USA
    J Cogn Neurosci 18:508-21. 2006
    ..In addition, our results demonstrate that exposure to dim light (approximately 25 lx) is sufficient to expand the range of entrainment in humans...
  7. pmc Intrinsic period and light intensity determine the phase relationship between melatonin and sleep in humans
    Kenneth P Wright
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Biol Rhythms 20:168-77. 2005
    ..This finding has important implications for understanding physiological organization by the brain's master circadian clock and may have implications for understanding mechanisms underlying circadian sleep disorders...
  8. ncbi request reprint Relationship between alertness, performance, and body temperature in humans
    Kenneth P Wright
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol Regul Integr Comp Physiol 283:R1370-7. 2002
    ..These results support the hypothesis that body temperature modulates neurobehavioral function in humans...
  9. ncbi request reprint The influence of subjective alertness and motivation on human performance independent of circadian and homeostatic regulation
    Joseph T Hull
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Biol Rhythms 18:329-38. 2003
    ..Such studies also may aid in the development of countermeasures to improve human performance...
  10. pmc Effect of modafinil on impairments in neurobehavioral performance and learning associated with extended wakefulness and circadian misalignment
    Scott Grady
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neuropsychopharmacology 35:1910-20. 2010
    ..These features suggest that modafinil might be a particularly relevant countermeasure against the deleterious effects of prolonged work hours, shift work, and transmeridian travel...
  11. pmc Individual differences in childhood sleep problems predict later cognitive executive control
    Naomi P Friedman
    Institute for Behavioral Genetics, University of Colorado at Boulder Boulder CO 80309, USA
    Sleep 32:323-33. 2009
    ..To determine whether individual differences in developmental patterns of general sleep problems are associated with 3 executive function abilities-inhibiting, updating working memory, and task shifting-in late adolescence...
  12. pmc Plasticity of the intrinsic period of the human circadian timing system
    Frank A J L Scheer
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital and Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 2:e721. 2007
    ..Both findings have important implications for the treatment of circadian rhythm sleep disorders and human space exploration...
  13. ncbi request reprint Absence of circadian phase resetting in response to bright light behind the knees
    Kenneth P Wright
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Suite 438, Boston, MA 02115, USA
    Science 297:571. 2002
  14. pmc Addition of a non-photic component to a light-based mathematical model of the human circadian pacemaker
    Melissa A St Hilaire
    Analytic and Modeling Unit, Division of Sleep Medicine, Brigham and Women s Hospital Harvard Medical School, Boston, MA 02115, USA
    J Theor Biol 247:583-99. 2007
    ..Further experiments are required to validate fully our model and to understand the exact effect of the sleep-wake cycle as a non-photic stimulus for the human circadian pacemaker...
  15. ncbi request reprint Daily exercise facilitates phase delays of circadian melatonin rhythm in very dim light
    Laura K Barger
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Physiol Regul Integr Comp Physiol 286:R1077-84. 2004
    ..73, P < 0.05) such that the closer to the DLMO(25%), the greater the phase shift. These data suggest that exercise may help to facilitate circadian adaptation to schedules requiring a delay in the sleep-wake cycle...
  16. pmc Entrainment of the human circadian pacemaker to longer-than-24-h days
    Claude Gronfier
    Division of Sleep Medicine, Department of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:9081-6. 2007
    ..The implications of these findings are important because they could be used to treat circadian misalignment associated with space flight and circadian rhythm sleep disorders such as shift-work disorder...
  17. ncbi request reprint Modafinil for excessive sleepiness associated with shift-work sleep disorder
    Charles A Czeisler
    Division of Sleep Medicine, Harvard Medical School, and Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 353:476-86. 2005
    ..Patients with shift-work sleep disorder chronically have excessive sleepiness during night work and insomnia when attempting to sleep during the day. We evaluated the use of modafinil for treating sleepiness in patients with this disorder...
  18. ncbi request reprint Entrainment of the human circadian system by light
    Jeanne F Duffy
    Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Biol Rhythms 20:326-38. 2005
    ..We provide an integrated perspective on circadian entrainment in humans with respect to recent advances in our knowledge of circadian period and of the effects of light on the biological clock in humans...
  19. ncbi request reprint Inter- and intra-individual variability in performance near the circadian nadir during sleep deprivation
    Danielle J Frey
    Sleep and Chronobiology Laboratory, Department of Integrative Physiology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309, USA
    J Sleep Res 13:305-15. 2004
    ..The finding that subjective sleepiness and objective alertness were not related to any performance measure during sleep deprivation suggests that these measures may assess independent brain functions...
  20. ncbi request reprint Effects of sleep inertia on cognition
    Adam T Wertz
    JAMA 295:163-4. 2006
  21. pmc Efficacy of a single sequence of intermittent bright light pulses for delaying circadian phase in humans
    Claude Gronfier
    INSERM U371, 18 Avenue du Doyen Lepine, 69675 Bron Cedex, France
    Am J Physiol Endocrinol Metab 287:E174-81. 2004
    ....
  22. pmc Circadian rhythm sleep disorders: part II, advanced sleep phase disorder, delayed sleep phase disorder, free-running disorder, and irregular sleep-wake rhythm. An American Academy of Sleep Medicine review
    Robert L Sack
    Department of Psychiatry, Oregon Health Sciences University, Portland, OR, USA
    Sleep 30:1484-501. 2007
    ..We herein report on the accumulated evidence regarding the evaluation and treatment of Advamced Sleep Phase Disorder (ASPD), Delayed Sleep Phase Disorder (DSPD), Free-Running Disorder (FRD) and Irregular Sleep-Wake Rhythm ISWR)...
  23. ncbi request reprint Modeling the effectiveness of naps as a countermeasure to driver sleepiness and accidents. Comment on Garbarino et al. Professional shift-work drivers adopting prophylactic naps can reduce the risk of car accidents during night work. Sleep 2004;27(7):1295
    Kenneth P Wright
    Sleep 27:1446-8. 2004

Research Grants9

  1. Effect of Sleep Deprivation on Inflammatory Markers
    Kenneth Wright; Fiscal Year: 2003
    ..This work could also have a significant impact on our understanding of the health consequences of sleep loss, which would have implications for public health and safety. ..
  2. Effect of Sleep Deprivation on Inflammatory Markers
    Kenneth Wright; Fiscal Year: 2004
    ..This work could also have a significant impact on our understanding of the health consequences of sleep loss, which would have implications for public health and safety. ..
  3. Aging, Hypnotics, Sleep Inertia and the Risk of Falling
    Kenneth Wright; Fiscal Year: 2005
    ..The results of the proposed research could have a significant impact on the health, safety and quality of life of older adults. ..
  4. Circadian Integration of Photic and Non-photic Stimuli
    Kenneth Wright; Fiscal Year: 2006
    ..The proposed treatments may also have implications for improving sleep in environments such as space flight. ..
  5. Circadian Integration of Photic and Non-photic Stimuli
    Kenneth Wright; Fiscal Year: 2007
    ..The proposed treatments may also have implications for improving sleep in environments such as space flight. ..
  6. Health and Safety Consequences of Sleep Loss
    Kenneth Wright; Fiscal Year: 2009
    ..abstract_text> ..
  7. Circadian Integration of Photic and Non-photic Stimuli
    Kenneth Wright; Fiscal Year: 2009
    ..The proposed treatments may also have implications for improving sleep in environments such as space flight. ..
  8. Health and Safety Consequences of Sleep Loss
    Kenneth P Wright; Fiscal Year: 2010
    ..abstract_text> ..