GEORGE F WOOTEN
Affiliation: University of Virginia
- The Gly2019Ser mutation in LRRK2 is not fully penetrant in familial Parkinson's disease: the GenePD studyJeanne C Latourelle
Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA, USA
BMC Med 6:32. 2008..Studies of the penetrance of LRRK2 mutations have produced a wide range of estimates, possibly due to differences in study design and recruitment, including in particular differences between samples of familial PD versus sporadic PD...
- Anatomy and function of dopamine receptors: understanding the pathophysiology of fluctuations in Parkinson's diseaseG F Wooten
Department of Neurology, University of Virginia Health System, Box 800394, Charlottesville, VA 22908, USA
Parkinsonism Relat Disord 8:79-83. 2001..These mechanisms result in excessive, pathological inhibition of basal ganglia output neurons in the GPi producing dyskinesias and the short duration response...
- Are men at greater risk for Parkinson's disease than women?G F Wooten
Department of Neurology, Box 800394, University Health System, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
J Neurol Neurosurg Psychiatry 75:637-9. 2004..5 times greater in men than women. Possible reasons for this increased risk of Parkinson's disease in men are toxicant exposure, head trauma, neuroprotection by oestrogen, mitochondrial dysfunction, or X linkage of genetic risk factors...
- Parkinson's Disease Neuroprotection Clinical TrialGEORGE WOOTEN; Fiscal Year: 2007..Our team is experienced, productive, and fully able to meet the requirements to become a Clinical Cente for the Parkinson's Disease Neuroprotection Trial. ..