James S Woods

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Mercury and the central nervous system
    James S Woods
    Environ Health Perspect 110:A177. 2002
  2. doi Genetic polymorphisms of catechol-O-methyltransferase modify the neurobehavioral effects of mercury in children
    James S Woods
    a Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, USA
    J Toxicol Environ Health A 77:293-312. 2014
  3. pmc Modification of neurobehavioral effects of mercury by genetic polymorphisms of metallothionein in children
    James S Woods
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA Electronic address
    Neurotoxicol Teratol 39:36-44. 2013
  4. pmc Modification of neurobehavioral effects of mercury by a genetic polymorphism of coproporphyrinogen oxidase in children
    James S Woods
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA
    Neurotoxicol Teratol 34:513-21. 2012
  5. ncbi The association between genetic polymorphisms of coproporphyrinogen oxidase and an atypical porphyrinogenic response to mercury exposure in humans
    James S Woods
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98101, USA Battelle Centers for Public Health Research and Evaluation, Seattle, WA 98105, USA
    Toxicol Appl Pharmacol 206:113-20. 2005
  6. pmc The contribution of dental amalgam to urinary mercury excretion in children
    James S Woods
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington8105, USA
    Environ Health Perspect 115:1527-31. 2007
  7. pmc Attenuation of nuclear factor kappa B (NF-kappaB) promotes apoptosis of kidney epithelial cells: a potential mechanism of mercury-induced nephrotoxicity
    James S Woods
    Center for Ecogenetics and Environmental Health, Department of Environmental Health, University of Washington, 4225 Roosevelt Way, Suite 100, Seattle, WA 98105, USA
    Environ Health Perspect 110:819-22. 2002
  8. ncbi The role of glutathione in chronic adaptation to oxidative stress: studies in a normal rat kidney epithelial (NRK52E) cell model of sustained upregulation of glutathione biosynthesis
    J S Woods
    Department of Environmental Health, University of Washington, Suite 100, Seattle, Washington, 98105, USA
    Toxicol Appl Pharmacol 160:207-16. 1999
  9. pmc Biomarkers of kidney integrity in children and adolescents with dental amalgam mercury exposure: findings from the Casa Pia children's amalgam trial
    James S Woods
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA
    Environ Res 108:393-9. 2008
  10. pmc Urinary porphyrin excretion in neurotypical and autistic children
    James S Woods
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105, USA
    Environ Health Perspect 118:1450-7. 2010

Collaborators

Detail Information

Publications50

  1. pmc Mercury and the central nervous system
    James S Woods
    Environ Health Perspect 110:A177. 2002
  2. doi Genetic polymorphisms of catechol-O-methyltransferase modify the neurobehavioral effects of mercury in children
    James S Woods
    a Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, USA
    J Toxicol Environ Health A 77:293-312. 2014
    ....
  3. pmc Modification of neurobehavioral effects of mercury by genetic polymorphisms of metallothionein in children
    James S Woods
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA Electronic address
    Neurotoxicol Teratol 39:36-44. 2013
    ....
  4. pmc Modification of neurobehavioral effects of mercury by a genetic polymorphism of coproporphyrinogen oxidase in children
    James S Woods
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA
    Neurotoxicol Teratol 34:513-21. 2012
    ..The paucity of responses among same-age girls with comparable Hg exposure provides evidence of sexual dimorphism in genetic susceptibility to the adverse neurobehavioral effects of Hg in children and adolescents...
  5. ncbi The association between genetic polymorphisms of coproporphyrinogen oxidase and an atypical porphyrinogenic response to mercury exposure in humans
    James S Woods
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98101, USA Battelle Centers for Public Health Research and Evaluation, Seattle, WA 98105, USA
    Toxicol Appl Pharmacol 206:113-20. 2005
    ..This finding represents the first report of a polymorphism in a human gene that modifies the effect of Hg on a biological process. The APR might serve as a biomarker of both Hg exposure and susceptibility to Hg toxicity...
  6. pmc The contribution of dental amalgam to urinary mercury excretion in children
    James S Woods
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington8105, USA
    Environ Health Perspect 115:1527-31. 2007
    ..Urinary mercury concentrations are widely used as a measure of mercury exposure from dental amalgam fillings. No studies have evaluated the relationship of these measures in a longitudinal context in children...
  7. pmc Attenuation of nuclear factor kappa B (NF-kappaB) promotes apoptosis of kidney epithelial cells: a potential mechanism of mercury-induced nephrotoxicity
    James S Woods
    Center for Ecogenetics and Environmental Health, Department of Environmental Health, University of Washington, 4225 Roosevelt Way, Suite 100, Seattle, WA 98105, USA
    Environ Health Perspect 110:819-22. 2002
    ....
  8. ncbi The role of glutathione in chronic adaptation to oxidative stress: studies in a normal rat kidney epithelial (NRK52E) cell model of sustained upregulation of glutathione biosynthesis
    J S Woods
    Department of Environmental Health, University of Washington, Suite 100, Seattle, Washington, 98105, USA
    Toxicol Appl Pharmacol 160:207-16. 1999
    ....
  9. pmc Biomarkers of kidney integrity in children and adolescents with dental amalgam mercury exposure: findings from the Casa Pia children's amalgam trial
    James S Woods
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA
    Environ Res 108:393-9. 2008
    ..These data also provide normative values for sensitive indices of renal functional integrity that may serve in the evaluation of children and adolescents with renal disorders...
  10. pmc Urinary porphyrin excretion in neurotypical and autistic children
    James S Woods
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105, USA
    Environ Health Perspect 118:1450-7. 2010
    ....
  11. doi Urinary porphyrin excretion in children with mercury amalgam treatment: findings from the Casa Pia Children's Dental Amalgam Trial
    James S Woods
    Department of Environmental and Occupational Health Sciences, University of Wahington, Seattle, Washington 98105, USA
    J Toxicol Environ Health A 72:891-6. 2009
    ..These findings are consistent with growing evidence supporting the sensitivity of urinary porphyrins as a biological indicator of subclinical Hg exposure in children...
  12. pmc Urinary porphyrin excretion in normal children and adolescents
    James S Woods
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105, USA
    Clin Chim Acta 405:104-9. 2009
    ..Urinary porphyrins are diagnostic of various metabolic disorders and xenobiotic exposures, but comprehensive normative data for urinary porphyrin concentrations in children are currently unavailable...
  13. pmc The association between serotonin transporter gene promotor polymorphism (5-HTTLPR) and elemental mercury exposure on mood and behavior in humans
    Diana Echeverria
    Battelle Centers for Public Health Research and Evaluation, 1100 Dexter Ave N, Suite 400, Seattle, WA 98109 3598, USA
    J Toxicol Environ Health A 73:1003-20. 2010
    ..These results add to the growing evidence of genetic determinants of mood and behavior that potentially increase susceptibility to Hg toxicity in humans...
  14. ncbi Chronic low-level mercury exposure, BDNF polymorphism, and associations with cognitive and motor function
    Diana Echeverria
    Battelle Centers for Public Health Research and Evaluation, Seattle, WA 98109, USA
    Neurotoxicol Teratol 27:781-96. 2005
    ..No associations were observed with estimates of chronic mercury exposure. Our findings are applicable to exposure levels of the general population and identify a potentially vulnerable group with a BDNF polymorphism...
  15. pmc Catechol O-methyltransferase (COMT) VAL158MET functional polymorphism, dental mercury exposure, and self-reported symptoms and mood
    Nicholas J Heyer
    Battelle Centers for Public Health Research and Evaluation, Seattle, WA, USA
    J Toxicol Environ Health A 72:599-609. 2009
    ..These findings extend evidence of genetic factors potentially affecting human susceptibility to the toxic effects of mercury and other environmental chemicals...
  16. ncbi Neurobehavioral effects of dental amalgam in children: a randomized clinical trial
    Timothy A DeRouen
    Department of Dental Public Health Sciences, School of Dentistry, University of Washington, Seattle, WA 98195, USA
    JAMA 295:1784-92. 2006
    ..No randomized clinical trials have determined whether there are significant health risks associated with this low-level mercury exposure...
  17. ncbi The association of dental caries with blood lead in children when adjusted for IQ and neurobehavioral performance
    Michael D Martin
    Box 356370, Department of Oral Medicine, University of Washington, Seattle, WA 98195, USA
    Sci Total Environ 377:159-64. 2007
    ....
  18. pmc The association between serotonin transporter gene promoter polymorphism (5-HTTLPR), self-reported symptoms, and dental mercury exposure
    Nicholas J Heyer
    Battelle Centers for Public Health Research and Evaluation, Seattle, Washington 98109 3598, USA
    J Toxicol Environ Health A 71:1318-26. 2008
    ..These findings suggest that within this restricted population increased symptoms of depression, anxiety, and memory are associated with the 5-HTTLPR polymorphism among both males and females...
  19. ncbi Longitudinal urinary creatinine excretion values among preadolescents and adolescents
    Michael D Martin
    Department of Oral Medicine, University of Washington, Seattle, Wash 98115, USA
    Transl Res 151:51-6. 2008
    ..No sexual differences are observed, although blacks excrete significantly higher levels of urinary creatinine than do whites...
  20. ncbi A cascade analysis of the interaction of mercury and coproporphyrinogen oxidase (CPOX) polymorphism on the heme biosynthetic pathway and porphyrin production
    Nicholas J Heyer
    Battelle Centers for Public Health Research and Evaluation, 1100 Dexter Avenue N, Suite 400, Seattle, WA 98109, USA
    Toxicol Lett 161:159-66. 2006
    ..Additionally, these findings demonstrate the successful application of a computational model for characterizing complex metabolic responses and interactions associated with both toxicant exposure and genetic variation in human subjects...
  21. ncbi Chronic low-level mercury exposure, BDNF polymorphism, and associations with self-reported symptoms and mood
    Nicholas J Heyer
    Battelle Centers for Public Health Research and Evaluation, Seattle, Washington, USA
    Toxicol Sci 81:354-63. 2004
    ..The BDNF polymorphism is also associated with increased symptom and mood scores. Notably, Hg degrees and BDNF polymorphism were additive with respect to their associations with the same symptom group...
  22. pmc Disordered porphyrin metabolism: a potential biological marker for autism risk assessment
    Nicholas J Heyer
    Battelle Centers for Public Health Research and Evaluation, Seattle, Washington, USA
    Autism Res 5:84-92. 2012
    ....
  23. ncbi RhoA regulation of NF-kappaB activation is mediated by COX-2-dependent feedback inhibition of IKK in kidney epithelial cells
    William W Polk
    Dept of Environmental and Occupational Health Sciences, Univ of Washington, 4225 Roosevelt Way NE, Suite 100, Seattle, WA 98105, USA
    Am J Physiol Cell Physiol 293:C1160-70. 2007
    ....
  24. ncbi Issues in design and analysis of a randomized clinical trial to assess the safety of dental amalgam restorations in children
    Timothy A DeRouen
    Department of Dental Public Health Sciences, University of Washington, Seattle, WA 98195 7475, USA
    Control Clin Trials 23:301-20. 2002
    ..Approaches taken to address these and other design issues are described...
  25. pmc Cloning, expression, and biochemical properties of CPOX4, a genetic variant of coproporphyrinogen oxidase that affects susceptibility to mercury toxicity in humans
    Tingting Li
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105, USA
    Toxicol Sci 109:228-36. 2009
    ..These effects may underlie increased susceptibility to neurological deficits previously observed in Hg-exposed humans with CPOX4...
  26. ncbi The safety of dental amalgam in children
    Michael D Martin
    Associate Professor of Oral Medicine, University of Washington, School of Dentistry, Department of Oral Medicine, Box 356370, Seattle, WA 98195, USA
    Expert Opin Drug Saf 5:773-81. 2006
    ..The purpose of this review is to discuss the scientific evidence on the safety of the use of mercury-containing dental amalgam as a treatment for dental caries...
  27. ncbi Nuclear factor kappaB activation by muscarinic receptors in astroglial cells: effect of ethanol
    M Guizzetti
    Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way Northeast 100, Seattle, WA 98105, USA
    Neuroscience 120:941-50. 2003
    ....
  28. ncbi Mercuric ion attenuates nuclear factor-kappaB activation and DNA binding in normal rat kidney epithelial cells: implications for mercury-induced nephrotoxicity
    F J Dieguez-Acuna
    Center for Ecogenetics and Environmental Health, University of Washington, Seattle, Washington, 98105, USA
    Toxicol Appl Pharmacol 173:176-87. 2001
    ..Attenuation of NF-kappaB activation by Hg(2+) through these mechanisms may underlie apoptotic or other cytotoxic responses that are known to be associated with low level Hg(2+) exposure in kidney epithelial cells...
  29. pmc Environmental chemical exposures and disturbances of heme synthesis
    W E Daniell
    Department of Environmental Health, University of Washington, Seattle 98195 7234, USA
    Environ Health Perspect 105:37-53. 1997
    ..This review discusses the limitations of laboratory measures of heme synthesis, and diagnostic guidelines are provided to assist in evaluating the symptomatic individual suspected of having a porphyria...
  30. ncbi Mercury exposure from dental filling placement during pregnancy and low birth weight risk
    P P Hujoel
    Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA 98195 7475, USA
    Am J Epidemiol 161:734-40. 2005
    ..00, 95% confidence interval: 0.27, 3.68). This study found no evidence that mercury-containing dental fillings placed during pregnancy increased low-birth-weight risk...
  31. ncbi Test-retest reliability and factor stability of the behavioral evaluation for epidemiology studies test battery
    Diana Echeverria
    Battelle Center for Public Health Research and Evaluation, Seattle, WA 98105, USA
    Percept Mot Skills 95:845-67. 2002
    ..These results strongly support recommendation of the new test battery for use in repeated-measures epidemiologic studies where first trial stability is desired...
  32. ncbi Stimulation of porphyrinogen oxidation by mercuric ion. I. Evidence of free radical formation in the presence of thiols and hydrogen peroxide
    J S Woods
    Department of Environmental Health, University of Washington, Seattle 98195
    Mol Pharmacol 38:253-60. 1990
    ..These findings suggest a mechanistic basis underlying the porphyrinogenic as well as tissue-damaging properties of mercuric ions...
  33. ncbi Redox activities of mercury-thiol complexes: implications for mercury-induced porphyria and toxicity
    D M Miller
    Department of Environmental Health, School of Public Health and Community Medicine, University of Washington, Seattle 98195
    Chem Biol Interact 88:23-35. 1993
    ..These findings suggest that mercury-thiol complexes possess redox activity in biological systems, which promotes the oxidation of porphyrinogens and possibly other biomolecules...
  34. ncbi Quantitative evaluation of urinary porphyrins as a measure of kidney mercury content and mercury body burden during prolonged methylmercury exposure in rats
    S D Pingree
    Department of Environmental Health, University of Washington, 4225 Roosevelt Way NE, Suite 100, Seattle, Washington 98105, USA
    Toxicol Sci 61:234-40. 2001
    ..These findings demonstrate that urinary porphyrin concentrations relate quantitatively to DMPS-mobilizable mercury in the kidney and, therefore, serve as a biochemical measure of renal mercury content...
  35. ncbi Studies on Hg(II)-induced H2O2 formation and oxidative stress in vivo and in vitro in rat kidney mitochondria
    B O Lund
    Department of Environmental Health, University of Washington, Seattle 98195
    Biochem Pharmacol 45:2017-24. 1993
    ..Moreover, Hg(II)-induced alterations in mitochondrial Ca2+ homeostasis may exacerbate Hg(II)-induced oxidative stress in kidney cells...
  36. ncbi Iron stimulation of free radical-mediated porphyrinogen oxidation by hepatic and renal mitochondria
    J S Woods
    Department of Environmental Health, School of Public Health and Community Medicine, University of Washington, Seattle 98195
    Biochem Biophys Res Commun 160:101-8. 1989
    ..These observations suggest a mechanism by which iron could contribute to excess porphyrin excretion in various inherited or chemically-induced porphyrias...
  37. ncbi Stimulation of porphyrinogen oxidation by mercuric ion. II. Promotion of oxidation from the interaction of mercuric ion, glutathione, and mitochondria-generated hydrogen peroxide
    J S Woods
    Department of Environmental Health, University of Washington, Seattle 98195
    Mol Pharmacol 38:261-6. 1990
    ..These results suggest a mechanistic explanation for the porphyrinogenic action of mercury compounds, as well as for the oxidative damage to target cell constituents associated with mercury exposure...
  38. ncbi Attenuation of porphyrinogen oxidation by glutathione in vitro and reversal by porphyrinogenic trace metals
    J S Woods
    Department of Environmental Health, School of Public Health and Community Medicine, University of Washington, Seattle 98195
    Biochem Biophys Res Commun 152:1428-34. 1988
    ..These observations may, in part, underlie the etiology of porphyrinurias induced during prolonged trace metal exposures...
  39. ncbi Urinary porphyrins as biological indicators of oxidative stress in the kidney. Interaction of mercury and cephaloridine
    D M Miller
    Department of Environmental Health, University of Washington, Seattle 98195
    Biochem Pharmacol 46:2235-41. 1993
    ..Increased urinary porphyrin levels may, therefore, represent a sensitive indicator of oxidative stress in the kidney in vivo...
  40. ncbi Effects of ozone exposure on nuclear factor-kappaB activation and tumor necrosis factor-alpha expression in human nasal epithelial cells
    B G Nichols
    Department of Environmental Health, University of Washington, Seattle, Washington, USA
    Toxicol Sci 60:356-62. 2001
    ..These results support the hypothesis that the human airway epithelium plays a role in directing the inflammatory response to inhaled O(3) via free radical-mediated NF-kappaB activation...
  41. ncbi Effects of 2,3-dimercapto-1-propanesulfonic acid (DMPS) on tissue and urine mercury levels following prolonged methylmercury exposure in rats
    S D Pingree
    Department of Environmental Health, University of Washington, 4225 Roosevelt Way NE, Suite 100, Seattle, Washington 98105, USA
    Toxicol Sci 61:224-33. 2001
    ..In light of this observation, the inability of DMPS to reduce Hg2+ levels in brain or blood may explain the inefficacy of DMPS and similar chelating agents in the remediation of neurotoxicity associated with prolonged MMH exposure...
  42. ncbi Inhibition of NF-kappaB-DNA binding by mercuric ion: utility of the non-thiol reductant, tris(2-carboxyethyl)phosphine hydrochloride (TCEP), on detection of impaired NF-kappaB-DNA binding by thiol-directed agents
    F J Dieguez-Acuna
    Department of Environmental Health, 4225 Roosevelt Way NE, Suite 100, University of Washington, Seattle, WA 98105, USA
    Toxicol In Vitro 14:7-16. 2000
    ..They also demonstrate inhibition of NF-kappaB-DNA binding at Hg(2+) concentrations comparable to those known to initiate toxicity and apoptotic cell death in vivo...
  43. ncbi Quantitative measurement of porphyrins in biological tissues and evaluation of tissue porphyrins during toxicant exposures
    J S Woods
    Department of Environmental Health, School of Public Health and Community Medicine, University of Washington, Seattle 98195
    Fundam Appl Toxicol 21:291-7. 1993
    ..This method is applicable to the measurement of tissue porphyrin changes resulting from drug or toxicant exposures in clinical, experimental or environmental assessments...
  44. ncbi Studies on the etiology of trace metal-induced porphyria: effects of porphyrinogenic metals on coproporphyrinogen oxidase in rat liver and kidney
    J S Woods
    Department of Environmental Health, University of Washington, Seattle 98195
    Toxicol Appl Pharmacol 97:183-90. 1989
    ..These observations demonstrate that metal-induced coproporphyrinuria is predominantly of renal etiology and that impairment of renal coproporphyrinogen oxidase is a principal cause of this effect...
  45. ncbi Examination of dietary methylmercury exposure in the Casa Pia Study of the health effects of dental amalgams in children
    C C Evens
    Department of Oral Medicine, University of Washington, Seattle 98195, USA
    J Toxicol Environ Health A 64:521-30. 2001
    ..The present findings indicate that dietary methylmercury is not a significant source of mercury exposure and is not likely to confound the association of dental amalgam mercury with potential health effects in the present study...
  46. ncbi Genetic polymorphisms of superoxide dismutase in Parkinson's disease
    F M Farin
    Department of Environmental Health, University of Washington, Seattle, Washington 98195 7234, USA
    Mov Disord 16:705-7. 2001
    ..These results indicate that SOD gene variants do not contribute to PD pathogenesis...
  47. ncbi The association between a genetic polymorphism of coproporphyrinogen oxidase, dental mercury exposure and neurobehavioral response in humans
    Diana Echeverria
    Battelle Centers for Public Health Research and Evaluation, 1100 Dexter Avenue North, Suite 400, Seattle, WA 98109, United States
    Neurotoxicol Teratol 28:39-48. 2006
    ..These exploratory findings suggest that the CPOX4 polymorphism may affect susceptibility for specific neurobehavioral functions associated with mercury exposure in human subjects...
  48. ncbi Nuclear factor kappaB activity determines the sensitivity of kidney epithelial cells to apoptosis: implications for mercury-induced renal failure
    Francisco J Dieguez-Acuna
    Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA
    Toxicol Sci 82:114-23. 2004
    ....
  49. ncbi Neurological outcomes in children with and without amalgam-related mercury exposure: seven years of longitudinal observations in a randomized trial
    Martin Lauterbach
    Laboratorio de Estudios de Linguagem, Faculty of Medicine, University of Lisbon, Portugal
    J Am Dent Assoc 139:138-45. 2008
    ....
  50. ncbi Mercury exposure in an urban pediatric population
    Philip O Ozuah
    Albert Einstein College of Medicine Children s Hospital at Montefiore, Bronx, NY 10467, USA
    Ambul Pediatr 3:24-6. 2003
    ..To determine the prevalence of elevated urinary mercury (Hg), as a marker of exposure, in a population of children drawn from an inner-city community with documented access to elemental mercury...