Research Topics
Genomes and Genes
Species | Margaret R WrenschSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Recent changes in breast cancer incidence and risk factor prevalence in San Francisco Bay area and California women: 1988 to 2004Theresa H M Keegan
Northern California Cancer Center, 2201 Walnut Ave, Suite 300, Fremont, CA 94538, USA
Breast Cancer Res 9:R62. 2007..In light of these reports, we examined recent changes in breast cancer incidence and risk factor prevalence among non-Hispanic white women in the SFBA and other regions of California...- Epithelial cells in nipple aspirate fluid and subsequent breast cancer risk: a historic prospective studyKimberly A Baltzell
University of California San Francisco, Department of Physiological Nursing, San Francisco, CA, USA
BMC Cancer 8:75. 2008.... - Daily intake of antioxidants in relation to survival among adult patients diagnosed with malignant gliomaGerald N DeLorenze
Division of Research, Kaiser Permanente Northern California, 2000 Broadway, Oakland, CA, USA
BMC Cancer 10:215. 2010..The influence of diet and antioxidant intake on glioma survival is not well understood. The current study examines the association between antioxidant intake and survival after glioma diagnosis... - Model-based clustering of DNA methylation array data: a recursive-partitioning algorithm for high-dimensional data arising as a mixture of beta distributionsE Andres Houseman
Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, 02115, USA
BMC Bioinformatics 9:365. 2008..Model-based cluster analysis is often used to identify DNA methylation subgroups in data, but it is unclear how to cluster DNA methylation data from arrays in a scalable and reliable manner... 
Nonsynonymous coding single-nucleotide polymorphisms spanning the genome in relation to glioblastoma survival and age at diagnosisMargaret Wrensch
Division of Neuroepidemiology, Department of Neurological Surgery, School of Medicine, University of California at San Francisco, 94102, USA
Clin Cancer Res 13:197-205. 2007..Our aim was to discover possible inherited factors associated with glioblastoma age at diagnosis and survival. Although new genotyping technologies allow greatly expanded exploration of such factors, they pose many challenges...- Serum IgE, tumor epidermal growth factor receptor expression, and inherited polymorphisms associated with glioma survivalMargaret Wrensch
Department of Neurological Surgery, University of California San Francisco, San Francisco, California 94102, USA
Cancer Res 66:4531-41. 2006..3 region influence survival. We also suggest that tumor EGFR expression be incorporated into clinical evaluation of anaplastic astrocytoma patients... - Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibilityMargaret Wrensch
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA
Nat Genet 41:905-8. 2009..85 x 10(-10). On 20q13.3, rs6010620 intronic to RTEL1 had discovery P = 1.5 x 10(-7), replication P = 0.00035 and combined P = 3.40 x 10(-9). For both SNPs, the direction of association was the same in discovery and replication phases... - CYP1A1/2 haplotypes and lung cancer and assessment of confounding by population stratificationMelinda C Aldrich
Department of Medicine and Division of Neuroepidemiology, University of California, San Francisco, California, USA
Cancer Res 69:2340-8. 2009..These results suggest that a variant occurring within the CYP1A2 region may be conferring an increased risk of lung cancer in Latinos... - Base excision repair genes and risk of lung cancer among San Francisco Bay Area Latinos and African-AmericansJeffrey S Chang
Department of Epidemiology and Biostatistics, Division of Neuroepidemiology, University of California San Francisco, San Francisco, CA 94143 1215, USA
Carcinogenesis 30:78-87. 2009..This study suggests that there are genetic differences in the association between BER pathway and lung cancer between Latinos and African-Americans... - Nucleotide excision repair genes and risk of lung cancer among San Francisco Bay Area Latinos and African AmericansJeffrey S Chang
Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA
Int J Cancer 123:2095-104. 2008..61; 95% CI: 0.42-0.88). Our study suggests different elements of the NER pathway may be important in the different ethnic groups resulting either from different linkage relationship, genetic backgrounds and/or exposure histories... - Comparison of statistical methods for estimating genetic admixture in a lung cancer study of African Americans and LatinosMelinda C Aldrich
University of California, San Francisco, Box 2911 Rock Hall, Mission Bay 582, 1550 4th Street, San Francisco, CA 94143 2911, USA
Am J Epidemiol 168:1035-46. 2008..Genetic admixture proportions provide a quantitative measure of ancestry differences among Latinos that can be used in analyses of genetic risk factors... - Fine mapping of chromosome 15q25.1 lung cancer susceptibility in African-AmericansHelen M Hansen
Division of Neuroepidemiology, Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143, USA
Hum Mol Genet 19:3652-61. 2010..002). The identified regions contain SNPs predicted to affect gene regulation. There are multiple lung cancer risk loci in the 15q25.1 region in African-Americans... 
Pathway analysis of single-nucleotide polymorphisms potentially associated with glioblastoma multiforme susceptibility using random forestsJeffrey S Chang
Department of Epidemiology and Biostatistics, University of California, San Francisco, 44 Page Street, Suite 503, San Francisco, CA 94143 1215, USA
Cancer Epidemiol Biomarkers Prev 17:1368-73. 2008..Despite less than complete inclusion of genes and SNPs relevant to glioma and a small sample size, RF analysis identified one important biological pathway and several SNPs potentially associated with the development of glioblastoma...- SSBP2 variants are associated with survival in glioblastoma patientsYuanyuan Xiao
Department of Epidemiology and Biostatistics, University of California, San Francisco 185 Berry St, Suite 5700, San Francisco, CA 94107, USA
Clin Cancer Res 18:3154-62. 2012..Glioblastoma is a devastating, incurable disease with few known prognostic factors. Here, we present the first genome-wide survival and validation study for glioblastoma... - Circulating levels of the innate and humoral immune regulators CD14 and CD23 are associated with adult gliomaMi Zhou
Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California 94158, USA
Cancer Res 70:7534-42. 2010..These results augment the long-observed association between allergies and glioma and support a role for the innate and adaptive humoral functions of the immune system, in particular immunoregulatory proteins, in gliomagenesis... - DNA hypermethylation profiles associated with glioma subtypes and EZH2 and IGFBP2 mRNA expressionShichun Zheng
Department of Neurological Surgery, University of California San Francisco, Helen Diller Family Cancer Center, 1450 3rd Street, San Francisco, CA 94158, USA
Neuro Oncol 13:280-9. 2011..DNA methylation markers are useful in characterizing distinct glioma subtypes and may hold promise for clinical applications... - Epidemiology of primary brain tumors: current concepts and review of the literatureMargaret Wrensch
Department of Epidemiology and Biostatistics University of California at San Francisco, San Francisco, CA 94143, USA
Neuro Oncol 4:278-99. 2002..Such studies will require the cooperation of researchers from many disciplines... - CYP1A1 variants and smoking-related lung cancer in San Francisco Bay area Latinos and African AmericansMargaret R Wrensch
Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA, USA
Int J Cancer 113:141-7. 2005.... - IgE, allergy, and risk of glioma: update from the San Francisco Bay Area Adult Glioma Study in the temozolomide eraJoseph L Wiemels
Department of Neurosurgery and Epidemiology, UCSF, San Francisco, CA 94143 0441, USA
Int J Cancer 125:680-7. 2009..These results have implications for the study of immunologic factors in glioma as well as for immunotherapy protocols for treating glioma... - Analysis of 60 reported glioma risk SNPs replicates published GWAS findings but fails to replicate associations from published candidate-gene studiesKyle M Walsh
Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA
Genet Epidemiol 37:222-8. 2013..These results highlight that the deficiencies of the candidate-gene approach lay in selecting both appropriate genes and relevant SNPs within these genes... - Methylation of the PTEN promoter defines low-grade gliomas and secondary glioblastomaJohn K Wiencke
Department of Neurological Surgery and Brain Tumor Research Center, University of California, San Francisco, San Francisco, CA 94143, USA
Neuro Oncol 9:271-9. 2007.... - CD8+ T-cell infiltrate in newly diagnosed glioblastoma is associated with long-term survivalIsaac Yang
Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Avenue, San Francisco, California 94117, USA
J Clin Neurosci 17:1381-5. 2010..006). Thus, CD8+ T-cell infiltrate is associated with prolonged survival. Our data provide the impetus for more sophisticated studies to further elucidate prospectively the specific T-cell subtypes associated with long-term survival... - Nipple aspirate fluid cytology and the Gail model for breast cancer risk assessment in a screening populationJeffrey A Tice
Division of General Internal Medicine, Department of Medicine, University of California, San Francisco, 1701 Divisadero Street, Suite 554, San Francisco, CA 94143 1732, USA
Cancer Epidemiol Biomarkers Prev 14:324-8. 2005..Recent guidelines suggest that chemoprevention with tamoxifen may be appropriate for women who have a 5-year risk of breast cancer greater than 1.66% calculated using the Gail model... - Complementary and alternative medicine use among men with prostate cancer in 4 ethnic populationsMarion M Lee
Department of Epidemiology and Biostatistics, University of California-San Francisco, Box 560, San Francisco, CA 94143-0560, USA
Am J Public Health 92:1606-9. 2002 - DNA methylation, isocitrate dehydrogenase mutation, and survival in gliomaBrock C Christensen
Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA
J Natl Cancer Inst 103:143-53. 2011.... - Ventriculoperitoneal shunt complications in California: 1990 to 2000Yvonne Wu
Department of Neurology, University of California, San Francisco, San Francisco, California 94143 0137, USA
Neurosurgery 61:557-62; discussion 562-3. 2007..We examined demographic factors and VP shunt complications in a population-based retrospective cohort study of all nonfederal California hospital admissions between 1990 and 2000... - SNPLogic: an interactive single nucleotide polymorphism selection, annotation, and prioritization systemAlexander R Pico
Gladstone Institute of Cardiovascular Disease, 1650 Owens Street, San Francisco, CA 94158, USA
Nucleic Acids Res 37:D803-9. 2009..We have found integration of SNP annotation in the context of pathway information and functional prediction scores to be a powerful approach to the analysis and interpretation of SNP-disease association data... - Epidemiology and etiology of meningiomaJoseph Wiemels
Department of Epidemiology and Biostatistics, University of California San Francisco, Helen Diller Cancer Research Building, MC 0520, San Francisco, CA 94158, USA
J Neurooncol 99:307-14. 2010..In this review, we highlight current knowledge about meningioma epidemiology and etiology and suggest future research directions... - Risk factors for breast cancer in a population with high incidence ratesMargaret Wrensch
University of California, San Francisco, California, USA
Breast Cancer Res 5:R88-102. 2003..This report examines generally recognized breast cancer risk factors and years of residence in Marin County, California, an area with high breast cancer incidence and mortality rates... - Molecular features of adult glioma associated with patient race/ethnicity, age, and a polymorphism in O6-methylguanine-DNA-methyltransferaseJohn K Wiencke
Division of Neuroepidemiology, Department of Neurological Surgery, School of Medicine, University of California San Francisco, Box 0441, San Francisco, CA 94143 0441, USA
Cancer Epidemiol Biomarkers Prev 14:1774-83. 2005..MGMT expression may depend on the TP53 status of cells... - ERCC1 and ERCC2 polymorphisms and adult gliomaMargaret Wrensch
Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143, USA
Neuro Oncol 7:495-507. 2005..3). Given the numbers of comparisons made, these findings could be due to chance. However, the results might warrant clarification in additional series in conjunction with the nearby putative glioma suppressor genes (GLTSCR1 and GLTSCR2)... - The molecular epidemiology of gliomas in adultsMargaret Wrensch
Department of Neurological Surgery, University of California, San Francisco, California 94102, USA
Neurosurg Focus 19:E5. 2005..Improving survival rates for patients harboring astrocytic tumors will probably require many randomized clinical trials of novel treatment strategies... - Allergy-related polymorphisms influence glioma status and serum IgE levelsJoseph L Wiemels
Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA 94143 0441, USA
Cancer Epidemiol Biomarkers Prev 16:1229-35. 2007..Further exploration of immune susceptibility factors, including genetics, in glioma etiology is advisable... - Long-term outcomes in patients with treated childhood hydrocephalusNalin Gupta
Department of Neurological Surgery, University of California, San Francisco 94102, USA
J Neurosurg 106:334-9. 2007..The goal in this study was to determine the long-term effects of childhood hydrocephalus... - Reduced immunoglobulin E and allergy among adults with glioma compared with controlsJoseph L Wiemels
Laboratory for Molecular Epidemiology, Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California 94143 0560, USA
Cancer Res 64:8468-73. 2004..Furthermore, the results indicate a complex relationship between allergic disease and glioma risk that varies by allergen and allergic pathology... - Diagnostic, treatment, and demographic factors influencing survival in a population-based study of adult glioma patients in the San Francisco Bay AreaMargaret Wrensch
Department of Neurological Surgery, University of California, San Francisco, 44 Page Street Suite 503, San Francisco, CA 94102 1215, USA
Neuro Oncol 8:12-26. 2006..Further consideration of impact of marital status, education, and other social factors in glioma survival may be warranted... - Glutathione-S-transferase variants and adult gliomaMargaret Wrensch
University of California, San Francisco, CA 94143, USA
Cancer Epidemiol Biomarkers Prev 13:461-7. 2004..Conflicting findings have been reported for associations of primary brain tumors and constitutive polymorphisms in glutathione-S-transferases (GSTs)... - History of chickenpox and shingles and prevalence of antibodies to varicella-zoster virus and three other herpesviruses among adults with glioma and controlsMargaret Wrensch
Department of Neurological Surgery, School of Medicine, University of California, San Francisco, CA 94102, USA
Am J Epidemiol 161:929-38. 2005..Cohort studies may help to clarify the nature of the association between immunity to and/or clinical manifestations of varicella-zoster virus and glioblastoma... - Occupation and adult gliomas in the San Francisco Bay AreaGeetha Krishnan
Touro University College of Osteopathic Medicine, Vallejo, California 94102, USA
J Occup Environ Med 45:639-47. 2003..This study supports previously observed occupational associations and is one of the few studies with sufficient numbers to separately analyze occupations by gender... - History of allergies among adults with glioma and controlsJoseph L Wiemels
Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA 94102, USA
Int J Cancer 98:609-15. 2002..Future work might reveal an important role for immunologic factors in gliomagenesis and potential preventative and/or therapeutic modalities... - Association study of nicotinic acetylcholine receptor genes identifies a novel lung cancer susceptibility locus near CHRNA1 in African-AmericansKyle M Walsh
Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA
Oncotarget 3:1428-38. 2012..These findings identify a novel lung cancer risk locus on 2q31.1 which correlates with CHRNA1 expression and replicate previous associations on 15q25.1 in African-Americans... - Strengths and limitations of breast cancer risk assessmentKimberly Baltzell
Department of Physiological Nursing, University of California, San Francisco, USA
Oncol Nurs Forum 32:605-16. 2005..To evaluate current definitions of breast cancer risk and breast cancer risk assessment models, including the Gail, Claus, and BRCAPRO models, and discuss potential markers to enhance and standardize individual risk assessment... - DNA quantification of whole genome amplified samples for genotyping on a multiplexed bead array platformHelen M Hansen
Department of Neurological Surgery, University of California, Suite AC 34, 1 Irving Street, San Francisco, CA 94143 0441, USA
Cancer Epidemiol Biomarkers Prev 16:1686-90. 2007..14-118.32, 0.29-2.19, and 0.01-0.27 ng/microL, respectively). Human-specific quantitative PCR is a highly useful guide for determining the suitability of wgaDNA before high-throughput single-nucleotide polymorphism analysis... - Multiple sampling for increasing the diagnostic sensitivity of nipple aspirate fluid for atypical cytologyEileen B King
Department of Epidemiology and Biostatistics, School of Medicine, University of California San Francisco, San Francisco, California 94143-0560, USA
Acta Cytol 48:813-7. 2004..Reviewing repeated multiple samples instead of 1 increases the number of women who can be evaluated and the likelihood of detecting cytologic atypia... - Risk factors for estrogen receptor-positive breast cancerE Shelley Hwang
Department of Surgery, University of California, San Francisco, Cancer Center, 94115, USA
Arch Surg 140:58-62. 2005..Some risk factors associated with breast cancer may be more predictive of estrogen receptor (ER)- positive than ER-negative tumors... - Breast carcinogenesis: can the examination of ductal fluid enhance our understanding?Kimberly Baltzell
Department of Physiologic Nursing, University of California, San Francisco, CA, USA
Oncol Nurs Forum 32:33-9. 2005.... - Population- and community-based recruitment of African Americans and Latinos: the San Francisco Bay Area Lung Cancer StudyDaramöla N Cabral
Northern California Cancer Center, Union City, CA 94587, USA
Am J Epidemiol 158:272-9. 2003..05). Further assessment of strategies for successful recruitment of minority participants into epidemiologic studies is warranted... - DNA repair polymorphisms XRCC1 and MGMT and risk of adult gliomasMartha J Felini
Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
Neuroepidemiology 29:55-8. 2007..26; CI 0.90-1.75) and the MGMT Ile143Val polymorphism (Ile or Val/Val versus Ile/Ile: adjusted OR = 1.20; CI 0.85-1.71)... - Breast cancer incidence and mortality trends in an affluent population: Marin County, California, USA, 1990-1999Christina A Clarke
Northern California Cancer Center, Union City, California 94587, USA
Breast Cancer Res 4:R13. 2002..Close surveillance of Marin County breast cancer trends has nevertheless continued, in part because distinctive breast cancer patterns in well-defined populations may inform understanding of breast cancer etiology... - Issues of diagnostic review in brain tumor studies: from the Brain Tumor Epidemiology ConsortiumFaith G Davis
Division of Epidemiology Biostatistics, School of Public Health, University of Illinois at Chicago, Chicago, IL 60612, USA
Cancer Epidemiol Biomarkers Prev 17:484-9. 2008..It is essential that epidemiologists and neuropathologists collaborate to develop appropriate study designs and protocols for specific hypothesis and populations...
Research Grants
- Genetic and Molecular Epidemiology of Adult GliomaMargaret Wrensch; Fiscal Year: 2005..abstract_text> ..
- Genetic and Molecular Epidemiology of Adult GliomaMargaret Wrensch; Fiscal Year: 2009..Enhanced understanding of these factors may provide targets for future interventions. ..
- Genetic and Molecular Epidemiology of Adult GliomaMargaret R Wrensch; Fiscal Year: 2010..Enhanced understanding of these factors may provide targets for future interventions. ..
- GENETIC EPIDEMIOLOGY OF MALIGNANT GLIOMAMargaret Wrensch; Fiscal Year: 2001..High risk families will be ascertained to facilitate future linkage studies. ..
- GENETIC EPIDEMIOLOGY OF MALIGNANT GLIOMAMargaret Wrensch; Fiscal Year: 1993....
- Genetic and Molecular Epidemiology of Adult GliomaMargaret Wrensch; Fiscal Year: 2009..Enhanced understanding of these factors may provide targets for future interventions. ..