Research Topics
Genomes and Genes | ROBERT THOMAS WOODLANDSummaryAffiliation: University of Massachusetts Medical School Country: USA Publications
Research Grants
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Detail Information
Publications
BLyS and B cell homeostasisRobert T Woodland
Department of Molecular Genetics and Microbiolgy, Immunology and Virology Program, University of Massachusetts Medical School, Worcester, MA 01655, USA
Semin Immunol 18:318-26. 2006..We also examine the role of BLyS as a growth factor and propose that BLyS induced metabolic enhancement optimizes the B cell response to BCR and TLR-dependent signaling...
Multiple signaling pathways promote B lymphocyte stimulator dependent B-cell growth and survivalRobert T Woodland
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester 01655, USA
Blood 111:750-60. 2008..Because BlyS is required for the normal homeostasis of all B cells, these data suggest a therapeutic strategy simultaneously inhibiting mTOR and Pim 2 could target pathogenic B cells...- Homeostatic proliferation of B cellsRobert T Woodland
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA
Semin Immunol 17:209-17. 2005..In this communication we discuss the cytokine requirements for B cell HP, extend the murine studies to human cells, and propose the hypothesis that B cell HP may provide an antigen-independent mechanism for maintaining B cell memory... - Naive B lymphocytes undergo homeostatic proliferation in response to B cell deficitMark S Cabatingan
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
J Immunol 169:6795-805. 2002..Homeostatic B cell proliferation provides an Ag-independent mechanism for the maintenance and expansion of naive B cells selected into the mature B cell pool... - Expanded CD34+ human umbilical cord blood cells generate multiple lymphohematopoietic lineages in NOD-scid IL2rgamma(null) miceLisa J Giassi
Division of Diabetes, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Exp Biol Med (Maywood) 233:997-1012. 2008..Ex vivo expanded CD34(+) human UCB cells have the capacity to generate multiple hematopoietic lineages and a functional human immune system upon transplantation into TNFalpha-treated NOD-scid IL2rgamma(null) mice... - Inducible DNA breaks in Ig S regions are dependent on AID and UNGCarol E Schrader
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
J Exp Med 202:561-8. 2005..Our results indicate that AID attacks cytosines on both DNA strands, and staggered breaks are processed to blunt DSBs at the initiating ss break sites. We propose a model to explain the types of end-processing events observed... - B1b lymphocytes confer T cell-independent long-lasting immunityKishore R Alugupalli
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester 01655, USA
Immunity 21:379-90. 2004..These data demonstrate that B1b lymphocytes can provide long-lasting T cell-independent IgM memory... - The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytesKishore R Alugupalli
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
J Immunol 170:3819-27. 2003..hermsii. Together these results support the model that B1b cells generate the T-independent IgM required for the control and resolution of relapsing fever borreliosis... - Human BLyS facilitates engraftment of human PBL derived B cells in immunodeficient miceMadelyn R Schmidt
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
PLoS ONE 3:e3192. 2008..The data indicate that production of fully immunologically competent humanized mice from PBL can be markedly facilitated by providing human BLyS... - A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain geneMarie King
Department of Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01655, USA
Clin Immunol 126:303-14. 2008..These data suggest that humanized NOD-scid Il2rgamma(null) mice may represent an important surrogate for investigating in vivo mechanisms of human islet allograft rejection...
Research Grants
- HIV vaccine development using humanized miceROBERT THOMAS WOODLAND; Fiscal Year: 2010..These studies provide a new approach for the design and testing of HIV vaccines. ..
- IMMUNODEFICIENCIES THAT IMPAIR LYMPHOCYTE SURVIVALRobert Woodland; Fiscal Year: 2009..Understanding the mechanism of B cell HP will provide new strategies for effecting immune reconstitution in the aged or immunodeficient or following chemotherapy or recovery from lymphotoxic infections. ..
- IMMUNODEFICIENCIES THAT IMPAIR LYMPHOCYTE SURVIVALRobert Woodland; Fiscal Year: 2007..We further propose the antibodies produced by this immunization regimen will have broad neutralizing activity for HIV isolates. ..
- IMMUNODEFICIENCIES THAT IMPAIR LYMPHOCYTE SURVIVALRobert Woodland; Fiscal Year: 2007..Understanding the mechanism of B cell HP will provide new strategies for effecting immune reconstitution in the aged or immunodeficient or following chemotherapy or recovery from lymphotoxic infections. ..
- Human B cell homeostasis in a new transgenic xenochimeraRobert Woodland; Fiscal Year: 2005..Furthermore, These transgenic mice will form the basis of a new test system to study the efficacy of adjuvants and vaccines currently being developed against agents of bioterrorism. ..
- IMMUNODEFICIENCIES THAT IMPAIR LYMPHOCYTE SURVIVALRobert Woodland; Fiscal Year: 2001..These studies will develop an animal model system where critical approaches and pitfalls of gene therapy can be directly tested, and determine the suitability of long-lived mature lymphocytes as vehicles for gene therapy. ..
- HIV vaccine development using humanized miceROBERT THOMAS WOODLAND; Fiscal Year: 2010..These studies provide a new approach for the design and testing of HIV vaccines. ..