R J Woods

Summary

Affiliation: University of Georgia
Country: USA

Publications

  1. ncbi request reprint The high degree of internal flexibility observed for an oligomannose oligosaccharide does not alter the overall topology of the molecule
    R J Woods
    Complex Carbohydrate Research Center, Department of Biochemistry, University of Georgia, Athens, USA
    Eur J Biochem 258:372-86. 1998
  2. doi request reprint Computational glycoscience: characterizing the spatial and temporal properties of glycans and glycan-protein complexes
    Robert J Woods
    Complex Carbohydrate Research Center, University of Georgia, 315 Riverbend Road, Athens, GA 30602, USA
    Curr Opin Struct Biol 20:575-83. 2010
  3. ncbi request reprint Involvement of water in carbohydrate-protein binding
    C Clarke
    Complex Carbohydrate Research Center, 220 Riverbend Road, Athens, GA 30602, USA
    J Am Chem Soc 123:12238-47. 2001
  4. pmc Solvent interactions determine carbohydrate conformation
    K N Kirschner
    Complex Carbohydrate Research Center, University of Georgia, 220 Riverbend Road, Athens, GA 30606, USA
    Proc Natl Acad Sci U S A 98:10541-5. 2001
  5. ncbi request reprint The xenograft antigen in complex with GS-1-B4 lectin: crystallization and preliminary X-ray analysis
    W Tempel
    Complex Carbohydrate Research Center, The University of Georgia, 220 Riverbend Road, Athens, GA 30602, USA
    Acta Crystallogr D Biol Crystallogr 57:1639-42. 2001

Collaborators

  • A Cooper
  • C Clarke
  • W Tempel
  • K N Kirschner
  • L A Lipscomb
  • J P Rose
  • G J Boons
  • J Gluska
  • M A Nutley

Detail Information

Publications5

  1. ncbi request reprint The high degree of internal flexibility observed for an oligomannose oligosaccharide does not alter the overall topology of the molecule
    R J Woods
    Complex Carbohydrate Research Center, Department of Biochemistry, University of Georgia, Athens, USA
    Eur J Biochem 258:372-86. 1998
    ..The control exerted by the solvent over both the flexibility and overall topology of an oligosaccharide has important implications for recognition processes and for the conformational properties of glycans attached to glycoproteins...
  2. doi request reprint Computational glycoscience: characterizing the spatial and temporal properties of glycans and glycan-protein complexes
    Robert J Woods
    Complex Carbohydrate Research Center, University of Georgia, 315 Riverbend Road, Athens, GA 30602, USA
    Curr Opin Struct Biol 20:575-83. 2010
    ....
  3. ncbi request reprint Involvement of water in carbohydrate-protein binding
    C Clarke
    Complex Carbohydrate Research Center, 220 Riverbend Road, Athens, GA 30602, USA
    J Am Chem Soc 123:12238-47. 2001
    ..It is proposed that an indirect interaction through a water molecule will provide a larger number of hydrogen bonds in the complex that have higher occupancies than in bulk solution, thereby stabilizing the complex...
  4. pmc Solvent interactions determine carbohydrate conformation
    K N Kirschner
    Complex Carbohydrate Research Center, University of Georgia, 220 Riverbend Road, Athens, GA 30606, USA
    Proc Natl Acad Sci U S A 98:10541-5. 2001
    ..The results reported here provide a quantitative explanation of the conformational behavior of (1-->6)-linked carbohydrates...
  5. ncbi request reprint The xenograft antigen in complex with GS-1-B4 lectin: crystallization and preliminary X-ray analysis
    W Tempel
    Complex Carbohydrate Research Center, The University of Georgia, 220 Riverbend Road, Athens, GA 30602, USA
    Acta Crystallogr D Biol Crystallogr 57:1639-42. 2001
    ..They belong to the P2(1)2(1)2 space group, with unit-cell parameters a = 111.0, b = 51.3, c = 76.9 A, and contain two molecules per asymmetric unit...

Research Grants12

  1. COMPUTATIONAL ANALYSIS OF CARBOHYDRATE ANTIGENICITY
    Robert J Woods; Fiscal Year: 2010
    ..abstract_text> ..
  2. Integrating Experiment and Theory to Characterize Diagnostic Antibody Specificity
    Robert J Woods; Fiscal Year: 2010
    ....
  3. COMPUTATIONAL ANALYSIS OF CARBOHYDRATE ANTIGENICITY
    Robert Woods; Fiscal Year: 2006
    ..Validation of the MD simulations will be based on comparisons with NMR and X-ray data and binding affinity measurements. ..
  4. ORAL CANDIDASIS: ANTIGEN STRUCTURE AND VACCINE DESIGN
    Robert Woods; Fiscal Year: 2003
    ..Insight into the antigenic conformations of the peptides and endogenous antigens will provide a model for the further design and optimization of anti-Candida vaccines. ..
  5. COMPUTATIONAL ANALYSIS OF CARBOHYDRATE ANTIGENICITY
    Robert Woods; Fiscal Year: 2001
    ..A better understanding of the conformational properties of the serotypes may provide a basis for rational vaccine design. ..