Stephen C Woods

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. pmc Fatty acid synthase inhibitors modulate energy balance via mammalian target of rapamycin complex 1 signaling in the central nervous system
    Karine Proulx
    Department of Psychiatry, University of Cincinnati, Genome Research Institute, Cincinnati, OH, USA
    Diabetes 57:3231-8. 2008
  2. ncbi request reprint Food intake-independent effects of CB1 antagonism on glucose and lipid metabolism
    Daniela Cota
    Department of Psychiatry, University of Cincinnati, Genome Research Institute, Cincinnati, Ohio, USA
    Obesity (Silver Spring) 17:1641-5. 2009
  3. ncbi request reprint Regulation of food intake through hypothalamic signaling networks involving mTOR
    Stephen C Woods
    Department of Psychiatry, Genome Research Institute, University of Cincinnati, Cincinnati, Ohio 45237, USA
    Annu Rev Nutr 28:295-311. 2008
  4. pmc Cholecystokinin knockout mice are resistant to high-fat diet-induced obesity
    Chun Min Lo
    Cincinnati Obesity Research Center, Genome Research Institute, University of Cincinnati, Cincinnati, Ohio 45237, USA
    Gastroenterology 138:1997-2005. 2010
  5. pmc Effect of vertical sleeve gastrectomy on food selection and satiation in rats
    Adam P Chambers
    Metabolic Diseases Institute, University of Cincinnati, Cincinnati, OH 45237, USA
    Am J Physiol Endocrinol Metab 303:E1076-84. 2012
  6. ncbi request reprint Increased dietary fat attenuates the anorexic effects of intracerebroventricular injections of MTII
    Deborah J Clegg
    Department of Psychiatry, University of Cincinnati Medical Center, PO Box 670559, Cincinnati, OH 45267 0559, USA
    Endocrinology 144:2941-6. 2003
  7. pmc Glucose parameters are altered in mouse offspring produced by assisted reproductive technologies and somatic cell nuclear transfer
    Karen A Scott
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Biol Reprod 83:220-7. 2010
  8. pmc Antiobesity and antihyperglycemic effects of ginsenoside Rb1 in rats
    Ye Xiong
    Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Diabetes 59:2505-12. 2010
  9. ncbi request reprint Characterization of mice lacking the gene for cholecystokinin
    Chun Min Lo
    Department of Pathology and Laboratory Medicine, University of Cincinnati, Genome Research Institute, 2120 E Galbraith Rd, Bldg A, ML 0507, Cincinnati, OH 45237, USA
    Am J Physiol Regul Integr Comp Physiol 294:R803-10. 2008
  10. ncbi request reprint Estradiol-dependent decrease in the orexigenic potency of ghrelin in female rats
    Deborah J Clegg
    Department of Psychiatry, University of Cincinnati, P O Box 670559, Cincinnati, OH 45267 0559, USA
    Diabetes 56:1051-8. 2007

Collaborators

Detail Information

Publications110 found, 100 shown here

  1. pmc Fatty acid synthase inhibitors modulate energy balance via mammalian target of rapamycin complex 1 signaling in the central nervous system
    Karine Proulx
    Department of Psychiatry, University of Cincinnati, Genome Research Institute, Cincinnati, OH, USA
    Diabetes 57:3231-8. 2008
    ..The purpose of these experiments was to determine whether hypothalamic mTOR complex 1 (mTORC1) signaling is involved in mediating the effects of FAS inhibitors...
  2. ncbi request reprint Food intake-independent effects of CB1 antagonism on glucose and lipid metabolism
    Daniela Cota
    Department of Psychiatry, University of Cincinnati, Genome Research Institute, Cincinnati, Ohio, USA
    Obesity (Silver Spring) 17:1641-5. 2009
    ..These effects are independent of the anorectic action of the drug...
  3. ncbi request reprint Regulation of food intake through hypothalamic signaling networks involving mTOR
    Stephen C Woods
    Department of Psychiatry, Genome Research Institute, University of Cincinnati, Cincinnati, Ohio 45237, USA
    Annu Rev Nutr 28:295-311. 2008
    ....
  4. pmc Cholecystokinin knockout mice are resistant to high-fat diet-induced obesity
    Chun Min Lo
    Cincinnati Obesity Research Center, Genome Research Institute, University of Cincinnati, Cincinnati, Ohio 45237, USA
    Gastroenterology 138:1997-2005. 2010
    ..We proposed that mice with a disruption in the CCK gene (CCK knockout [CCK-KO] mice) that were fed a diet of 20% butter fat would have altered fat metabolism...
  5. pmc Effect of vertical sleeve gastrectomy on food selection and satiation in rats
    Adam P Chambers
    Metabolic Diseases Institute, University of Cincinnati, Cincinnati, OH 45237, USA
    Am J Physiol Endocrinol Metab 303:E1076-84. 2012
    ..VSG alters nutrient sensing in a manner that lowers the threshold for satiety and reduces fat preference to induce and maintain weight loss...
  6. ncbi request reprint Increased dietary fat attenuates the anorexic effects of intracerebroventricular injections of MTII
    Deborah J Clegg
    Department of Psychiatry, University of Cincinnati Medical Center, PO Box 670559, Cincinnati, OH 45267 0559, USA
    Endocrinology 144:2941-6. 2003
    ..These results indicate that consumption of a HF diet decreases signaling through the melanocortin system, an abnormality that could contribute to diet-induced obesity...
  7. pmc Glucose parameters are altered in mouse offspring produced by assisted reproductive technologies and somatic cell nuclear transfer
    Karen A Scott
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Biol Reprod 83:220-7. 2010
    ..The present study suggests that more investigation regarding the long-term effects of manipulations associated with ART is warranted...
  8. pmc Antiobesity and antihyperglycemic effects of ginsenoside Rb1 in rats
    Ye Xiong
    Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Diabetes 59:2505-12. 2010
    ....
  9. ncbi request reprint Characterization of mice lacking the gene for cholecystokinin
    Chun Min Lo
    Department of Pathology and Laboratory Medicine, University of Cincinnati, Genome Research Institute, 2120 E Galbraith Rd, Bldg A, ML 0507, Cincinnati, OH 45237, USA
    Am J Physiol Regul Integr Comp Physiol 294:R803-10. 2008
    ..We conclude that CCK is involved in metabolic rate and is important for memory and exploration. CCK is intimately involved in multiple processes related to cognitive function and food intake regulation...
  10. ncbi request reprint Estradiol-dependent decrease in the orexigenic potency of ghrelin in female rats
    Deborah J Clegg
    Department of Psychiatry, University of Cincinnati, P O Box 670559, Cincinnati, OH 45267 0559, USA
    Diabetes 56:1051-8. 2007
    ....
  11. pmc Weight-independent changes in blood glucose homeostasis after gastric bypass or vertical sleeve gastrectomy in rats
    Adam P Chambers
    Obesity Research Center and the Metabolic Diseases Institute, University of Cincinnati, Cincinnati, Ohio, USA
    Gastroenterology 141:950-8. 2011
    ..We investigated alterations in glucose metabolism in rats following RYGB or VSG...
  12. doi request reprint Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity
    Ruben Nogueiras
    Department of Psychiatry, Obesity Research Centre, University of Cincinnati, Cincinnati, Ohio 45226, USA
    J Neurosci 29:5916-25. 2009
    ..Importantly, the CNS GLP-1 system loses the capacity to modulate adipocyte metabolism in obese states, suggesting an obesity-induced adipocyte resistance to CNS GLP-1...
  13. pmc Brain apolipoprotein E: an important regulator of food intake in rats
    Ling Shen
    Cincinnati Obesity Research Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Diabetes 57:2092-8. 2008
    ....
  14. pmc Peptide designed to elicit apoptosis in adipose tissue endothelium reduces food intake and body weight
    Dong Hoon Kim
    Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio, USA
    Diabetes 59:907-15. 2010
    ..We sought to determine how inhibiting adipose tissue vasculature changes key aspects of energy balance regulation and the neuroendocrine system that maintains energy balance...
  15. ncbi request reprint High-fat diet induced adiposity in mice with targeted disruption of the dopamine-3 receptor gene
    John Andrews McQuade
    Department of Psychiatry, University of Cincinnati, P O Box 670559, Cincinnati, OH 45267 0559, USA
    Behav Brain Res 151:313-9. 2004
    ..These findings suggest the D3-R signaling is involved in the regulation of body weight and body fat when mice are given access to diets differing in palatability and fat content...
  16. ncbi request reprint Differential effects of adrenalectomy on melanin-concentrating hormone and orexin A
    Deborah L Drazen
    Department of Psychiatry, Genome Research Institute, University of Cincinnati, 2170 East Galbraith Road, Building 43, Third Floor, Cincinnati, Ohio 45237, USA
    Endocrinology 145:3404-12. 2004
    ....
  17. ncbi request reprint Alcohol drinking in MCH receptor-1-deficient mice
    Elizabeth A Duncan
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio, USA
    Alcohol Clin Exp Res 31:1325-37. 2007
    ..However, because the physiological relevance of this finding is unclear, we tested the hypothesis that endogenous MCH signaling enhances alcohol consumption...
  18. ncbi request reprint The impact of moderate daily alcohol consumption on aggression and the formation of dominance hierarchies in rats
    Elizabeth A Duncan
    Program in Neuroscience, University of Cincinnati, Cincinnati, OH, USA
    Psychopharmacology (Berl) 189:83-94. 2006
    ..We tested the hypothesis that a history of drinking alcohol would cause SUB rats to consume even greater amounts of alcohol...
  19. ncbi request reprint Consumption of a high-fat diet alters the homeostatic regulation of energy balance
    Stephen C Woods
    Department of Psychiatry, University of Cincinnati, 2170 East Galbraith Road, Cincinnati, OH 45237, USA
    Physiol Behav 83:573-8. 2004
    ..HF-fed animals, independent of whether they become obese or not, also have central insulin and MTII insensitivity. Finally, HF rats have a down-regulated hypothalamic apo A-IV system that could contribute to their hyperphagia...
  20. ncbi request reprint Adrenalectomy alters the sensitivity of the central nervous system melanocortin system
    Deborah L Drazen
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45237, USA
    Diabetes 52:2928-34. 2003
    ..We conclude that the potent weight-reducing effects of ADX likely involve heightened responsiveness to melanocortin receptor stimulation...
  21. pmc Effect of intraperitoneal and intravenous administration of cholecystokinin-8 and apolipoprotein AIV on intestinal lymphatic CCK-8 and apo AIV concentration
    Chun Min Lo
    Cincinnati Obesity Research Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45237, USA
    Am J Physiol Regul Integr Comp Physiol 296:R43-50. 2009
    ....
  22. ncbi request reprint Apolipoprotein A-IV interacts synergistically with melanocortins to reduce food intake
    Koro Gotoh
    Department of Psychiatry, University of Cincinnati, 2170 East Galbraith Road, Cincinnati, OH 45237, USA
    Am J Physiol Regul Integr Comp Physiol 290:R202-7. 2006
    ..In addition, c-Fos expression was not colocalized with proopiomelanocortin-positive neurons. These data support a synergistic interaction between apo A-IV and melanocortins that reduces food intake by acting downstream of the arcuate...
  23. pmc Intraperitoneal CCK and fourth-intraventricular Apo AIV require both peripheral and NTS CCK1R to reduce food intake in male rats
    Chunmin C Lo
    Departments of Pathology and Laboratory Medicine C C L, W S D, S K H, M G, A L, P T and Psychiatry and Behavioral Neuroscience S C W, Metabolic Diseases Institute, University of Cincinnati, Cincinnati, Ohio 45237 0507
    Endocrinology 155:1700-7. 2014
    ..These observations suggest that NTS Apo AIV or/and peripheral CCK requires vagal CCK-1R signaling to elicit satiation and that maintenance on a HFD reduces the satiating capacity of these 2 signals. ..
  24. pmc Melanocortin signaling in the CNS directly regulates circulating cholesterol
    Diego Perez-Tilve
    Metabolic Diseases Institute, Division of Endocrinology, Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Nat Neurosci 13:877-82. 2010
    ..Our data suggest that a neural circuit in the brain is directly involved in the control of cholesterol metabolism by the liver...
  25. pmc Caloric restriction chronically impairs metabolic programming in mice
    Henriette Kirchner
    Department of Internal Medicine, Metabolic Diseases Institute, Division of Endocrinology, University of Cincinnati, Cincinnati, OH, USA
    Diabetes 61:2734-42. 2012
    ..These results suggest that although caloric restriction on a HFD provides metabolic benefits, maintaining those benefits may require lifelong continuation, at least in individuals with a history of obesity...
  26. ncbi request reprint Social stress and recovery: implications for body weight and body composition
    Kellie L K Tamashiro
    Neuroscience Graduate Program, University of Cincinnati, Cincinnati, OH 45237, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1864-74. 2007
    ..Therefore, chronic social stress causes social status-dependent changes in BW, composition and endocrine measures that persist after repeated stress and recovery cycles and that may ultimately lead to metabolic disorders and obesity...
  27. pmc Hyperphagia and increased fat accumulation in two models of chronic CNS glucagon-like peptide-1 loss of function
    Jason G Barrera
    Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio 45237, USA
    J Neurosci 31:3904-13. 2011
    ..Moreover, they suggest that this role is distinct from that of circulating GLP-1 as a short-term satiation signal. Therefore, it may be possible to tailor GLP-1-based therapies for the prevention and/or treatment of obesity...
  28. ncbi request reprint Hypothalamic mTOR signaling regulates food intake
    Daniela Cota
    Department of Psychiatry, University of Cincinnati, Genome Research Institute, 2170 East Galbraith Road, Cincinnati, OH 45237, USA
    Science 312:927-30. 2006
    ..Thus, mTOR is a cellular fuel sensor whose hypothalamic activity is directly tied to the regulation of energy intake...
  29. ncbi request reprint Intraventricular insulin and leptin reduce food intake and body weight in C57BL/6J mice
    Lynda M Brown
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45237, USA
    Physiol Behav 89:687-91. 2006
    ..Hence, genetic manipulations that influence brain insulin sensitivity in mice can now more easily be integrated with the broader literature on energy homeostasis...
  30. pmc High-fat diet changes the temporal profile of GLP-1 receptor-mediated hypophagia in rats
    Joram D Mul
    Metabolic Diseases Institute, University of Cincinnati, Cincinnati, OH 45327, USA
    Am J Physiol Regul Integr Comp Physiol 305:R68-77. 2013
    ..Taken together, these findings demonstrate that dietary composition alters the temporal profile of the anorectic response to exogenous GLP-1r agonists. ..
  31. pmc Removal of intra-abdominal visceral adipose tissue improves glucose tolerance in rats: role of hepatic triglyceride storage
    Michelle T Foster
    Obesity Research Center, Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45237, United States
    Physiol Behav 104:845-54. 2011
    ..Overall, our results indicate surgical removal of intra-abdominal fat improves glucose tolerance through mechanism that may be mediated by reductions in liver triglyceride...
  32. doi request reprint Sexually different actions of leptin in proopiomelanocortin neurons to regulate glucose homeostasis
    Haifei Shi
    Department of Psychiatry, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45237, USA
    Am J Physiol Endocrinol Metab 294:E630-9. 2008
    ..Collectively, these data indicate that the action of leptin in POMC neurons is sexually different to influence the regulation of energy balance, fat distribution, and glucose homeostasis...
  33. pmc Sleeve gastrectomy in rats improves postprandial lipid clearance by reducing intestinal triglyceride secretion
    Margaret A Stefater
    Metabolic Diseases Institute and Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Gastroenterology 141:939-949.e1-4. 2011
    ..We investigated whether the beneficial effects of vertical sleeve gastrectomy (VSG) on plasma lipid levels are weight independent...
  34. pmc The regulation of alcohol intake by melanin-concentrating hormone in rats
    Elizabeth A Duncan
    Department of Psychiatry, University of Cincinnati, USA
    Pharmacol Biochem Behav 85:728-35. 2006
    ..Further, endogenous MCH does not seem to regulate alcohol drinking, however because the antagonist failed to attenuate MCH-induced alcohol intake this conclusion is tentative...
  35. ncbi request reprint Hypothalamic apolipoprotein A-IV is regulated by leptin
    Ling Shen
    Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45237 0507, USA
    Endocrinology 148:2681-9. 2007
    ..5 microg) reduction of feeding, indicating the existence of a functional synergistic interaction between leptin and apo A-IV, leading to suppression of food intake...
  36. ncbi request reprint Interaction of apolipoprotein AIV with cholecystokinin on the control of food intake
    Chun Min Lo
    Dept of Pathology and Laboratory Medicine, Univ of Cincinnati, 2120 E Galbraith Rd, Cincinnati, OH 45237 0507, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1490-4. 2007
    ....
  37. pmc Differences in the central anorectic effects of glucagon-like peptide-1 and exendin-4 in rats
    Jason G Barrera
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio, USA
    Diabetes 58:2820-7. 2009
    ..It has generally been hypothesized that this difference is due to the relative pharmacokinetic profiles of GLP-1 and Ex4, but it is possible that the two peptides control feeding via distinct mechanisms...
  38. pmc Food-entrained rhythmic expression of apolipoprotein E expression in the hypothalamus of rats
    Ling Shen
    Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0529, USA
    Brain Res 1273:66-71. 2009
    ....
  39. ncbi request reprint Neuropeptide Y prepares rats for scheduled feeding
    Deborah L Drazen
    Department of Psychiatry, University of Cincinnati, 2170 E Galbraith Rd, Bldg E, Rm 313, Cincinnati, OH 45237, USA
    Am J Physiol Regul Integr Comp Physiol 288:R1606-11. 2005
    ..These data suggest that NPY plays a role in mediating conditionable food-anticipatory responses that help to cope with the effects of large caloric loads...
  40. ncbi request reprint Reduced anorexic effects of insulin in obesity-prone rats fed a moderate-fat diet
    Deborah J Clegg
    University of Cincinnati, Department of Psychiatry, Cincinnati, Ohio, USA
    Am J Physiol Regul Integr Comp Physiol 288:R981-6. 2005
    ....
  41. pmc Apolipoprotein AIV requires cholecystokinin and vagal nerves to suppress food intake
    Chunmin C Lo
    Departments of Pathology and Laboratory Medicine, Cincinnati, OH 45237 0507, USA
    Endocrinology 153:5857-65. 2012
    ..These observations imply that peripheral apo AIV requires an intact CCK system and vagal afferents to activate neurons in the hindbrain to reduce food intake...
  42. pmc Physiological responses to acute psychological stress are reduced by the PPARγ agonist rosiglitazone
    Karen K Ryan
    Department of Internal Medicine, Division of Endocrinology, Diabetes, and Metabolism, The University of Cincinnati College of Medicine, Cincinnati, Ohio 45237, USA
    Endocrinology 153:1279-87. 2012
    ..Taken as a whole, these data suggest that PPARγ stimulation potently inhibits physiological responses to psychological stress, prescribing a novel role for PPARγ signaling in the regulation of brain stress integration...
  43. pmc Meal patterns and hypothalamic NPY expression during chronic social stress and recovery
    Susan J Melhorn
    Department of Psychiatry, University of Cincinnati, College of Medicine, Cincinnati, Ohio, USA
    Am J Physiol Regul Integr Comp Physiol 299:R813-22. 2010
    ....
  44. pmc The role of GM-CSF in adipose tissue inflammation
    Dong Hoon Kim
    Department of Psychiartry, University of Cincinnati, Cincinnati, OH, USA
    Am J Physiol Endocrinol Metab 295:E1038-46. 2008
    ..Collectively, the data suggest that the GM-CSF knockout mutation ameliorates peripheral insulin resistance in spite of increased adiposity by reducing inflammation in adipose tissue in response to a HFD...
  45. pmc Peripheral, but not central, CB1 antagonism provides food intake-independent metabolic benefits in diet-induced obese rats
    Ruben Nogueiras
    Department of Psychiatry, Obesity Research Centre, Genome Research Institute, University of Cincinnati, Cincinnati, Ohio, USA
    Diabetes 57:2977-91. 2008
    ....
  46. pmc Estradiol increases the anorectic effect of central apolipoprotein A-IV
    Ling Shen
    Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45237 0507, USA
    Endocrinology 151:3163-8. 2010
    ..These data indicate that an increased signaling of endogenous apo A-IV may partially mediate estradiol-induced inhibitory effect on feeding...
  47. ncbi request reprint Using the lymph fistula rat model to study the potentiation of GIP secretion by the ingestion of fat and glucose
    Wendell J Lu
    Department of Molecular and Cellular Physiology, Medicine, University of Cincinnati, Cincinnati, OH 45267, USA
    Am J Physiol Gastrointest Liver Physiol 294:G1130-8. 2008
    ..We conclude from these studies that the lymph fistula rat is a novel approach to study in vivo GIP secretion in response to nutrient feeding in conscious rats...
  48. pmc Differential effects of glucocorticoids on energy homeostasis in Syrian hamsters
    Matia B Solomon
    Department of Psychiatry and Behavioral Neuroscience, Obesity Research Center, Metabolic Disease Institute, University of Cincinnati, 2170 E Galbraith Rd, Cincinnati, OH 45237, USA
    Am J Physiol Endocrinol Metab 301:E307-16. 2011
    ..However, the data suggest that cortisol alone does not mediate stress-induced increases in food intake or body mass in this species...
  49. pmc The effect of angiotensin-converting enzyme inhibition using captopril on energy balance and glucose homeostasis
    Annette D de Kloet
    Program in Neuroscience, University of Cincinnati, Cincinnati, Ohio 45237, USA
    Endocrinology 150:4114-23. 2009
    ..These results suggest that angiotensin-converting enzyme inhibition protects against the development of diet-induced obesity and glucose intolerance...
  50. ncbi request reprint Small molecule insulin mimetics reduce food intake and body weight and prevent development of obesity
    Ellen L Air
    Department of Biomedical Sciences and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Nat Med 8:179-83. 2002
    ..Thus, insulin mimetics have a unique advantage over insulin in the control of body weight and hold potential as a novel anti-obesity treatment...
  51. pmc Oral L-arginine stimulates GLP-1 secretion to improve glucose tolerance in male mice
    Christoffer Clemmensen
    2170 East Galbraith Road, A125, Cincinnati, Ohio 45237
    Endocrinology 154:3978-83. 2013
    ..These findings raise the intriguing possibility that L-arginine-based nutritional and/or pharmaceutical therapies may benefit glucose tolerance by improving the postprandial GLP-1 response in obese individuals...
  52. pmc Regulation of gastric emptying rate and its role in nutrient-induced GLP-1 secretion in rats after vertical sleeve gastrectomy
    Adam P Chambers
    Division of Endocrinology and Metabolism, University of Cincinnati, Cincinnati, Ohio
    Am J Physiol Endocrinol Metab 306:E424-32. 2014
    ..These findings demonstrate greatly accelerated gastric emptying in rat models of RYGB and VSG. In VSG this is likely due to increased gastric pressure and reduced responses to inhibitory feedback from the intestine. ..
  53. pmc Effect of peripheral administration of cholecystokinin on food intake in apolipoprotein AIV knockout mice
    Go Yoshimichi
    Department of Pathology and Laboratory Medicine, University of Cincinnati, OH 45237, USA
    Am J Physiol Gastrointest Liver Physiol 302:G1336-42. 2012
    ....
  54. pmc Impaired insulin secretion and enhanced insulin sensitivity in cholecystokinin-deficient mice
    Chun Min Lo
    Cincinnati Obesity Research Center, Metabolic Diseases Institute, University of Cincinnati, Cincinnati, Ohio, USA
    Diabetes 60:2000-7. 2011
    ..Cholecystokinin (CCK) is released in response to lipid intake and stimulates insulin secretion. We hypothesized that CCK deficiency would alter the regulation of insulin secretion and glucose homeostasis...
  55. ncbi request reprint Mechanisms of oleoylethanolamide-induced changes in feeding behavior and motor activity
    Karine Proulx
    Genome Research Institute, ML 0506, University of Cincinnati, 2170 E Galbraith Road, Cincinnati, OH 45237, USA
    Am J Physiol Regul Integr Comp Physiol 289:R729-37. 2005
    ..Despite that OEA-induced anorexia is unlikely to be due to impaired motor activity, our data raise a cautionary note in how specific behavioral and metabolic effects of OEA should be interpreted...
  56. pmc Characterization of apolipoprotein A-IV in brain areas involved in energy homeostasis
    Ling Shen
    Obesity Research Center, University of Cincinnati College of Medicine, Cincinnati, OH 45237, USA
    Physiol Behav 95:161-7. 2008
    ..These data collectively support the hypothesis that apo A-IV, produced by neuronal cells, may exert its anorectic action by interacting with catabolic regulatory neuropeptides...
  57. pmc Meal-anticipatory glucagon-like peptide-1 secretion in rats
    Torsten P Vahl
    Department of Psychiatry, University of Cincinnati, 2170 East Galbraith Road, Cincinnati, Ohio 45237, USA
    Endocrinology 151:569-75. 2010
    ..These findings document for the first time a cephalic increase of plasma GLP-1 and suggest that it functions to facilitate consumption of a large meal...
  58. pmc The role of hypothalamic mammalian target of rapamycin complex 1 signaling in diet-induced obesity
    Daniela Cota
    Department of Psychiatry, University of Cincinnati, Genome Research Institute, Cincinnati, Ohio 45237, USA
    J Neurosci 28:7202-8. 2008
    ..Overall, these findings point strongly to the possibility that reduced hypothalamic mTORC1 signaling contributes to the development of hyperphagia, weight gain, and leptin resistance during diet-induced obesity...
  59. pmc Acute exposure to a high-fat diet alters meal patterns and body composition
    Susan J Melhorn
    Department of Psychiatry, Program in Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH 45237, USA
    Physiol Behav 99:33-9. 2010
    ..Together, these results suggest that consumption of a high-fat diet can rapidly alter meal patterns, which in turn contribute to the development of adiposity...
  60. ncbi request reprint Phenotype of cloned mice: development, behavior, and physiology
    Kellie L K Tamashiro
    Department of Psychiatry and Neuroscience Program, University of Cincinnati, Cincinnati, Ohio 45267 0559, USA
    Exp Biol Med (Maywood) 228:1193-200. 2003
    ..These studies represent the first comprehensive set of data to characterize cloned mice and provide critical information about the long-term effects of somatic cell cloning...
  61. ncbi request reprint Two novel paradigms for the simultaneous assessment of conditioned taste aversion and food intake effects of anorexic agents
    Stephen C Benoit
    Department of Psychiatry, University of Cincinnati Medical Center, P O Box 670559, Cincinnati, OH 45267, USA
    Physiol Behav 79:761-6. 2003
    ..These results suggest that both the appetitive and aversive consequences of anorexic agents can be assessed simultaneously during either acute or chronic drug administration...
  62. ncbi request reprint Learned meal initiation attenuates the anorexic effects of the melanocortin agonist MTII
    Stephen C Benoit
    Department of Psychiatry, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 0559, USA
    Diabetes 52:2684-8. 2003
    ..These results support the hypothesis that meal-feeding schedules can lead to anticipatory physiological responses that attenuate the anorexic effects of exogenous melanocortin agonists...
  63. pmc Sleeve gastrectomy induces loss of weight and fat mass in obese rats, but does not affect leptin sensitivity
    Margaret A Stefater
    Metabolic Disease Institute and Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Gastroenterology 138:2426-36, 2436.e1-3. 2010
    ..Vertical sleeve gastrectomy (VSG) produces dramatic, sustained weight loss; we investigated whether these changes result from improved sensitivity to leptin...
  64. ncbi request reprint Differential sensitivity to central leptin and insulin in male and female rats
    Deborah J Clegg
    Department of Psychiatry, University of Cincinnati Medical Center, Cincinnati, OH 45267 0559, USA
    Diabetes 52:682-7. 2003
    ..Because insulin and leptin reflect different fat beds and are differentially distributed in the male and female sexes, the implication is that the male and female sexes regulate adiposity-relevant parameters differently...
  65. ncbi request reprint Central administration of melanin-concentrating hormone increases alcohol and sucrose/quinine intake in rats
    Elizabeth A Duncan
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45237, USA
    Alcohol Clin Exp Res 29:958-64. 2005
    ..e., anxiety, fluid balance, and reward). We tested the hypothesis that MCH would decrease the motivation to consume alcohol secondarily to reducing anxiety...
  66. ncbi request reprint Diurnal rhythm of apolipoprotein A-IV in rat hypothalamus and its relation to food intake and corticosterone
    Min Liu
    Cincinnati Obesity Research Center, Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0507, USA
    Endocrinology 145:3232-8. 2004
    ....
  67. ncbi request reprint The effect of fat removal on glucose tolerance is depot specific in male and female mice
    Haifei Shi
    University of Cincinnati, Cincinnati, Ohio 45237, USA
    Am J Physiol Endocrinol Metab 293:E1012-20. 2007
    ..These data illustrate both critical differences among various WAT depots and how they influence glucose homeostasis and highlight important differences between males and females in glucose regulation...
  68. ncbi request reprint The role of previous exposure in the appetitive and consummatory effects of orexigenic neuropeptides
    Stephen C Benoit
    University of Cincinnati, Department of Psychiatry North, 2170 East Galbraith Rd, Cincinnati, OH 45243, USA
    Peptides 26:751-7. 2005
    ....
  69. pmc Molecular neuroendocrine targets for obesity therapy
    Annette D de Kloet
    Program in Neuroscience, University of Cincinnati, Cincinnati, Ohio 45237, USA
    Curr Opin Endocrinol Diabetes Obes 17:441-5. 2010
    ..This review provides a brief update on some recent advances in the characterization of neuroendocrine targets for obesity therapy...
  70. ncbi request reprint Sexually dimorphic responses to fat loss after caloric restriction or surgical lipectomy
    Haifei Shi
    University of Cincinnati, Cincinnati, OH, USA
    Am J Physiol Endocrinol Metab 293:E316-26. 2007
    ..In summary, we have found sexual dimorphisms in the response to fat loss that point to important underlying differences in the strategies by which male and female mice regulate body weight...
  71. ncbi request reprint Insulin and leptin combine additively to reduce food intake and body weight in rats
    Ellen L Air
    Department of Biomedical Sciences, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45267 0555, USA
    Endocrinology 143:2449-52. 2002
    ....
  72. pmc Mice lacking the syndecan-3 gene are resistant to diet-induced obesity
    April D Strader
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45237, USA
    J Clin Invest 114:1354-60. 2004
    ..The data implicate syndecan-3 in the regulation of body weight and suggest that inhibition of syndecan-3 may provide a therapeutic approach for the treatment of obesity resulting from exposure to high-fat diets...
  73. pmc Hydration state controls stress responsiveness and social behavior
    Eric G Krause
    Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45219, USA
    J Neurosci 31:5470-6. 2011
    ....
  74. pmc The central melanocortin system directly controls peripheral lipid metabolism
    Ruben Nogueiras
    Obesity Research Center, Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45237, USA
    J Clin Invest 117:3475-88. 2007
    ..We also reveal molecular underpinnings for direct control of the CNS-Mcr over lipid metabolism. These results suggest ways to design more efficient pharmacological methods for controlling adiposity...
  75. ncbi request reprint Metabolic and endocrine consequences of social stress in a visible burrow system
    Kellie L K Tamashiro
    Department of Psychiatry, University of Cincinnati Medical Center, 231 Albert Sabin Way, Box 670559, Cincinnati, OH 45267 0559, USA
    Physiol Behav 80:683-93. 2004
    ..In summary, the VBS model of chronic social stress is an ethologically relevant animal model and provides a valuable tool for studies of stress-related conditions and pathologies...
  76. ncbi request reprint Cloned mice have an obese phenotype not transmitted to their offspring
    Kellie L K Tamashiro
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Nat Med 8:262-7. 2002
    ..We also show that the obese phenotype is not transmitted to offspring generated by mating male and female cloned mice...
  77. ncbi request reprint Glucagon-like peptide-1 (GLP-1) receptors expressed on nerve terminals in the portal vein mediate the effects of endogenous GLP-1 on glucose tolerance in rats
    Torsten P Vahl
    Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Cincinnati, 2170 East Galbraith Road, Cincinnati, Ohio 45267, USA
    Endocrinology 148:4965-73. 2007
    ..These data are consistent with an important component of neural mediation of GLP-1 action...
  78. ncbi request reprint Acute 3rd-ventricular amylin infusion potently reduces food intake but does not produce aversive consequences
    Paul A Rushing
    Department of Psychiatry, College of Medicine, University of Cincinnati, Cincinnati, OH 45267 0559, USA
    Peptides 23:985-8. 2002
    ..In summary, these data are consistent with the conclusion that acute i3vt amylin infusion does not reduce food intake by producing aversive consequences...
  79. ncbi request reprint Gastrointestinal hormones and food intake
    April D Strader
    Genome Research Institute, University of Cincinnati Medical Center, 2170 E Galbraith Road, Cincinnati, OH 45237, USA
    Gastroenterology 128:175-91. 2005
    ....
  80. pmc High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis
    Rohit Kohli
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Hepatology 52:934-44. 2010
    ..001) levels were significantly increased in HFHC mice. Hepatic oxidative stress, as indicated by liver superoxide expression (P = 0.002), 4-hydroxynonenal, and plasma (ox)CoQ9 (P < 0.001) levels, was highest in HFHC mice...
  81. ncbi request reprint Effects of a fixed meal pattern on ghrelin secretion: evidence for a learned response independent of nutrient status
    Deborah L Drazen
    Department of Psychiatry, Genome Research Institute, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Endocrinology 147:23-30. 2006
    ..Together, these data are consistent with a role for ghrelin in the regulation of anticipatory processes involved in food intake and nutrient disposition...
  82. ncbi request reprint Mechanism of the induction of brain c-Fos-positive neurons by lipid absorption
    Chun Min Lo
    Department of Pathology, University of Cincinnati, Cincinnati, OH 45237, USA
    Am J Physiol Regul Integr Comp Physiol 292:R268-73. 2007
    ..We conclude that the formation and/or secretion of chylomicron are critical steps for initiating neuronal activation in the brain...
  83. ncbi request reprint Insulin and leptin as adiposity signals
    Stephen C Benoit
    Department of Psychiatry, University of Cincinnati Medical Center, Cincinnati, Ohio 45267, USA
    Recent Prog Horm Res 59:267-85. 2004
    ..Hence, insulin and leptin provide important negative feedback signals to the central nervous system, proportional to peripheral energy stores and coupled with catabolic circuits...
  84. ncbi request reprint [American Gastroenterological Association. Gastrointestinal hormones and food intake]
    April D Strader
    University of Cincinnati Medical Center, Genome Research Institute, Cincinnati, Ohio 45237, USA
    Rev Gastroenterol Mex 70:439-57. 2005
  85. ncbi request reprint Intraventricular (i3vt) ghrelin increases food intake in fatty Zucker rats
    Lynda M Brown
    Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45237, United States
    Peptides 28:612-6. 2007
    ..Fatty Zucker rats had 4.5 times more ghrelin receptor mRNA in the hypothalamus than lean Zucker rats, suggesting a possible mechanism for the increased sensitivity...
  86. ncbi request reprint Ethanol consumption in mice with a targeted disruption of the dopamine-3 receptor gene
    John Andrews McQuade
    Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45267 0559, USA
    Addict Biol 8:295-303. 2003
    ..Furthermore, the D3-R -/- mice adequately learn a CTA to ethanol and do not ham differing taste reactivity to saccharin or quinine. However, D3-R -/- mice do appear to have a slower rate of ethanol metabolism...
  87. pmc The effects of GLP-1 infusion in the hepatic portal region on food intake
    Dong Hoon Kim
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45237, USA
    Regul Pept 155:110-4. 2009
    ..Taken together, these data suggest that while peripheral GLP-1 may be involved in the regulation of food intake, the key GLP-1 receptors are unlikely to be those associated with vagal afferent nerves innervating the hepatic portal vein...
  88. ncbi request reprint Chronic food restriction and reduced dietary fat: risk factors for bouts of overeating
    Ryuichi Ogawa
    Obesity Research Center, Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45237 1625, USA
    Physiol Behav 86:578-85. 2005
    ..Chronic food restriction accompanied by reduced dietary fat may increase risk for bouts of overeating...
  89. ncbi request reprint The endocannabinoid system: mechanisms behind metabolic homeostasis and imbalance
    Stephen C Woods
    Obesity Research Center, University of Cincinnati, 231 Albert Sabin Way, Room G 059, Cincinnati, Ohio, 45267, USA
    Am J Med 120:S9-17; discussion S29-32. 2007
    ..Further research into the EC system is warranted to elucidate its role in metabolic homeostasis...
  90. ncbi request reprint Weight loss through ileal transposition is accompanied by increased ileal hormone secretion and synthesis in rats
    April D Strader
    Genome Research Institute, Department of Psychiatry, University of Cincinnati, 2071 E Galbraith Rd, Reading, OH 45237, USA
    Am J Physiol Endocrinol Metab 288:E447-53. 2005
    ..These findings support the importance of evaluating the contribution of gastrointestinal hormones to the weight loss seen with bariatric surgery...
  91. ncbi request reprint Dietary synergies in appetite control: distal gastrointestinal tract
    Stephen C Woods
    Department of Psychiatry, University of Cincinnati, 2170 East Galbraith Road, Cincinnati, OH 45237, USA
    Obesity (Silver Spring) 14:171S-178S. 2006
  92. doi request reprint Minireview: Endocannabinoids and their receptors as targets for obesity therapy
    Annette D de Kloet
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45237, USA
    Endocrinology 150:2531-6. 2009
    ..Although clinical trials with CB1 antagonists have yielded beneficial metabolic effects, concerns about negative affect have limited the therapeutic potential of the first class of CB1 antagonists available...
  93. ncbi request reprint The house economist and the eating paradox
    Stephen C Woods
    Department of Psychiatry, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA
    Appetite 38:161-5. 2002
    ....
  94. ncbi request reprint Intraventricular insulin potentiates the anorexic effect of corticotropin releasing hormone in rats
    Ralph D Richardson
    Veterans Affairs Puget Sound Health Care System, Seattle 98108, USA
    Am J Physiol Regul Integr Comp Physiol 283:R1321-6. 2002
    ..These findings suggest that stress-related influences over food intake, particularly those mediated via CRH, interact with relative adiposity as signaled to the brain by central insulin...
  95. ncbi request reprint Attenuated feeding responses to circadian and palatability cues in mice lacking neuropeptide Y
    Dana K Sindelar
    Department of Medicine, University of Washington, Harborview Hospital, Division of Endocrinology, Box 359757, 325 9th Avenue, Seattle, WA 98104, USA
    Peptides 26:2597-602. 2005
    ....
  96. ncbi request reprint Changes in the satiating effect of cholecystokinin over repeated trials
    Elizabeth A Duncan
    Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45237, USA
    Physiol Behav 85:387-93. 2005
    ..e., that the diminution of the effect of CCK-8 over consecutive administrations is due to the extinction of a previously learned response to endogenous CCK...
  97. ncbi request reprint Peripheral signals in the control of satiety and hunger
    Deborah L Drazen
    Department of Psychiatry, University of Cincinnati College of Medicine, 231 Albert Sabin Way, MSB G059, Cincinnati, OH 45267 0559, USA
    Curr Opin Clin Nutr Metab Care 6:621-9. 2003
    ....
  98. ncbi request reprint Insulin and the blood-brain barrier
    Stephen C Woods
    Department of Psychiatry, Box 670559, University of Cincinnati, Cincinnati, OH 45267, USA
    Curr Pharm Des 9:795-800. 2003
    ..Within the brain insulin acts on specific receptors to influence a number of behaviors, and especially caloric homeostasis and cognition...
  99. ncbi request reprint Acute third ventricular administration of insulin decreases food intake in two paradigms
    Ellen L Air
    Department of Biomedical Sciences, University of Cincinnati, Cincinnati, OH 45267, USA
    Pharmacol Biochem Behav 72:423-9. 2002
    ..These data suggest that insulin can reduce food intake in acute delivery paradigms and provide another means by which to assess the roles of other central systems in the mediation of insulin's effects on energy homeostasis...
  100. ncbi request reprint Clinical endocrinology and metabolism. Regulation of energy homeostasis by peripheral signals
    Stephen C Woods
    Department of Psychiatry, University of Cincinnati, 2170 East Galbraith Road, Cincinnati, OH 45237, USA
    Best Pract Res Clin Endocrinol Metab 18:497-515. 2004
    ..Considerable effort is being directed towards finding ways to intervene in specific circuits to help accomplish weight loss...
  101. ncbi request reprint Altered feeding responses in mice with targeted disruption of the dopamine-3 receptor gene
    Stephen C Benoit
    Department of Psychiatry, University of Cincinnati, Ohio 45267 0559, USA
    Behav Neurosci 117:46-54. 2003
    ..These results support the hypothesis that D3Rs chronically inhibit the effects of adiposity hormones, thereby contributing to a net anabolic state...