Barbara E Wright

Summary

Affiliation: University of Montana
Country: USA

Publications

  1. pmc Kinetic models reveal the in vivo mechanisms of mutagenesis in microbes and man
    Barbara E Wright
    Division of Biological Sciences, The University of Montana, Missoula, MT 59812, United States Electronic address
    Mutat Res 752:129-37. 2013
  2. pmc Evolution of coordinated mutagenesis and somatic hypermutation in VH5
    Barbara E Wright
    Division of Biological Sciences, The University of Montana, Missoula, MT 59812, USA
    Mol Immunol 49:537-48. 2011
  3. ncbi request reprint Stress-directed adaptive mutations and evolution
    Barbara E Wright
    Division of Biological Sciences, University of Montana, Missoula, MT 59812, USA
    Mol Microbiol 52:643-50. 2004
  4. pmc The roles of transcription and genotoxins underlying p53 mutagenesis in vivo
    Barbara E Wright
    The University of Montana, Missoula, MT 59812, USA
    Carcinogenesis 32:1559-67. 2011
  5. pmc I. VH gene transcription creates stabilized secondary structures for coordinated mutagenesis during somatic hypermutation
    Barbara E Wright
    Division of Biological Sciences, The University of Montana, Missoula, MT 59812, USA
    Mol Immunol 45:3589-99. 2008
  6. pmc II. Correlations between secondary structure stability and mutation frequency during somatic hypermutation
    Barbara E Wright
    Division of Biological Sciences, The University of Montana, Missoula, MT 59812, USA
    Mol Immunol 45:3600-8. 2008
  7. ncbi request reprint Secondary structures as predictors of mutation potential in the lacZ gene of Escherichia coli
    Evan Burkala
    Division of Biological Sciences, University of Montana, Missoula, MT 59812, USA
    Microbiology 153:2180-9. 2007
  8. ncbi request reprint Increased transcription rates correlate with increased reversion rates in leuB and argH Escherichia coli auxotrophs
    Jacqueline M Reimers
    Division of Biological Sciences, University of Montana, Missoula, MT 59812, USA
    Microbiology 150:1457-66. 2004
  9. ncbi request reprint The effect of promoter strength, supercoiling and secondary structure on mutation rates in Escherichia coli
    Karen H Schmidt
    Division of Biological Sciences, The University of Montana, Missoula, MT 59812, USA
    Mol Microbiol 60:1251-61. 2006
  10. ncbi request reprint Hypermutable bases in the p53 cancer gene are at vulnerable positions in DNA secondary structures
    Barbara E Wright
    Division of Biological Sciences University of Montana, Missoula 59812, USA
    Cancer Res 62:5641-4. 2002

Research Grants

Collaborators

  • Michael F Minnick
  • Karen H Schmidt
  • Jacqueline M Reimers
  • Evan Burkala
  • Nick Davis
  • Ping Wei
  • Angelika Longacre
  • Dennis K Reschke

Detail Information

Publications11

  1. pmc Kinetic models reveal the in vivo mechanisms of mutagenesis in microbes and man
    Barbara E Wright
    Division of Biological Sciences, The University of Montana, Missoula, MT 59812, United States Electronic address
    Mutat Res 752:129-37. 2013
    ..In vitro analyses also verify the conclusion that intrinsically mutable bases are in fact located in ssDNA loops of predicted stem-loop structures (SLSs)...
  2. pmc Evolution of coordinated mutagenesis and somatic hypermutation in VH5
    Barbara E Wright
    Division of Biological Sciences, The University of Montana, Missoula, MT 59812, USA
    Mol Immunol 49:537-48. 2011
    ..The data suggest that many mutable bases are exposed simultaneously at pause sites, allowing for coordinated mutagenesis...
  3. ncbi request reprint Stress-directed adaptive mutations and evolution
    Barbara E Wright
    Division of Biological Sciences, University of Montana, Missoula, MT 59812, USA
    Mol Microbiol 52:643-50. 2004
    ..When this occurs in repair-deficient mutator strains with high rates of random mutation, the specific stress-directed mutations are also enhanced...
  4. pmc The roles of transcription and genotoxins underlying p53 mutagenesis in vivo
    Barbara E Wright
    The University of Montana, Missoula, MT 59812, USA
    Carcinogenesis 32:1559-67. 2011
    ..Moreover, it is consistent with our proposed mechanism of mutagenesis in which the frequency of G exposure in ssDNA via transcription is rate limiting for mutation frequency in vivo...
  5. pmc I. VH gene transcription creates stabilized secondary structures for coordinated mutagenesis during somatic hypermutation
    Barbara E Wright
    Division of Biological Sciences, The University of Montana, Missoula, MT 59812, USA
    Mol Immunol 45:3589-99. 2008
    ..Such a complex of secondary structures may be the source of ssDNA for enzyme-based diversification, which ultimately results in high affinity antibodies...
  6. pmc II. Correlations between secondary structure stability and mutation frequency during somatic hypermutation
    Barbara E Wright
    Division of Biological Sciences, The University of Montana, Missoula, MT 59812, USA
    Mol Immunol 45:3600-8. 2008
    ..These circumstances simplify the complexities of coordinating mutagenesis by confining this process to each mutable site successively, as they form in response to increasing levels of transcription during affinity maturation...
  7. ncbi request reprint Secondary structures as predictors of mutation potential in the lacZ gene of Escherichia coli
    Evan Burkala
    Division of Biological Sciences, University of Montana, Missoula, MT 59812, USA
    Microbiology 153:2180-9. 2007
    ....
  8. ncbi request reprint Increased transcription rates correlate with increased reversion rates in leuB and argH Escherichia coli auxotrophs
    Jacqueline M Reimers
    Division of Biological Sciences, University of Montana, Missoula, MT 59812, USA
    Microbiology 150:1457-66. 2004
    ..The results suggest that specific starvation conditions target the biosynthetic genes for derepression and increased rates of transcription and mutation...
  9. ncbi request reprint The effect of promoter strength, supercoiling and secondary structure on mutation rates in Escherichia coli
    Karen H Schmidt
    Division of Biological Sciences, The University of Montana, Missoula, MT 59812, USA
    Mol Microbiol 60:1251-61. 2006
    ....
  10. ncbi request reprint Hypermutable bases in the p53 cancer gene are at vulnerable positions in DNA secondary structures
    Barbara E Wright
    Division of Biological Sciences University of Montana, Missoula 59812, USA
    Cancer Res 62:5641-4. 2002
    ..The correlation of hypermutable base frequencies with -DeltaG values is poor (R(2) = 0.19), indicating that the extent to which a base is unpaired during transcription is a significant contribution to predicting mutation frequencies...
  11. ncbi request reprint Predicting mutation frequencies in stem-loop structures of derepressed genes: implications for evolution
    Barbara E Wright
    Division of Biological Sciences, University of Montana, Missoula, MT 59812, USA
    Mol Microbiol 48:429-41. 2003
    ..iv) The data suggest that environmental stressors may cause as well as select mutations in derepressed genes. The implications of these results for evolution are discussed...

Research Grants4

  1. Mechanisms of mutagenesis in hot spots causing cancer
    Barbara Wright; Fiscal Year: 2007
    ..These investigations should provide new insights into the mechanisms of mutagenesis and carcinogenesis. ..