Research Topics
| CHRISTOPHER WOODCOCKSummaryAffiliation: University of Massachusetts Country: USA Publications
Research Grants
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Detail Information
Publications
Higher-order structure of chromatin and chromosomesC L Woodcock
Biology Department, University of Massachusetts, Amherst 01003, USA
Curr Opin Genet Dev 11:130-5. 2001..We discuss the recent findings from novel experimental approaches that have yielded significant new information on the different hierarchical levels of chromatin folding and their functional significance...
Chromatin higher-order structure and dynamicsChristopher L Woodcock
Biology Department, University of Massachusetts, Amherst, Massachusetts 01003, USA
Cold Spring Harb Perspect Biol 2:a000596. 2010..We also discuss novel approaches likely to yield important insights in the near future, and suggest research areas that merit further study...- Chromatin architectureChristopher L Woodcock
Department of Biology and Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, MA 01003, USA
Curr Opin Struct Biol 16:213-20. 2006..In addition, the diverse structural consequences of the binding of specific chromatin 'architectural' proteins are becoming apparent. These approaches provide an essential basis for understanding the conformation of the 'epigenome'... - Role of linker histone in chromatin structure and function: H1 stoichiometry and nucleosome repeat lengthChristopher L Woodcock
Biology Department and Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, 01003, USA
Chromosome Res 14:17-25. 2006..This, together with the high mobility of H1 within the nucleus, prompts a reappraisal of the role of linker histone as an obligatory chromatin architectural protein... - Closed chromatin loops at the ends of chromosomesTatiana Nikitina
Biology Department, University of Massachusetts, Amherst, MA 01003, USA
J Cell Biol 166:161-5. 2004..The ability to recognize isolated telomeres in their native chromatin conformation opens the way for detailed structural and compositional studies... - MeCP2 binds cooperatively to its substrate and competes with histone H1 for chromatin binding sitesRajarshi P Ghosh
Program in Molecular and Cellular Biology, University of Massachusetts, 611 N Pleasant Street, Amherst, MA 01003, USA
Mol Cell Biol 30:4656-70. 2010..This suggests that chromatin binding by MeCP2 and H1 in vivo should be viewed in the context of competitive multifactorial regulation... - MeCP2-chromatin interactions include the formation of chromatosome-like structures and are altered in mutations causing Rett syndromeTatiana Nikitina
Department of Biology, University of Massachusetts, Amherst, Massachusetts 01003, USA
J Biol Chem 282:28237-45. 2007.... - Multiple modes of interaction between the methylated DNA binding protein MeCP2 and chromatinTatiana Nikitina
Biology Department, University of Massachusetts, Amherst, MA 01003, USA
Mol Cell Biol 27:864-77. 2007..MeCP2 binding to DNA and chromatin involves a number of different molecular interactions, some of which result in compaction and oligomerization. The multifunctional roles of MeCP2 may be reflected in these different interactions... - Visualization and 3D structure determination of defined sequence chromatin and chromatin remodeling complexesRachel A Horowitz-Scherer
Department of Biology, University of Massachusetts, Amherst 01003, USA
Methods Enzymol 376:29-48. 2004 - Organization of interphase chromatinRachel A Horowitz-Scherer
Biology Department and Molecular and Cellular Biology Program, University of Massachusetts at Amherst, 01003, USA
Chromosoma 115:1-14. 2006..We consider strategies that may assist in the integration process, and we review emerging technologies that promise to reduce the "resolution gap.".. - Unique physical properties and interactions of the domains of methylated DNA binding protein 2Rajarshi P Ghosh
Department of Biology, University of Massachusetts, Amherst, Massachusetts 01003, USA
Biochemistry 49:4395-410. 2010..These findings led to new mechanistic and biochemical insights regarding the conformational modulations of this intrinsically disordered protein, and its context-dependent in vivo roles... - Rett syndrome-causing mutations in human MeCP2 result in diverse structural changes that impact folding and DNA interactionsRajarshi P Ghosh
Department of Biology, Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, MA 01003, USA
J Biol Chem 283:20523-34. 2008..For each mutation, we examined the extent to which the magnitude of these differences correlated with the severity of RTT patient symptoms... - Structural analysis of the yeast SWI/SNF chromatin remodeling complexCorey L Smith
University of Massachusetts Medical School, Program in Molecular Medicine, Worcester 01605, USA
Nat Struct Biol 10:141-5. 2003..We also report a three-dimensional reconstruction of yeast SWI/SNF derived from electron micrographs... - Architecture of the SWI/SNF-nucleosome complexMekonnen Lemma Dechassa
Department of Biochemistry and Molecular Biology, Southern Illinois University, 1245 Lincoln Drive, Carbondale, IL 62901 4413, USA
Mol Cell Biol 28:6010-21. 2008..The highly conserved Snf5 subunit associates with the histone octamer and not with nucleosomal DNA. The model of the binding trough of SWI/SNF illustrates how nucleosomal DNA can be mobilized while SWI/SNF remains bound... - The silent information regulator 3 protein, SIR3p, binds to chromatin fibers and assembles a hypercondensed chromatin architecture in the presence of saltSteven J McBryant
Department of Biochemistry and Molecular Biology, Colorado State University, 381 MRB, Fort Collins, CO 80523 1870, USA
Mol Cell Biol 28:3563-72. 2008..Collectively, these results define how SIR3p may function as a chromatin architectural protein and provide new insight into the interplay between endogenous and protein-mediated chromatin fiber condensation pathways... - Dynamic relocation of epigenetic chromatin markers reveals an active role of constitutive heterochromatin in the transition from proliferation to quiescenceSergei A Grigoryev
Department of Biochemistry and Molecular Biology, Penn State University College of Medicine, Hershey, PA 17033, USA
J Cell Sci 117:6153-62. 2004..Our results suggest that constitutive centromeric heterochromatin plays an active role in cell differentiation and reactivation... - Chromatin compaction by a polycomb group protein complexNicole J Francis
Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
Science 306:1574-7. 2004..This mechanism of chromatin compaction might be central to stable gene silencing by the Polycomb group... - H1 linker histones are essential for mouse development and affect nucleosome spacing in vivoYuhong Fan
Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Mol Cell Biol 23:4559-72. 2003..Extensive reduction of H1 in certain tissues did not lead to changes in nuclear size, but it did result in global shortening of the spacing between nucleosomes... - Intrinsic disorder and autonomous domain function in the multifunctional nuclear protein, MeCP2Valerie H Adams
Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado 80523, USA
J Biol Chem 282:15057-64. 2007..These studies also establish an experimental paradigm for characterizing the tertiary structures of other highly disordered proteins... - Chromatin compaction by human MeCP2. Assembly of novel secondary chromatin structures in the absence of DNA methylationPhilippe T Georgel
Department of Biochemistry, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
J Biol Chem 278:32181-8. 2003.... - Histone H1 depletion in mammals alters global chromatin structure but causes specific changes in gene regulationYuhong Fan
Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Cell 123:1199-212. 2005..These results indicate that linker histones can participate in epigenetic regulation of gene expression by contributing to the maintenance or establishment of specific DNA methylation patterns... - A milestone in the odyssey of higher-order chromatin structureChristopher L Woodcock
Nat Struct Mol Biol 12:639-40. 2005
Research Grants
- Role of MeCP2 as a Chromatin Architectural ProteinCHRISTOPHER WOODCOCK; Fiscal Year: 2007..The results will provide fundamental new information of the interactions of MeCP2 with chromatin, information that can be drawn on as potential therapies for RTT are formulated and evaluated. ..
- 3D STRUCTURE OF CHROMATINCHRISTOPHER WOODCOCK; Fiscal Year: 2002..5. The process of transcription on nucleosomal templates will be studied using EC-M, providing new information on the manner in which RNA polymerase molecules are able to transcribe through nucleosomes. ..
- 3D STRUCTURE OF CHROMATINCHRISTOPHER WOODCOCK; Fiscal Year: 1992....
- Role of MeCP2 as a Chromatin Architectural ProteinCHRISTOPHER WOODCOCK; Fiscal Year: 2007..The¿work¿will¿also¿contribute¿significantly¿to¿understanding¿a¿fundamental¿aspect¿of¿ epigenetic¿control¿and¿chromatin¿remodeling.¿¿ Project Description Page 6 ..