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Genomes and Genes | James S WoodsSummaryAffiliation: University of Washington Country: USA Publications
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Publications
Mercury and the central nervous systemJames S Woods
Environ Health Perspect 110:A177. 2002- Modification of neurobehavioral effects of mercury by a genetic polymorphism of coproporphyrinogen oxidase in childrenJames S Woods
Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA
Neurotoxicol Teratol 34:513-21. 2012..The paucity of responses among same-age girls with comparable Hg exposure provides evidence of sexual dimorphism in genetic susceptibility to the adverse neurobehavioral effects of Hg in children and adolescents... - Biomarkers of kidney integrity in children and adolescents with dental amalgam mercury exposure: findings from the Casa Pia children's amalgam trialJames S Woods
Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA
Environ Res 108:393-9. 2008..These data also provide normative values for sensitive indices of renal functional integrity that may serve in the evaluation of children and adolescents with renal disorders... 
The role of glutathione in chronic adaptation to oxidative stress: studies in a normal rat kidney epithelial (NRK52E) cell model of sustained upregulation of glutathione biosynthesisJ S Woods
Department of Environmental Health, University of Washington, Suite 100, Seattle, Washington, 98105, USA
Toxicol Appl Pharmacol 160:207-16. 1999....- Urinary porphyrin excretion in normal children and adolescentsJames S Woods
Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105, USA
Clin Chim Acta 405:104-9. 2009..Urinary porphyrins are diagnostic of various metabolic disorders and xenobiotic exposures, but comprehensive normative data for urinary porphyrin concentrations in children are currently unavailable... - The contribution of dental amalgam to urinary mercury excretion in childrenJames S Woods
Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington8105, USA
Environ Health Perspect 115:1527-31. 2007..Urinary mercury concentrations are widely used as a measure of mercury exposure from dental amalgam fillings. No studies have evaluated the relationship of these measures in a longitudinal context in children... 
Urinary porphyrin excretion in children with mercury amalgam treatment: findings from the Casa Pia Children's Dental Amalgam TrialJames S Woods
Department of Environmental and Occupational Health Sciences, University of Wahington, Seattle, Washington 98105, USA
J Toxicol Environ Health A 72:891-6. 2009..These findings are consistent with growing evidence supporting the sensitivity of urinary porphyrins as a biological indicator of subclinical Hg exposure in children...- Urinary porphyrin excretion in neurotypical and autistic childrenJames S Woods
Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105, USA
Environ Health Perspect 118:1450-7. 2010.... - Attenuation of nuclear factor kappa B (NF-kappaB) promotes apoptosis of kidney epithelial cells: a potential mechanism of mercury-induced nephrotoxicityJames S Woods
Center for Ecogenetics and Environmental Health, Department of Environmental Health, University of Washington, 4225 Roosevelt Way, Suite 100, Seattle, WA 98105, USA
Environ Health Perspect 110:819-22. 2002.... - The association between genetic polymorphisms of coproporphyrinogen oxidase and an atypical porphyrinogenic response to mercury exposure in humansJames S Woods
Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98101, USA Battelle Centers for Public Health Research and Evaluation, Seattle, WA 98105, USA
Toxicol Appl Pharmacol 206:113-20. 2005..This finding represents the first report of a polymorphism in a human gene that modifies the effect of Hg on a biological process. The APR might serve as a biomarker of both Hg exposure and susceptibility to Hg toxicity... - The association between serotonin transporter gene promotor polymorphism (5-HTTLPR) and elemental mercury exposure on mood and behavior in humansDiana Echeverria
Battelle Centers for Public Health Research and Evaluation, 1100 Dexter Ave N, Suite 400, Seattle, WA 98109 3598, USA
J Toxicol Environ Health A 73:1003-20. 2010..These results add to the growing evidence of genetic determinants of mood and behavior that potentially increase susceptibility to Hg toxicity in humans... - Catechol O-methyltransferase (COMT) VAL158MET functional polymorphism, dental mercury exposure, and self-reported symptoms and moodNicholas J Heyer
Battelle Centers for Public Health Research and Evaluation, Seattle, WA, USA
J Toxicol Environ Health A 72:599-609. 2009..These findings extend evidence of genetic factors potentially affecting human susceptibility to the toxic effects of mercury and other environmental chemicals... - Chronic low-level mercury exposure, BDNF polymorphism, and associations with cognitive and motor functionDiana Echeverria
Battelle Centers for Public Health Research and Evaluation, Seattle, WA 98109, USA
Neurotoxicol Teratol 27:781-96. 2005..No associations were observed with estimates of chronic mercury exposure. Our findings are applicable to exposure levels of the general population and identify a potentially vulnerable group with a BDNF polymorphism... - Longitudinal urinary creatinine excretion values among preadolescents and adolescentsMichael D Martin
Department of Oral Medicine, University of Washington, Seattle, Wash 98115, USA
Transl Res 151:51-6. 2008..No sexual differences are observed, although blacks excrete significantly higher levels of urinary creatinine than do whites... - The association between serotonin transporter gene promoter polymorphism (5-HTTLPR), self-reported symptoms, and dental mercury exposureNicholas J Heyer
Battelle Centers for Public Health Research and Evaluation, Seattle, Washington 98109 3598, USA
J Toxicol Environ Health A 71:1318-26. 2008..These findings suggest that within this restricted population increased symptoms of depression, anxiety, and memory are associated with the 5-HTTLPR polymorphism among both males and females... - Neurobehavioral effects of dental amalgam in children: a randomized clinical trialTimothy A DeRouen
Department of Dental Public Health Sciences, School of Dentistry, University of Washington, Seattle, WA 98195, USA
JAMA 295:1784-92. 2006..No randomized clinical trials have determined whether there are significant health risks associated with this low-level mercury exposure... - The association of dental caries with blood lead in children when adjusted for IQ and neurobehavioral performanceMichael D Martin
Box 356370, Department of Oral Medicine, University of Washington, Seattle, WA 98195, USA
Sci Total Environ 377:159-64. 2007.... - A cascade analysis of the interaction of mercury and coproporphyrinogen oxidase (CPOX) polymorphism on the heme biosynthetic pathway and porphyrin productionNicholas J Heyer
Battelle Centers for Public Health Research and Evaluation, 1100 Dexter Avenue N, Suite 400, Seattle, WA 98109, USA
Toxicol Lett 161:159-66. 2006..Additionally, these findings demonstrate the successful application of a computational model for characterizing complex metabolic responses and interactions associated with both toxicant exposure and genetic variation in human subjects... - Chronic low-level mercury exposure, BDNF polymorphism, and associations with self-reported symptoms and moodNicholas J Heyer
Battelle Centers for Public Health Research and Evaluation, Seattle, Washington, USA
Toxicol Sci 81:354-63. 2004..The BDNF polymorphism is also associated with increased symptom and mood scores. Notably, Hg degrees and BDNF polymorphism were additive with respect to their associations with the same symptom group... - Disordered porphyrin metabolism: a potential biological marker for autism risk assessmentNicholas J Heyer
Battelle Centers for Public Health Research and Evaluation, Seattle, Washington, USA
Autism Res 5:84-92. 2012.... - RhoA regulation of NF-kappaB activation is mediated by COX-2-dependent feedback inhibition of IKK in kidney epithelial cellsWilliam W Polk
Dept of Environmental and Occupational Health Sciences, Univ of Washington, 4225 Roosevelt Way NE, Suite 100, Seattle, WA 98105, USA
Am J Physiol Cell Physiol 293:C1160-70. 2007.... - Issues in design and analysis of a randomized clinical trial to assess the safety of dental amalgam restorations in childrenTimothy A DeRouen
Department of Dental Public Health Sciences, University of Washington, Seattle, WA 98195 7475, USA
Control Clin Trials 23:301-20. 2002..Approaches taken to address these and other design issues are described... - Cloning, expression, and biochemical properties of CPOX4, a genetic variant of coproporphyrinogen oxidase that affects susceptibility to mercury toxicity in humansTingting Li
Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105, USA
Toxicol Sci 109:228-36. 2009..These effects may underlie increased susceptibility to neurological deficits previously observed in Hg-exposed humans with CPOX4... - The safety of dental amalgam in childrenMichael D Martin
Associate Professor of Oral Medicine, University of Washington, School of Dentistry, Department of Oral Medicine, Box 356370, Seattle, WA 98195, USA
Expert Opin Drug Saf 5:773-81. 2006..The purpose of this review is to discuss the scientific evidence on the safety of the use of mercury-containing dental amalgam as a treatment for dental caries... - Mercury exposure from dental filling placement during pregnancy and low birth weight riskP P Hujoel
Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA 98195 7475, USA
Am J Epidemiol 161:734-40. 2005..00, 95% confidence interval: 0.27, 3.68). This study found no evidence that mercury-containing dental fillings placed during pregnancy increased low-birth-weight risk... - Nuclear factor kappaB activation by muscarinic receptors in astroglial cells: effect of ethanolM Guizzetti
Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way Northeast 100, Seattle, WA 98105, USA
Neuroscience 120:941-50. 2003.... - Mercuric ion attenuates nuclear factor-kappaB activation and DNA binding in normal rat kidney epithelial cells: implications for mercury-induced nephrotoxicityF J Dieguez-Acuna
Center for Ecogenetics and Environmental Health, University of Washington, Seattle, Washington, 98105, USA
Toxicol Appl Pharmacol 173:176-87. 2001..Attenuation of NF-kappaB activation by Hg(2+) through these mechanisms may underlie apoptotic or other cytotoxic responses that are known to be associated with low level Hg(2+) exposure in kidney epithelial cells... - Environmental chemical exposures and disturbances of heme synthesisW E Daniell
Department of Environmental Health, University of Washington, Seattle 98195 7234, USA
Environ Health Perspect 105:37-53. 1997..This review discusses the limitations of laboratory measures of heme synthesis, and diagnostic guidelines are provided to assist in evaluating the symptomatic individual suspected of having a porphyria... - Test-retest reliability and factor stability of the behavioral evaluation for epidemiology studies test batteryDiana Echeverria
Battelle Center for Public Health Research and Evaluation, Seattle, WA 98105, USA
Percept Mot Skills 95:845-67. 2002..These results strongly support recommendation of the new test battery for use in repeated-measures epidemiologic studies where first trial stability is desired... - Quantitative evaluation of urinary porphyrins as a measure of kidney mercury content and mercury body burden during prolonged methylmercury exposure in ratsS D Pingree
Department of Environmental Health, University of Washington, 4225 Roosevelt Way NE, Suite 100, Seattle, Washington 98105, USA
Toxicol Sci 61:234-40. 2001..These findings demonstrate that urinary porphyrin concentrations relate quantitatively to DMPS-mobilizable mercury in the kidney and, therefore, serve as a biochemical measure of renal mercury content... - Redox activities of mercury-thiol complexes: implications for mercury-induced porphyria and toxicityD M Miller
Department of Environmental Health, School of Public Health and Community Medicine, University of Washington, Seattle 98195
Chem Biol Interact 88:23-35. 1993..These findings suggest that mercury-thiol complexes possess redox activity in biological systems, which promotes the oxidation of porphyrinogens and possibly other biomolecules... - Stimulation of porphyrinogen oxidation by mercuric ion. I. Evidence of free radical formation in the presence of thiols and hydrogen peroxideJ S Woods
Department of Environmental Health, University of Washington, Seattle 98195
Mol Pharmacol 38:253-60. 1990..These findings suggest a mechanistic basis underlying the porphyrinogenic as well as tissue-damaging properties of mercuric ions... - Stimulation of porphyrinogen oxidation by mercuric ion. II. Promotion of oxidation from the interaction of mercuric ion, glutathione, and mitochondria-generated hydrogen peroxideJ S Woods
Department of Environmental Health, University of Washington, Seattle 98195
Mol Pharmacol 38:261-6. 1990..These results suggest a mechanistic explanation for the porphyrinogenic action of mercury compounds, as well as for the oxidative damage to target cell constituents associated with mercury exposure... - Iron stimulation of free radical-mediated porphyrinogen oxidation by hepatic and renal mitochondriaJ S Woods
Department of Environmental Health, School of Public Health and Community Medicine, University of Washington, Seattle 98195
Biochem Biophys Res Commun 160:101-8. 1989..These observations suggest a mechanism by which iron could contribute to excess porphyrin excretion in various inherited or chemically-induced porphyrias... - Attenuation of porphyrinogen oxidation by glutathione in vitro and reversal by porphyrinogenic trace metalsJ S Woods
Department of Environmental Health, School of Public Health and Community Medicine, University of Washington, Seattle 98195
Biochem Biophys Res Commun 152:1428-34. 1988..These observations may, in part, underlie the etiology of porphyrinurias induced during prolonged trace metal exposures... - Studies on Hg(II)-induced H2O2 formation and oxidative stress in vivo and in vitro in rat kidney mitochondriaB O Lund
Department of Environmental Health, University of Washington, Seattle 98195
Biochem Pharmacol 45:2017-24. 1993..Moreover, Hg(II)-induced alterations in mitochondrial Ca2+ homeostasis may exacerbate Hg(II)-induced oxidative stress in kidney cells... - Effects of ozone exposure on nuclear factor-kappaB activation and tumor necrosis factor-alpha expression in human nasal epithelial cellsB G Nichols
Department of Environmental Health, University of Washington, Seattle, Washington, USA
Toxicol Sci 60:356-62. 2001..These results support the hypothesis that the human airway epithelium plays a role in directing the inflammatory response to inhaled O(3) via free radical-mediated NF-kappaB activation... - Effects of 2,3-dimercapto-1-propanesulfonic acid (DMPS) on tissue and urine mercury levels following prolonged methylmercury exposure in ratsS D Pingree
Department of Environmental Health, University of Washington, 4225 Roosevelt Way NE, Suite 100, Seattle, Washington 98105, USA
Toxicol Sci 61:224-33. 2001..In light of this observation, the inability of DMPS to reduce Hg2+ levels in brain or blood may explain the inefficacy of DMPS and similar chelating agents in the remediation of neurotoxicity associated with prolonged MMH exposure... - Urinary porphyrins as biological indicators of oxidative stress in the kidney. Interaction of mercury and cephaloridineD M Miller
Department of Environmental Health, University of Washington, Seattle 98195
Biochem Pharmacol 46:2235-41. 1993..Increased urinary porphyrin levels may, therefore, represent a sensitive indicator of oxidative stress in the kidney in vivo... - Inhibition of NF-kappaB-DNA binding by mercuric ion: utility of the non-thiol reductant, tris(2-carboxyethyl)phosphine hydrochloride (TCEP), on detection of impaired NF-kappaB-DNA binding by thiol-directed agentsF J Dieguez-Acuna
Department of Environmental Health, 4225 Roosevelt Way NE, Suite 100, University of Washington, Seattle, WA 98105, USA
Toxicol In Vitro 14:7-16. 2000..They also demonstrate inhibition of NF-kappaB-DNA binding at Hg(2+) concentrations comparable to those known to initiate toxicity and apoptotic cell death in vivo... - Studies on the etiology of trace metal-induced porphyria: effects of porphyrinogenic metals on coproporphyrinogen oxidase in rat liver and kidneyJ S Woods
Department of Environmental Health, University of Washington, Seattle 98195
Toxicol Appl Pharmacol 97:183-90. 1989..These observations demonstrate that metal-induced coproporphyrinuria is predominantly of renal etiology and that impairment of renal coproporphyrinogen oxidase is a principal cause of this effect... - Quantitative measurement of porphyrins in biological tissues and evaluation of tissue porphyrins during toxicant exposuresJ S Woods
Department of Environmental Health, School of Public Health and Community Medicine, University of Washington, Seattle 98195
Fundam Appl Toxicol 21:291-7. 1993..This method is applicable to the measurement of tissue porphyrin changes resulting from drug or toxicant exposures in clinical, experimental or environmental assessments... - Genetic polymorphisms of superoxide dismutase in Parkinson's diseaseF M Farin
Department of Environmental Health, University of Washington, Seattle, Washington 98195 7234, USA
Mov Disord 16:705-7. 2001..These results indicate that SOD gene variants do not contribute to PD pathogenesis... - Examination of dietary methylmercury exposure in the Casa Pia Study of the health effects of dental amalgams in childrenC C Evens
Department of Oral Medicine, University of Washington, Seattle 98195, USA
J Toxicol Environ Health A 64:521-30. 2001..The present findings indicate that dietary methylmercury is not a significant source of mercury exposure and is not likely to confound the association of dental amalgam mercury with potential health effects in the present study... - Neurological outcomes in children with and without amalgam-related mercury exposure: seven years of longitudinal observations in a randomized trialMartin Lauterbach
Laboratorio de Estudios de Linguagem, Faculty of Medicine, University of Lisbon, Portugal
J Am Dent Assoc 139:138-45. 2008.... - Nuclear factor kappaB activity determines the sensitivity of kidney epithelial cells to apoptosis: implications for mercury-induced renal failureFrancisco J Dieguez-Acuna
Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA
Toxicol Sci 82:114-23. 2004.... - The association between a genetic polymorphism of coproporphyrinogen oxidase, dental mercury exposure and neurobehavioral response in humansDiana Echeverria
Battelle Centers for Public Health Research and Evaluation, 1100 Dexter Avenue North, Suite 400, Seattle, WA 98109, United States
Neurotoxicol Teratol 28:39-48. 2006..These exploratory findings suggest that the CPOX4 polymorphism may affect susceptibility for specific neurobehavioral functions associated with mercury exposure in human subjects... - Mercury exposure in an urban pediatric populationPhilip O Ozuah
Albert Einstein College of Medicine Children s Hospital at Montefiore, Bronx, NY 10467, USA
Ambul Pediatr 3:24-6. 2003..To determine the prevalence of elevated urinary mercury (Hg), as a marker of exposure, in a population of children drawn from an inner-city community with documented access to elemental mercury...