ROGER WORRELL

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. ncbi Apical ammonium inhibition of cAMP-stimulated secretion in T84 cells is bicarbonate dependent
    Roger T Worrell
    Epithelial Pathobioloby Group, Dept of Surgery, University of Cincinnati, OH 45219, USA
    Am J Physiol Gastrointest Liver Physiol 289:G768-78. 2005
  2. ncbi Effects of ammonium on ion channels and transporters in colonic secretory cells
    Roger T Worrell
    Department of Surgery, University of Cincinnati, Cincinnati, OH 45219, USA
    Adv Exp Med Biol 559:131-9. 2004
  3. ncbi Ammonium transport in the colonic crypt cell line, T84: role for Rhesus glycoproteins and NKCC1
    Roger T Worrell
    Department of Surgery, University of Cincinnati, Cincinnati, OH 45219 0581, USA
    Am J Physiol Gastrointest Liver Physiol 294:G429-40. 2008
  4. ncbi Ammonium effects on colonic Cl- secretion: anomalous mole fraction behavior
    Roger T Worrell
    Epithelial Pathobiology Group, Department of Surgery, University of Cincinnati, Cincinnati, OH 45219, USA
    Am J Physiol Gastrointest Liver Physiol 286:G14-22. 2004
  5. ncbi Intestinal ischemia-reperfusion injury: reversible and irreversible damage imaged in vivo
    Yanfang Guan
    Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0576, USA
    Am J Physiol Gastrointest Liver Physiol 297:G187-96. 2009
  6. ncbi Identification of a carboxyl-terminal motif essential for the targeting of Na+-HCO-3 cotransporter NBC1 to the basolateral membrane
    Hong C Li
    Department of Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Biol Chem 279:43190-7. 2004
  7. ncbi Angiotensin II evokes calcium-mediated signaling events in isolated dog pancreatic epithelial cells
    Aaron S Fink
    Department of Surgery, Atlanta VAMC and Emory University, Atlanta VAMC, Atlanta, Georgia 30033, USA
    Pancreas 25:290-5. 2002
  8. ncbi Differential subcellular targeting of PKC-epsilon in response to pharmacological or ischemic stimuli in intestinal epithelia
    Joshua M V Mammen
    Epithelial Pathobiology Research Group, Dept. of Surgery, University of Cincinnati College of Medicine, PO Box 670558, Cincinnati, OH 45267-0558, USA
    Am J Physiol Gastrointest Liver Physiol 288:G135-42. 2005
  9. ncbi Chloride/bicarbonate exchanger SLC26A7 is localized in endosomes in medullary collecting duct cells and is targeted to the basolateral membrane in hypertonicity and potassium depletion
    Jie Xu
    Division of Nephrology and Hypertension, Department of Medicine, University of Cincinnati, 231 Albert Sabin Way, MSB 259G, Cincinnati, OH 45267 0585, USA
    J Am Soc Nephrol 17:956-67. 2006
  10. ncbi Bryostatin-1 attenuates TNF-induced epithelial barrier dysfunction: role of novel PKC isozymes
    James Yoo
    Department of Surgery, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Am J Physiol Gastrointest Liver Physiol 284:G703-12. 2003

Research Grants

  1. Intestinal Epithelia Ammonium Transport
    Roger T Worrell; Fiscal Year: 2010
  2. Intestinal Epithelia Ammonium Transport
    Roger T Worrell; Fiscal Year: 2010

Collaborators

Detail Information

Publications14

  1. ncbi Apical ammonium inhibition of cAMP-stimulated secretion in T84 cells is bicarbonate dependent
    Roger T Worrell
    Epithelial Pathobioloby Group, Dept of Surgery, University of Cincinnati, OH 45219, USA
    Am J Physiol Gastrointest Liver Physiol 289:G768-78. 2005
    ..DRA and PAT1 appear to associate with CFTR in the apical membrane. We conclude that the HCO(3)(-) dependence of apical NH(4)(+) inhibition of secretion is due to the action of NH(4)(+) on an apical anion exchanger...
  2. ncbi Effects of ammonium on ion channels and transporters in colonic secretory cells
    Roger T Worrell
    Department of Surgery, University of Cincinnati, Cincinnati, OH 45219, USA
    Adv Exp Med Biol 559:131-9. 2004
    ..This suggests that, similar to the kidney, colonic secretory cells have the capacity to secrete NH4+ when in a K(+)-secreting mode with elevated basolateral NH4+ levels...
  3. ncbi Ammonium transport in the colonic crypt cell line, T84: role for Rhesus glycoproteins and NKCC1
    Roger T Worrell
    Department of Surgery, University of Cincinnati, Cincinnati, OH 45219 0581, USA
    Am J Physiol Gastrointest Liver Physiol 294:G429-40. 2008
    ..These findings suggest that we rethink the present limited understanding of NH(4)(+) handling by the distal colon as being due solely to passive absorption...
  4. ncbi Ammonium effects on colonic Cl- secretion: anomalous mole fraction behavior
    Roger T Worrell
    Epithelial Pathobiology Group, Department of Surgery, University of Cincinnati, Cincinnati, OH 45219, USA
    Am J Physiol Gastrointest Liver Physiol 286:G14-22. 2004
    ..The effect on TER did not exhibit anomalous mole fraction behavior. The overall effect of basolateral NH4+ on cAMP-stimulated transport is dependent on the [K+]o /[NH4+]o ratio at the basolateral membrane, where o is outside of the cell...
  5. ncbi Intestinal ischemia-reperfusion injury: reversible and irreversible damage imaged in vivo
    Yanfang Guan
    Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0576, USA
    Am J Physiol Gastrointest Liver Physiol 297:G187-96. 2009
    ..Our results provide a basis for defining the cellular events that cause tissue to transit from reversible to irreversible damage during IR...
  6. ncbi Identification of a carboxyl-terminal motif essential for the targeting of Na+-HCO-3 cotransporter NBC1 to the basolateral membrane
    Hong C Li
    Department of Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Biol Chem 279:43190-7. 2004
    ....
  7. ncbi Angiotensin II evokes calcium-mediated signaling events in isolated dog pancreatic epithelial cells
    Aaron S Fink
    Department of Surgery, Atlanta VAMC and Emory University, Atlanta VAMC, Atlanta, Georgia 30033, USA
    Pancreas 25:290-5. 2002
    ..Recent in vitro evidence suggests that angiotensin II (AngII) stimulates pancreatic secretion in both cystic fibrosis (CFPAC) and transformed pancreatic cells...
  8. ncbi Differential subcellular targeting of PKC-epsilon in response to pharmacological or ischemic stimuli in intestinal epithelia
    Joshua M V Mammen
    Epithelial Pathobiology Research Group, Dept. of Surgery, University of Cincinnati College of Medicine, PO Box 670558, Cincinnati, OH 45267-0558, USA
    Am J Physiol Gastrointest Liver Physiol 288:G135-42. 2005
    ..The data suggest that the differential translocation of PKC-epsilon in response to pharmacological agonists versus ischemic stress may lead to different effects on downstream targets...
  9. ncbi Chloride/bicarbonate exchanger SLC26A7 is localized in endosomes in medullary collecting duct cells and is targeted to the basolateral membrane in hypertonicity and potassium depletion
    Jie Xu
    Division of Nephrology and Hypertension, Department of Medicine, University of Cincinnati, 231 Albert Sabin Way, MSB 259G, Cincinnati, OH 45267 0585, USA
    J Am Soc Nephrol 17:956-67. 2006
    ....
  10. ncbi Bryostatin-1 attenuates TNF-induced epithelial barrier dysfunction: role of novel PKC isozymes
    James Yoo
    Department of Surgery, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Am J Physiol Gastrointest Liver Physiol 284:G703-12. 2003
    ..TNF-induced barrier dysfunction occurs independently of PKC, but selective modulation of novel PKC isozymes may regulate TNF-R1 signaling...
  11. ncbi Bryostatin-1 enhances barrier function in T84 epithelia through PKC-dependent regulation of tight junction proteins
    James Yoo
    Department of Surgery, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Am J Physiol Cell Physiol 285:C300-9. 2003
    ....
  12. ncbi Regulation of Na+ transport by aldosterone: signaling convergence and cross talk between the PI3-K and MAPK1/2 cascades
    Qiusheng Tong
    Dept. of Chemistry and Biochemistry, Texas State Univ, 601 University Dr, CHEM 216, San Marcos, TX, USA
    Am J Physiol Renal Physiol 286:F1232-8. 2004
    ....
  13. ncbi Effect of Slc26a6 deletion on apical Cl-/HCO3- exchanger activity and cAMP-stimulated bicarbonate secretion in pancreatic duct
    Hiroshi Ishiguro
    Laboratory of Human Nutrition, Nagoya Univ Graduate School of Medicine, Nagoya, Japan
    Am J Physiol Gastrointest Liver Physiol 292:G447-55. 2007
    ..In conclusion, these results point to the role of Slc26a6 in HCO3- efflux at the apical membrane and also suggest the presence of a robust Slc26a3 compensatory upregulation, which can replace the function of Slc26a6 in pancreatic ducts...
  14. ncbi slc26a3 (dra)-deficient mice display chloride-losing diarrhea, enhanced colonic proliferation, and distinct up-regulation of ion transporters in the colon
    Clifford W Schweinfest
    Hollings Cancer Center and the Departments of Pathology and Laboratory Medicine and of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 281:37962-71. 2006
    ..In addition, slc26a3 regulates colonic crypt proliferation. Deletion of slc26a3 results in chloride-rich diarrhea and is associated with compensatory adaptive up-regulation of ion-absorbing transporters...

Research Grants6

  1. Intestinal Epithelia Ammonium Transport
    Roger T Worrell; Fiscal Year: 2010
    ..The long term goal of this project is to provide improved treatment for hyperammonemia. ..
  2. Intestinal Epithelia Ammonium Transport
    Roger T Worrell; Fiscal Year: 2010
    ..The long term goal of this project is to provide improved treatment for hyperammonemia. ..