Stephen Wooding

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. pmc Identification of polymorphisms and balancing selection in the male infertility candidate gene, ornithine decarboxylase antizyme 3
    Greg L Christensen
    Andrology and IVF Laboratories, University of Utah School of Medicine, Salt Lake City, UT, USA
    BMC Med Genet 7:27. 2006
  2. ncbi request reprint Natural selection: sign, sign, everywhere a sign
    Stephen Wooding
    Department of Human Genetics, University of Utah, 15 North 2030 East, Salt Lake City, Utah 84112 5330, USA
    Curr Biol 14:R700-1. 2004
  3. ncbi request reprint Evolution: a study in bad taste?
    Stephen Wooding
    Department of Human Genetics, University of Utah, Salt Lake City, 84112 5330, USA
    Curr Biol 15:R805-7. 2005
  4. ncbi request reprint Independent evolution of bitter-taste sensitivity in humans and chimpanzees
    Stephen Wooding
    Department of Human Genetics, University of Utah, 15 North 2030 East, Salt Lake City, Utah 84112 5330, USA
    Nature 440:930-4. 2006
  5. pmc Natural selection and molecular evolution in PTC, a bitter-taste receptor gene
    Stephen Wooding
    Department of Human Genetics, University of Utah, Salt Lake City 84112 5330, USA
    Am J Hum Genet 74:637-46. 2004
  6. ncbi request reprint PopHist: inferring population history from the spectrum of allele frequencies
    Stephen Wooding
    Eccles Institute of Human Genetics, University of Utah, 15 North 2030 East, Salt Lake City, UT 84112 5330, USA
    Bioinformatics 19:539-40. 2003
  7. pmc Phenylthiocarbamide: a 75-year adventure in genetics and natural selection
    Stephen Wooding
    Department of Human Genetics, University of Utah, Salt Lake City, Utah 84112 5330, USA
    Genetics 172:2015-23. 2006
  8. pmc The matrix coalescent and an application to human single-nucleotide polymorphisms
    Stephen Wooding
    Eccles Instititute of Human Genetics, University of Utah, Salt Lake City, Utah 84112 5330, USA
    Genetics 161:1641-50. 2002
  9. ncbi request reprint Ancestral alleles and population origins: inferences depend on mutation rate
    Alan R Rogers
    Department of Anthropology, University of Utah, USA
    Mol Biol Evol 24:990-7. 2007
  10. pmc A strong signature of balancing selection in the 5' cis-regulatory region of CCR5
    Michael J Bamshad
    Department of Pediatrics, University of Utah, Salt Lake City, UT 84112, USA
    Proc Natl Acad Sci U S A 99:10539-44. 2002

Collaborators

Detail Information

Publications20

  1. pmc Identification of polymorphisms and balancing selection in the male infertility candidate gene, ornithine decarboxylase antizyme 3
    Greg L Christensen
    Andrology and IVF Laboratories, University of Utah School of Medicine, Salt Lake City, UT, USA
    BMC Med Genet 7:27. 2006
    ..Ornithine decarboxylase antizyme 3 (OAZ3) is a testis-specific antizyme paralog and the only antizyme expressed in the mid to late stages of spermatogenesis...
  2. ncbi request reprint Natural selection: sign, sign, everywhere a sign
    Stephen Wooding
    Department of Human Genetics, University of Utah, 15 North 2030 East, Salt Lake City, Utah 84112 5330, USA
    Curr Biol 14:R700-1. 2004
    ..This trend is changing. New studies are rapidly revealing the effects of natural selection on genetic variants of known or likely functional importance...
  3. ncbi request reprint Evolution: a study in bad taste?
    Stephen Wooding
    Department of Human Genetics, University of Utah, Salt Lake City, 84112 5330, USA
    Curr Biol 15:R805-7. 2005
    ....
  4. ncbi request reprint Independent evolution of bitter-taste sensitivity in humans and chimpanzees
    Stephen Wooding
    Department of Human Genetics, University of Utah, 15 North 2030 East, Salt Lake City, Utah 84112 5330, USA
    Nature 440:930-4. 2006
    ..Humans and chimpanzees share variable taste sensitivity to bitter compounds mediated by PTC receptor variants, but the molecular basis of this variation has arisen twice, independently, in the two species...
  5. pmc Natural selection and molecular evolution in PTC, a bitter-taste receptor gene
    Stephen Wooding
    Department of Human Genetics, University of Utah, Salt Lake City 84112 5330, USA
    Am J Hum Genet 74:637-46. 2004
    ..01). These results combine to suggest that balancing natural selection has acted to maintain "taster" and "nontaster" alleles at the PTC locus in humans...
  6. ncbi request reprint PopHist: inferring population history from the spectrum of allele frequencies
    Stephen Wooding
    Eccles Institute of Human Genetics, University of Utah, 15 North 2030 East, Salt Lake City, UT 84112 5330, USA
    Bioinformatics 19:539-40. 2003
    ..The program uses the matrix coalescent, a method for calculating theoretical frequency spectra that can be applied to sets of unlinked sites...
  7. pmc Phenylthiocarbamide: a 75-year adventure in genetics and natural selection
    Stephen Wooding
    Department of Human Genetics, University of Utah, Salt Lake City, Utah 84112 5330, USA
    Genetics 172:2015-23. 2006
  8. pmc The matrix coalescent and an application to human single-nucleotide polymorphisms
    Stephen Wooding
    Eccles Instititute of Human Genetics, University of Utah, Salt Lake City, Utah 84112 5330, USA
    Genetics 161:1641-50. 2002
    ..To illustrate how this method can be used with data, we then use it in conjunction with a set of SNPs to test hypotheses about the history of human population size...
  9. ncbi request reprint Ancestral alleles and population origins: inferences depend on mutation rate
    Alan R Rogers
    Department of Anthropology, University of Utah, USA
    Mol Biol Evol 24:990-7. 2007
    ..This is true of one data set, but not of 2 others. This also suggests the action of some factor, such as selection or ascertainment bias, that varies among data sets...
  10. pmc A strong signature of balancing selection in the 5' cis-regulatory region of CCR5
    Michael J Bamshad
    Department of Pediatrics, University of Utah, Salt Lake City, UT 84112, USA
    Proc Natl Acad Sci U S A 99:10539-44. 2002
    ....
  11. pmc Contrasting effects of natural selection on human and chimpanzee CC chemokine receptor 5
    Stephen Wooding
    Department of Human Genetics, University of Utah, Salt Lake City UT, USA
    Am J Hum Genet 76:291-301. 2005
    ..This result suggests that chimpanzee 5'CCR5 might harbor or be linked to functional variants that influence chimpanzee resistance to disease caused by SIVcpz/HIV-1...
  12. ncbi request reprint Directional migration in the Hindu castes: inferences from mitochondrial, autosomal and Y-chromosomal data
    Stephen Wooding
    Department of Human Genetics, University of Utah, 15 North 2030 East, Salt Lake City, UT 84112 5330, USA
    Hum Genet 115:221-9. 2004
    ..Our findings support earlier evidence that the caste system has been a significant, long-term source of population structuring in South Indian Hindu populations, and that patterns of migration differ between males and females...
  13. pmc Human population genetic structure and inference of group membership
    Michael J Bamshad
    Department of Pediatrics, University of Utah, Salt Lake City, Utah 84112, USA
    Am J Hum Genet 72:578-89. 2003
    ..This suggests that a more flexible framework is needed for making inferences about population structure and the utility of proxies...
  14. ncbi request reprint Deconstructing the relationship between genetics and race
    Michael Bamshad
    Department of Human Genetics, University of Utah, Salt Lake City, Utah 84112, USA
    Nat Rev Genet 5:598-609. 2004
  15. ncbi request reprint Duplication and divergence in humans and chimpanzees
    Stephen Wooding
    Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, 84112, USA
    Bioessays 28:335-8. 2006
    ..4) Further, such changes have been implicated in a number of genetic disorders, such as DiGeorge, Angelman/Prader-Willi and Charcot-Marie-Tooth syndromes.(5)..
  16. pmc Signatures of founder effects, admixture, and selection in the Ashkenazi Jewish population
    Steven M Bray
    Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 107:16222-7. 2010
    ..Thus, the AJ population shows evidence of past founding events; however, admixture and selection have also strongly influenced its current genetic makeup...
  17. ncbi request reprint Worldwide haplotype diversity and coding sequence variation at human bitter taste receptor loci
    Unkyung Kim
    Department of Biology, Kyungpook National University, Daegu, Republic of Korea
    Hum Mutat 26:199-204. 2005
    ....
  18. pmc Natural selection and population history in the human angiotensinogen gene (AGT): 736 complete AGT sequences in chromosomes from around the world
    Toshiaki Nakajima
    Division of Genetic Diagnosis, The University of Tokyo, Tokyo 108 8639, Japan
    Am J Hum Genet 74:898-916. 2004
    ..Taken together, patterns of genetic diversity in AGT suggest that natural selection has generally favored the G(-6) variant over the A(-6) variant in non-African populations. However, important localized effects may also be present...
  19. ncbi request reprint Variation in the human TAS1R taste receptor genes
    Un Kyung Kim
    National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 5 Research Court, Rockville, MD 20850, USA
    Chem Senses 31:599-611. 2006
    ....
  20. pmc Sequence variations in the public human genome data reflect a bottlenecked population history
    Gabor Marth
    National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD 20894, USA
    Proc Natl Acad Sci U S A 100:376-81. 2003
    ..The inferred times of collapse and recovery are Upper Paleolithic, in agreement with archaeological evidence of the initial modern human colonization of Europe...