Affiliation: University of Virginia
Woodfolk J. T-cell responses to allergens. J Allergy Clin Immunol. 2007;119:280-94; quiz 295-6 pubmed
..Experimental techniques and approaches for analyzing allergen-specific T cells and identifying novel T-cell epitopes are described that may lead to new T-cell-based therapies. ..
Woodfolk J. Allergy and dermatophytes. Clin Microbiol Rev. 2005;18:30-43 pubmed
..Characterization of additional molecular targets by using new techniques may aid not only in the eradication of infection but also in the resolution of allergic symptoms. ..
Muehling L, Mai D, Kwok W, Heymann P, Pomes A, Woodfolk J. Circulating Memory CD4+ T Cells Target Conserved Epitopes of Rhinovirus Capsid Proteins and Respond Rapidly to Experimental Infection in Humans. J Immunol. 2016;197:3214-3224 pubmed
..The preferential persistence of high-frequency RV-specific memory Th1 cells that recognize a limited set of conserved epitopes likely arises from iterative priming by previous exposures to different RV strains. ..
Muehling L, Lawrence M, Woodfolk J. Pathogenic CD4+ T cells in patients with asthma. J Allergy Clin Immunol. 2017;140:1523-1540 pubmed publisher
..These developments, along with novel T cell-based therapies, position us to expand the assortment of molecular targets that could facilitate personalized treatments. ..
Wisniewski J, Muehling L, Eccles J, Capaldo B, Agrawal R, Shirley D, et al
. TH1 signatures are present in the lower airways of children with severe asthma, regardless of allergic status. J Allergy Clin Immunol. 2018;141:2048-2060.e13 pubmed publisher
..Our findings deviate from established paradigms and warrant further assessment of the pathogenicity of TH1 cells in patients with severe asthma. ..