D Walter Wray

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. pmc Does brachial artery flow-mediated vasodilation provide a bioassay for NO?
    D Walter Wray
    Division of Geriatrics, Department of Internal Medicine, University of Utah, VAMC SLC, GRECC 182, Bldg 2 Rm 1C03, 500 Foothill Dr, Salt Lake City, UT 84148, USA
    Hypertension 62:345-51. 2013
  2. pmc Acute reversal of endothelial dysfunction in the elderly after antioxidant consumption
    D Walter Wray
    Geriatric Research, Education, and Clinical Center, Salt Lake City Veterans Affairs Medical Center, Salt Lake City, UT 84132, USA
    Hypertension 59:818-24. 2012
  3. pmc Antioxidants and aging: NMR-based evidence of improved skeletal muscle perfusion and energetics
    D Walter Wray
    Department of Medicine, University of California San Diego, La Jolla, CA, USA
    Am J Physiol Heart Circ Physiol 297:H1870-5. 2009
  4. pmc Role of {alpha}1-adrenergic vasoconstriction in the regulation of skeletal muscle blood flow with advancing age
    D Walter Wray
    Deptartment of Medicine, Univers9ty of Utah, VAMC SLC, Bldg 2, Salt Lake City, UT 84132, USA
    Am J Physiol Heart Circ Physiol 296:H497-504. 2009
  5. pmc Multiparametric NMR-based assessment of skeletal muscle perfusion and metabolism during exercise in elderly persons: preliminary findings
    D Walter Wray
    Department of Internal Medicine, University of California San Diego, La Jolla, CA, USA
    J Gerontol A Biol Sci Med Sci 64:968-74. 2009
  6. doi request reprint Impact of aldosterone receptor blockade compared with thiazide therapy on sympathetic nervous system function in geriatric hypertension
    D Walter Wray
    Division of Geriatrics, Department of Internal Medicine, University of Utah, Salt Lake City, UT 84132, USA
    Hypertension 55:1217-23. 2010
  7. pmc Progressive handgrip exercise: evidence of nitric oxide-dependent vasodilation and blood flow regulation in humans
    D Walter Wray
    Division of Geriatrics, Department of Internal Medicine, University of Utah, Salt Lake City, Utah 84148, USA
    Am J Physiol Heart Circ Physiol 300:H1101-7. 2011
  8. doi request reprint Oral antioxidants and cardiovascular health in the exercise-trained and untrained elderly: a radically different outcome
    D Walter Wray
    Department of Medicine, University of California La Jolla, 92093, USA
    Clin Sci (Lond) 116:433-41. 2009
  9. pmc A differing role of oxidative stress in the regulation of central and peripheral hemodynamics during exercise in heart failure
    Melissa A H Witman
    Geriatric Research, Education, and Clinical Center, George E Whalen Veterans Affairs Medical Center, Salt Lake City, UT 84148, USA
    Am J Physiol Heart Circ Physiol 303:H1237-44. 2012
  10. ncbi request reprint Exercise-induced brachial artery vasodilation: role of free radicals
    Russell S Richardson
    Dept of Medicine, Physiology Division, Univ of California San Diego, La Jolla, CA 92093 0623, USA
    Am J Physiol Heart Circ Physiol 292:H1516-22. 2007

Collaborators

Detail Information

Publications38

  1. pmc Does brachial artery flow-mediated vasodilation provide a bioassay for NO?
    D Walter Wray
    Division of Geriatrics, Department of Internal Medicine, University of Utah, VAMC SLC, GRECC 182, Bldg 2 Rm 1C03, 500 Foothill Dr, Salt Lake City, UT 84148, USA
    Hypertension 62:345-51. 2013
    ..89) FMD trials. These findings challenge the assertion that NO is obligatory for brachial artery FMD and call into question the sensitivity of this procedure for noninvasive determination of NO bioavailability in young, healthy humans...
  2. pmc Acute reversal of endothelial dysfunction in the elderly after antioxidant consumption
    D Walter Wray
    Geriatric Research, Education, and Clinical Center, Salt Lake City Veterans Affairs Medical Center, Salt Lake City, UT 84132, USA
    Hypertension 59:818-24. 2012
    ....
  3. pmc Antioxidants and aging: NMR-based evidence of improved skeletal muscle perfusion and energetics
    D Walter Wray
    Department of Medicine, University of California San Diego, La Jolla, CA, USA
    Am J Physiol Heart Circ Physiol 297:H1870-5. 2009
    ....
  4. pmc Role of {alpha}1-adrenergic vasoconstriction in the regulation of skeletal muscle blood flow with advancing age
    D Walter Wray
    Deptartment of Medicine, Univers9ty of Utah, VAMC SLC, Bldg 2, Salt Lake City, UT 84132, USA
    Am J Physiol Heart Circ Physiol 296:H497-504. 2009
    ....
  5. pmc Multiparametric NMR-based assessment of skeletal muscle perfusion and metabolism during exercise in elderly persons: preliminary findings
    D Walter Wray
    Department of Internal Medicine, University of California San Diego, La Jolla, CA, USA
    J Gerontol A Biol Sci Med Sci 64:968-74. 2009
    ..Therefore, we utilized an unique nuclear magnetic resonance sequence to concomitantly examine changes in lower leg skeletal muscle perfusion and metabolism...
  6. doi request reprint Impact of aldosterone receptor blockade compared with thiazide therapy on sympathetic nervous system function in geriatric hypertension
    D Walter Wray
    Division of Geriatrics, Department of Internal Medicine, University of Utah, Salt Lake City, UT 84132, USA
    Hypertension 55:1217-23. 2010
    ..These findings demonstrate a beneficial effect of aldosterone receptor blockade on reducing sympathetic nervous system activity and blood pressure in hypertensive older patients...
  7. pmc Progressive handgrip exercise: evidence of nitric oxide-dependent vasodilation and blood flow regulation in humans
    D Walter Wray
    Division of Geriatrics, Department of Internal Medicine, University of Utah, Salt Lake City, Utah 84148, USA
    Am J Physiol Heart Circ Physiol 300:H1101-7. 2011
    ..These results support this paradigm as a novel and valid approach for a noninvasive assessment of NO-dependent vasodilation in humans...
  8. doi request reprint Oral antioxidants and cardiovascular health in the exercise-trained and untrained elderly: a radically different outcome
    D Walter Wray
    Department of Medicine, University of California La Jolla, 92093, USA
    Clin Sci (Lond) 116:433-41. 2009
    ..In conclusion, the paradoxical effects of these interventions suggest a need for caution when exercise and acute antioxidant supplementation are combined in elderly mildly hypertensive individuals...
  9. pmc A differing role of oxidative stress in the regulation of central and peripheral hemodynamics during exercise in heart failure
    Melissa A H Witman
    Geriatric Research, Education, and Clinical Center, George E Whalen Veterans Affairs Medical Center, Salt Lake City, UT 84148, USA
    Am J Physiol Heart Circ Physiol 303:H1237-44. 2012
    ..In conclusion, these data imply that SVR in patients with HF is, at least in part, mediated by oxidative stress. However, this finding does not appear to be the direct result of muscle-specific changes in PVR...
  10. ncbi request reprint Exercise-induced brachial artery vasodilation: role of free radicals
    Russell S Richardson
    Dept of Medicine, Physiology Division, Univ of California San Diego, La Jolla, CA 92093 0623, USA
    Am J Physiol Heart Circ Physiol 292:H1516-22. 2007
    ..These findings implicate an exercise-induced reliance upon pro-oxidant-stimulated vasodilation, thereby revealing an important and positive vascular role for free radicals...
  11. pmc On the contribution of group III and IV muscle afferents to the circulatory response to rhythmic exercise in humans
    Markus Amann
    Department of Medicine, University of Utah, Salt Lake City, UT
    J Physiol 589:3855-66. 2011
    ..05). Our findings reveal an essential contribution of continuous muscle afferent feedback to ensure the appropriate haemodynamic and ultimately metabolic response to rhythmic exercise in humans..
  12. pmc Vascular function and the role of oxidative stress in heart failure, heart transplant, and beyond
    Melissa A H Witman
    Geriatric Research Education and Clinical Center, George E Whalen VA Medical Center, Salt Lake City, UT, USA
    Hypertension 60:659-68. 2012
    ..This cross-sectional study reveals that, compared with controls, vascular function is blunted in HFrEF, is similar soon after HTx, but is decreased with greater time post-HTx with free radicals implicated in this progression...
  13. ncbi request reprint Endothelin-1-mediated vasoconstriction at rest and during dynamic exercise in healthy humans
    D Walter Wray
    Dept of Medicine, 9500 Gilman Dr, Univ of California San Diego, La Jolla, CA 92093 0623, USA
    Am J Physiol Heart Circ Physiol 293:H2550-6. 2007
    ....
  14. pmc Contribution of nitric oxide to brachial artery vasodilation during progressive handgrip exercise in the elderly
    Joel D Trinity
    Geriatric Research, Education, and Clinical Center, George E Whalen VA Medical Center, Salt Lake City, Utah
    Am J Physiol Regul Integr Comp Physiol 305:R893-9. 2013
    ..This modest contribution of NO to BA vasodilation in the elderly supports the use of the handgrip exercise paradigm to assess NO-dependent vasodilation across the life span. ..
  15. pmc Impact of body position on central and peripheral hemodynamic contributions to movement-induced hyperemia: implications for rehabilitative medicine
    Joel D Trinity
    Geriatric Research, Education, and Clinical Center, George E Whalen Veterans Affairs Medical Center, Salt Lake City, Utah, USA
    Am J Physiol Heart Circ Physiol 300:H1885-91. 2011
    ....
  16. pmc Limb movement-induced hyperemia has a central hemodynamic component: evidence from a neural blockade study
    Joel D Trinity
    Geriatric Research, Education, and Clinical Center, George E Whalen Veterans Affairs Medical Center, Salt Lake City, Utah, USA
    Am J Physiol Heart Circ Physiol 299:H1693-700. 2010
    ..In combination, these findings provide evidence that limb movement-induced hyperemia has a significant central hemodynamic component induced by peripheral nerve activation...
  17. ncbi request reprint Differential effects of aging on limb blood flow in humans
    Anthony J Donato
    Dept of Medicine, Physiology Division, 9500 Gilman Drive, Univ of California, San Diego, La Jolla, CA 92093 0623, USA
    Am J Physiol Heart Circ Physiol 290:H272-8. 2006
    ..In conclusion, aging induces limb-specific alterations in exercise blood flow regulation. These alterations result in reductions in leg blood flow during exercise but do not impact forearm blood flow...
  18. pmc Exercise-induced brachial artery vasodilation: effects of antioxidants and exercise training in elderly men
    Anthony J Donato
    Department of Medicine, Division of Geriatrics, University of Utah, Salt Lake City, USA
    Am J Physiol Heart Circ Physiol 298:H671-8. 2010
    ....
  19. doi request reprint Taming the "sleeping giant": the role of endothelin-1 in the regulation of skeletal muscle blood flow and arterial blood pressure during exercise
    Zachary Barrett-O'Keefe
    Department of Exercise and Sport Science, University of Utah, Salt Lake City, UT 84148, USA
    Am J Physiol Heart Circ Physiol 304:H162-9. 2013
    ....
  20. ncbi request reprint Acute sympathetic vasoconstriction at rest and during dynamic exercise in cyclists and sedentary humans
    D Walter Wray
    Dept of Medicine, Physiology Div, 9500 Gilman Dr, Univ of California San Diego, La Jolla, CA 92093 0623, USA
    J Appl Physiol (1985) 102:704-12. 2007
    ....
  21. doi request reprint Angiotensin II potentiates α-adrenergic vasoconstriction in the elderly
    Zachary Barrett-O'Keefe
    Department of Exercise and Sport Science, University of Utah, Salt Lake City, UT 84148, USA
    Clin Sci (Lond) 124:413-22. 2013
    ....
  22. doi request reprint Angiotensin II in the elderly: impact of angiotensin II type 1 receptor sensitivity on peripheral hemodynamics
    D Walter Wray
    Department of Medicine, University of California San Diego, La Jolla, CA 92093 0623, USA
    Hypertension 51:1611-6. 2008
    ....
  23. pmc Onset exercise hyperaemia in humans: partitioning the contributors
    D Walter Wray
    Department of Medicine, Physiology Division, 9500 Gilman Drive, University of California San Diego, La Jolla, CA 92093 0623, USA
    J Physiol 565:1053-60. 2005
    ....
  24. doi request reprint The paradox of oxidative stress and exercise with advancing age
    D Walter Wray
    George E Whalen VA Medical Center, Salt Lake City, UT 84148, USA
    Exerc Sport Sci Rev 39:68-76. 2011
    ..Both antioxidant supplementation and exercise training have been identified as interventions that may reduce oxidative stress, but their interaction in older humans is not well understood...
  25. doi request reprint Aging affects vascular structure and function in a limb-specific manner
    Steven K Nishiyama
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0623, USA
    J Appl Physiol (1985) 105:1661-70. 2008
    ....
  26. doi request reprint Human skeletal muscle feed arteries studied in vitro: the effect of temperature on α(1)-adrenergic responsiveness
    Stephen J Ives
    Geriatric Research Education and Clinical Center, George E Whalen VA Medical Center, Salt Lake City, UT, USA
    Exp Physiol 96:907-18. 2011
    ....
  27. pmc Human skeletal muscle intracellular oxygenation: the impact of ambient oxygen availability
    Russell S Richardson
    Department of Medicine, Physiology Division, 9500 Gilman Drive, University of California, San Diego, La Jolla, CA 92093 0623, USA
    J Physiol 571:415-24. 2006
    ....
  28. pmc Attenuated exercise induced hyperaemia with age: mechanistic insight from passive limb movement
    John McDaniel
    George E Whalen VA Medical Center, Salt Lake City, Utah 84148, USA
    J Physiol 588:4507-17. 2010
    ..In a paradigm where metabolism does not play a role, these data reveal that both central and peripheral haemodynamic mechanisms are likely to be responsible for the 30% reduction in exercise-induced hyperaemia with age...
  29. doi request reprint Vascular function and multiple sclerosis
    Anette S Fjeldstad
    Division of Geriatrics, Department of Internal Medicine, George E Whalen VA Medical Center, University of Utah, Salt Lake City, UT 84148, USA
    J Neurol 258:2036-42. 2011
    ..These findings suggest that impaired vascular function, elevated inflammation and oxidative stress are not an obligatory accompaniment to MS...
  30. pmc Sex and limb-specific ischemic reperfusion and vascular reactivity
    Steven K Nishiyama
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0623, USA
    Am J Physiol Heart Circ Physiol 295:H1100-H1108. 2008
    ....
  31. ncbi request reprint Limitations to vasodilatory capacity and .VO2 max in trained human skeletal muscle
    Jeremy Barden
    Department of Medicine, 9500 Gilman Drive, Univeesity of California San Diego, La Jolla, CA 92093 0623, USA
    Am J Physiol Heart Circ Physiol 292:H2491-7. 2007
    ..VO(2 max) with significantly increased O(2) delivery (hyperoxia + ADO), with a degree of uncertainty as to the site of this dilation, suggests an ADO-induced mismatch between O(2) consumption and blood flow in the exercising limb...
  32. ncbi request reprint Evidence of preserved endothelial function and vascular plasticity with age
    D Walter Wray
    Physiology Division, Department of Medicine, University of California, San Diego, 9500 Gilman Dr, La Jolla, California 92093 0623, USA
    Am J Physiol Heart Circ Physiol 290:H1271-7. 2006
    ..Likewise, exercise training improved arm vasodilation, indicating some preservation of vascular plasticity with age...
  33. ncbi request reprint Metabolic and vascular limb differences affected by exercise, gender, age, and disease
    Russell S Richardson
    Department of Medicine, University of California San Diego, La Jolla, CA 92009, USA
    Med Sci Sports Exerc 38:1792-6. 2006
    ....
  34. doi request reprint Human vascular aging: limb-specific lessons
    D Walter Wray
    Geriatric Research, Education, and Clinical Center, George E Whalen VA Medical Center, University of Utah, Salt Lake City, UT 84148, USA
    Exerc Sport Sci Rev 38:177-85. 2010
    ..This raises the question of whether vascular function and skeletal muscle blood flow regulation differs between human limbs and whether these limb-specific parameters may be altered during exercise as a consequence of aging and disease...
  35. pmc Effect of acetazolamide on pulmonary and muscle gas exchange during normoxic and hypoxic exercise
    Amy M Jonk
    Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0623, USA
    J Physiol 579:909-21. 2007
    ..05). In summary, ACZ improved arterial oxygenation during exercise, due to both greater ventilation and more efficient pulmonary gas exchange. However, muscle gas exchange was unaffected...
  36. pmc Diminished baroreflex-induced vasoconstriction following alpha-2 adrenergic receptor blockade in humans
    D Walter Wray
    Department of Medicine, University of California San Diego, La Jolla, CA 92093 0623, United States
    Auton Neurosci 138:114-7. 2008
    ..These data indicate that alpha-2 adrenergic receptors contribute significantly to CBR-induced vasoconstriction in the human leg under resting conditions...
  37. ncbi request reprint Heterogeneous limb vascular responsiveness to shear stimuli during dynamic exercise in humans
    D Walter Wray
    Dept of Medicine, Physiology Division, Univ of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0623, USA
    J Appl Physiol (1985) 99:81-6. 2005
    ....
  38. ncbi request reprint In FMD, NO is actually "the middle man"
    D Walter Wray
    Department of Medicine, Physiology Division, University of California San Diego, La Jolla, 92093, USA
    J Appl Physiol 99:1624. 2005