RUTH WORD

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc The impact of reference gene selection in quantification of gene expression levels in guinea pig cervical tissues and cells
    Annika Lindqvist
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd F2, 302, Dallas, TX 75390, USA
    BMC Res Notes 6:34. 2013
  2. pmc Hypoxia and PGE(2) regulate MiTF-CX during cervical ripening
    Annavarapu Hari Kishore
    The Cecil H and Ida Green Center for Reproductive Biology, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9032, USA
    Mol Endocrinol 26:2031-45. 2012
  3. pmc Transforming growth factor β1 (TGFβ1) and progesterone regulate matrix metalloproteinases (MMP) in human endometrial stromal cells
    Hiroko Itoh
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75235 9032, USA
    J Clin Endocrinol Metab 97:E888-97. 2012
  4. doi Pathophysiology of pelvic organ prolapse
    R Ann Word
    Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9032, USA
    Obstet Gynecol Clin North Am 36:521-39. 2009
  5. ncbi Dynamics of cervical remodeling during pregnancy and parturition: mechanisms and current concepts
    R Ann Word
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9032, USA
    Semin Reprod Med 25:69-79. 2007
  6. doi Effects of pregnancy, parturition, and anal sphincter transection on function of the external anal sphincter in an animal model
    David D Rahn
    Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9032, USA
    Obstet Gynecol 113:909-16. 2009
  7. pmc Estrogen and progesterone metabolism in the cervix during pregnancy and parturition
    Stefan Andersson
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9032, USA
    J Clin Endocrinol Metab 93:2366-74. 2008
  8. doi Recovery of external anal sphincter contractile function after prolonged vaginal distention or sphincter transection in an animal model
    Clifford Y Wai
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9032, USA
    Obstet Gynecol 111:1426-34. 2008
  9. pmc Large conductance Ca2+-activated K+ channels contribute to vascular function in nonpregnant human uterine arteries
    Charles R Rosenfeld
    Division of Neonatal Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, TX 75390, USA
    Reprod Sci 15:651-60. 2008
  10. doi Effect of prolonged vaginal distention and sphincter transection on physiologic function of the external anal sphincter in an animal model
    Clifford Y Wai
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9032, USA
    Obstet Gynecol 111:332-40. 2008

Research Grants

Collaborators

Detail Information

Publications30

  1. pmc The impact of reference gene selection in quantification of gene expression levels in guinea pig cervical tissues and cells
    Annika Lindqvist
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd F2, 302, Dallas, TX 75390, USA
    BMC Res Notes 6:34. 2013
    ..In this study we used quantitative real-time PCR and two Excel-based applets (geNorm and BestKeeper) to determine the best reference genes for quantification of target gene mRNA in a complex tissue organ such as the guinea pig cervix...
  2. pmc Hypoxia and PGE(2) regulate MiTF-CX during cervical ripening
    Annavarapu Hari Kishore
    The Cecil H and Ida Green Center for Reproductive Biology, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9032, USA
    Mol Endocrinol 26:2031-45. 2012
    ..Hypoxia also up-regulated cyclooxygenase-2, leading to prostaglandin E(2)-mediated loss of MiTF in cervical stromal cells. The results support a pivotal role for hypoxia and HIF-1α in the cervical ripening process during pregnancy...
  3. pmc Transforming growth factor β1 (TGFβ1) and progesterone regulate matrix metalloproteinases (MMP) in human endometrial stromal cells
    Hiroko Itoh
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75235 9032, USA
    J Clin Endocrinol Metab 97:E888-97. 2012
    ..Menstruation is preceded by progesterone withdrawal and endometrial matrix remodeling predominantly through induction of matrix metalloproteinases (MMP) and recruitment of invading neutrophils...
  4. doi Pathophysiology of pelvic organ prolapse
    R Ann Word
    Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9032, USA
    Obstet Gynecol Clin North Am 36:521-39. 2009
    ..In this article, the cellular, biochemical, and molecular basis of pelvic organ prolapse is discussed with a focus on the new theory of elastinopathy as an etiology of prolapse...
  5. ncbi Dynamics of cervical remodeling during pregnancy and parturition: mechanisms and current concepts
    R Ann Word
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9032, USA
    Semin Reprod Med 25:69-79. 2007
    ..A clear understanding of the biologic mechanisms that regulate cervical remodeling during pregnancy is needed to influence the preterm birth rate and to develop strategies to prevent preterm dilation of the cervix...
  6. doi Effects of pregnancy, parturition, and anal sphincter transection on function of the external anal sphincter in an animal model
    David D Rahn
    Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9032, USA
    Obstet Gynecol 113:909-16. 2009
    ..To estimate the effects of pregnancy, parturition, and anal sphincter laceration (with repair) on external anal sphincter morphology and neurophysiology and to define the time course of these effects after injury...
  7. pmc Estrogen and progesterone metabolism in the cervix during pregnancy and parturition
    Stefan Andersson
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9032, USA
    J Clin Endocrinol Metab 93:2366-74. 2008
    ..Mice deficient in 5alpha-reductase type I fail to undergo cervical ripening at term despite the timely onset of luteolysis and progesterone withdrawal in blood...
  8. doi Recovery of external anal sphincter contractile function after prolonged vaginal distention or sphincter transection in an animal model
    Clifford Y Wai
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9032, USA
    Obstet Gynecol 111:1426-34. 2008
    ..To estimate the effect of prolonged vaginal distention and anal sphincter transection on contractile properties of the external anal sphincter as a function of time...
  9. pmc Large conductance Ca2+-activated K+ channels contribute to vascular function in nonpregnant human uterine arteries
    Charles R Rosenfeld
    Division of Neonatal Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, TX 75390, USA
    Reprod Sci 15:651-60. 2008
    ..04), and attenuated SNP-induced relaxation at 1.0 mM (P = .02). BK( Ca) are expressed in human UA and modulate vascular function by attenuating vasoconstrictor responses and contributing to nitric oxide-induced vasorelaxation...
  10. doi Effect of prolonged vaginal distention and sphincter transection on physiologic function of the external anal sphincter in an animal model
    Clifford Y Wai
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9032, USA
    Obstet Gynecol 111:332-40. 2008
    ..To estimate the effect of prolonged vaginal distention and anal sphincter transection on contractile properties of the external anal sphincter...
  11. ncbi Aromatase deficiency causes altered expression of molecules critical for calcium reabsorption in the kidneys of female mice *
    Orhan K Oz
    Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9153, USA
    J Bone Miner Res 22:1893-902. 2007
    ..ArKO mice have hypercalciuria and lower levels of calcium transport proteins, whereas levels of the klotho protein are elevated. Thus, estrogen deficiency is sufficient to cause altered renal calcium handling...
  12. ncbi Morphometric properties of the posterior vaginal wall in women with pelvic organ prolapse
    Muriel K Boreham
    Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas 75390, USA
    Am J Obstet Gynecol 187:1501-8; discussion 1508-9. 2002
    ..Our purpose was to analyze the morphometric properties of the posterior vaginal wall and compare the smooth muscle distribution in the posterior vaginal muscularis in women with and without pelvic organ prolapse...
  13. ncbi Morphometric analysis of smooth muscle in the anterior vaginal wall of women with pelvic organ prolapse
    Muriel K Boreham
    Division of Urogynecology and Reconstructive Pelvic Surgery, University of Texas Southwestern Medical Center, Dallas, 75390 9032, USA
    Am J Obstet Gynecol 187:56-63. 2002
    ..The purpose of this study was to compare the smooth muscle content of the anterior vaginal wall in normal women and women with pelvic organ prolapse...
  14. pmc Biomechanical properties of the vaginal wall: effect of pregnancy, elastic fiber deficiency, and pelvic organ prolapse
    David D Rahn
    University of Texas Southwestern Medical Center, Dallas, TX, USA
    Am J Obstet Gynecol 198:590.e1-6. 2008
    ..The purpose of this study was to identify pregnancy-induced changes in biomechanical properties of the vaginal wall and to compare these with fibulin-5 knockout mice (Fbln5(-/-)) with and without prolapse...
  15. pmc Quantification of pelvic organ prolapse in mice: vaginal protease activity precedes increased MOPQ scores in fibulin 5 knockout mice
    Cecilia K Wieslander
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9032, USA
    Biol Reprod 80:407-14. 2009
    ..The results indicate that >90% of Fbln5(-/-) mice develop prolapse by 6 mo of age, even in the absence of vaginal delivery, and that increased vaginal protease activity precedes the development of prolapse...
  16. ncbi Effect of periurethral denervation on smooth muscles of the lower urinary tract
    Clifford Y Wai
    Divisions of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Tex, USA
    Am J Obstet Gynecol 191:1950-60. 2004
    ..This study was undertaken to determine the effect of periurethral denervation on contractile function of the smooth muscle of the lower urinary tract of the female rat...
  17. pmc Failure of pelvic organ support in mice deficient in fibulin-3
    David D Rahn
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9032, USA
    Am J Pathol 174:206-15. 2009
    ..We suggest that increased vaginal protease activity and abnormal elastic fibers in the vaginal wall are important components in the pathogenesis of pelvic organ prolapse...
  18. ncbi Transgene insertion on mouse chromosome 6 impairs function of the uterine cervix and causes failure of parturition
    R Ann Word
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas 75390, USA
    Biol Reprod 73:1046-56. 2005
    ..Characterization of the transgene insertional mutant, Tg/Tg, indicates that progesterone withdrawal is insufficient to complete parturition in the presence of inadequate cervical ripening at term...
  19. pmc Pelvic organ prolapse in fibulin-5 knockout mice: pregnancy-induced changes in elastic fiber homeostasis in mouse vagina
    Peter G Drewes
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9032, USA
    Am J Pathol 170:578-89. 2007
    ....
  20. ncbi Cervical remodeling during pregnancy and parturition: molecular characterization of the softening phase in mice
    Charles P Read
    Department of Obstetrics and Gynecology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9032, USA
    Reproduction 134:327-40. 2007
    ....
  21. ncbi Telomerase immortalization of human myometrial cells
    Jennifer Condon
    Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9032, USA
    Biol Reprod 67:506-14. 2002
    ..The expression of various smooth muscle/myometrium cell markers suggests that these cells may be an appropriate model system to study certain aspects of human myometrial function...
  22. ncbi Human myometrial gene expression before and during parturition
    Jon C Havelock
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9032, USA
    Biol Reprod 72:707-19. 2005
    ..The cellular properties of S100A9, its spatial localization, and dramatic increase in cervix and myometrium of women in labor suggest that this protein may be very important in the initiation or propagation of human labor...
  23. pmc A novel isoform of microphthalmia-associated transcription factor inhibits IL-8 gene expression in human cervical stromal cells
    Xiang Hong Li
    Division of Reproductive Endocrinology and Urogynecology, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9032, USA
    Mol Endocrinol 24:1512-28. 2010
    ....
  24. doi Effect of myogenic stem cells on contractile properties of the repaired and unrepaired transected external anal sphincter in an animal model
    Amanda B White
    Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9032, USA
    Obstet Gynecol 115:815-23. 2010
    ..To estimate the effect of myogenic stem cells on contractile function of the external anal sphincter after transection with or without repair in an animal model...
  25. pmc Fibulin-4 deficiency results in ascending aortic aneurysms: a potential link between abnormal smooth muscle cell phenotype and aneurysm progression
    Jianbin Huang
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Circ Res 106:583-92. 2010
    ..However, aneurysms are never seen in mice deficient for elastin, or for fibulin-5, which absence also leads to compromised elastic fibers...
  26. ncbi Regulation of elastolytic proteases in the mouse vagina during pregnancy, parturition, and puerperium
    Cecilia K Wieslander
    Division of Urogynecology and Reconstructive Surgery, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Biol Reprod 78:521-8. 2008
    ..We conclude that recovery of the vaginal wall from pregnancy and parturition requires increased elastic fiber assembly and synthesis to counteract the marked increase in elastolytic activity of the postpartum vagina...
  27. pmc Androstenedione up-regulation of endometrial aromatase expression via local conversion to estrogen: potential relevance to the pathogenesis of endometriosis
    Orhan Bukulmez
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Florida College of Medicine, 1600 SW Archer Road, Gainesville, Florida 32610 0294, USA
    J Clin Endocrinol Metab 93:3471-7. 2008
    ..The factors that mediate induction of aromatase in the endometrium are not well defined, but increased expression of steroidogenic factor (SF)-1 may play a role...
  28. pmc Inflammatory status influences aromatase and steroid receptor expression in endometriosis
    Orhan Bukulmez
    Department of Obstetrics, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9032, USA
    Endocrinology 149:1190-204. 2008
    ..PR-A protein was barely detectable in endometriomas. Thus, whereas PR-C may enhance disease progression, up-regulation of ERbeta may play an antiinflammatory and opposing role...
  29. doi Optimal location and orientation of suture placement in abdominal sacrocolpopexy
    Amanda B White
    Departments of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Obstet Gynecol 113:1098-103. 2009
    ..To estimate the strongest location and optimal orientation of suture placement in the anterior longitudinal ligament for abdominal sacrocolpopexy in female cadavers...
  30. doi Contractile properties of the denervated external anal sphincter
    Clifford Y Wai
    Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Am J Obstet Gynecol 200:653.e1-7. 2009
    ..The purpose of this study was to evaluate the effect of denervation on contractile properties of the external anal sphincter (EAS) of the female rat...

Research Grants5

  1. Elastic Fiber Homeostasis in the Vaginal Wall
    RUTH WORD; Fiscal Year: 2007
    ....
  2. Elastic Fiber Homeostasis in the Vaginal Wall
    RUTH WORD; Fiscal Year: 2009
    ....
  3. Elastic Fiber Homeostasis in the Vaginal Wall
    RUTH A WORD; Fiscal Year: 2010
    ....