Christine Schubert Wright

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi Crystal structure of human GM2-activator protein with a novel beta-cup topology
    C S Wright
    Department of Pharmacology, X ray Crystallography Laboratory, University of Virginia, Charlottesville, VA 22908 0735, USA
    J Mol Biol 304:411-22. 2000
  2. ncbi Structural analysis of lipid complexes of GM2-activator protein
    Christine Schubert Wright
    Department of Pharmacology, X ray Laboratory and University of Virginia Health System, PO Box 800735, Charlottesville, VA 22908 0735, USA
    J Mol Biol 331:951-64. 2003
  3. ncbi Evidence for lipid packaging in the crystal structure of the GM2-activator complex with platelet activating factor
    Christine S Wright
    Department of Pharmacology, X ray Crystallography Laboratory, University of Virginia, Charlottesville, VA 22908 0735, USA
    J Mol Biol 342:585-92. 2004
  4. ncbi Crystal structure analysis of phosphatidylcholine-GM2-activator product complexes: evidence for hydrolase activity
    Christine S Wright
    Department of Pharmacology, X ray Crystallography Laboratory, University of Virginia, Charlottesville, Virginia 22908 0735, USA
    Biochemistry 44:13510-21. 2005

Detail Information

Publications4

  1. ncbi Crystal structure of human GM2-activator protein with a novel beta-cup topology
    C S Wright
    Department of Pharmacology, X ray Crystallography Laboratory, University of Virginia, Charlottesville, VA 22908 0735, USA
    J Mol Biol 304:411-22. 2000
    ..The dimensions of this cavity (12 Ax14 Ax22 A) are suitable for binding 18-carbon lipid acyl chains. Flexible surface loops and a short alpha-helix decorate the mouth of the beta-cup and may control lipid entry to the cavity...
  2. ncbi Structural analysis of lipid complexes of GM2-activator protein
    Christine Schubert Wright
    Department of Pharmacology, X ray Laboratory and University of Virginia Health System, PO Box 800735, Charlottesville, VA 22908 0735, USA
    J Mol Biol 331:951-64. 2003
    ....
  3. ncbi Evidence for lipid packaging in the crystal structure of the GM2-activator complex with platelet activating factor
    Christine S Wright
    Department of Pharmacology, X ray Crystallography Laboratory, University of Virginia, Charlottesville, VA 22908 0735, USA
    J Mol Biol 342:585-92. 2004
    ....
  4. ncbi Crystal structure analysis of phosphatidylcholine-GM2-activator product complexes: evidence for hydrolase activity
    Christine S Wright
    Department of Pharmacology, X ray Crystallography Laboratory, University of Virginia, Charlottesville, Virginia 22908 0735, USA
    Biochemistry 44:13510-21. 2005
    ..Our structural results provide new insights into the biological functions of GM2AP. The combined effect of hydrolytic and lipid transfer properties has profound implications in cellular signaling...