Research Topics
Genomes and Genes | W M WoodSummaryAffiliation: University of Colorado Health Sciences Center Country: USA Publications
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Publications
An upstream regulator of the glycoprotein hormone alpha-subunit gene mediates pituitary cell type activation and repression by different mechanismsW M Wood
Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Biol Chem 274:15526-32. 1999....- Structural and functional characterization of the genomic locus encoding the murine beta 2 thyroid hormone receptorW M Wood
Department of Medicine, University of Colorado Health Sciences Center, Denver 80262
Mol Endocrinol 8:1605-17. 1994..We therefore conclude that the promoter region responsible for expression of the TR beta 2 isoform in pituitary thyrotropes is distinct from that described for TR beta 1 and is located many kilobases upstream from their common exons... - Msx1 is present in thyrotropic cells and binds to a consensus site on the glycoprotein hormone alpha-subunit promoterV D Sarapura
University of Colorado Health Sciences Center, Denver 80262, USA
Mol Endocrinol 11:1782-94. 1997..These studies suggest that Msx1 may play a role in the expression of the alpha-subunit gene in thyrotrope cells... - The effect of thyroid hormone and a long-acting somatostatin analogue on TtT-97 murine thyrotropic tumorsW W Woodmansee
Division of Endocrinology, University of Colorado Health Sciences Center, Denver 80262, USA
Thyroid 10:533-41. 2000..These data suggest an important interaction between the somatostatinergic system and thyroid hormone in the regulation of thyrotrope cell structure and function... - Pit-1 and GATA-2 interact and functionally cooperate to activate the thyrotropin beta-subunit promoterD F Gordon
Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Biol Chem 272:24339-47. 1997..In summary, these data demonstrate functional synergy and physical interaction between homeobox and zinc finger factors and provide insights into the transcriptional mechanisms of thyrotrope-specific gene expression... - Activation of the glycoprotein hormone alpha-subunit gene promoter in thyrotropesV D Sarapura
Department of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
Mol Cell Endocrinol 146:77-86. 1998..This analysis provides basic information important to identify common and unique factors contributing to the cell-specific expression of the alpha-subunit gene... - Analysis of Pit-1 in regulating mouse TSH beta promoter activity in thyrotropesD F Gordon
Department of Medicine, University of Colorado Health Sciences Center, Denver 80262
Mol Cell Endocrinol 96:75-84. 1993..These studies suggest that Pit-1 is not limiting for cell-specific expression of the TSH beta gene in thyrotrope-derived cells and implies that additional thyrotropic factors are likely required... - Cloning of the mouse somatostatin receptor subtype 5 gene: promoter structure and functionD F Gordon
Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Health Sciences Center, Denver 80262, USA
Endocrinology 140:5598-608. 1999..Cloning of the sst5 gene will facilitate the mapping of basal and regulated responses at the transcriptional level... - A thyrotrope-specific variant of Pit-1 transactivates the thyrotropin beta promoterB R Haugen
Department of Medicine, University of Colorado Health Sciences Center, Denver 80262
J Biol Chem 268:20818-24. 1993..These data suggest that Pit-1T is a thyrotrope-specific splice variant of Pit-1 that is required for TSH beta promoter stimulation; furthermore, both Pit-1 and Pit-1T are required for TSH beta promoter activity in thyrotrope cells... - Reverse transcription polymerase chain reaction analysis of pituitary hormone, Pit-1 and steroidogenic factor-1 messenger RNA expression in pituitary tumorsM T McDermott
Division of Endocrinology, University of Colorado Health Sciences Center, Denver 80262, USA
Pituitary 2:217-24. 1999..Combined analysis of hormone and transcription factor mRNA in pituitary tumor tissue may therefore be a more meaningful approach to pituitary tumor characterization... - Organization and nucleotide sequence of the gene encoding the beta-subunit of murine thyrotropinD F Gordon
Department of Medicine, University of Colorado Health Sciences Center, Denver 80262
DNA 7:17-26. 1988.... - Expression of the beta-subunit gene of murine thyrotropin results in multiple messenger ribonucleic acid species which are generated by alternative exon splicingW M Wood
Department of Medicine, University of Colorado Health Sciences Center, Denver 80262
Mol Endocrinol 1:875-83. 1987..In the hypothyroid state, transcripts initiated at the upstream site were considerably less abundant than those initiated at the downstream site. Transcription from both start sites was inhibited by thyroid hormone in both mice and rats... - Organization and nucleotide sequence of the mouse alpha-subunit gene of the pituitary glycoprotein hormonesD F Gordon
Department of Medicine, University of Colorado Health Sciences Center, Denver 80262
DNA 7:679-90. 1988.... - Role of glucocorticoid hormones in arginine vasopressin gene regulationJ K Kim
Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Biochem Biophys Res Commun 289:1252-6. 2001..In conclusion, the data presented here support a central mechanism to explain, at least in part, the nonosmotic increase in AVP with glucocorticoid deficiency... - Lipoprotein lipase gene expression in rat adipocytes is regulated by isoproterenol and insulin through different mechanismsM V Raynolds
Department of Medicine, University of Colorado Health Sciences Center, Denver 80262
Mol Endocrinol 4:1416-22. 1990..Insulin, which does not affect LPL gene transcription, increases LPL enzyme activity and steady state mRNA levels. The effect of insulin on LPL mRNA is probably due to insulin-induced changes in mRNA stability... - Signaling pathways responsible for fetal gene induction in the failing human heart: evidence for altered thyroid hormone receptor gene expressionK Kinugawa
Division of Cardiology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Circulation 103:1089-94. 2001.... - Isolation and characterization of mouse complementary DNAs encoding alpha and beta thyroid hormone receptors from thyrotrope cells: the mouse pituitary-specific beta 2 isoform differs at the amino terminus from the corresponding species from rat pituitaryW M Wood
Department of Medicine, University of Colorado Health Sciences Center, Denver 80262
Mol Endocrinol 5:1049-61. 1991..Levels of TR beta 1 mRNA were not changed in liver, but were increased in thyrotropic tumors and also somewhat in brain, an organ that is not responsive to T3 by classical criteria... - Enhancer-mediated high level expression of mouse pituitary glycoprotein hormone alpha-subunit transgene in thyrotropes, gonadotropes, and developing pituitary glandS K Kendall
Department of Human Genetics, University of Michigan Medical School, Ann Arbor 48109 0618
Mol Endocrinol 8:1420-33. 1994.... - Chromosomal localization of the large subunit of mouse replication factor C in the mouse and humanA C Lossie
Department of Human Genetics, University of Michigan Medical School, Ann Arbor 48109-0618
Mamm Genome 6:58-9. 1995 - N-terminal variants of thyroid hormone receptor beta: differential function and potential contribution to syndrome of resistance to thyroid hormoneL Ng
Roche Institute of Molecular Biology, Nutley, New Jersey 07110, USA
Mol Endocrinol 9:1202-13. 1995....