CHRISTOPHER WOODCOCK

Summary

Affiliation: University of Massachusetts
Country: USA

Publications

  1. ncbi request reprint Higher-order structure of chromatin and chromosomes
    C L Woodcock
    Biology Department, University of Massachusetts, Amherst 01003, USA
    Curr Opin Genet Dev 11:130-5. 2001
  2. pmc Chromatin higher-order structure and dynamics
    Christopher L Woodcock
    Biology Department, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Cold Spring Harb Perspect Biol 2:a000596. 2010
  3. ncbi request reprint Chromatin architecture
    Christopher L Woodcock
    Department of Biology and Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, MA 01003, USA
    Curr Opin Struct Biol 16:213-20. 2006
  4. ncbi request reprint Role of linker histone in chromatin structure and function: H1 stoichiometry and nucleosome repeat length
    Christopher L Woodcock
    Biology Department and Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, 01003, USA
    Chromosome Res 14:17-25. 2006
  5. pmc Closed chromatin loops at the ends of chromosomes
    Tatiana Nikitina
    Biology Department, University of Massachusetts, Amherst, MA 01003, USA
    J Cell Biol 166:161-5. 2004
  6. pmc MeCP2 binds cooperatively to its substrate and competes with histone H1 for chromatin binding sites
    Rajarshi P Ghosh
    Program in Molecular and Cellular Biology, University of Massachusetts, 611 N Pleasant Street, Amherst, MA 01003, USA
    Mol Cell Biol 30:4656-70. 2010
  7. ncbi request reprint MeCP2-chromatin interactions include the formation of chromatosome-like structures and are altered in mutations causing Rett syndrome
    Tatiana Nikitina
    Department of Biology, University of Massachusetts, Amherst, Massachusetts 01003, USA
    J Biol Chem 282:28237-45. 2007
  8. pmc Multiple modes of interaction between the methylated DNA binding protein MeCP2 and chromatin
    Tatiana Nikitina
    Biology Department, University of Massachusetts, Amherst, MA 01003, USA
    Mol Cell Biol 27:864-77. 2007
  9. ncbi request reprint Visualization and 3D structure determination of defined sequence chromatin and chromatin remodeling complexes
    Rachel A Horowitz-Scherer
    Department of Biology, University of Massachusetts, Amherst 01003, USA
    Methods Enzymol 376:29-48. 2004
  10. ncbi request reprint Organization of interphase chromatin
    Rachel A Horowitz-Scherer
    Biology Department and Molecular and Cellular Biology Program, University of Massachusetts at Amherst, 01003, USA
    Chromosoma 115:1-14. 2006

Research Grants

  1. Role of MeCP2 as a Chromatin Architectural Protein
    CHRISTOPHER WOODCOCK; Fiscal Year: 2007
  2. 3D STRUCTURE OF CHROMATIN
    CHRISTOPHER WOODCOCK; Fiscal Year: 2002
  3. 3D STRUCTURE OF CHROMATIN
    CHRISTOPHER WOODCOCK; Fiscal Year: 1992
  4. Role of MeCP2 as a Chromatin Architectural Protein
    CHRISTOPHER WOODCOCK; Fiscal Year: 2007

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Higher-order structure of chromatin and chromosomes
    C L Woodcock
    Biology Department, University of Massachusetts, Amherst 01003, USA
    Curr Opin Genet Dev 11:130-5. 2001
    ..We discuss the recent findings from novel experimental approaches that have yielded significant new information on the different hierarchical levels of chromatin folding and their functional significance...
  2. pmc Chromatin higher-order structure and dynamics
    Christopher L Woodcock
    Biology Department, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Cold Spring Harb Perspect Biol 2:a000596. 2010
    ..We also discuss novel approaches likely to yield important insights in the near future, and suggest research areas that merit further study...
  3. ncbi request reprint Chromatin architecture
    Christopher L Woodcock
    Department of Biology and Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, MA 01003, USA
    Curr Opin Struct Biol 16:213-20. 2006
    ..In addition, the diverse structural consequences of the binding of specific chromatin 'architectural' proteins are becoming apparent. These approaches provide an essential basis for understanding the conformation of the 'epigenome'...
  4. ncbi request reprint Role of linker histone in chromatin structure and function: H1 stoichiometry and nucleosome repeat length
    Christopher L Woodcock
    Biology Department and Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, 01003, USA
    Chromosome Res 14:17-25. 2006
    ..This, together with the high mobility of H1 within the nucleus, prompts a reappraisal of the role of linker histone as an obligatory chromatin architectural protein...
  5. pmc Closed chromatin loops at the ends of chromosomes
    Tatiana Nikitina
    Biology Department, University of Massachusetts, Amherst, MA 01003, USA
    J Cell Biol 166:161-5. 2004
    ..The ability to recognize isolated telomeres in their native chromatin conformation opens the way for detailed structural and compositional studies...
  6. pmc MeCP2 binds cooperatively to its substrate and competes with histone H1 for chromatin binding sites
    Rajarshi P Ghosh
    Program in Molecular and Cellular Biology, University of Massachusetts, 611 N Pleasant Street, Amherst, MA 01003, USA
    Mol Cell Biol 30:4656-70. 2010
    ..This suggests that chromatin binding by MeCP2 and H1 in vivo should be viewed in the context of competitive multifactorial regulation...
  7. ncbi request reprint MeCP2-chromatin interactions include the formation of chromatosome-like structures and are altered in mutations causing Rett syndrome
    Tatiana Nikitina
    Department of Biology, University of Massachusetts, Amherst, Massachusetts 01003, USA
    J Biol Chem 282:28237-45. 2007
    ....
  8. pmc Multiple modes of interaction between the methylated DNA binding protein MeCP2 and chromatin
    Tatiana Nikitina
    Biology Department, University of Massachusetts, Amherst, MA 01003, USA
    Mol Cell Biol 27:864-77. 2007
    ..MeCP2 binding to DNA and chromatin involves a number of different molecular interactions, some of which result in compaction and oligomerization. The multifunctional roles of MeCP2 may be reflected in these different interactions...
  9. ncbi request reprint Visualization and 3D structure determination of defined sequence chromatin and chromatin remodeling complexes
    Rachel A Horowitz-Scherer
    Department of Biology, University of Massachusetts, Amherst 01003, USA
    Methods Enzymol 376:29-48. 2004
  10. ncbi request reprint Organization of interphase chromatin
    Rachel A Horowitz-Scherer
    Biology Department and Molecular and Cellular Biology Program, University of Massachusetts at Amherst, 01003, USA
    Chromosoma 115:1-14. 2006
    ..We consider strategies that may assist in the integration process, and we review emerging technologies that promise to reduce the "resolution gap."..
  11. pmc Unique physical properties and interactions of the domains of methylated DNA binding protein 2
    Rajarshi P Ghosh
    Department of Biology, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Biochemistry 49:4395-410. 2010
    ..These findings led to new mechanistic and biochemical insights regarding the conformational modulations of this intrinsically disordered protein, and its context-dependent in vivo roles...
  12. pmc Rett syndrome-causing mutations in human MeCP2 result in diverse structural changes that impact folding and DNA interactions
    Rajarshi P Ghosh
    Department of Biology, Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, MA 01003, USA
    J Biol Chem 283:20523-34. 2008
    ..For each mutation, we examined the extent to which the magnitude of these differences correlated with the severity of RTT patient symptoms...
  13. ncbi request reprint Structural analysis of the yeast SWI/SNF chromatin remodeling complex
    Corey L Smith
    University of Massachusetts Medical School, Program in Molecular Medicine, Worcester 01605, USA
    Nat Struct Biol 10:141-5. 2003
    ..We also report a three-dimensional reconstruction of yeast SWI/SNF derived from electron micrographs...
  14. pmc Architecture of the SWI/SNF-nucleosome complex
    Mekonnen Lemma Dechassa
    Department of Biochemistry and Molecular Biology, Southern Illinois University, 1245 Lincoln Drive, Carbondale, IL 62901 4413, USA
    Mol Cell Biol 28:6010-21. 2008
    ..The highly conserved Snf5 subunit associates with the histone octamer and not with nucleosomal DNA. The model of the binding trough of SWI/SNF illustrates how nucleosomal DNA can be mobilized while SWI/SNF remains bound...
  15. pmc The silent information regulator 3 protein, SIR3p, binds to chromatin fibers and assembles a hypercondensed chromatin architecture in the presence of salt
    Steven J McBryant
    Department of Biochemistry and Molecular Biology, Colorado State University, 381 MRB, Fort Collins, CO 80523 1870, USA
    Mol Cell Biol 28:3563-72. 2008
    ..Collectively, these results define how SIR3p may function as a chromatin architectural protein and provide new insight into the interplay between endogenous and protein-mediated chromatin fiber condensation pathways...
  16. ncbi request reprint Dynamic relocation of epigenetic chromatin markers reveals an active role of constitutive heterochromatin in the transition from proliferation to quiescence
    Sergei A Grigoryev
    Department of Biochemistry and Molecular Biology, Penn State University College of Medicine, Hershey, PA 17033, USA
    J Cell Sci 117:6153-62. 2004
    ..Our results suggest that constitutive centromeric heterochromatin plays an active role in cell differentiation and reactivation...
  17. ncbi request reprint Chromatin compaction by a polycomb group protein complex
    Nicole J Francis
    Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Science 306:1574-7. 2004
    ..This mechanism of chromatin compaction might be central to stable gene silencing by the Polycomb group...
  18. pmc H1 linker histones are essential for mouse development and affect nucleosome spacing in vivo
    Yuhong Fan
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Mol Cell Biol 23:4559-72. 2003
    ..Extensive reduction of H1 in certain tissues did not lead to changes in nuclear size, but it did result in global shortening of the spacing between nucleosomes...
  19. ncbi request reprint Intrinsic disorder and autonomous domain function in the multifunctional nuclear protein, MeCP2
    Valerie H Adams
    Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado 80523, USA
    J Biol Chem 282:15057-64. 2007
    ..These studies also establish an experimental paradigm for characterizing the tertiary structures of other highly disordered proteins...
  20. ncbi request reprint Chromatin compaction by human MeCP2. Assembly of novel secondary chromatin structures in the absence of DNA methylation
    Philippe T Georgel
    Department of Biochemistry, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Biol Chem 278:32181-8. 2003
    ....
  21. ncbi request reprint Histone H1 depletion in mammals alters global chromatin structure but causes specific changes in gene regulation
    Yuhong Fan
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Cell 123:1199-212. 2005
    ..These results indicate that linker histones can participate in epigenetic regulation of gene expression by contributing to the maintenance or establishment of specific DNA methylation patterns...
  22. ncbi request reprint A milestone in the odyssey of higher-order chromatin structure
    Christopher L Woodcock
    Nat Struct Mol Biol 12:639-40. 2005

Research Grants16

  1. Role of MeCP2 as a Chromatin Architectural Protein
    CHRISTOPHER WOODCOCK; Fiscal Year: 2007
    ..The results will provide fundamental new information of the interactions of MeCP2 with chromatin, information that can be drawn on as potential therapies for RTT are formulated and evaluated. ..
  2. 3D STRUCTURE OF CHROMATIN
    CHRISTOPHER WOODCOCK; Fiscal Year: 2002
    ..5. The process of transcription on nucleosomal templates will be studied using EC-M, providing new information on the manner in which RNA polymerase molecules are able to transcribe through nucleosomes. ..
  3. 3D STRUCTURE OF CHROMATIN
    CHRISTOPHER WOODCOCK; Fiscal Year: 1992
    ....
  4. Role of MeCP2 as a Chromatin Architectural Protein
    CHRISTOPHER WOODCOCK; Fiscal Year: 2007
    ..The¿work¿will¿also¿contribute¿significantly¿to¿understanding¿a¿fundamental¿aspect¿of¿ epigenetic¿control¿and¿chromatin¿remodeling.¿¿ Project Description Page 6 ..