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Genomes and Genes | Prescott G WoodruffSummaryAffiliation: University of California Country: USA Publications
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Publications
Gene expression in asthmatic airway smooth musclePrescott G Woodruff
Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0111, USA
Proc Am Thorac Soc 5:113-8. 2008..g., protein phosphorylation). Thus, gene expression studies ultimately must be integrated with other methodological approaches to adequately study airway smooth muscle in asthma in vivo...
Hyperplasia of smooth muscle in mild to moderate asthma without changes in cell size or gene expressionPrescott G Woodruff
Division of Pulmonary and Critical Care Medicine, Department of Medicine, and Cardiovascular Research Institute, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA
Am J Respir Crit Care Med 169:1001-6. 2004..However, smooth muscle cells in mild to moderate asthma do not show hypertrophy or gene expression changes of a hypercontractile phenotype observed in vitro...- T-helper type 2-driven inflammation defines major subphenotypes of asthmaPrescott G Woodruff
Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, San Francisco, CA 94143 0111, USA
Am J Respir Crit Care Med 180:388-95. 2009..However, clinical studies increasingly suggest that asthma is heterogeneous... - Accumulation of intraepithelial mast cells with a unique protease phenotype in T(H)2-high asthmaRyan H Dougherty
Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, CA, USA
J Allergy Clin Immunol 125:1046-1053.e8. 2010..We also found that asthmatic subjects can be divided into 2 subgroups ("T(H)2 high" and "T(H)2 low" asthma) based on epithelial cell gene signatures for the activity of T(H)2 cytokines... - Chitotriosidase is the primary active chitinase in the human lung and is modulated by genotype and smoking habitMax A Seibold
Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, CA 94143, USA
J Allergy Clin Immunol 122:944-950.e3. 2008..Acidic mammalian chitinase (AMCase) and chitotriosidase (CHIT1) have chitinolytic activity, but relatively little is known about their expression in human asthma... - Epithelial mucin stores are increased in the large airways of smokers with airflow obstructionAnh L Innes
Department of Medicine, Division of Pulmonary and Critical Care Medicine, Cardiovascular Research Institute, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA 94143, USA
Chest 130:1102-8. 2006..The highest epithelial mucin stores are found in smokers with airflow obstruction, suggesting a mechanistic link between epithelial mucin dysregulation and airflow obstruction... - Distinct roles of FOXA2 and FOXA3 in allergic airway disease and asthmaSung Woo Park
Lung Biology Center, University of California San Francisco, San Francisco, California 94143, USA
Am J Respir Crit Care Med 180:603-10. 2009..IL-13-driven mucous cell metaplasia is associated with decreased expression of the transcription factor FOXA2 and increased expression of the related transcription factor FOXA3 in animal and cell culture models... 
DAP12 is required for macrophage recruitment to the lung in response to cigarette smoke and chemotaxis toward CCL2Laura L Koth
Division of Pulmonary and Critical Care Medicine, Lung Biology Center, University of California at San Francisco, San Francisco, CA 94143, USA
J Immunol 184:6522-8. 2010..These findings indicate that DAP12, possibly through association with TREM2, contributes to alveolar macrophage chemotaxis and recruitment to the lung and may mediate macrophage accumulation in lung diseases such as emphysema...- Roles of epithelial cell-derived periostin in TGF-beta activation, collagen production, and collagen gel elasticity in asthmaSukhvinder S Sidhu
Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 107:14170-5. 2010..Epithelial cell-derived periostin in asthma has roles in TGF-beta activation and collagen gel elasticity in asthma... - Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroidsPrescott G Woodruff
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 104:15858-63. 2007.... - Sarcoidosis blood transcriptome reflects lung inflammation and overlaps with tuberculosisLaura L Koth
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California, USA
Am J Respir Crit Care Med 184:1153-63. 2011..Sarcoidosis is a granulomatous disease of unknown etiology, although M. tuberculosis may play a role in the pathogenesis. The traditional view holds that inflammation in sarcoidosis is compartmentalized to involved organs... - Alveolar macrophage recruitment and activation by chronic second hand smoke exposure in micePrescott G Woodruff
Division of Pulmonary and Critical Care Medicine, Dept of Medicine and Cardiovascular Research Institute, UCSF, San Francisco, California 94143, USA
COPD 6:86-94. 2009..These findings indicate that second smoke exposure can cause macrophage recruitment and activation, providing a biological link between second-hand smoke exposure and the development of inflammatory processes linked to COPD... - A distinctive alveolar macrophage activation state induced by cigarette smokingPrescott G Woodruff
UCSF Mission Bay Rock Hall, Room 545, 1550 4th Street, San Francisco, CA 94158, USA
Am J Respir Crit Care Med 172:1383-92. 2005..Macrophages are believed to play a central role in emphysema based largely on data from mouse models. However, the relevance of these models to smoking-related lung disease in humans is uncertain... - The H antigen at epithelial surfaces is associated with susceptibility to asthma exacerbationAnh L Innes
The Cardiovascular Research Institute, University of California, San Francisco, California, USA
Am J Respir Crit Care Med 183:189-94. 2011..Acute asthma exacerbations, precipitated by viral infections, are a significant cause of morbidity, but not all patients with asthma are equally susceptible... - Human asthma phenotypes: from the clinic, to cytokines, and back againNirav R Bhakta
Division of Pulmonary and Critical Care Medicine, Department of Medicine and Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA
Immunol Rev 242:220-32. 2011..Furthermore, whether other non-Th2 cytokine pathways underlie airway inflammation in specific subsets of patients with asthma is an unresolved question and an important goal of future research using both mouse models and human studies... - Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contractionFen Huang
Howard Hughes Medical Institute and Department of Physiology, University of California, San Francisco, CA 94158, USA
Proc Natl Acad Sci U S A 109:16354-9. 2012..TMEM16A-CaCC blockers, including those identified here, may positively impact multiple causes of asthma symptoms... - Safety and efficacy of an inhaled epidermal growth factor receptor inhibitor (BIBW 2948 BS) in chronic obstructive pulmonary diseasePrescott G Woodruff
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, USA
Am J Respir Crit Care Med 181:438-45. 2010..Epidermal growth factor receptor (EGFR) activation is implicated in mucin hypersecretion in chronic obstructive pulmonary disease (COPD)... - Dissecting asthma using focused transgenic modeling and functional genomicsDouglas A Kuperman
Department of Medicine, Allergy-Immunology Division, Northwestern University Feinberg School of Medicine, Chicago, USA
J Allergy Clin Immunol 116:305-11. 2005.... - Airway epithelial miRNA expression is altered in asthmaOwen D Solberg
Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA
Am J Respir Crit Care Med 186:965-74. 2012..Changes in airway epithelial cell differentiation, driven in part by IL-13, are important in asthma. Micro-RNAs (miRNAs) regulate cell differentiation in many systems and could contribute to epithelial abnormalities in asthma... - Randomized trial of zileuton for treatment of COPD exacerbations requiring hospitalizationPrescott G Woodruff
Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, San Francisco, California, USA
COPD 8:21-9. 2011..Leukotrienes have been implicated in the pathogenesis of acute exacerbations of COPD, but leukotriene modifiers have not been studied as a possible therapy for exacerbations... - Monocyte chemotactic protein-4 (MCP-4; CCL-13): a biomarker of asthmaOmer Kalayci
The Combined Program in Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Asthma 41:27-33. 2004..Elevated MCP-4 levels identify a group of asthmatics with systemic evidence of allergic inflammation who may be at risk for exacerbations or may benefit from abrogation of MCP-4... - Prevalence and risk factors for depressive symptoms in persons with chronic obstructive pulmonary diseaseRebecca E Schane
Department of Medicine, Division of Pulmonary Critical Care Medicine, Cardiovascular Research Institute, University of California, San Francisco, CA 94143 1390, USA
J Gen Intern Med 23:1757-62. 2008..Although depression is a risk factor for adverse outcomes in chronic illness, little is known about the prevalence or risk factors for depressive symptoms in chronic obstructive pulmonary disease (COPD)... - Mfge8 suppresses airway hyperresponsiveness in asthma by regulating smooth muscle contractionMakoto Kudo
Lung Biology Center, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 110:660-5. 2013..These data indicate that Mfge8 binding to integrin receptors on ASM opposes the effect of allergic inflammation on RhoA activity and identify a pathway for specific inhibition of ASM hypercontractility in asthma... - A prospective multicenter study of factors associated with hospital admission among adults with acute asthmaEllen J Weber
Division of Emergency Medicine, University of California, San Francisco, San Francisco, California 94143, USA
Am J Med 113:371-8. 2002..We sought to determine patient characteristics associated with hospital admission after emergency treatment for asthma, and whether disposition guidelines are followed... - Novel outcomes and end points: biomarkers in chronic obstructive pulmonary disease clinical trialsPrescott G Woodruff
Division of Pulmonary and Critical Care Medicine, Department of Medicine and Cardiovascular Research Institute, University of California, San Francisco, USA
Proc Am Thorac Soc 8:350-5. 2011..This process has been designed to be more efficient and to promote consensus building and sharing of preclinical data... - Cigarette smoking among asthmatic adults presenting to 64 emergency departmentsRobert A Silverman
Department of Emergency Medicine, Long Island Jewish Medical Center, New Hyde Park, NY 11040, USA
Chest 123:1472-9. 2003..The present study determined the prevalence of cigarette smoking among adults presenting to the ED with acute asthma and identified the factors associated with current smoking status... - Applying stereology to measure thickness of the basement membrane zone in bronchial biopsy specimensRonald E Ferrando
J Allergy Clin Immunol 112:1243-5. 2003 - Methodologic advancements in the study of airway smooth muscleMichael I Kotlikoff
Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
J Allergy Clin Immunol 114:S18-31. 2004.... - Insurance and quality of care for adults with acute asthmaTimothy G Ferris
Institute for Health Policy, Division of General Medicine, Massachusetts General Hospital, Partners HealthCare System and Harvard Medical School, Boston, Mass 02114, USA
J Gen Intern Med 17:905-13. 2002..We sought to determine whether type of patient insurance is related to quality of care and subsequent outcomes for patients who arrive in the emergency department (ED) for acute asthma... - Airway smooth muscle in bronchial tone, inflammation, and remodeling: basic knowledge to clinical relevanceReynold A Panettieri
Airway Biology and Disease Program, Division of Lung Diseases, National Heart, Lung, and Blood Institute, Two Rockledge Center, Suite 10042, 6701 Rockledge Drive, MSC 7952, Bethesda, MD 20892 7952, USA
Am J Respir Crit Care Med 177:248-52. 2008.... - A prospective multicenter study of patient factors associated with hospital admission from the emergency department among children with acute asthmaCharles V Pollack
Department of Emergency Medicine, Pennsylvania Hospital, 800 Spruce St, Philadelphia, PA 19107, USA
Arch Pediatr Adolesc Med 156:934-40. 2002.... - A role for neutrophils in asthma?Prescott G Woodruff
Am J Med 112:498-500. 2002