David Walter Wray

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Aging, exercise, and limb vascular heterogeneity in humans
    David Walter Wray
    University of California San Diego Department of Medicine, La Jolla, CA 92093 0623, USA
    Med Sci Sports Exerc 38:1804-10. 2006
  2. ncbi Endothelin-1-mediated vasoconstriction at rest and during dynamic exercise in healthy humans
    D Walter Wray
    Dept of Medicine, 9500 Gilman Dr, Univ of California San Diego, La Jolla, CA 92093 0623, USA
    Am J Physiol Heart Circ Physiol 293:H2550-6. 2007
  3. ncbi Evidence of preserved endothelial function and vascular plasticity with age
    D Walter Wray
    Physiology Division, Department of Medicine, University of California, San Diego, 9500 Gilman Dr, La Jolla, California 92093 0623, USA
    Am J Physiol Heart Circ Physiol 290:H1271-7. 2006
  4. ncbi In FMD, NO is actually "the middle man"
    D Walter Wray
    Department of Medicine, Physiology Division, University of California San Diego, La Jolla, 92093, USA
    J Appl Physiol 99:1624. 2005
  5. pmc Onset exercise hyperaemia in humans: partitioning the contributors
    D Walter Wray
    Department of Medicine, Physiology Division, 9500 Gilman Drive, University of California San Diego, La Jolla, CA 92093 0623, USA
    J Physiol 565:1053-60. 2005
  6. doi Angiotensin II in the elderly: impact of angiotensin II type 1 receptor sensitivity on peripheral hemodynamics
    D Walter Wray
    Department of Medicine, University of California San Diego, La Jolla, CA 92093 0623, USA
    Hypertension 51:1611-6. 2008
  7. ncbi Heterogeneous limb vascular responsiveness to shear stimuli during dynamic exercise in humans
    D Walter Wray
    Dept of Medicine, Physiology Division, Univ of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0623, USA
    J Appl Physiol (1985) 99:81-6. 2005
  8. pmc Dynamic carotid baroreflex control of the peripheral circulation during exercise in humans
    D Walter Wray
    Department of Integrative Physiology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    J Physiol 559:675-84. 2004
  9. ncbi Acute sympathetic vasoconstriction at rest and during dynamic exercise in cyclists and sedentary humans
    D Walter Wray
    Dept of Medicine, Physiology Div, 9500 Gilman Dr, Univ of California San Diego, La Jolla, CA 92093 0623, USA
    J Appl Physiol (1985) 102:704-12. 2007
  10. pmc Exercise-induced inhibition of angiotensin II vasoconstriction in human thigh muscle
    R Matthew Brothers
    Department of Integrative Physiology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA, and Copenhagen Muscle Research Centre, Department of Cardiology, National Hospital, Blegdamsvej 9, DK 2100 Copenhagen O, Denmark
    J Physiol 577:727-37. 2006

Detail Information

Publications27

  1. ncbi Aging, exercise, and limb vascular heterogeneity in humans
    David Walter Wray
    University of California San Diego Department of Medicine, La Jolla, CA 92093 0623, USA
    Med Sci Sports Exerc 38:1804-10. 2006
    ..Collectively, these studies demonstrate a significant between-limb vascular heterogeneity in humans that is influenced by age and by exercise training...
  2. ncbi Endothelin-1-mediated vasoconstriction at rest and during dynamic exercise in healthy humans
    D Walter Wray
    Dept of Medicine, 9500 Gilman Dr, Univ of California San Diego, La Jolla, CA 92093 0623, USA
    Am J Physiol Heart Circ Physiol 293:H2550-6. 2007
    ....
  3. ncbi Evidence of preserved endothelial function and vascular plasticity with age
    D Walter Wray
    Physiology Division, Department of Medicine, University of California, San Diego, 9500 Gilman Dr, La Jolla, California 92093 0623, USA
    Am J Physiol Heart Circ Physiol 290:H1271-7. 2006
    ..Likewise, exercise training improved arm vasodilation, indicating some preservation of vascular plasticity with age...
  4. ncbi In FMD, NO is actually "the middle man"
    D Walter Wray
    Department of Medicine, Physiology Division, University of California San Diego, La Jolla, 92093, USA
    J Appl Physiol 99:1624. 2005
  5. pmc Onset exercise hyperaemia in humans: partitioning the contributors
    D Walter Wray
    Department of Medicine, Physiology Division, 9500 Gilman Drive, University of California San Diego, La Jolla, CA 92093 0623, USA
    J Physiol 565:1053-60. 2005
    ....
  6. doi Angiotensin II in the elderly: impact of angiotensin II type 1 receptor sensitivity on peripheral hemodynamics
    D Walter Wray
    Department of Medicine, University of California San Diego, La Jolla, CA 92093 0623, USA
    Hypertension 51:1611-6. 2008
    ....
  7. ncbi Heterogeneous limb vascular responsiveness to shear stimuli during dynamic exercise in humans
    D Walter Wray
    Dept of Medicine, Physiology Division, Univ of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0623, USA
    J Appl Physiol (1985) 99:81-6. 2005
    ....
  8. pmc Dynamic carotid baroreflex control of the peripheral circulation during exercise in humans
    D Walter Wray
    Department of Integrative Physiology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    J Physiol 559:675-84. 2004
    ..However, despite a shift towards more predominant local control over the exercising muscle vasculature, systemic arterial blood pressure was well preserved...
  9. ncbi Acute sympathetic vasoconstriction at rest and during dynamic exercise in cyclists and sedentary humans
    D Walter Wray
    Dept of Medicine, Physiology Div, 9500 Gilman Dr, Univ of California San Diego, La Jolla, CA 92093 0623, USA
    J Appl Physiol (1985) 102:704-12. 2007
    ....
  10. pmc Exercise-induced inhibition of angiotensin II vasoconstriction in human thigh muscle
    R Matthew Brothers
    Department of Integrative Physiology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA, and Copenhagen Muscle Research Centre, Department of Cardiology, National Hospital, Blegdamsvej 9, DK 2100 Copenhagen O, Denmark
    J Physiol 577:727-37. 2006
    ....
  11. ncbi Differential effects of aging on limb blood flow in humans
    Anthony J Donato
    Dept of Medicine, Physiology Division, 9500 Gilman Drive, Univ of California, San Diego, La Jolla, CA 92093 0623, USA
    Am J Physiol Heart Circ Physiol 290:H272-8. 2006
    ..In conclusion, aging induces limb-specific alterations in exercise blood flow regulation. These alterations result in reductions in leg blood flow during exercise but do not impact forearm blood flow...
  12. pmc Antioxidants and aging: NMR-based evidence of improved skeletal muscle perfusion and energetics
    D Walter Wray
    Department of Medicine, University of California San Diego, La Jolla, CA, USA
    Am J Physiol Heart Circ Physiol 297:H1870-5. 2009
    ....
  13. doi Aging affects vascular structure and function in a limb-specific manner
    Steven K Nishiyama
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0623, USA
    J Appl Physiol (1985) 105:1661-70. 2008
    ....
  14. ncbi Carotid baroreflex control of leg vascular conductance at rest and during exercise
    David M Keller
    Department of Integrative Physiology, University of North Texas Health Science Center, Fort Worth 76107, USA
    J Appl Physiol (1985) 94:542-8. 2003
    ..Furthermore, despite alterations in CBR-induced changes in LVC during exercise, CBR control of blood pressure was well maintained...
  15. pmc Exercise-induced brachial artery vasodilation: effects of antioxidants and exercise training in elderly men
    Anthony J Donato
    Department of Medicine, Division of Geriatrics, University of Utah, Salt Lake City, USA
    Am J Physiol Heart Circ Physiol 298:H671-8. 2010
    ....
  16. pmc Inhibition of alpha-adrenergic vasoconstriction in exercising human thigh muscles
    D Walter Wray
    Department of Integrative Physiology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    J Physiol 555:545-63. 2004
    ..However, alpha(2)-mediated vasoconstriction appears more sensitive to metabolic inhibition, because alpha(2) is completely inhibited even at low workloads, whereas alpha(1) becomes progressively inhibited with increasing workloads...
  17. pmc Diminished baroreflex-induced vasoconstriction following alpha-2 adrenergic receptor blockade in humans
    D Walter Wray
    Department of Medicine, University of California San Diego, La Jolla, CA 92093 0623, United States
    Auton Neurosci 138:114-7. 2008
    ..These data indicate that alpha-2 adrenergic receptors contribute significantly to CBR-induced vasoconstriction in the human leg under resting conditions...
  18. pmc Carotid baroreflex responsiveness to head-up tilt-induced central hypovolaemia: effect of aerobic fitness
    Shigehiko Ogoh
    Department of Integrative Physiology, University of North Texas Health Science Center at Fort Worth, TX 76107, USA
    J Physiol 551:601-8. 2003
    ..These findings provide an explanation for the predisposition to orthostatic hypotension and intolerance in well-trained athletes...
  19. doi Oral antioxidants and cardiovascular health in the exercise-trained and untrained elderly: a radically different outcome
    D Walter Wray
    Department of Medicine, University of California La Jolla, 92093, USA
    Clin Sci (Lond) 116:433-41. 2009
    ..In conclusion, the paradoxical effects of these interventions suggest a need for caution when exercise and acute antioxidant supplementation are combined in elderly mildly hypertensive individuals...
  20. pmc Sex and limb-specific ischemic reperfusion and vascular reactivity
    Steven K Nishiyama
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0623, USA
    Am J Physiol Heart Circ Physiol 295:H1100-H1108. 2008
    ....
  21. ncbi Sympathetic cardiac influence and arterial blood pressure instability
    Kevin J Formes
    Department of Integrative Physiology, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
    Auton Neurosci 118:116-24. 2005
    ..91+/-0.05 ms/mm Hg). These data suggested that removal of sympathetic cardiac influence improved cardiovascular stability as indicated by a diminished LF ABP variability, which was related to an enhanced cardiac responsiveness...
  22. pmc Effect of acetazolamide on pulmonary and muscle gas exchange during normoxic and hypoxic exercise
    Amy M Jonk
    Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0623, USA
    J Physiol 579:909-21. 2007
    ..05). In summary, ACZ improved arterial oxygenation during exercise, due to both greater ventilation and more efficient pulmonary gas exchange. However, muscle gas exchange was unaffected...
  23. pmc Human skeletal muscle intracellular oxygenation: the impact of ambient oxygen availability
    Russell S Richardson
    Department of Medicine, Physiology Division, 9500 Gilman Drive, University of California, San Diego, La Jolla, CA 92093 0623, USA
    J Physiol 571:415-24. 2006
    ....
  24. ncbi Limitations to vasodilatory capacity and .VO2 max in trained human skeletal muscle
    Jeremy Barden
    Department of Medicine, 9500 Gilman Drive, Univeesity of California San Diego, La Jolla, CA 92093 0623, USA
    Am J Physiol Heart Circ Physiol 292:H2491-7. 2007
    ..VO(2 max) with significantly increased O(2) delivery (hyperoxia + ADO), with a degree of uncertainty as to the site of this dilation, suggests an ADO-induced mismatch between O(2) consumption and blood flow in the exercising limb...
  25. ncbi Exercise-induced brachial artery vasodilation: role of free radicals
    Russell S Richardson
    Dept of Medicine, Physiology Division, Univ of California San Diego, La Jolla, CA 92093 0623, USA
    Am J Physiol Heart Circ Physiol 292:H1516-22. 2007
    ..These findings implicate an exercise-induced reliance upon pro-oxidant-stimulated vasodilation, thereby revealing an important and positive vascular role for free radicals...
  26. ncbi Metabolic and vascular limb differences affected by exercise, gender, age, and disease
    Russell S Richardson
    Department of Medicine, University of California San Diego, La Jolla, CA 92009, USA
    Med Sci Sports Exerc 38:1792-6. 2006
    ....
  27. pmc Multiparametric NMR-based assessment of skeletal muscle perfusion and metabolism during exercise in elderly persons: preliminary findings
    D Walter Wray
    Department of Internal Medicine, University of California San Diego, La Jolla, CA, USA
    J Gerontol A Biol Sci Med Sci 64:968-74. 2009
    ..Therefore, we utilized an unique nuclear magnetic resonance sequence to concomitantly examine changes in lower leg skeletal muscle perfusion and metabolism...