ROBERT THOMAS WOODLAND

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. ncbi request reprint BLyS and B cell homeostasis
    Robert T Woodland
    Department of Molecular Genetics and Microbiolgy, Immunology and Virology Program, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Semin Immunol 18:318-26. 2006
  2. pmc Multiple signaling pathways promote B lymphocyte stimulator dependent B-cell growth and survival
    Robert T Woodland
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester 01655, USA
    Blood 111:750-60. 2008
  3. ncbi request reprint Homeostatic proliferation of B cells
    Robert T Woodland
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA
    Semin Immunol 17:209-17. 2005
  4. ncbi request reprint Naive B lymphocytes undergo homeostatic proliferation in response to B cell deficit
    Mark S Cabatingan
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 169:6795-805. 2002
  5. pmc Expanded CD34+ human umbilical cord blood cells generate multiple lymphohematopoietic lineages in NOD-scid IL2rgamma(null) mice
    Lisa J Giassi
    Division of Diabetes, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Exp Biol Med (Maywood) 233:997-1012. 2008
  6. pmc Inducible DNA breaks in Ig S regions are dependent on AID and UNG
    Carol E Schrader
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Exp Med 202:561-8. 2005
  7. ncbi request reprint B1b lymphocytes confer T cell-independent long-lasting immunity
    Kishore R Alugupalli
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester 01655, USA
    Immunity 21:379-90. 2004
  8. ncbi request reprint The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes
    Kishore R Alugupalli
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 170:3819-27. 2003
  9. pmc Human BLyS facilitates engraftment of human PBL derived B cells in immunodeficient mice
    Madelyn R Schmidt
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 3:e3192. 2008
  10. ncbi request reprint A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene
    Marie King
    Department of Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01655, USA
    Clin Immunol 126:303-14. 2008

Research Grants

  1. HIV vaccine development using humanized mice
    ROBERT THOMAS WOODLAND; Fiscal Year: 2010
  2. IMMUNODEFICIENCIES THAT IMPAIR LYMPHOCYTE SURVIVAL
    Robert Woodland; Fiscal Year: 2009
  3. IMMUNODEFICIENCIES THAT IMPAIR LYMPHOCYTE SURVIVAL
    Robert Woodland; Fiscal Year: 2007
  4. IMMUNODEFICIENCIES THAT IMPAIR LYMPHOCYTE SURVIVAL
    Robert Woodland; Fiscal Year: 2007
  5. Human B cell homeostasis in a new transgenic xenochimera
    Robert Woodland; Fiscal Year: 2005
  6. IMMUNODEFICIENCIES THAT IMPAIR LYMPHOCYTE SURVIVAL
    Robert Woodland; Fiscal Year: 2001
  7. HIV vaccine development using humanized mice
    ROBERT THOMAS WOODLAND; Fiscal Year: 2010

Collaborators

Detail Information

Publications10

  1. ncbi request reprint BLyS and B cell homeostasis
    Robert T Woodland
    Department of Molecular Genetics and Microbiolgy, Immunology and Virology Program, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Semin Immunol 18:318-26. 2006
    ..We also examine the role of BLyS as a growth factor and propose that BLyS induced metabolic enhancement optimizes the B cell response to BCR and TLR-dependent signaling...
  2. pmc Multiple signaling pathways promote B lymphocyte stimulator dependent B-cell growth and survival
    Robert T Woodland
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester 01655, USA
    Blood 111:750-60. 2008
    ..Because BlyS is required for the normal homeostasis of all B cells, these data suggest a therapeutic strategy simultaneously inhibiting mTOR and Pim 2 could target pathogenic B cells...
  3. ncbi request reprint Homeostatic proliferation of B cells
    Robert T Woodland
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA
    Semin Immunol 17:209-17. 2005
    ..In this communication we discuss the cytokine requirements for B cell HP, extend the murine studies to human cells, and propose the hypothesis that B cell HP may provide an antigen-independent mechanism for maintaining B cell memory...
  4. ncbi request reprint Naive B lymphocytes undergo homeostatic proliferation in response to B cell deficit
    Mark S Cabatingan
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 169:6795-805. 2002
    ..Homeostatic B cell proliferation provides an Ag-independent mechanism for the maintenance and expansion of naive B cells selected into the mature B cell pool...
  5. pmc Expanded CD34+ human umbilical cord blood cells generate multiple lymphohematopoietic lineages in NOD-scid IL2rgamma(null) mice
    Lisa J Giassi
    Division of Diabetes, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Exp Biol Med (Maywood) 233:997-1012. 2008
    ..Ex vivo expanded CD34(+) human UCB cells have the capacity to generate multiple hematopoietic lineages and a functional human immune system upon transplantation into TNFalpha-treated NOD-scid IL2rgamma(null) mice...
  6. pmc Inducible DNA breaks in Ig S regions are dependent on AID and UNG
    Carol E Schrader
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Exp Med 202:561-8. 2005
    ..Our results indicate that AID attacks cytosines on both DNA strands, and staggered breaks are processed to blunt DSBs at the initiating ss break sites. We propose a model to explain the types of end-processing events observed...
  7. ncbi request reprint B1b lymphocytes confer T cell-independent long-lasting immunity
    Kishore R Alugupalli
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester 01655, USA
    Immunity 21:379-90. 2004
    ..These data demonstrate that B1b lymphocytes can provide long-lasting T cell-independent IgM memory...
  8. ncbi request reprint The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes
    Kishore R Alugupalli
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 170:3819-27. 2003
    ..hermsii. Together these results support the model that B1b cells generate the T-independent IgM required for the control and resolution of relapsing fever borreliosis...
  9. pmc Human BLyS facilitates engraftment of human PBL derived B cells in immunodeficient mice
    Madelyn R Schmidt
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 3:e3192. 2008
    ..The data indicate that production of fully immunologically competent humanized mice from PBL can be markedly facilitated by providing human BLyS...
  10. ncbi request reprint A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene
    Marie King
    Department of Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01655, USA
    Clin Immunol 126:303-14. 2008
    ..These data suggest that humanized NOD-scid Il2rgamma(null) mice may represent an important surrogate for investigating in vivo mechanisms of human islet allograft rejection...

Research Grants17

  1. HIV vaccine development using humanized mice
    ROBERT THOMAS WOODLAND; Fiscal Year: 2010
    ..These studies provide a new approach for the design and testing of HIV vaccines. ..
  2. IMMUNODEFICIENCIES THAT IMPAIR LYMPHOCYTE SURVIVAL
    Robert Woodland; Fiscal Year: 2009
    ..Understanding the mechanism of B cell HP will provide new strategies for effecting immune reconstitution in the aged or immunodeficient or following chemotherapy or recovery from lymphotoxic infections. ..
  3. IMMUNODEFICIENCIES THAT IMPAIR LYMPHOCYTE SURVIVAL
    Robert Woodland; Fiscal Year: 2007
    ..We further propose the antibodies produced by this immunization regimen will have broad neutralizing activity for HIV isolates. ..
  4. IMMUNODEFICIENCIES THAT IMPAIR LYMPHOCYTE SURVIVAL
    Robert Woodland; Fiscal Year: 2007
    ..Understanding the mechanism of B cell HP will provide new strategies for effecting immune reconstitution in the aged or immunodeficient or following chemotherapy or recovery from lymphotoxic infections. ..
  5. Human B cell homeostasis in a new transgenic xenochimera
    Robert Woodland; Fiscal Year: 2005
    ..Furthermore, These transgenic mice will form the basis of a new test system to study the efficacy of adjuvants and vaccines currently being developed against agents of bioterrorism. ..
  6. IMMUNODEFICIENCIES THAT IMPAIR LYMPHOCYTE SURVIVAL
    Robert Woodland; Fiscal Year: 2001
    ..These studies will develop an animal model system where critical approaches and pitfalls of gene therapy can be directly tested, and determine the suitability of long-lived mature lymphocytes as vehicles for gene therapy. ..
  7. HIV vaccine development using humanized mice
    ROBERT THOMAS WOODLAND; Fiscal Year: 2010
    ..These studies provide a new approach for the design and testing of HIV vaccines. ..