ROBERT THOMAS WOODLAND

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. ncbi request reprint BLyS and B cell homeostasis
    Robert T Woodland
    Department of Molecular Genetics and Microbiolgy, Immunology and Virology Program, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Semin Immunol 18:318-26. 2006
  2. pmc Multiple signaling pathways promote B lymphocyte stimulator dependent B-cell growth and survival
    Robert T Woodland
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester 01655, USA
    Blood 111:750-60. 2008
  3. ncbi request reprint Homeostatic proliferation of B cells
    Robert T Woodland
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA
    Semin Immunol 17:209-17. 2005
  4. ncbi request reprint Naive B lymphocytes undergo homeostatic proliferation in response to B cell deficit
    Mark S Cabatingan
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 169:6795-805. 2002
  5. pmc Expanded CD34+ human umbilical cord blood cells generate multiple lymphohematopoietic lineages in NOD-scid IL2rgamma(null) mice
    Lisa J Giassi
    Division of Diabetes, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Exp Biol Med (Maywood) 233:997-1012. 2008
  6. pmc Inducible DNA breaks in Ig S regions are dependent on AID and UNG
    Carol E Schrader
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Exp Med 202:561-8. 2005
  7. ncbi request reprint B1b lymphocytes confer T cell-independent long-lasting immunity
    Kishore R Alugupalli
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester 01655, USA
    Immunity 21:379-90. 2004
  8. ncbi request reprint The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes
    Kishore R Alugupalli
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 170:3819-27. 2003
  9. pmc Human BLyS facilitates engraftment of human PBL derived B cells in immunodeficient mice
    Madelyn R Schmidt
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 3:e3192. 2008
  10. ncbi request reprint A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene
    Marie King
    Department of Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01655, USA
    Clin Immunol 126:303-14. 2008

Collaborators

Detail Information

Publications10

  1. ncbi request reprint BLyS and B cell homeostasis
    Robert T Woodland
    Department of Molecular Genetics and Microbiolgy, Immunology and Virology Program, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Semin Immunol 18:318-26. 2006
    ..We also examine the role of BLyS as a growth factor and propose that BLyS induced metabolic enhancement optimizes the B cell response to BCR and TLR-dependent signaling...
  2. pmc Multiple signaling pathways promote B lymphocyte stimulator dependent B-cell growth and survival
    Robert T Woodland
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester 01655, USA
    Blood 111:750-60. 2008
    ..Because BlyS is required for the normal homeostasis of all B cells, these data suggest a therapeutic strategy simultaneously inhibiting mTOR and Pim 2 could target pathogenic B cells...
  3. ncbi request reprint Homeostatic proliferation of B cells
    Robert T Woodland
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA
    Semin Immunol 17:209-17. 2005
    ..In this communication we discuss the cytokine requirements for B cell HP, extend the murine studies to human cells, and propose the hypothesis that B cell HP may provide an antigen-independent mechanism for maintaining B cell memory...
  4. ncbi request reprint Naive B lymphocytes undergo homeostatic proliferation in response to B cell deficit
    Mark S Cabatingan
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 169:6795-805. 2002
    ..Homeostatic B cell proliferation provides an Ag-independent mechanism for the maintenance and expansion of naive B cells selected into the mature B cell pool...
  5. pmc Expanded CD34+ human umbilical cord blood cells generate multiple lymphohematopoietic lineages in NOD-scid IL2rgamma(null) mice
    Lisa J Giassi
    Division of Diabetes, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Exp Biol Med (Maywood) 233:997-1012. 2008
    ..Ex vivo expanded CD34(+) human UCB cells have the capacity to generate multiple hematopoietic lineages and a functional human immune system upon transplantation into TNFalpha-treated NOD-scid IL2rgamma(null) mice...
  6. pmc Inducible DNA breaks in Ig S regions are dependent on AID and UNG
    Carol E Schrader
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Exp Med 202:561-8. 2005
    ..Our results indicate that AID attacks cytosines on both DNA strands, and staggered breaks are processed to blunt DSBs at the initiating ss break sites. We propose a model to explain the types of end-processing events observed...
  7. ncbi request reprint B1b lymphocytes confer T cell-independent long-lasting immunity
    Kishore R Alugupalli
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester 01655, USA
    Immunity 21:379-90. 2004
    ..These data demonstrate that B1b lymphocytes can provide long-lasting T cell-independent IgM memory...
  8. ncbi request reprint The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes
    Kishore R Alugupalli
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 170:3819-27. 2003
    ..hermsii. Together these results support the model that B1b cells generate the T-independent IgM required for the control and resolution of relapsing fever borreliosis...
  9. pmc Human BLyS facilitates engraftment of human PBL derived B cells in immunodeficient mice
    Madelyn R Schmidt
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 3:e3192. 2008
    ..The data indicate that production of fully immunologically competent humanized mice from PBL can be markedly facilitated by providing human BLyS...
  10. ncbi request reprint A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene
    Marie King
    Department of Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01655, USA
    Clin Immunol 126:303-14. 2008
    ..These data suggest that humanized NOD-scid Il2rgamma(null) mice may represent an important surrogate for investigating in vivo mechanisms of human islet allograft rejection...