Stephen Woods

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. ncbi Food intake and the regulation of body weight
    S C Woods
    Department of Psychiatry, University of Cincinnati Medical Center, Ohio 45267, USA
    Annu Rev Psychol 51:255-77. 2000
  2. pmc The regulation of alcohol intake by melanin-concentrating hormone in rats
    Elizabeth A Duncan
    Department of Psychiatry, University of Cincinnati, USA
    Pharmacol Biochem Behav 85:728-35. 2006
  3. ncbi A controlled high-fat diet induces an obese syndrome in rats
    Stephen C Woods
    Department of Psychiatry, University of Cincinnati School of Medicine, OH 45267, USA
    J Nutr 133:1081-7. 2003
  4. ncbi Insulin and the blood-brain barrier
    Stephen C Woods
    Department of Psychiatry, Box 670559, University of Cincinnati, Cincinnati, OH 45267, USA
    Curr Pharm Des 9:795-800. 2003
  5. ncbi Gender differences in the control of energy homeostasis
    Stephen C Woods
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Exp Biol Med (Maywood) 228:1175-80. 2003
  6. pmc Homeostasis: beyond Curt Richter
    Stephen C Woods
    Department of Psychiatry, University of Cincinnati, Cincinnati, OH, USA
    Appetite 49:388-98. 2007
  7. ncbi The endocannabinoid system: mechanisms behind metabolic homeostasis and imbalance
    Stephen C Woods
    Obesity Research Center, University of Cincinnati, 231 Albert Sabin Way, Room G 059, Cincinnati, Ohio, 45267, USA
    Am J Med 120:S9-17; discussion S29-32. 2007
  8. ncbi Dietary synergies in appetite control: distal gastrointestinal tract
    Stephen C Woods
    Department of Psychiatry, University of Cincinnati, 2170 East Galbraith Road, Cincinnati, OH 45237, USA
    Obesity (Silver Spring) 14:171S-178S. 2006
  9. pmc Pancreatic signals controlling food intake; insulin, glucagon and amylin
    Stephen C Woods
    Department of Psychiatry, University of Cincinnati, OH 45237 USA
    Philos Trans R Soc Lond B Biol Sci 361:1219-35. 2006
  10. ncbi Lessons in the interactions of hormones and ingestive behavior
    Stephen C Woods
    Department of Psychiatry, Medical Center, University of Cincinnati, 2170 East Galbraith Road, Box 670559, Cincinnati, OH 45237, USA
    Physiol Behav 82:187-90. 2004

Research Grants

  1. CEPHALIC RESPONSES AND MEAL FEEDING
    Stephen Woods; Fiscal Year: 2007
  2. Training Program in Neuroendocrinology of Homeostasis
    Stephen Woods; Fiscal Year: 2007
  3. The Role of TNF Alpha in Obesity
    Stephen Woods; Fiscal Year: 2008
  4. CEPHALIC RESPONSES AND MEAL FEEDING
    Stephen Woods; Fiscal Year: 2008
  5. High Fat Diet-Induced Obesity
    Stephen Woods; Fiscal Year: 2008
  6. Training Program in Neuroendocrinology of Homeostasis
    Stephen Woods; Fiscal Year: 2008
  7. The Role of TNF Alpha in Obesity
    Stephen Woods; Fiscal Year: 2009

Collaborators

Detail Information

Publications88

  1. ncbi Food intake and the regulation of body weight
    S C Woods
    Department of Psychiatry, University of Cincinnati Medical Center, Ohio 45267, USA
    Annu Rev Psychol 51:255-77. 2000
    ..The final section reviews how these signals are received and integrated by the CNS, as well as the neural circuits and transmitters involved...
  2. pmc The regulation of alcohol intake by melanin-concentrating hormone in rats
    Elizabeth A Duncan
    Department of Psychiatry, University of Cincinnati, USA
    Pharmacol Biochem Behav 85:728-35. 2006
    ..Further, endogenous MCH does not seem to regulate alcohol drinking, however because the antagonist failed to attenuate MCH-induced alcohol intake this conclusion is tentative...
  3. ncbi A controlled high-fat diet induces an obese syndrome in rats
    Stephen C Woods
    Department of Psychiatry, University of Cincinnati School of Medicine, OH 45267, USA
    J Nutr 133:1081-7. 2003
    ..This model of diet-induced obesity will be a useful tool for studying the mechanisms by which dietary fat influences the regulation of energy balance...
  4. ncbi Insulin and the blood-brain barrier
    Stephen C Woods
    Department of Psychiatry, Box 670559, University of Cincinnati, Cincinnati, OH 45267, USA
    Curr Pharm Des 9:795-800. 2003
    ..Within the brain insulin acts on specific receptors to influence a number of behaviors, and especially caloric homeostasis and cognition...
  5. ncbi Gender differences in the control of energy homeostasis
    Stephen C Woods
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Exp Biol Med (Maywood) 228:1175-80. 2003
    ..The implications of this are discussed...
  6. pmc Homeostasis: beyond Curt Richter
    Stephen C Woods
    Department of Psychiatry, University of Cincinnati, Cincinnati, OH, USA
    Appetite 49:388-98. 2007
    ....
  7. ncbi The endocannabinoid system: mechanisms behind metabolic homeostasis and imbalance
    Stephen C Woods
    Obesity Research Center, University of Cincinnati, 231 Albert Sabin Way, Room G 059, Cincinnati, Ohio, 45267, USA
    Am J Med 120:S9-17; discussion S29-32. 2007
    ..Further research into the EC system is warranted to elucidate its role in metabolic homeostasis...
  8. ncbi Dietary synergies in appetite control: distal gastrointestinal tract
    Stephen C Woods
    Department of Psychiatry, University of Cincinnati, 2170 East Galbraith Road, Cincinnati, OH 45237, USA
    Obesity (Silver Spring) 14:171S-178S. 2006
  9. pmc Pancreatic signals controlling food intake; insulin, glucagon and amylin
    Stephen C Woods
    Department of Psychiatry, University of Cincinnati, OH 45237 USA
    Philos Trans R Soc Lond B Biol Sci 361:1219-35. 2006
    ..Finally, their actions include gastrointestinal and metabolic as well as behavioural effects...
  10. ncbi Lessons in the interactions of hormones and ingestive behavior
    Stephen C Woods
    Department of Psychiatry, Medical Center, University of Cincinnati, 2170 East Galbraith Road, Box 670559, Cincinnati, OH 45237, USA
    Physiol Behav 82:187-90. 2004
    ..This short article documents that progress...
  11. ncbi Signals that influence food intake and body weight
    Stephen C Woods
    Department of Psychiatry, University of Cincinnati, 2170 East Galbraith Road, Cincinnati, OH 45237, United States
    Physiol Behav 86:709-16. 2005
    ..This review discusses hormonal and related satiety signals generated as food is being consumed, and upon adiposity signals related to the amount of fat stored in the body, that influence energy intake and ultimately body weight...
  12. ncbi Clinical endocrinology and metabolism. Regulation of energy homeostasis by peripheral signals
    Stephen C Woods
    Department of Psychiatry, University of Cincinnati, 2170 East Galbraith Road, Cincinnati, OH 45237, USA
    Best Pract Res Clin Endocrinol Metab 18:497-515. 2004
    ..Considerable effort is being directed towards finding ways to intervene in specific circuits to help accomplish weight loss...
  13. ncbi Consumption of a high-fat diet alters the homeostatic regulation of energy balance
    Stephen C Woods
    Department of Psychiatry, University of Cincinnati, 2170 East Galbraith Road, Cincinnati, OH 45237, USA
    Physiol Behav 83:573-8. 2004
    ..HF-fed animals, independent of whether they become obese or not, also have central insulin and MTII insensitivity. Finally, HF rats have a down-regulated hypothalamic apo A-IV system that could contribute to their hyperphagia...
  14. pmc The control of food intake: behavioral versus molecular perspectives
    Stephen C Woods
    Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45237, USA
    Cell Metab 9:489-98. 2009
    ..It is argued that the malleability of satiation signals renders them poor candidates as pharmacological targets to control body weight...
  15. pmc Central control of body weight and appetite
    Stephen C Woods
    Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45237, USA
    J Clin Endocrinol Metab 93:S37-50. 2008
    ..Energy balance is critical for survival and health, and control of food intake is an integral part of this process. This report reviews hormonal signals that influence food intake and their clinical applications...
  16. ncbi Understanding the physiology of obesity: review of recent developments in obesity research
    S C Woods
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio, USA
    Int J Obes Relat Metab Disord 26:S8-S10. 2002
    ..In view of the complexities of the energy control system, therapeutic strategies that target only one site are likely to be less effective than those targeting two or more sites...
  17. ncbi Pavlovian influences over food and drug intake
    S C Woods
    Department of Psychiatry, Box 670559, University of Cincinnati School of Medicine, Cincinnati, OH 45267, USA
    Behav Brain Res 110:175-82. 2000
    ..In a final section, drug tolerance is discussed as a natural consequence of evolution-derived, meal-related learning processes, with associated negative consequences...
  18. ncbi Gastrointestinal satiety signals I. An overview of gastrointestinal signals that influence food intake
    Stephen C Woods
    Dept of Psychiatry, Univ of Cincinnati, Cincinnati, OH 45267, USA
    Am J Physiol Gastrointest Liver Physiol 286:G7-13. 2004
    ..Most factors that influence how much food is eaten during individual meals act by changing the sensitivity to satiety signals. This includes adiposity signals as well as habits and learning, the social situation, and stressors...
  19. ncbi Adiposity signals and the control of energy homeostasis
    S C Woods
    Department of Psychiatry, University of Cincinnati Medical Center, Cincinnati, Ohio 45267, USA
    Nutrition 16:894-902. 2000
    ..Body-weight regulation occurs as adiposity signals alter the efficacy of meal-generated satiety signals...
  20. ncbi Insulin as an adiposity signal
    S C Woods
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio, USA
    Int J Obes Relat Metab Disord 25:S35-8. 2001
    ....
  21. ncbi The house economist and the eating paradox
    Stephen C Woods
    Department of Psychiatry, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA
    Appetite 38:161-5. 2002
    ....
  22. ncbi Small molecule insulin mimetics reduce food intake and body weight and prevent development of obesity
    Ellen L Air
    Department of Biomedical Sciences and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Nat Med 8:179-83. 2002
    ..Thus, insulin mimetics have a unique advantage over insulin in the control of body weight and hold potential as a novel anti-obesity treatment...
  23. pmc The roles of leptin receptors on POMC neurons in the regulation of sex-specific energy homeostasis
    Haifei Shi
    Department of Zoology, Miami University, Oxford, OH, United States
    Physiol Behav 100:165-72. 2010
    ..The sex difference in leptin signaling on POMC neurons on glucose tolerance appears independent of ovarian hormones...
  24. pmc Peptide designed to elicit apoptosis in adipose tissue endothelium reduces food intake and body weight
    Dong Hoon Kim
    Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio, USA
    Diabetes 59:907-15. 2010
    ..We sought to determine how inhibiting adipose tissue vasculature changes key aspects of energy balance regulation and the neuroendocrine system that maintains energy balance...
  25. ncbi Intraventricular insulin and leptin reduce food intake and body weight in C57BL/6J mice
    Lynda M Brown
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45237, USA
    Physiol Behav 89:687-91. 2006
    ..Hence, genetic manipulations that influence brain insulin sensitivity in mice can now more easily be integrated with the broader literature on energy homeostasis...
  26. ncbi Alcohol drinking in MCH receptor-1-deficient mice
    Elizabeth A Duncan
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio, USA
    Alcohol Clin Exp Res 31:1325-37. 2007
    ..However, because the physiological relevance of this finding is unclear, we tested the hypothesis that endogenous MCH signaling enhances alcohol consumption...
  27. pmc Antiobesity and antihyperglycemic effects of ginsenoside Rb1 in rats
    Ye Xiong
    Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Diabetes 59:2505-12. 2010
    ....
  28. ncbi High-fat diet induced adiposity in mice with targeted disruption of the dopamine-3 receptor gene
    John Andrews McQuade
    Department of Psychiatry, University of Cincinnati, P O Box 670559, Cincinnati, OH 45267 0559, USA
    Behav Brain Res 151:313-9. 2004
    ..These findings suggest the D3-R signaling is involved in the regulation of body weight and body fat when mice are given access to diets differing in palatability and fat content...
  29. ncbi Hypothalamic mTOR signaling regulates food intake
    Daniela Cota
    Department of Psychiatry, University of Cincinnati, Genome Research Institute, 2170 East Galbraith Road, Cincinnati, OH 45237, USA
    Science 312:927-30. 2006
    ..Thus, mTOR is a cellular fuel sensor whose hypothalamic activity is directly tied to the regulation of energy intake...
  30. ncbi Reduced anorexic effects of insulin in obesity-prone rats fed a moderate-fat diet
    Deborah J Clegg
    University of Cincinnati, Department of Psychiatry, Cincinnati, Ohio, USA
    Am J Physiol Regul Integr Comp Physiol 288:R981-6. 2005
    ....
  31. doi Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity
    Ruben Nogueiras
    Department of Psychiatry, Obesity Research Centre, University of Cincinnati, Cincinnati, Ohio 45226, USA
    J Neurosci 29:5916-25. 2009
    ..Importantly, the CNS GLP-1 system loses the capacity to modulate adipocyte metabolism in obese states, suggesting an obesity-induced adipocyte resistance to CNS GLP-1...
  32. pmc Brain apolipoprotein E: an important regulator of food intake in rats
    Ling Shen
    Cincinnati Obesity Research Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Diabetes 57:2092-8. 2008
    ....
  33. ncbi Characterization of mice lacking the gene for cholecystokinin
    Chun Min Lo
    Department of Pathology and Laboratory Medicine, University of Cincinnati, Genome Research Institute, 2120 E Galbraith Rd, Bldg A, ML 0507, Cincinnati, OH 45237, USA
    Am J Physiol Regul Integr Comp Physiol 294:R803-10. 2008
    ..We conclude that CCK is involved in metabolic rate and is important for memory and exploration. CCK is intimately involved in multiple processes related to cognitive function and food intake regulation...
  34. ncbi The impact of moderate daily alcohol consumption on aggression and the formation of dominance hierarchies in rats
    Elizabeth A Duncan
    Program in Neuroscience, University of Cincinnati, Cincinnati, OH, USA
    Psychopharmacology (Berl) 189:83-94. 2006
    ..We tested the hypothesis that a history of drinking alcohol would cause SUB rats to consume even greater amounts of alcohol...
  35. pmc Cholecystokinin knockout mice are resistant to high-fat diet-induced obesity
    Chun Min Lo
    Cincinnati Obesity Research Center, Genome Research Institute, University of Cincinnati, Cincinnati, Ohio 45237, USA
    Gastroenterology 138:1997-2005. 2010
    ..We proposed that mice with a disruption in the CCK gene (CCK knockout [CCK-KO] mice) that were fed a diet of 20% butter fat would have altered fat metabolism...
  36. ncbi Neuropeptide Y prepares rats for scheduled feeding
    Deborah L Drazen
    Department of Psychiatry, University of Cincinnati, 2170 E Galbraith Rd, Bldg E, Rm 313, Cincinnati, OH 45237, USA
    Am J Physiol Regul Integr Comp Physiol 288:R1606-11. 2005
    ..These data suggest that NPY plays a role in mediating conditionable food-anticipatory responses that help to cope with the effects of large caloric loads...
  37. ncbi Differential sensitivity to central leptin and insulin in male and female rats
    Deborah J Clegg
    Department of Psychiatry, University of Cincinnati Medical Center, Cincinnati, OH 45267 0559, USA
    Diabetes 52:682-7. 2003
    ..Because insulin and leptin reflect different fat beds and are differentially distributed in the male and female sexes, the implication is that the male and female sexes regulate adiposity-relevant parameters differently...
  38. pmc The central melanocortin system directly controls peripheral lipid metabolism
    Ruben Nogueiras
    Obesity Research Center, Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45237, USA
    J Clin Invest 117:3475-88. 2007
    ..We also reveal molecular underpinnings for direct control of the CNS-Mcr over lipid metabolism. These results suggest ways to design more efficient pharmacological methods for controlling adiposity...
  39. doi Sexually different actions of leptin in proopiomelanocortin neurons to regulate glucose homeostasis
    Haifei Shi
    Department of Psychiatry, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45237, USA
    Am J Physiol Endocrinol Metab 294:E630-9. 2008
    ..Collectively, these data indicate that the action of leptin in POMC neurons is sexually different to influence the regulation of energy balance, fat distribution, and glucose homeostasis...
  40. pmc Effect of intraperitoneal and intravenous administration of cholecystokinin-8 and apolipoprotein AIV on intestinal lymphatic CCK-8 and apo AIV concentration
    Chun Min Lo
    Cincinnati Obesity Research Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45237, USA
    Am J Physiol Regul Integr Comp Physiol 296:R43-50. 2009
    ....
  41. ncbi Hypothalamic apolipoprotein A-IV is regulated by leptin
    Ling Shen
    Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45237 0507, USA
    Endocrinology 148:2681-9. 2007
    ..5 microg) reduction of feeding, indicating the existence of a functional synergistic interaction between leptin and apo A-IV, leading to suppression of food intake...
  42. ncbi Glucagon-like peptide-1 (GLP-1) receptors expressed on nerve terminals in the portal vein mediate the effects of endogenous GLP-1 on glucose tolerance in rats
    Torsten P Vahl
    Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Cincinnati, 2170 East Galbraith Road, Cincinnati, Ohio 45267, USA
    Endocrinology 148:4965-73. 2007
    ..These data are consistent with an important component of neural mediation of GLP-1 action...
  43. pmc The role of hypothalamic mammalian target of rapamycin complex 1 signaling in diet-induced obesity
    Daniela Cota
    Department of Psychiatry, University of Cincinnati, Genome Research Institute, Cincinnati, Ohio 45237, USA
    J Neurosci 28:7202-8. 2008
    ..Overall, these findings point strongly to the possibility that reduced hypothalamic mTORC1 signaling contributes to the development of hyperphagia, weight gain, and leptin resistance during diet-induced obesity...
  44. pmc The role of GM-CSF in adipose tissue inflammation
    Dong Hoon Kim
    Department of Psychiartry, University of Cincinnati, Cincinnati, OH, USA
    Am J Physiol Endocrinol Metab 295:E1038-46. 2008
    ..Collectively, the data suggest that the GM-CSF knockout mutation ameliorates peripheral insulin resistance in spite of increased adiposity by reducing inflammation in adipose tissue in response to a HFD...
  45. ncbi Metabolic and endocrine consequences of social stress in a visible burrow system
    Kellie L K Tamashiro
    Department of Psychiatry, University of Cincinnati Medical Center, 231 Albert Sabin Way, Box 670559, Cincinnati, OH 45267 0559, USA
    Physiol Behav 80:683-93. 2004
    ..In summary, the VBS model of chronic social stress is an ethologically relevant animal model and provides a valuable tool for studies of stress-related conditions and pathologies...
  46. ncbi Food intake-independent effects of CB1 antagonism on glucose and lipid metabolism
    Daniela Cota
    Department of Psychiatry, University of Cincinnati, Genome Research Institute, Cincinnati, Ohio, USA
    Obesity (Silver Spring) 17:1641-5. 2009
    ..These effects are independent of the anorectic action of the drug...
  47. ncbi Apolipoprotein A-IV interacts synergistically with melanocortins to reduce food intake
    Koro Gotoh
    Department of Psychiatry, University of Cincinnati, 2170 East Galbraith Road, Cincinnati, OH 45237, USA
    Am J Physiol Regul Integr Comp Physiol 290:R202-7. 2006
    ..In addition, c-Fos expression was not colocalized with proopiomelanocortin-positive neurons. These data support a synergistic interaction between apo A-IV and melanocortins that reduces food intake by acting downstream of the arcuate...
  48. ncbi Cloned mice have an obese phenotype not transmitted to their offspring
    Kellie L K Tamashiro
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Nat Med 8:262-7. 2002
    ..We also show that the obese phenotype is not transmitted to offspring generated by mating male and female cloned mice...
  49. ncbi Effects of a fixed meal pattern on ghrelin secretion: evidence for a learned response independent of nutrient status
    Deborah L Drazen
    Department of Psychiatry, Genome Research Institute, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Endocrinology 147:23-30. 2006
    ..Together, these data are consistent with a role for ghrelin in the regulation of anticipatory processes involved in food intake and nutrient disposition...
  50. pmc Acute exposure to a high-fat diet alters meal patterns and body composition
    Susan J Melhorn
    Department of Psychiatry, Program in Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH 45237, USA
    Physiol Behav 99:33-9. 2010
    ..Together, these results suggest that consumption of a high-fat diet can rapidly alter meal patterns, which in turn contribute to the development of adiposity...
  51. ncbi Insulin and leptin combine additively to reduce food intake and body weight in rats
    Ellen L Air
    Department of Biomedical Sciences, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45267 0555, USA
    Endocrinology 143:2449-52. 2002
    ....
  52. pmc High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis
    Rohit Kohli
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Hepatology 52:934-44. 2010
    ..001) levels were significantly increased in HFHC mice. Hepatic oxidative stress, as indicated by liver superoxide expression (P = 0.002), 4-hydroxynonenal, and plasma (ox)CoQ9 (P < 0.001) levels, was highest in HFHC mice...
  53. ncbi Acute 3rd-ventricular amylin infusion potently reduces food intake but does not produce aversive consequences
    Paul A Rushing
    Department of Psychiatry, College of Medicine, University of Cincinnati, Cincinnati, OH 45267 0559, USA
    Peptides 23:985-8. 2002
    ..In summary, these data are consistent with the conclusion that acute i3vt amylin infusion does not reduce food intake by producing aversive consequences...
  54. pmc Melanocortin signaling in the CNS directly regulates circulating cholesterol
    Diego Perez-Tilve
    Metabolic Diseases Institute, Division of Endocrinology, Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Nat Neurosci 13:877-82. 2010
    ..Our data suggest that a neural circuit in the brain is directly involved in the control of cholesterol metabolism by the liver...
  55. ncbi Gastrointestinal hormones and food intake
    April D Strader
    Genome Research Institute, University of Cincinnati Medical Center, 2170 E Galbraith Road, Cincinnati, OH 45237, USA
    Gastroenterology 128:175-91. 2005
    ....
  56. pmc Characterization of apolipoprotein A-IV in brain areas involved in energy homeostasis
    Ling Shen
    Obesity Research Center, University of Cincinnati College of Medicine, Cincinnati, OH 45237, USA
    Physiol Behav 95:161-7. 2008
    ..These data collectively support the hypothesis that apo A-IV, produced by neuronal cells, may exert its anorectic action by interacting with catabolic regulatory neuropeptides...
  57. pmc Meal-anticipatory glucagon-like peptide-1 secretion in rats
    Torsten P Vahl
    Department of Psychiatry, University of Cincinnati, 2170 East Galbraith Road, Cincinnati, Ohio 45237, USA
    Endocrinology 151:569-75. 2010
    ..These findings document for the first time a cephalic increase of plasma GLP-1 and suggest that it functions to facilitate consumption of a large meal...
  58. pmc Estradiol increases the anorectic effect of central apolipoprotein A-IV
    Ling Shen
    Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45237 0507, USA
    Endocrinology 151:3163-8. 2010
    ..These data indicate that an increased signaling of endogenous apo A-IV may partially mediate estradiol-induced inhibitory effect on feeding...
  59. ncbi Mechanism of the induction of brain c-Fos-positive neurons by lipid absorption
    Chun Min Lo
    Department of Pathology, University of Cincinnati, Cincinnati, OH 45237, USA
    Am J Physiol Regul Integr Comp Physiol 292:R268-73. 2007
    ..We conclude that the formation and/or secretion of chylomicron are critical steps for initiating neuronal activation in the brain...
  60. pmc Sleeve gastrectomy induces loss of weight and fat mass in obese rats, but does not affect leptin sensitivity
    Margaret A Stefater
    Metabolic Disease Institute and Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Gastroenterology 138:2426-36, 2436.e1-3. 2010
    ..Vertical sleeve gastrectomy (VSG) produces dramatic, sustained weight loss; we investigated whether these changes result from improved sensitivity to leptin...
  61. ncbi Intraventricular (i3vt) ghrelin increases food intake in fatty Zucker rats
    Lynda M Brown
    Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45237, United States
    Peptides 28:612-6. 2007
    ..Fatty Zucker rats had 4.5 times more ghrelin receptor mRNA in the hypothalamus than lean Zucker rats, suggesting a possible mechanism for the increased sensitivity...
  62. ncbi Insulin and leptin as adiposity signals
    Stephen C Benoit
    Department of Psychiatry, University of Cincinnati Medical Center, Cincinnati, Ohio 45267, USA
    Recent Prog Horm Res 59:267-85. 2004
    ..Hence, insulin and leptin provide important negative feedback signals to the central nervous system, proportional to peripheral energy stores and coupled with catabolic circuits...
  63. ncbi Sexually dimorphic responses to fat loss after caloric restriction or surgical lipectomy
    Haifei Shi
    University of Cincinnati, Cincinnati, OH, USA
    Am J Physiol Endocrinol Metab 293:E316-26. 2007
    ..In summary, we have found sexual dimorphisms in the response to fat loss that point to important underlying differences in the strategies by which male and female mice regulate body weight...
  64. ncbi [American Gastroenterological Association. Gastrointestinal hormones and food intake]
    April D Strader
    University of Cincinnati Medical Center, Genome Research Institute, Cincinnati, Ohio 45237, USA
    Rev Gastroenterol Mex 70:439-57. 2005
  65. ncbi Ethanol consumption in mice with a targeted disruption of the dopamine-3 receptor gene
    John Andrews McQuade
    Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45267 0559, USA
    Addict Biol 8:295-303. 2003
    ..Furthermore, the D3-R -/- mice adequately learn a CTA to ethanol and do not ham differing taste reactivity to saccharin or quinine. However, D3-R -/- mice do appear to have a slower rate of ethanol metabolism...
  66. pmc The effects of GLP-1 infusion in the hepatic portal region on food intake
    Dong Hoon Kim
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45237, USA
    Regul Pept 155:110-4. 2009
    ..Taken together, these data suggest that while peripheral GLP-1 may be involved in the regulation of food intake, the key GLP-1 receptors are unlikely to be those associated with vagal afferent nerves innervating the hepatic portal vein...
  67. pmc Fatty acid synthase inhibitors modulate energy balance via mammalian target of rapamycin complex 1 signaling in the central nervous system
    Karine Proulx
    Department of Psychiatry, University of Cincinnati, Genome Research Institute, Cincinnati, OH, USA
    Diabetes 57:3231-8. 2008
    ..The purpose of these experiments was to determine whether hypothalamic mTOR complex 1 (mTORC1) signaling is involved in mediating the effects of FAS inhibitors...
  68. pmc Peripheral, but not central, CB1 antagonism provides food intake-independent metabolic benefits in diet-induced obese rats
    Ruben Nogueiras
    Department of Psychiatry, Obesity Research Centre, Genome Research Institute, University of Cincinnati, Cincinnati, Ohio, USA
    Diabetes 57:2977-91. 2008
    ....
  69. ncbi Interaction of apolipoprotein AIV with cholecystokinin on the control of food intake
    Chun Min Lo
    Dept of Pathology and Laboratory Medicine, Univ of Cincinnati, 2120 E Galbraith Rd, Cincinnati, OH 45237 0507, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1490-4. 2007
    ....
  70. ncbi Social stress and recovery: implications for body weight and body composition
    Kellie L K Tamashiro
    Neuroscience Graduate Program, University of Cincinnati, Cincinnati, OH 45237, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1864-74. 2007
    ..Therefore, chronic social stress causes social status-dependent changes in BW, composition and endocrine measures that persist after repeated stress and recovery cycles and that may ultimately lead to metabolic disorders and obesity...
  71. ncbi The effect of fat removal on glucose tolerance is depot specific in male and female mice
    Haifei Shi
    University of Cincinnati, Cincinnati, Ohio 45237, USA
    Am J Physiol Endocrinol Metab 293:E1012-20. 2007
    ..These data illustrate both critical differences among various WAT depots and how they influence glucose homeostasis and highlight important differences between males and females in glucose regulation...
  72. pmc Food-entrained rhythmic expression of apolipoprotein E expression in the hypothalamus of rats
    Ling Shen
    Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0529, USA
    Brain Res 1273:66-71. 2009
    ....
  73. doi Stephen C. Woods: a precocious scientist
    Gerard P Smith
    Department of Psychiatry, Weill Cornell Medical College of Cornell University, Payne Whitney Westchester, New York Presbyterian Hospital, 21 Bloomingdale Road, White Plains, NY 10605, United States
    Physiol Behav 103:4-9. 2011
    ..The most unusual and exemplary aspect of his precocity is that the outstanding performance of his first decade was maintained during the subsequent 30years...
  74. ncbi Acute third ventricular administration of insulin decreases food intake in two paradigms
    Ellen L Air
    Department of Biomedical Sciences, University of Cincinnati, Cincinnati, OH 45267, USA
    Pharmacol Biochem Behav 72:423-9. 2002
    ..These data suggest that insulin can reduce food intake in acute delivery paradigms and provide another means by which to assess the roles of other central systems in the mediation of insulin's effects on energy homeostasis...
  75. ncbi The catabolic action of insulin in the brain is mediated by melanocortins
    Stephen C Benoit
    Department of Psychiatry, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267 0559, USA
    J Neurosci 22:9048-52. 2002
    ..These data suggest that the hypothalamic melanocortin system mediates the anorexic effects of central insulin, as well as of leptin...
  76. ncbi Is the energy homeostasis system inherently biased toward weight gain?
    Michael W Schwartz
    Department of Medicine, University of Washington, Seattle, USA
    Diabetes 52:232-8. 2003
    ..Teleological, molecular, physiological, and clinical aspects of this hypothesis are presented, along with a discussion of currently available supporting evidence...
  77. ncbi Chronic food restriction and reduced dietary fat: risk factors for bouts of overeating
    Ryuichi Ogawa
    Obesity Research Center, Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45237 1625, USA
    Physiol Behav 86:578-85. 2005
    ..Chronic food restriction accompanied by reduced dietary fat may increase risk for bouts of overeating...
  78. ncbi Weight loss through ileal transposition is accompanied by increased ileal hormone secretion and synthesis in rats
    April D Strader
    Genome Research Institute, Department of Psychiatry, University of Cincinnati, 2071 E Galbraith Rd, Reading, OH 45237, USA
    Am J Physiol Endocrinol Metab 288:E447-53. 2005
    ..These findings support the importance of evaluating the contribution of gastrointestinal hormones to the weight loss seen with bariatric surgery...
  79. ncbi Differential effects of adrenalectomy on melanin-concentrating hormone and orexin A
    Deborah L Drazen
    Department of Psychiatry, Genome Research Institute, University of Cincinnati, 2170 East Galbraith Road, Building 43, Third Floor, Cincinnati, Ohio 45237, USA
    Endocrinology 145:3404-12. 2004
    ....
  80. ncbi Intraventricular insulin potentiates the anorexic effect of corticotropin releasing hormone in rats
    Ralph D Richardson
    Veterans Affairs Puget Sound Health Care System, Seattle 98108, USA
    Am J Physiol Regul Integr Comp Physiol 283:R1321-6. 2002
    ..These findings suggest that stress-related influences over food intake, particularly those mediated via CRH, interact with relative adiposity as signaled to the brain by central insulin...
  81. ncbi The role of previous exposure in the appetitive and consummatory effects of orexigenic neuropeptides
    Stephen C Benoit
    University of Cincinnati, Department of Psychiatry North, 2170 East Galbraith Rd, Cincinnati, OH 45243, USA
    Peptides 26:751-7. 2005
    ....
  82. ncbi 7-OH-DPAT selectively reduces intake of both chow and high fat diets in different food intake regimens
    John Andrews M McQuade
    Department of Psychiatry, University of Cincinnati, P O Box 670559, Cincinnati, OH 45267 0559, USA
    Pharmacol Biochem Behav 76:517-23. 2003
    ..However, in animals that had access to HF diet, 7-OH-DPAT dose-dependently reduced intake. These results support a potential role for the D3-R in ingestive behavior particularly in situations that involve a significant learned component...
  83. ncbi Cardiometabolic risk modification: current trends and emerging therapies
    Joseph L Lillo
    Scottsdale Family Health, Arizona, USA
    JAAPA . 2006
  84. ncbi Phenotype of cloned mice: development, behavior, and physiology
    Kellie L K Tamashiro
    Department of Psychiatry and Neuroscience Program, University of Cincinnati, Cincinnati, Ohio 45267 0559, USA
    Exp Biol Med (Maywood) 228:1193-200. 2003
    ..These studies represent the first comprehensive set of data to characterize cloned mice and provide critical information about the long-term effects of somatic cell cloning...
  85. ncbi Fat hormones pull their weight in the CNS
    Randy J Seeley
    Nat Med 10:454-5. 2004
  86. ncbi Regulation of food intake through hypothalamic signaling networks involving mTOR
    Stephen C Woods
    Department of Psychiatry, Genome Research Institute, University of Cincinnati, Cincinnati, Ohio 45237, USA
    Annu Rev Nutr 28:295-311. 2008
    ....
  87. ncbi Altered feeding responses in mice with targeted disruption of the dopamine-3 receptor gene
    Stephen C Benoit
    Department of Psychiatry, University of Cincinnati, Ohio 45267 0559, USA
    Behav Neurosci 117:46-54. 2003
    ..These results support the hypothesis that D3Rs chronically inhibit the effects of adiposity hormones, thereby contributing to a net anabolic state...
  88. ncbi Mechanisms of oleoylethanolamide-induced changes in feeding behavior and motor activity
    Karine Proulx
    Genome Research Institute, ML 0506, University of Cincinnati, 2170 E Galbraith Road, Cincinnati, OH 45237, USA
    Am J Physiol Regul Integr Comp Physiol 289:R729-37. 2005
    ..Despite that OEA-induced anorexia is unlikely to be due to impaired motor activity, our data raise a cautionary note in how specific behavioral and metabolic effects of OEA should be interpreted...

Research Grants7

  1. CEPHALIC RESPONSES AND MEAL FEEDING
    Stephen Woods; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  2. Training Program in Neuroendocrinology of Homeostasis
    Stephen Woods; Fiscal Year: 2007
    ..The strength of the faculty has enabled us to recruit outstanding trainees, and the fruits of this effort are manifest in the productivity and job opportunities that accrued to the trainees supported in the current funding period. ..
  3. The Role of TNF Alpha in Obesity
    Stephen Woods; Fiscal Year: 2008
    ..Experiments will use normal (wild-type) mice and mice lacking TNF1 or its receptors. ..
  4. CEPHALIC RESPONSES AND MEAL FEEDING
    Stephen Woods; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  5. High Fat Diet-Induced Obesity
    Stephen Woods; Fiscal Year: 2008
    ..Project 3 seeks to elucidate the mechanisms in the CNS that contribute to the defense of increased body fat that occurs on high saturated fat diet. ..
  6. Training Program in Neuroendocrinology of Homeostasis
    Stephen Woods; Fiscal Year: 2008
    ..The strength of the faculty has enabled us to recruit outstanding trainees, and the fruits of this effort are manifest in the productivity and job opportunities that accrued to the trainees supported in the current funding period. ..
  7. The Role of TNF Alpha in Obesity
    Stephen Woods; Fiscal Year: 2009
    ..Experiments will use normal (wild-type) mice and mice lacking TNF1 or its receptors. ..