Christine Schubert Wright

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi Crystal structure of human GM2-activator protein with a novel beta-cup topology
    C S Wright
    Department of Pharmacology, X ray Crystallography Laboratory, University of Virginia, Charlottesville, VA 22908 0735, USA
    J Mol Biol 304:411-22. 2000
  2. ncbi Structural analysis of lipid complexes of GM2-activator protein
    Christine Schubert Wright
    Department of Pharmacology, X ray Laboratory and University of Virginia Health System, PO Box 800735, Charlottesville, VA 22908 0735, USA
    J Mol Biol 331:951-64. 2003
  3. ncbi Evidence for lipid packaging in the crystal structure of the GM2-activator complex with platelet activating factor
    Christine S Wright
    Department of Pharmacology, X ray Crystallography Laboratory, University of Virginia, Charlottesville, VA 22908 0735, USA
    J Mol Biol 342:585-92. 2004
  4. ncbi Crystal structure analysis of phosphatidylcholine-GM2-activator product complexes: evidence for hydrolase activity
    Christine S Wright
    Department of Pharmacology, X ray Crystallography Laboratory, University of Virginia, Charlottesville, Virginia 22908 0735, USA
    Biochemistry 44:13510-21. 2005

Research Grants

  1. STRUCTURAL BASIS OF GANGLIOSIDE RECOGNITION
    Christine Wright; Fiscal Year: 2003

Detail Information

Publications4

  1. ncbi Crystal structure of human GM2-activator protein with a novel beta-cup topology
    C S Wright
    Department of Pharmacology, X ray Crystallography Laboratory, University of Virginia, Charlottesville, VA 22908 0735, USA
    J Mol Biol 304:411-22. 2000
    ..The dimensions of this cavity (12 Ax14 Ax22 A) are suitable for binding 18-carbon lipid acyl chains. Flexible surface loops and a short alpha-helix decorate the mouth of the beta-cup and may control lipid entry to the cavity...
  2. ncbi Structural analysis of lipid complexes of GM2-activator protein
    Christine Schubert Wright
    Department of Pharmacology, X ray Laboratory and University of Virginia Health System, PO Box 800735, Charlottesville, VA 22908 0735, USA
    J Mol Biol 331:951-64. 2003
    ....
  3. ncbi Evidence for lipid packaging in the crystal structure of the GM2-activator complex with platelet activating factor
    Christine S Wright
    Department of Pharmacology, X ray Crystallography Laboratory, University of Virginia, Charlottesville, VA 22908 0735, USA
    J Mol Biol 342:585-92. 2004
    ....
  4. ncbi Crystal structure analysis of phosphatidylcholine-GM2-activator product complexes: evidence for hydrolase activity
    Christine S Wright
    Department of Pharmacology, X ray Crystallography Laboratory, University of Virginia, Charlottesville, Virginia 22908 0735, USA
    Biochemistry 44:13510-21. 2005
    ..Our structural results provide new insights into the biological functions of GM2AP. The combined effect of hydrolytic and lipid transfer properties has profound implications in cellular signaling...

Research Grants4

  1. STRUCTURAL BASIS OF GANGLIOSIDE RECOGNITION
    Christine Wright; Fiscal Year: 2003
    ....