Genomes and Genes
Affiliation: University of Michigan
- The phosphatase laforin crosses evolutionary boundaries and links carbohydrate metabolism to neuronal diseaseMatthew S Gentry
Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA
J Cell Biol 178:477-88. 2007..Finally, we show that laforins and SEX4 dephosphorylate a complex carbohydrate and form the only family of phosphatases with this activity. These results provide a molecular explanation for the etiology of LD...
- A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori's diseaseAlan Cheng
Department of Internal Medicine, Life Sciences Institute, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
Genes Dev 21:2399-409. 2007..Taken together, these results indicate that binding to glycogen crucially regulates the stability of AGL and, further, that its ubiquitination may play an important role in the pathophysiology of both Lafora and Cori's disease...
- Malin decreases glycogen accumulation by promoting the degradation of protein targeting to glycogen (PTG)Carolyn A Worby
Department of Pharmacology, University of California at San Diego, La Jolla, California 92093 0721, USA
J Biol Chem 283:4069-76. 2008..These results suggest an additional mechanism, involving laforin and malin, in regulating glycogen metabolism...
- Positive versus negative signaling of LET-23: regulation through the adaptor protein, SEM-5C Worby
Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI, USA
Sci STKE 2000:pe2. 2000..Thus, Grb2 may function in a cellular decision point for transducing the incoming signals...
- Sorting out the cellular functions of sorting nexinsCarolyn A Worby
Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA
Nat Rev Mol Cell Biol 3:919-31. 2002..It will be interesting to determine whether the various sorting nexins have specialized or generalized roles in protein trafficking...
- Drosophila Ack targets its substrate, the sorting nexin DSH3PX1, to a protein complex involved in axonal guidanceCarolyn A Worby
Life Sciences Institute and Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109 0606, USA
J Biol Chem 277:9422-8. 2002..These results suggest that the phosphorylation of DSH3PX1 by DAck targets this sorting nexin to a protein complex that includes Dock, an adaptor protein important for axonal guidance...
- Use of double-stranded RNA-mediated interference to determine the substrates of protein tyrosine kinases and phosphatasesMarco Muda
Serono Reproductive Biology Institute, Inc, Randolph, MA 02368, U S A
Biochem J 366:73-7. 2002..The present study illustrates the versatility of RNAi in the identification of the physiological substrates for protein kinases and phosphatases...
- A PTEN-like phosphatase with a novel substrate specificityDavid J Pagliarini
Department of Pharmacology, University of California, San Diego, La Jolla, California 92093 0721, USA
J Biol Chem 279:38590-6. 2004..The unique in vitro catalytic activity and detailed biochemical and kinetic analyses reported here will be of great value in our continued efforts to identify in vivo substrate(s) for this highly conserved phosphatase...
- Insights into Lafora disease: malin is an E3 ubiquitin ligase that ubiquitinates and promotes the degradation of laforinMatthew S Gentry
Department of Pharmacology, School of Medicine, University of California at San Diego, La Jolla, CA 92093 0721, USA
Proc Natl Acad Sci U S A 102:8501-6. 2005..Furthermore, these data distinguish malin as an E3 Ub ligase whose activity is necessary to prevent a neurodegenerative disease that involves formation of nonproteinacious inclusion bodies...