Stephen P Wooding
Affiliation: University of Texas Southwestern Medical Center
- Association of a bitter taste receptor mutation with Balkan Endemic Nephropathy (BEN)Stephen P Wooding
McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX 75244, USA
BMC Med Genet 13:96. 2012..This suggests that genetic variation in TAS2R43 might affect susceptibility to BEN, with individuals carrying functional forms of the receptor being protected by an ability to detect tainted foods...
- Signatures of natural selection in a primate bitter taste receptorStephen Wooding
McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX 75390 8591, USA
J Mol Evol 73:257-65. 2011..53) consistent with rapid shifts in ligand targeting. These patterns point to a history of rapid yet constrained change in bitter taste responses in the course of primate evolution...
- Genetics and bitter taste responses to goitrin, a plant toxin found in vegetablesStephen Wooding
McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390 8591, USA
Chem Senses 35:685-92. 2010..16) than for PROP (r(2) = 0.50) and PTC (r(2) = 0.57). These findings suggest that mutations in TAS2R38 play a role in shaping goitrin perception, but the majority of variance must be explained by other factors...
- Genetic, functional, and phenotypic diversity in TAS2R38-mediated bitter taste perceptionMaik Behrens
Department of Molecular Genetics, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, Nuthetal 14558, Germany
Chem Senses 38:475-84. 2013..However, prior studies have indicated that these alleles are common in some global regions, suggesting that alleles rare in our sample may be phenotypically relevant in other populations...
- Evolutionary Dissection of complex traitsStephen Wooding; Fiscal Year: 2007..By applying a combined evolutionary and epidemiological approach, these analyses may shed new light on the relationship between genetic variation, environmental response, and human health. ..