Prescott G Woodruff

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Gene expression in asthmatic airway smooth muscle
    Prescott G Woodruff
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0111, USA
    Proc Am Thorac Soc 5:113-8. 2008
  2. ncbi request reprint Hyperplasia of smooth muscle in mild to moderate asthma without changes in cell size or gene expression
    Prescott G Woodruff
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, and Cardiovascular Research Institute, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA
    Am J Respir Crit Care Med 169:1001-6. 2004
  3. pmc T-helper type 2-driven inflammation defines major subphenotypes of asthma
    Prescott G Woodruff
    Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, San Francisco, CA 94143 0111, USA
    Am J Respir Crit Care Med 180:388-95. 2009
  4. pmc Accumulation of intraepithelial mast cells with a unique protease phenotype in T(H)2-high asthma
    Ryan H Dougherty
    Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, CA, USA
    J Allergy Clin Immunol 125:1046-1053.e8. 2010
  5. pmc Chitotriosidase is the primary active chitinase in the human lung and is modulated by genotype and smoking habit
    Max A Seibold
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, CA 94143, USA
    J Allergy Clin Immunol 122:944-950.e3. 2008
  6. ncbi request reprint Epithelial mucin stores are increased in the large airways of smokers with airflow obstruction
    Anh L Innes
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Cardiovascular Research Institute, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA 94143, USA
    Chest 130:1102-8. 2006
  7. pmc Distinct roles of FOXA2 and FOXA3 in allergic airway disease and asthma
    Sung Woo Park
    Lung Biology Center, University of California San Francisco, San Francisco, California 94143, USA
    Am J Respir Crit Care Med 180:603-10. 2009
  8. pmc Airway epithelial miRNA expression is altered in asthma
    Owen D Solberg
    Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA
    Am J Respir Crit Care Med 186:965-74. 2012
  9. doi request reprint DAP12 is required for macrophage recruitment to the lung in response to cigarette smoke and chemotaxis toward CCL2
    Laura L Koth
    Division of Pulmonary and Critical Care Medicine, Lung Biology Center, University of California at San Francisco, San Francisco, CA 94143, USA
    J Immunol 184:6522-8. 2010
  10. pmc Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids
    Prescott G Woodruff
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 104:15858-63. 2007

Detail Information

Publications34

  1. pmc Gene expression in asthmatic airway smooth muscle
    Prescott G Woodruff
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0111, USA
    Proc Am Thorac Soc 5:113-8. 2008
    ..g., protein phosphorylation). Thus, gene expression studies ultimately must be integrated with other methodological approaches to adequately study airway smooth muscle in asthma in vivo...
  2. ncbi request reprint Hyperplasia of smooth muscle in mild to moderate asthma without changes in cell size or gene expression
    Prescott G Woodruff
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, and Cardiovascular Research Institute, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA
    Am J Respir Crit Care Med 169:1001-6. 2004
    ..However, smooth muscle cells in mild to moderate asthma do not show hypertrophy or gene expression changes of a hypercontractile phenotype observed in vitro...
  3. pmc T-helper type 2-driven inflammation defines major subphenotypes of asthma
    Prescott G Woodruff
    Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, San Francisco, CA 94143 0111, USA
    Am J Respir Crit Care Med 180:388-95. 2009
    ..However, clinical studies increasingly suggest that asthma is heterogeneous...
  4. pmc Accumulation of intraepithelial mast cells with a unique protease phenotype in T(H)2-high asthma
    Ryan H Dougherty
    Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, CA, USA
    J Allergy Clin Immunol 125:1046-1053.e8. 2010
    ..We also found that asthmatic subjects can be divided into 2 subgroups ("T(H)2 high" and "T(H)2 low" asthma) based on epithelial cell gene signatures for the activity of T(H)2 cytokines...
  5. pmc Chitotriosidase is the primary active chitinase in the human lung and is modulated by genotype and smoking habit
    Max A Seibold
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, CA 94143, USA
    J Allergy Clin Immunol 122:944-950.e3. 2008
    ..Acidic mammalian chitinase (AMCase) and chitotriosidase (CHIT1) have chitinolytic activity, but relatively little is known about their expression in human asthma...
  6. ncbi request reprint Epithelial mucin stores are increased in the large airways of smokers with airflow obstruction
    Anh L Innes
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Cardiovascular Research Institute, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA 94143, USA
    Chest 130:1102-8. 2006
    ..Habitual cigarette smoking is associated with chronic mucus hypersecretion, but the relationship between mucus abnormalities and airflow obstruction in smokers is uncertain...
  7. pmc Distinct roles of FOXA2 and FOXA3 in allergic airway disease and asthma
    Sung Woo Park
    Lung Biology Center, University of California San Francisco, San Francisco, California 94143, USA
    Am J Respir Crit Care Med 180:603-10. 2009
    ..IL-13-driven mucous cell metaplasia is associated with decreased expression of the transcription factor FOXA2 and increased expression of the related transcription factor FOXA3 in animal and cell culture models...
  8. pmc Airway epithelial miRNA expression is altered in asthma
    Owen D Solberg
    Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA
    Am J Respir Crit Care Med 186:965-74. 2012
    ..Changes in airway epithelial cell differentiation, driven in part by IL-13, are important in asthma. Micro-RNAs (miRNAs) regulate cell differentiation in many systems and could contribute to epithelial abnormalities in asthma...
  9. doi request reprint DAP12 is required for macrophage recruitment to the lung in response to cigarette smoke and chemotaxis toward CCL2
    Laura L Koth
    Division of Pulmonary and Critical Care Medicine, Lung Biology Center, University of California at San Francisco, San Francisco, CA 94143, USA
    J Immunol 184:6522-8. 2010
    ..These findings indicate that DAP12, possibly through association with TREM2, contributes to alveolar macrophage chemotaxis and recruitment to the lung and may mediate macrophage accumulation in lung diseases such as emphysema...
  10. pmc Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids
    Prescott G Woodruff
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 104:15858-63. 2007
    ....
  11. pmc Roles of epithelial cell-derived periostin in TGF-beta activation, collagen production, and collagen gel elasticity in asthma
    Sukhvinder S Sidhu
    Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 107:14170-5. 2010
    ..Epithelial cell-derived periostin in asthma has roles in TGF-beta activation and collagen gel elasticity in asthma...
  12. pmc Mfge8 suppresses airway hyperresponsiveness in asthma by regulating smooth muscle contraction
    Makoto Kudo
    Lung Biology Center, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 110:660-5. 2013
    ..These data indicate that Mfge8 binding to integrin receptors on ASM opposes the effect of allergic inflammation on RhoA activity and identify a pathway for specific inhibition of ASM hypercontractility in asthma...
  13. pmc Alveolar macrophage recruitment and activation by chronic second hand smoke exposure in mice
    Prescott G Woodruff
    Division of Pulmonary and Critical Care Medicine, Dept of Medicine and Cardiovascular Research Institute, UCSF, San Francisco, California 94143, USA
    COPD 6:86-94. 2009
    ..These findings indicate that second smoke exposure can cause macrophage recruitment and activation, providing a biological link between second-hand smoke exposure and the development of inflammatory processes linked to COPD...
  14. pmc Sarcoidosis blood transcriptome reflects lung inflammation and overlaps with tuberculosis
    Laura L Koth
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California, USA
    Am J Respir Crit Care Med 184:1153-63. 2011
    ..Sarcoidosis is a granulomatous disease of unknown etiology, although M. tuberculosis may play a role in the pathogenesis. The traditional view holds that inflammation in sarcoidosis is compartmentalized to involved organs...
  15. pmc The H antigen at epithelial surfaces is associated with susceptibility to asthma exacerbation
    Anh L Innes
    The Cardiovascular Research Institute, University of California, San Francisco, California, USA
    Am J Respir Crit Care Med 183:189-94. 2011
    ..Acute asthma exacerbations, precipitated by viral infections, are a significant cause of morbidity, but not all patients with asthma are equally susceptible...
  16. pmc Human asthma phenotypes: from the clinic, to cytokines, and back again
    Nirav R Bhakta
    Division of Pulmonary and Critical Care Medicine, Department of Medicine and Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA
    Immunol Rev 242:220-32. 2011
    ..Furthermore, whether other non-Th2 cytokine pathways underlie airway inflammation in specific subsets of patients with asthma is an unresolved question and an important goal of future research using both mouse models and human studies...
  17. pmc A distinctive alveolar macrophage activation state induced by cigarette smoking
    Prescott G Woodruff
    UCSF Mission Bay Rock Hall, Room 545, 1550 4th Street, San Francisco, CA 94158, USA
    Am J Respir Crit Care Med 172:1383-92. 2005
    ..Macrophages are believed to play a central role in emphysema based largely on data from mouse models. However, the relevance of these models to smoking-related lung disease in humans is uncertain...
  18. pmc Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction
    Fen Huang
    Howard Hughes Medical Institute and Department of Physiology, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 109:16354-9. 2012
    ..TMEM16A-CaCC blockers, including those identified here, may positively impact multiple causes of asthma symptoms...
  19. doi request reprint Safety and efficacy of an inhaled epidermal growth factor receptor inhibitor (BIBW 2948 BS) in chronic obstructive pulmonary disease
    Prescott G Woodruff
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, USA
    Am J Respir Crit Care Med 181:438-45. 2010
    ..Epidermal growth factor receptor (EGFR) activation is implicated in mucin hypersecretion in chronic obstructive pulmonary disease (COPD)...
  20. ncbi request reprint Dissecting asthma using focused transgenic modeling and functional genomics
    Douglas A Kuperman
    Department of Medicine, Allergy Immunology Division, Northwestern University Feinberg School of Medicine, Chicago, USA
    J Allergy Clin Immunol 116:305-11. 2005
    ..These mice develop airway hyperreactivity and mucus overproduction but not airway inflammation...
  21. pmc Regulation and function of epithelial secreted phospholipase A2 group X in asthma
    Teal S Hallstrand
    Department of Medicine, University ofWashington, Seattle, WA, USA
    Am J Respir Crit Care Med 188:42-50. 2013
    ..Secreted phospholipase A2 group X (sPLA2-X) plays a key role in regulating eicosanoid formation and the development of inflammation and AHR in murine models...
  22. ncbi request reprint Monocyte chemotactic protein-4 (MCP-4; CCL-13): a biomarker of asthma
    Omer Kalayci
    The Combined Program in Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Asthma 41:27-33. 2004
    ..Elevated MCP-4 levels identify a group of asthmatics with systemic evidence of allergic inflammation who may be at risk for exacerbations or may benefit from abrogation of MCP-4...
  23. pmc Randomized trial of zileuton for treatment of COPD exacerbations requiring hospitalization
    Prescott G Woodruff
    Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, San Francisco, California, USA
    COPD 8:21-9. 2011
    ..Leukotrienes have been implicated in the pathogenesis of acute exacerbations of COPD, but leukotriene modifiers have not been studied as a possible therapy for exacerbations...
  24. pmc Prevalence and risk factors for depressive symptoms in persons with chronic obstructive pulmonary disease
    Rebecca E Schane
    Department of Medicine, Division of Pulmonary Critical Care Medicine, Cardiovascular Research Institute, University of California, San Francisco, CA 94143 1390, USA
    J Gen Intern Med 23:1757-62. 2008
    ..Although depression is a risk factor for adverse outcomes in chronic illness, little is known about the prevalence or risk factors for depressive symptoms in chronic obstructive pulmonary disease (COPD)...
  25. doi request reprint Interferon-inducible chemokines reflect severity and progression in sarcoidosis
    Robert Su
    Division of Pulmonary, Critical Care, Sleep and Allergy, University of California San Francisco, 505 Parnassus Avenue, Box 0111, San Francisco, CA 94143, USA
    Respir Res 14:121. 2013
    ..The objective of this study was to determine whether proteins encoded by these transcripts were elevated in serum and identified patients with remitting vs. chronic progressive sarcoidosis longitudinally...
  26. ncbi request reprint A prospective multicenter study of factors associated with hospital admission among adults with acute asthma
    Ellen J Weber
    Division of Emergency Medicine, University of California, San Francisco, San Francisco, California 94143, USA
    Am J Med 113:371-8. 2002
    ..We sought to determine patient characteristics associated with hospital admission after emergency treatment for asthma, and whether disposition guidelines are followed...
  27. pmc Novel outcomes and end points: biomarkers in chronic obstructive pulmonary disease clinical trials
    Prescott G Woodruff
    Division of Pulmonary and Critical Care Medicine, Department of Medicine and Cardiovascular Research Institute, University of California, San Francisco, USA
    Proc Am Thorac Soc 8:350-5. 2011
    ..This process has been designed to be more efficient and to promote consensus building and sharing of preclinical data...
  28. ncbi request reprint Cigarette smoking among asthmatic adults presenting to 64 emergency departments
    Robert A Silverman
    Department of Emergency Medicine, Long Island Jewish Medical Center, New Hyde Park, NY 11040, USA
    Chest 123:1472-9. 2003
    ..The present study determined the prevalence of cigarette smoking among adults presenting to the ED with acute asthma and identified the factors associated with current smoking status...
  29. ncbi request reprint Applying stereology to measure thickness of the basement membrane zone in bronchial biopsy specimens
    Ronald E Ferrando
    J Allergy Clin Immunol 112:1243-5. 2003
  30. ncbi request reprint Methodologic advancements in the study of airway smooth muscle
    Michael I Kotlikoff
    Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Allergy Clin Immunol 114:S18-31. 2004
    ....
  31. pmc Insurance and quality of care for adults with acute asthma
    Timothy G Ferris
    Institute for Health Policy, Division of General Medicine, Massachusetts General Hospital, Partners HealthCare System and Harvard Medical School, Boston, Mass 02114, USA
    J Gen Intern Med 17:905-13. 2002
    ..We sought to determine whether type of patient insurance is related to quality of care and subsequent outcomes for patients who arrive in the emergency department (ED) for acute asthma...
  32. pmc Airway smooth muscle in bronchial tone, inflammation, and remodeling: basic knowledge to clinical relevance
    Reynold A Panettieri
    Airway Biology and Disease Program, Division of Lung Diseases, National Heart, Lung, and Blood Institute, Two Rockledge Center, Suite 10042, 6701 Rockledge Drive, MSC 7952, Bethesda, MD 20892 7952, USA
    Am J Respir Crit Care Med 177:248-52. 2008
    ....
  33. ncbi request reprint A prospective multicenter study of patient factors associated with hospital admission from the emergency department among children with acute asthma
    Charles V Pollack
    Department of Emergency Medicine, Pennsylvania Hospital, 800 Spruce St, Philadelphia, PA 19107, USA
    Arch Pediatr Adolesc Med 156:934-40. 2002
    ..Recent studies show that objective measures such as peak flow rates are strongly associated with asthma admission among adults...
  34. ncbi request reprint A role for neutrophils in asthma?
    Prescott G Woodruff
    Am J Med 112:498-500. 2002