Anthony D Wright

Summary

Affiliation: University of Hawaii
Country: USA

Publications

  1. doi request reprint Anti-malarial, anti-algal, anti-tubercular, anti-bacterial, anti-photosynthetic, and anti-fouling activity of diterpene and diterpene isonitriles from the tropical marine sponge Cymbastela hooperi
    Anthony D Wright
    College of Pharmacy, University of Hawaii at Hilo, Hilo, Hawaii 96720, USA
    Org Biomol Chem 9:400-7. 2011
  2. doi request reprint Diterpene formamides from the tropical marine sponge Cymbastela hooperi and their antimalarial activity in vitro
    Anthony D Wright
    College of Pharmacy, University of Hawaii at Hilo, Hilo, Hawaii 96720, USA
    J Nat Prod 72:492-5. 2009
  3. pmc Detailed NMR, including 1,1-ADEQUATE, and anticancer studies of compounds from the echinoderm Colobometra perspinosa
    Anthony D Wright
    Australian Institute of Marine Science, PMB No 3, Townsville MC, Townsville 4810, Australia
    Mar Drugs 7:565-75. 2009
  4. doi request reprint Metachromins U-W: cytotoxic merosesquiterpenoids from an Australian specimen of the sponge Thorecta reticulata
    Simon P B Ovenden
    Australian Institute of Marine Science, PMB No 3, Townsville MC, Townsville, Qld 4810, Australia
    J Nat Prod 74:1335-8. 2011
  5. doi request reprint Update of spectroscopic data for 4-hydroxydictyolactone and dictyol E isolated from a Halimeda stuposa - Dictyota sp. assemblage
    Simon P B Ovenden
    Australian Institute of Marine Science, PMB No 3, Townsville MC, Townsville 4810, Australia
    Molecules 17:2929-38. 2012
  6. doi request reprint Comosusols A-D and comosone A: cytotoxic compounds from the brown alga Sporochnus comosus
    Simon P B Ovenden
    Australian Institute of Marine Science, PMB No 3, Townsville MC, Townsville, 4810, Australia
    J Nat Prod 74:739-43. 2011
  7. doi request reprint Sesquiterpene benzoxazoles and sesquiterpene quinones from the marine sponge Dactylospongia elegans
    Simon P B Ovenden
    Australian Institute of Marine Science, PMB No 3, Townsville MC, Townsville, 4810, Australia
    J Nat Prod 74:65-8. 2011
  8. pmc A great barrier reef Sinularia sp. yields two new cytotoxic diterpenes
    Anthony D Wright
    Australian Institute of Marine Science, PMB No 3, Townsville MC, Townsville, Qld 4810, Australia
    Mar Drugs 10:1619-30. 2012
  9. pmc A new diketopiperazine, cyclo-(4-S-hydroxy-R-proline-R-isoleucine), from an Australian specimen of the sponge Stelletta sp
    Simon P B Ovenden
    Australian Institute of Marine Science, Townsville MC, Australia
    Mar Drugs 9:2469-78. 2011
  10. ncbi request reprint Production of manoalide and its analogues by the sponge Luffariella variabilis Is hardwired
    Piers Ettinger-Epstein
    School of Marine and Tropical Biology, James Cook University, Townsville, Queensland, Australia
    Mar Biotechnol (NY) 10:64-74. 2008

Detail Information

Publications19

  1. doi request reprint Anti-malarial, anti-algal, anti-tubercular, anti-bacterial, anti-photosynthetic, and anti-fouling activity of diterpene and diterpene isonitriles from the tropical marine sponge Cymbastela hooperi
    Anthony D Wright
    College of Pharmacy, University of Hawaii at Hilo, Hilo, Hawaii 96720, USA
    Org Biomol Chem 9:400-7. 2011
    ..The results showed a positive correlation between reduction in photosynthetic activity and the interaction of the modelled compounds with a potential enzyme active site...
  2. doi request reprint Diterpene formamides from the tropical marine sponge Cymbastela hooperi and their antimalarial activity in vitro
    Anthony D Wright
    College of Pharmacy, University of Hawaii at Hilo, Hilo, Hawaii 96720, USA
    J Nat Prod 72:492-5. 2009
    ..5 microg/mL), 2 had weak activity (IC(50) 14.8 microg/mL), and 3-5 were inactive. The pattern of activity found for the metabolites investigated in the current study is consistent with previous findings for these classes of molecules...
  3. pmc Detailed NMR, including 1,1-ADEQUATE, and anticancer studies of compounds from the echinoderm Colobometra perspinosa
    Anthony D Wright
    Australian Institute of Marine Science, PMB No 3, Townsville MC, Townsville 4810, Australia
    Mar Drugs 7:565-75. 2009
    ..The NMR data for 4 and 5 are reported here for the first time, as is their occurrence from the marine environment. The in vitro anticancer activity of the original extract was found to be associated with 1, 3 and 5...
  4. doi request reprint Metachromins U-W: cytotoxic merosesquiterpenoids from an Australian specimen of the sponge Thorecta reticulata
    Simon P B Ovenden
    Australian Institute of Marine Science, PMB No 3, Townsville MC, Townsville, Qld 4810, Australia
    J Nat Prod 74:1335-8. 2011
    ..All compounds were found to have 50% growth inhibition activities in the range 2.1-130 μM, with 2 being the most active (GI50 2.1-10 μM)...
  5. doi request reprint Update of spectroscopic data for 4-hydroxydictyolactone and dictyol E isolated from a Halimeda stuposa - Dictyota sp. assemblage
    Simon P B Ovenden
    Australian Institute of Marine Science, PMB No 3, Townsville MC, Townsville 4810, Australia
    Molecules 17:2929-38. 2012
    ..A minor revision of 1 and new spectroscopic data for 1 and 2 are provided, along with associated anti-cancer activities of compounds...
  6. doi request reprint Comosusols A-D and comosone A: cytotoxic compounds from the brown alga Sporochnus comosus
    Simon P B Ovenden
    Australian Institute of Marine Science, PMB No 3, Townsville MC, Townsville, 4810, Australia
    J Nat Prod 74:739-43. 2011
    ..The cytotoxic activity of all compounds was investigated against a panel of human tumor and mammalian cell lines. These assays found eight of the nine compounds had GI(50) values in the 8-63 μM range...
  7. doi request reprint Sesquiterpene benzoxazoles and sesquiterpene quinones from the marine sponge Dactylospongia elegans
    Simon P B Ovenden
    Australian Institute of Marine Science, PMB No 3, Townsville MC, Townsville, 4810, Australia
    J Nat Prod 74:65-8. 2011
    ..All compounds were found to have activities in the range 1.8-46 μM and lacked selectivity for tumor versus normal cell lines...
  8. pmc A great barrier reef Sinularia sp. yields two new cytotoxic diterpenes
    Anthony D Wright
    Australian Institute of Marine Science, PMB No 3, Townsville MC, Townsville, Qld 4810, Australia
    Mar Drugs 10:1619-30. 2012
    ..The lobanes and cembranes tested demonstrated 50% growth inhibition in the range 6.8-18.5 µM, with no selectivity, whilst 1 was less active (GI₅₀ 70-175 µM)...
  9. pmc A new diketopiperazine, cyclo-(4-S-hydroxy-R-proline-R-isoleucine), from an Australian specimen of the sponge Stelletta sp
    Simon P B Ovenden
    Australian Institute of Marine Science, Townsville MC, Australia
    Mar Drugs 9:2469-78. 2011
    ..The isolation and structure elucidation of the diketopiperazine (1), together with the activity of 1-8 against a panel of human and mammalian cell lines are discussed...
  10. ncbi request reprint Production of manoalide and its analogues by the sponge Luffariella variabilis Is hardwired
    Piers Ettinger-Epstein
    School of Marine and Tropical Biology, James Cook University, Townsville, Queensland, Australia
    Mar Biotechnol (NY) 10:64-74. 2008
    ..However, these ratios varied between individuals, with some individuals consistently producing high levels of manoalide and manoalide monoacetate, providing the potential for selection of high-yielding stocks...
  11. pmc Design, synthesis, and biological evaluation of callophycin A and analogues as potential chemopreventive and anticancer agents
    Li Shen
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Hawai i at Hilo, Hilo, HI 96720, USA
    Bioorg Med Chem 19:6182-95. 2011
    ..7 μM). The S-isomer 12a of callophycin A showed the most potent activity in aromatase inhibition (IC(50)=10.5 μM)...
  12. ncbi request reprint Potential antimalarial lead structures from fungi of marine origin
    Anthony D Wright
    Australian Institute of Marine Science, Townsville MC, Queensland 4810, Australia
    Planta Med 71:964-6. 2005
    ..Although the mean selectivity index of 1 for the observed antiplasmodial activity of 4 is low, pycnidione's usefulness as a potential lead structure should not be ignored...
  13. pmc Twilight zone sponges from Guam yield theonellin isocyanate and psammaplysins I and J
    Anthony D Wright
    College of Pharmacy, University of Hawaii at Hilo, Hilo, 96720 Hawaii, United States
    J Nat Prod 75:502-6. 2012
    ..For the compounds isolated from the Rhaphoxya sp., this is the first report of the known compounds 2-4 being found in a single sponge. For previously reported compounds 2-4 complete unambiguous (1)H and (13)C NMR data are provided...
  14. doi request reprint Eusynstyelamides A, B, and C, nNOS inhibitors, from the ascidian Eusynstyela latericius
    Dianne M Tapiolas
    Australian Institute of Marine Science, PMB No 3, Townsville MC, Queensland, 4810, Australia
    J Nat Prod 72:1115-20. 2009
    ..6 and 6.5 mM, respectively) and mild inhibitory activity toward the C(4) plant regulatory enzyme pyruvate phosphate dikinase (PPDK) (IC(50) values of 19 and 20 mM, respectively)...
  15. ncbi request reprint Acetylated sesterterpenes from the Great Barrier Reef sponge Luffariella variabilis
    Piers Ettinger-Epstein
    Australian Institute of Marine Science PMB 3, Townsville MC, Queensland, 4810, Australia, School of Marine Biology and Aquaculture, James Cook University, Townsville, Queensland, 4811, Australia
    J Nat Prod 70:648-51. 2007
    ..Sponge samples that were completely thawed contained only hydroxylated compounds (alcohols). This finding supported the deduction that the acetylated compounds are being enzymatically transformed and/or degraded...
  16. pmc The importance of 1H-nuclear magnetic resonance spectroscopy for reference standard validation in analytical sciences
    Dovi Kelman
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Hawaii at Hilo, Hilo, Hawaii, United States of America
    PLoS ONE 7:e42061. 2012
    ..This paper clearly illustrates the importance of validation of all standards used in analysis of organic materials by recording at least a (1)H-NMR spectrum of them prior to their use...
  17. ncbi request reprint Biological activities and 3D QSAR studies of a series of Delisea pulchra (cf. fimbriata) derived natural products
    Anthony D Wright
    Australian Institute of Marine Science, PMB No 3, Townsville MC, Qld 4810, Australia
    J Nat Prod 69:1180-7. 2006
    ..This hypothesis is developed around an active molecule having a framework based on compound 11 with an OH function or OAc (assay dependent) at C-7 and bulky electron-rich groups at C-6, such as Cl and Br but not I...
  18. ncbi request reprint Effects of cyanobacterium Fischerella ambigua isolates and cell free culture media on zebrafish (Danio rerio) embryo development
    Anthony D Wright
    Australian Institute of Marine Science, PMB No 3, Townsville MC, Qld 4810, Australia
    Chemosphere 65:604-8. 2006
    ..Due to the high concentration of ambigol A used in this assay these effects were considered to be of minor importance when compared to those of the culture medium...
  19. ncbi request reprint Ambigol C and 2,4-dichlorobenzoic acid, natural products produced by the terrestrial cyanobacterium Fischerella ambigua
    Anthony D Wright
    Australian Institute of Marine Science, PMB No 3, Townsville MC, Qld 4810, Australia
    J Nat Prod 68:459-61. 2005
    ..All structures were secured by extensive spectroscopic analysis (1D and 2D NMR, MS, UV, IR). Ambigol C has moderate activity against Trypanosoma rhodesiense...