Michael Worobey

Summary

Affiliation: University of Arizona
Country: USA

Publications

  1. ncbi request reprint Epidemiology: Sexual transmission of HIV in Africa
    Polly R Walker
    Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
    Nature 422:679. 2003
  2. ncbi request reprint Genesis and pathogenesis of the 1918 pandemic H1N1 influenza A virus
    Michael Worobey
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721
    Proc Natl Acad Sci U S A 111:8107-12. 2014
  3. ncbi request reprint Origin of AIDS: contaminated polio vaccine theory refuted
    Michael Worobey
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
    Nature 428:820. 2004
  4. pmc Phylogenetic evidence against evolutionary stasis and natural abiotic reservoirs of influenza A virus
    Michael Worobey
    Ecology and Evolutionary Biology, Biosciences West, 1041 E Lowell St, University of Arizona, Tucson, AZ 85721, USA
    J Virol 82:3769-74. 2008
  5. pmc Direct evidence of extensive diversity of HIV-1 in Kinshasa by 1960
    Michael Worobey
    Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
    Nature 455:661-4. 2008
  6. pmc The isolation of nucleic acids from fixed, paraffin-embedded tissues-which methods are useful when?
    M Thomas P Gilbert
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona, United States of America
    PLoS ONE 2:e537. 2007
  7. pmc Dating the age of the SIV lineages that gave rise to HIV-1 and HIV-2
    Joel O Wertheim
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ, USA
    PLoS Comput Biol 5:e1000377. 2009
  8. doi request reprint Island biogeography reveals the deep history of SIV
    Michael Worobey
    University of Arizona, Tucson, AZ 85721, USA
    Science 329:1487. 2010
  9. pmc Relaxed molecular clocks, the bias-variance trade-off, and the quality of phylogenetic inference
    Joel O Wertheim
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
    Syst Biol 59:1-8. 2010
  10. pmc Evolutionary history of chimpanzees inferred from complete mitochondrial genomes
    Adam Bjork
    Department of Ecology and Evolutionary Biology, University of Arizona, USA
    Mol Biol Evol 28:615-23. 2011

Research Grants

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Epidemiology: Sexual transmission of HIV in Africa
    Polly R Walker
    Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
    Nature 422:679. 2003
  2. ncbi request reprint Genesis and pathogenesis of the 1918 pandemic H1N1 influenza A virus
    Michael Worobey
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721
    Proc Natl Acad Sci U S A 111:8107-12. 2014
    ..Similar processes may underlie age-specific mortality differences between seasonal H1N1 vs. H3N2 and human H5N1 vs. H7N9 infections. ..
  3. ncbi request reprint Origin of AIDS: contaminated polio vaccine theory refuted
    Michael Worobey
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
    Nature 428:820. 2004
    ....
  4. pmc Phylogenetic evidence against evolutionary stasis and natural abiotic reservoirs of influenza A virus
    Michael Worobey
    Ecology and Evolutionary Biology, Biosciences West, 1041 E Lowell St, University of Arizona, Tucson, AZ 85721, USA
    J Virol 82:3769-74. 2008
    ..K. Taubenberger, J. Virol. 76:7860-7862, 2002), can also be explained by laboratory contamination or other experimental errors. Many putative examples of evolutionary stasis in influenza A virus appear to be due to laboratory artifacts...
  5. pmc Direct evidence of extensive diversity of HIV-1 in Kinshasa by 1960
    Michael Worobey
    Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
    Nature 455:661-4. 2008
    ..The recovery of viral gene sequences from decades-old paraffin-embedded tissues opens the door to a detailed palaeovirological investigation of the evolutionary history of HIV-1 that is not accessible by other methods...
  6. pmc The isolation of nucleic acids from fixed, paraffin-embedded tissues-which methods are useful when?
    M Thomas P Gilbert
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona, United States of America
    PLoS ONE 2:e537. 2007
    ..Our findings recommend that the extraction methodology adopted should be chosen carefully. Here we provide a quick reference table that can be used to determine appropriate protocols for particular aims...
  7. pmc Dating the age of the SIV lineages that gave rise to HIV-1 and HIV-2
    Joel O Wertheim
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ, USA
    PLoS Comput Biol 5:e1000377. 2009
    ..Our results suggest either that SIV is a surprisingly young lentiviral lineage or that SIV and, perhaps, HIV dating estimates are seriously compromised by unaccounted-for biases...
  8. doi request reprint Island biogeography reveals the deep history of SIV
    Michael Worobey
    University of Arizona, Tucson, AZ 85721, USA
    Science 329:1487. 2010
    ..Our phylogeographic approach establishes that SIV is ancient and at least 32,000 years old. Our conservative calibration point and analyses of gene sequence saturation and dating bias suggest it may be much older...
  9. pmc Relaxed molecular clocks, the bias-variance trade-off, and the quality of phylogenetic inference
    Joel O Wertheim
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
    Syst Biol 59:1-8. 2010
    ..We also compared the quality of inference between Bayesian and maximum likelihood time-free inference models and found them to be qualitatively similar...
  10. pmc Evolutionary history of chimpanzees inferred from complete mitochondrial genomes
    Adam Bjork
    Department of Ecology and Evolutionary Biology, University of Arizona, USA
    Mol Biol Evol 28:615-23. 2011
    ..We also suggest that accurate tMRCA estimates from large computationally difficult sequence alignments may be obtained by implementing our novel method of bootstrapping smaller randomly subsampled alignments...
  11. ncbi request reprint A synchronized global sweep of the internal genes of modern avian influenza virus
    Michael Worobey
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
    Nature 508:254-7. 2014
    ..This approach provides a clear resolution of evolutionary patterns and processes in IAV, including the flow of viral genes and genomes within and between host lineages...
  12. pmc The emergence of HIV/AIDS in the Americas and beyond
    M Thomas P Gilbert
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
    Proc Natl Acad Sci U S A 104:18566-70. 2007
    ..Our results suggest that HIV-1 circulated cryptically in the United States for approximately 12 years before the recognition of AIDS in 1981...
  13. pmc DNA extraction from dry museum beetles without conferring external morphological damage
    M Thomas P Gilbert
    Department of Ecology and Evolutionary Biology, The University of Arizona, Tucson, Arizona, United States of America
    PLoS ONE 2:e272. 2007
    ..This is clearly undesirable when dealing with rare species or otherwise important specimens, such as type specimens...
  14. pmc Homologous recombination in negative sense RNA viruses
    Guan Zhu Han
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
    Viruses 3:1358-73. 2011
    ..Moreover, co-infection experiments should be performed to confirm whether recombination can occur...
  15. ncbi request reprint Multiplex PCR with minisequencing as an effective high-throughput SNP typing method for formalin-fixed tissue
    Marcus T P Gilbert
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ, USA
    Electrophoresis 28:2361-7. 2007
    ..In the light of this evidence, we suggest that the systematic screening of FFPE collections may in the future provide valuable insights into the past...
  16. pmc Endogenous lentiviral elements in the weasel family (Mustelidae)
    Guan Zhu Han
    Department of Ecology and Evolutionary Biology, University of Arizona
    Mol Biol Evol 29:2905-8. 2012
    ..8 and 11.8 Ma. The discovery of MELV in weasel genomes extends the host range of lentiviruses to the Caniformia (order Carnivora) and provides important insights into the prehistoric diversity of lentiviruses...
  17. pmc An endogenous foamy virus in the aye-aye (Daubentonia madagascariensis)
    Guan Zhu Han
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ, USA
    J Virol 86:7696-8. 2012
    ..The discovery of PSFVaye indicates that primate foamy virus might be more broadly distributed than previously thought...
  18. pmc A challenge to the ancient origin of SIVagm based on African green monkey mitochondrial genomes
    Joel O Wertheim
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona, United States of America
    PLoS Pathog 3:e95. 2007
    ..This study substantially weakens the theory of ancient SIV infection followed by codivergence with its primate hosts...
  19. pmc Evolutionary relationships of wild hominids recapitulated by gut microbial communities
    Howard Ochman
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona, United States of America
    PLoS Biol 8:e1000546. 2010
    ....
  20. pmc An endogenous foamy-like viral element in the coelacanth genome
    Guan Zhu Han
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ, USA
    PLoS Pathog 8:e1002790. 2012
    ..These findings suggest an ancient marine origin of retroviruses and have important implications in understanding foamy virus biology...
  21. pmc Relaxed selection and the evolution of RNA virus mucin-like pathogenicity factors
    Joel O Wertheim
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
    J Virol 83:4690-4. 2009
    ..This suggests that so long as these regions maintain sufficient O-linked glycosylation, they are free to evolve rapidly without loss of function as pathogenicity factors...
  22. ncbi request reprint Endogenous Viral Sequences from the Cape Golden Mole (Chrysochloris asiatica) Reveal the Presence of Foamy Viruses in All Major Placental Mammal Clades
    Guan Zhu Han
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona, United States of America
    PLoS ONE 9:e97931. 2014
    ..These findings have implications for understanding the long-term evolution, diversity, and biology of retroviruses. ..
  23. ncbi request reprint Population genetics provides evidence for recombination in Giardia
    Margarethe A Cooper
    Department of Veterinary Science and Microbiology, University of Arizona, Tucson, Arizona 85721, USA
    Curr Biol 17:1984-8. 2007
    ..These observations provide genetic data supportive of sexual reproduction in Giardia...
  24. pmc Molecular ecology and natural history of simian foamy virus infection in wild-living chimpanzees
    Weimin Liu
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS Pathog 4:e1000097. 2008
    ....
  25. pmc Reply to Pape et al.: the phylogeography of HIV-1 group M subtype B
    Michael Worobey
    Proc Natl Acad Sci U S A 105:E16. 2008
  26. ncbi request reprint Detection of TT virus among chimpanzees in the wild using a noninvasive technique
    Oliver E Barnett
    Department of Biological Sciences, The Open University, Walton Hall, Milton Keynes, Buckinghamshire MK7 6AA, UK
    J Wildl Dis 40:230-7. 2004
    ..Our findings are discussed with respect to potential zoonotic events that may result from increased levels of human encroachlment into wild habitats...
  27. pmc The molecular population genetics of HIV-1 group O
    Philippe Lemey
    Rega Institute for Medical Research, KULeuven, B 3000 Leuven, Belgium
    Genetics 167:1059-68. 2004
    ..In addition, we show that evolutionary rate estimates for different HIV genes accurately reflect differential selective constraints along the HIV genome...
  28. ncbi request reprint Identification of a highly divergent HIV type 2 and proposal for a change in HIV type 2 classification
    Florence Damond
    Virology Department, Hopital Bichat, 75877 Paris 18, France
    AIDS Res Hum Retroviruses 20:666-72. 2004
    ..The single-strain lineages C to G and the 96FR12034 lineage identified here should be considered only as putative groups until related strains are identified that confirm circulation of these viruses in the human population...
  29. ncbi request reprint Evolution of R5 and X4 human immunodeficiency virus type 1 gag sequences in vivo: evidence for recombination
    Ronald P Van Rij
    Sanquin Research at CLB and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Plesmanlaan 125, 1066 CX Amsterdam, Netherlands
    Virology 314:451-9. 2003
    ..Therefore, our data imply that recombination between R5 and X4 HIV-1 variants occurs in vivo...
  30. ncbi request reprint Questioning the evidence for genetic recombination in the 1918 "Spanish flu" virus
    Michael Worobey
    Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS, UK
    Science 296:211 discussion 211. 2002

Research Grants1

  1. The Emergence of HIV: A Molecular Archeology Approach
    Michael Worobey; Fiscal Year: 2006
    ..abstract_text> ..