Charles Wood

Summary

Affiliation: University of Nebraska
Country: USA

Publications

  1. pmc A comparative study of HIV-1 clade C env evolution in a Zambian infant with an infected rhesus macaque during disease progression
    For Yue Tso
    Nebraska Center for Virology and the School of Biological Sciences, University of Nebraska Lincoln, Lincoln, Nebraska 68583 0900, USA
    AIDS 23:1817-28. 2009
  2. pmc Higher levels of neutralizing antibodies against KSHV in KS patients compared to asymptomatic individuals from Zambia
    Pankaj Kumar
    Nebraska Center for Virology and the School of Biological Sciences, University of Nebraska Lincoln, Lincoln, Nebraska, United States of America
    PLoS ONE 8:e71254. 2013
  3. pmc Human Ubc9 is involved in intracellular HIV-1 Env stability after trafficking out of the trans-Golgi network in a Gag dependent manner
    Christopher R Bohl
    Nebraska Center for Virology and the School of Biological Sciences, University of Nebraska, Lincoln, Lincoln, Nebraska, USA
    PLoS ONE 8:e69359. 2013
  4. pmc Lysine residues of interferon regulatory factor 7 affect the replication and transcription activator-mediated lytic replication of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8
    Tianzheng Zhang
    TEDA School of Biological Sciences and Biotechnology, Nankai University, 23 HongDa Street, TEDA, Tianjin 300457, PR China
    J Gen Virol 92:181-7. 2011
  5. pmc Clade C HIV-1 isolates circulating in Southern Africa exhibit a greater frequency of dicysteine motif-containing Tat variants than those in Southeast Asia and cause increased neurovirulence
    Vasudev R Rao
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Retrovirology 10:61. 2013
  6. ncbi request reprint AIDS and associated malignancies
    Charles Wood
    Nebraska Center for Virology and School of Biological Sciences, University of Nebraska, Lincoln, NE 68588, USA
    Cell Res 15:947-52. 2005
  7. pmc Early childhood infection by human herpesvirus 8 in Zambia and the role of human immunodeficiency virus type 1 coinfection in a highly endemic area
    Veenu Minhas
    Nebraska Center for Virology and School of Biological Sciences, University of Nebraska Lincoln, Lincoln, NE 68583, USA
    Am J Epidemiol 168:311-20. 2008
  8. pmc Characterization of HIV-1 subtype C envelope glycoproteins from perinatally infected children with different courses of disease
    Hong Zhang
    Nebraska Center for Virology, University of Nebraska, Lincoln, NE, USA
    Retrovirology 3:73. 2006
  9. pmc Evolution of subtype C HIV-1 Env in a slowly progressing Zambian infant
    Hong Zhang
    Nebraska Center for Virology, University of Nebraska, Lincoln, NE, USA
    Retrovirology 2:67. 2005
  10. pmc Enhancement of autophagy during lytic replication by the Kaposi's sarcoma-associated herpesvirus replication and transcription activator
    Hui Ju Wen
    Nebraska Center for Virology and the School of Biological Sciences, University of Nebraska, Lincoln, Nebraska 68583 0900, USA
    J Virol 84:7448-58. 2010

Research Grants

  1. Kaposi's sarcoma and human herpesvirus in Africa
    Charles Wood; Fiscal Year: 2010
  2. Research and Training on HIV/AIDS Neuropathogenesis in Zambia
    Charles Wood; Fiscal Year: 2007
  3. Research Training in Comparative Viral Pathogenesis
    Charles Wood; Fiscal Year: 2007
  4. Kaposi's sarcoma and human herpesvirus in Africa
    Charles Wood; Fiscal Year: 2007
  5. Nebraska Center for Virology
    Charles Wood; Fiscal Year: 2006
  6. Kaposi's sarcoma and human herpesvirus in Africa
    Charles Wood; Fiscal Year: 2006
  7. Nebraska Center for Virology
    Charles Wood; Fiscal Year: 2005
  8. Kaposi's sarcoma and human herpesvirus in Africa
    Charles Wood; Fiscal Year: 2010
  9. Kaposi's sarcoma and human herpesvirus in Africa
    Charles Wood; Fiscal Year: 2009
  10. Kaposi's sarcoma and human herpesvirus in Africa
    Charles Wood; Fiscal Year: 2009

Collaborators

Detail Information

Publications58

  1. pmc A comparative study of HIV-1 clade C env evolution in a Zambian infant with an infected rhesus macaque during disease progression
    For Yue Tso
    Nebraska Center for Virology and the School of Biological Sciences, University of Nebraska Lincoln, Lincoln, Nebraska 68583 0900, USA
    AIDS 23:1817-28. 2009
    ..To evaluate whether HIV-1 clade C (HIV-C) envelope variations that arise during disease progression in rhesus macaque model reflect changes that occur naturally in human infection...
  2. pmc Higher levels of neutralizing antibodies against KSHV in KS patients compared to asymptomatic individuals from Zambia
    Pankaj Kumar
    Nebraska Center for Virology and the School of Biological Sciences, University of Nebraska Lincoln, Lincoln, Nebraska, United States of America
    PLoS ONE 8:e71254. 2013
    ..This study is first to compare prevalence and titers of neutralizing antibodies in participants with and without disease from a KSHV endemic region. ..
  3. pmc Human Ubc9 is involved in intracellular HIV-1 Env stability after trafficking out of the trans-Golgi network in a Gag dependent manner
    Christopher R Bohl
    Nebraska Center for Virology and the School of Biological Sciences, University of Nebraska, Lincoln, Lincoln, Nebraska, USA
    PLoS ONE 8:e69359. 2013
    ..This study provides further insight in the processing and packaging of the HIV-1 gp120 into mature HIV-1 virions. ..
  4. pmc Lysine residues of interferon regulatory factor 7 affect the replication and transcription activator-mediated lytic replication of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8
    Tianzheng Zhang
    TEDA School of Biological Sciences and Biotechnology, Nankai University, 23 HongDa Street, TEDA, Tianjin 300457, PR China
    J Gen Virol 92:181-7. 2011
    ..However, other mutations affect only a subset of these four functions. These findings demonstrate that the lysine residues of IRF-7 play important roles in mediating IFN synthesis and modulating viral lytic replication...
  5. pmc Clade C HIV-1 isolates circulating in Southern Africa exhibit a greater frequency of dicysteine motif-containing Tat variants than those in Southeast Asia and cause increased neurovirulence
    Vasudev R Rao
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Retrovirology 10:61. 2013
    ..HIV-1 Tat protein is a viral determinant of neurocognitive dysfunction. Therefore, we focused our study on the variations seen in tat gene and its contribution to HIV associated neuropathogenesis...
  6. ncbi request reprint AIDS and associated malignancies
    Charles Wood
    Nebraska Center for Virology and School of Biological Sciences, University of Nebraska, Lincoln, NE 68588, USA
    Cell Res 15:947-52. 2005
    ..The pathogenesis of ARLs is complex. B-cell proliferation driven by chronic antigenemia resulting in the induction of polyclonal and ultimately monoclonal lymphoproliferation may occur in the setting of severe immunosuppression...
  7. pmc Early childhood infection by human herpesvirus 8 in Zambia and the role of human immunodeficiency virus type 1 coinfection in a highly endemic area
    Veenu Minhas
    Nebraska Center for Virology and School of Biological Sciences, University of Nebraska Lincoln, Lincoln, NE 68583, USA
    Am J Epidemiol 168:311-20. 2008
    ..These results demonstrate that cross-sectional serologic screening probably underestimates true HHV-8 seroprevalence in young Zambian children because of fluctuations in detectable antibody titers...
  8. pmc Characterization of HIV-1 subtype C envelope glycoproteins from perinatally infected children with different courses of disease
    Hong Zhang
    Nebraska Center for Virology, University of Nebraska, Lincoln, NE, USA
    Retrovirology 3:73. 2006
    ..We investigated the possible influence of viral genotype and humoral immune response on disease progression in infants...
  9. pmc Evolution of subtype C HIV-1 Env in a slowly progressing Zambian infant
    Hong Zhang
    Nebraska Center for Virology, University of Nebraska, Lincoln, NE, USA
    Retrovirology 2:67. 2005
    ..Changes in genotype and phenotype were correlated to alterations of the host humoral immune response...
  10. pmc Enhancement of autophagy during lytic replication by the Kaposi's sarcoma-associated herpesvirus replication and transcription activator
    Hui Ju Wen
    Nebraska Center for Virology and the School of Biological Sciences, University of Nebraska, Lincoln, Nebraska 68583 0900, USA
    J Virol 84:7448-58. 2010
    ..These results suggest that RTA increases autophagy activation to facilitate KSHV lytic replication. This is the first report demonstrating that autophagy is involved in the lytic reactivation of KSHV...
  11. pmc The zinc finger DNA-binding domain of K-RBP plays an important role in regulating Kaposi's sarcoma-associated herpesvirus RTA-mediated gene expression
    Zhilong Yang
    Nebraska Center for Virology and School of Biological Sciences, University of Nebraska Lincoln, Lincoln NE 68583, USA
    Virology 391:221-31. 2009
    ..Finally, we show that K-RBP inhibits RTA binding to ORF57 promoter. These findings suggest that the DNA-binding activity of K-RBP plays an important role in repressing viral promoter activity...
  12. pmc Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 replication and transcription activator regulates viral and cellular genes via interferon-stimulated response elements
    Jun Zhang
    Nebraska Center for Virology, University of Nebraska, 1901 Vine St, Lincoln, NE 68588, USA
    J Virol 79:5640-52. 2005
    ..The sequence and functional similarities between RTA and IRFs suggest that the HHV-8 RTA may usurp the cellular IRF pathway...
  13. pmc Identification and characterization of a new Kaposi's sarcoma-associated herpesvirus replication and transcription activator (RTA)-responsive element involved in RTA-mediated transactivation
    Hui Ju Wen
    Nebraska Center for Virology, University of Nebraska Lincoln, Lincoln, NE 68583, USA
    J Gen Virol 90:944-53. 2009
    ..These results suggest that the ability of RTA to mediate transcriptional activation is distinct from its ability to bind to its target elements...
  14. pmc Restricted genetic diversity of HIV-1 subtype C envelope glycoprotein from perinatally infected Zambian infants
    Hong Zhang
    Nebraska Center for Virology, University of Nebraska, Lincoln, Nebraska, United States of America
    PLoS ONE 5:e9294. 2010
    ..In this study, we analyzed the viral env quasispecies of six mother-infant transmission pairs (MIPs) and characterized the genetic features of envelope glycoprotein that could influence HIV-1 subtype C perinatal transmission...
  15. ncbi request reprint Distribution of Kaposi sarcoma-associated herpesvirus/human herpesvirus 8 in maternal saliva and breast milk in Zambia: implications for transmission
    Brad P Brayfield
    Nebraska Center for Virology and School of Biological Sciences, University of Nebraska, Lincoln, Nebraska 68588 0666, USA
    J Infect Dis 189:2260-70. 2004
    ..In the present study, we examined 2 possible routes of mother-to-child transmission, through breast milk and saliva, during the first 6 months after delivery...
  16. pmc Functional properties of the HIV-1 subtype C envelope glycoprotein associated with mother-to-child transmission
    Hong Zhang
    Nebraska Center for Virology, University of Nebraska, Lincoln, NE 68583 0900, USA
    Virology 400:164-74. 2010
    ..These findings provide further insight into the characteristics of perinatally transmissible HIV-1 and may have implications for intervention approaches...
  17. pmc Primary gamma-herpesviral infection in Zambian children
    Veenu Minhas
    Nebraska Center for Virology and School of Biological Sciences, University of Nebraska Lincoln, Lincoln, NE 68583 USA
    BMC Infect Dis 10:115. 2010
    ..Here, we compare the natural history of infection by these two viruses along with the clinical manifestations and risk factors that are associated with early childhood infection in Zambia, which is an endemic area for HHV-8...
  18. pmc Development of an immunofluorescence assay using recombinant proteins expressed in insect cells to screen and confirm presence of human herpesvirus 8-specific antibodies
    Veenu Minhas
    Nebraska Center for Virology, School of Biological Sciences, University of Nebraska Lincoln, Lincoln, NE 68583, USA
    Clin Vaccine Immunol 15:1259-64. 2008
    ..The performance of these two assays when they were used together indicates that they may be useful for the reliable detection of HHV-8-specific immunoglobulin G antibodies in a population...
  19. ncbi request reprint Epidemiological characteristics of human herpesvirus-8 infection in a large population of antenatal women in Zambia
    W Klaskala
    Nebraska Center for Virology and the School of Biological Sciences, University of Nebraska, 1901 Vine Street, Lincoln, NE 68588, USA
    J Med Virol 75:93-100. 2005
    ..Since HHV-8 facilitates development of AIDS-related Kaposi's sarcoma (KS), the results of this study could be utilized to identify specific population groups of pregnant women who are at increased risk for this disease...
  20. pmc Early childhood infection of Kaposi's sarcoma-associated herpesvirus in Zambian households: a molecular analysis
    Landon N Olp
    Nebraska Center for Virology and School of Biological Sciences, University of Nebraska Lincoln, Lincoln, NE 68583, USA
    Int J Cancer 132:1182-90. 2013
    ..These results are important for developing KSHV intervention strategies...
  21. doi request reprint Genetic variation in mother-child acute seroconverter pairs from Zambia
    Federico G Hoffmann
    School of Biological Sciences, University of Nebraska, Lincoln, Nebraska 68588 0666, USA
    AIDS 22:817-24. 2008
    ....
  22. pmc The human immunodeficiency virus type 1 envelope confers higher rates of replicative fitness to perinatally transmitted viruses than to nontransmitted viruses
    Xiaohong Kong
    Nebraska Center for Virology, and the School of Biological Sciences, University of Nebraska, Lincoln, Nebraska 68583 0900, USA
    J Virol 82:11609-18. 2008
    ..This finding has important implications for vaccine design or development of strategies to prevent HIV-1 transmission...
  23. pmc Kaposi's sarcoma-associated herpesvirus transactivator RTA promotes degradation of the repressors to regulate viral lytic replication
    Zhilong Yang
    Nebraska Center for Virology and School of Biological Sciences, University of Nebraska, E249 Beadle Center, P O Box 880666, Lincoln, NE 68588 0666, USA
    J Virol 82:3590-603. 2008
    ....
  24. pmc The transcriptional repressor K-RBP modulates RTA-mediated transactivation and lytic replication of Kaposi's sarcoma-associated herpesvirus
    Zhilong Yang
    Nebraska Center for Virology and School of Biological Sciences, University of Nebraska, E249 Beadle Center, P O Box 880666, Lincoln, NE 68588 0666, USA
    J Virol 81:6294-306. 2007
    ....
  25. pmc Molecular determinants of HIV-1 subtype C coreceptor transition from R5 to R5X4
    Hong Zhang
    Nebraska Center for Virology, University of Nebraska, Lincoln, NE 68583 0900, USA
    Virology 407:68-79. 2010
    ..Determining what defines a subtype C X4 virus will lead to a better understanding of subtype C HIV-1 pathogenesis, and will provide important information relevant to anti-retroviral therapy...
  26. pmc Modulation of human herpesvirus 8/Kaposi's sarcoma-associated herpesvirus replication and transcription activator transactivation by interferon regulatory factor 7
    Jinzhong Wang
    Nebraska Center for Virology and School of Biological Sciences, University of Nebraska Lincoln, 1901 Vine St, Lincoln, NE 68588 0666, USA
    J Virol 79:2420-31. 2005
    ....
  27. pmc Short communication: antiretroviral therapy resistance mutations present in the HIV type 1 subtype C pol and env regions from therapy-naive patients in Zambia
    Sandra Gonzalez
    Nebraska Center for Virology and School of Biological Sciences, University of Nebraska Lincoln, Lincoln, Nebraska 68583 0900, USA
    AIDS Res Hum Retroviruses 26:795-803. 2010
    ..Moreover, the high prevalence of resistance mutations observed for maraviroc and vicriviroc in both cohorts may suggest a limited efficacy of entry inhibitors on HIV-1 subtype C...
  28. pmc Dynamics of envelope evolution in clade C SHIV-infected pig-tailed macaques during disease progression analyzed by ultra-deep pyrosequencing
    For Yue Tso
    Nebraska Center for Virology and the School of Biological Sciences, University of Nebraska Lincoln, Lincoln, Nebraska, United States of America
    PLoS ONE 7:e32827. 2012
    ..These recurring mutations in different envelopes suggest that there may be a common evolutionary pattern and selection pathway for the HIV-1 envelope during disease progression...
  29. pmc The Zambia Children's KS-HHV8 Study: rationale, study design, and study methods
    Veenu Minhas
    Nebraska Center for Virology, School of Biological Sciences, University of Nebraska Lincoln, Lincoln, Nebraska 68583, USA
    Am J Epidemiol 173:1085-92. 2011
    ..The authors describe the study rationale, design, execution, and characteristics of this cohort, which provides critical data on the epidemiology and transmission of HHV-8 to young children in Zambia...
  30. pmc Human Ubc9 contributes to production of fully infectious human immunodeficiency virus type 1 virions
    Tareq Jaber
    Nebraska Center for Virology and School of Biological Sciences, University of Nebraska Lincoln, Lincoln, NE 68583 0900, USA
    J Virol 83:10448-59. 2009
    ..This finding demonstrates that Ubc9 plays an important role in the production of infectious HIV-1 virions...
  31. doi request reprint Human papillomavirus 16 variants from Zambian women with normal pap smears
    Yan Jun Lei
    Nebraska Center for Virology, School of Biological Sciences, University of Nebraska Lincoln, Lincoln, Nebraska, USA
    J Med Virol 83:1230-7. 2011
    ..The decreased promoter activity of some HPV16 variants may decrease expression of viral oncogenes and may be linked with the development, phenotype and severity of the cervical lesions in women infected with these across HPV16 variants...
  32. pmc The distribution of sexually-transmitted Human Papillomaviruses in HIV positive and negative patients in Zambia, Africa
    Christopher Ng'andwe
    Nebraska Center for Virology, School of Biological Sciences, University of Nebraska Lincoln, Lincoln, Nebraska, USA
    BMC Infect Dis 7:77. 2007
    ..The rate of high-risk HPV genotypes worldwide varies within each country. Thus, we sought to investigate the rates of HPV infection in sub-Saharan Africa and the potential role of HIV in affecting the HPV genotype distribution...
  33. pmc Comparative analysis of the fusion efficiency elicited by the envelope glycoprotein V1-V5 regions derived from human immunodeficiency virus type 1 transmitted perinatally
    Hongyan Guo
    Laboratory of Medical Molecular Virology, School of Medicine, Nankai University, Tianjin, PR China
    J Gen Virol 93:2635-45. 2012
    ..Other factors such as the route and timing of transmission may also be involved...
  34. ncbi request reprint Compartmentalization of HIV-1 in the central nervous system: role of the choroid plexus
    Evan J Burkala
    Nebraska Center for Virology and the School of Biological Sciences, University of Nebraska, Lincoln, NE, USA
    AIDS 19:675-84. 2005
    ..To determine the genetic and phenotypic composition of HIV-1 found in the choroid plexus (CPx) and its relationship to virus in the brain and peripheral lymphoid tissue...
  35. pmc The viral etiology of AIDS-associated malignancies
    Peter C Angeletti
    Nebraska Center for Virology, School of Biological Sciences, University of Nebraska Lincoln, Lincoln, Nebraska 68588, USA
    Adv Pharmacol 56:509-57. 2008
  36. pmc Risk factors for early childhood infection of human herpesvirus-8 in zambian children: the role of early childhood feeding practices
    Kay L Crabtree
    Authors Affiliations Nebraska Center for Virology and School of Biological Sciences, University of Nebraska Lincoln, Lincoln, Nebraska Department of Pediatrics, University of California, San Francisco, California Department of Pathobiology and Population Medicine, Mississippi State University, Mississippi State, Mississippi University of Zambia, School of Medicine and University Teaching Hospital, Zambia and University of Miami Miller School of Medicine, Miami, Florida
    Cancer Epidemiol Biomarkers Prev 23:300-8. 2014
    ..Specific routes of transmission have not been clearly delineated, though HHV-8 is present in high concentrations in saliva...
  37. pmc Low-abundance resistant mutations in HIV-1 subtype C antiretroviral therapy-naive individuals as revealed by pyrosequencing
    Sandra Gonzalez
    Nebraska Center for Virology, University of Nebraska Lincoln, 102C Morrison Center, 4240 Fair St, Lincoln, NE 68583 0900, USA
    Curr HIV Res 11:43-9. 2013
    ..Moreover, the effectiveness of first-line and even some secondline ART may be compromised in this setting...
  38. pmc Kaposi's Sarcoma-Associated Herpesvirus Transactivator Rta Induces Cell Cycle Arrest in G0/G1 Phase by Stabilizing and Promoting Nuclear Localization of p27kip
    Pankaj Kumar
    Nebraska Center for Virology and the School of Biological Sciences, University of Nebraska Lincoln, Lincoln, Nebraska
    J Virol 87:13226-38. 2013
    ....
  39. pmc Use of average mutual information for studying changes in HIV populations
    Khalid Sayood
    Department of Electrical Engineering, University of Nebraska, Lincoln, 68588 0511, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:3861-4. 2009
    ..By examining the changes in AMI between populations we can distinguish between clones obtained from rapid progressor and slow progressor. A measure of this change can be used to enhance prediction of disease progression...
  40. ncbi request reprint Postnatal human herpesvirus 8 and human immunodeficiency virus type 1 infection in mothers and infants from Zambia
    Brad P Brayfield
    Nebraska Center for Virology, School of Biological Sciences, Lincoln, Nebraska 68588, USA
    J Infect Dis 187:559-68. 2003
    ..However, most HHV-8-positive infants appeared to have acquired infection either intrapartum or postpartum. The present study indicates that transmission of HHV-8 to infants can occur early and is likely via multiple routes...
  41. pmc A twin-cysteine motif in the V2 region of gp120 is associated with SIV envelope trimer stabilization
    Christopher Bohl
    Nebraska Center for Virology, University of Nebraska Lincoln, Lincoln, Nebraska, United States of America
    PLoS ONE 8:e69406. 2013
    ..This implies that HIV-1 lost the twin-cysteines, and may have relatively unstable Env trimers compared to SIV and HIV-2...
  42. pmc HIV-1 effects on neuropsychological performance in a resource-limited country, Zambia
    Adelina Holguin
    Nebraska Center for Virology, School of Biological Sciences, University of Nebraska, Lincoln, 68583 0900, USA
    AIDS Behav 15:1895-901. 2011
    ..Larger studies that will accommodate gender differences and age are necessary to generate appropriate norms in Zambia in order to better assess the prevalence of HAND in the developing country setting...
  43. pmc Chronology and evolution of the HIV-1 subtype C epidemic in Ethiopia
    Damien C Tully
    Nebraska Center for Virology and School of Biological Sciences, University of Nebraska Lincoln, Lincoln, Nebraska 68583 0900, USA
    AIDS 24:1577-82. 2010
    ..To reconstruct the onset date and evolutionary history of the HIV-1 subtype C epidemic in Ethiopia - one of the earliest recorded subtype C epidemics in the world...
  44. pmc Humanized-BLT mouse model of Kaposi's sarcoma-associated herpesvirus infection
    Lin xu Wang
    Nebraska Center for Virology and School of Biological Sciences, University of Nebraska, Lincoln, NE 68583 0900
    Proc Natl Acad Sci U S A 111:3146-51. 2014
    ..This hu-BLT mouse not only will be a useful model for studying the pathogenesis of KSHV in vivo but can potentially be used to study the routes and spread of viral infection in the infected host. ..
  45. ncbi request reprint The role of Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8 regulator of transcription activation (RTA) in control of gene expression
    John T West
    Nebraska Center for Virology, School of Biological Sciences, University of Nebraska, Lincoln, 1901 Vine Street, Lincoln, NE 68588, USA
    Oncogene 22:5150-63. 2003
    ..Modulation of transactivation, through alternate RTA-protein, or RTA-promoter interactions, is hypothesized to participate in the selective tissue tropism and differential pathogenesis observed in KS...
  46. ncbi request reprint AIDS-assoicated viral oncogenesis. Overview
    Charles Wood
    Nebraska Center for Virology and the School of Biological Sciences, University of Nebraska, Lincoln, NE, USA
    Cancer Treat Res 133:1-19. 2007
  47. pmc Subtype-associated differences in HIV-1 reverse transcription affect the viral replication
    Sergey Iordanskiy
    Nebraska Center for Virology, School of Biological Sciences, University of Nebraska Lincoln, 4240 Fair Street, East Campus, Lincoln, NE 68583 0900 USA
    Retrovirology 7:85. 2010
    ..For subtype C, which accounts of almost 60% of HIV cases worldwide, much less is known. It has been reported that subtype C HIV-1 isolates have a lower replication capacity than B; however, the basis of these differences remains unclear...
  48. ncbi request reprint Phylogenetic and phenotypic analysis of HIV type 1 env gp120 in cases of subtype C mother-to-child transmission
    Hong Zhang
    Nebraska Center for Virology, University of Nebraska, Lincoln 68588, USA
    AIDS Res Hum Retroviruses 18:1415-23. 2002
    ..The differences in the mode and timing of transmission may account for the observed transmission pattern among four MIPs...
  49. ncbi request reprint Inactivation and viral load quantitation of human immunodeficiency virus in blood collected into Cyto-Chex(®) BCT blood collection device
    Eunhee Kwon
    Nebraska Center for Virology, University of Nebraska Lincoln, Lincoln, NE, USA
    J Virol Methods 196:50-5. 2014
    ....
  50. ncbi request reprint Cellular tropisms and co-receptor usage of HIV-1 isolates from vertically infected children with neurological abnormalities and rapid disease progression
    Micheline McCarthy
    Department of Veterans Affairs Medical Center, Miami, Florida 33125, USA
    J Med Virol 67:1-8. 2002
    ..Viral phenotypic properties determined in cell culture did not specifically predict clinical features or course, and the development of AIDS did not coincide with, or depend on, the appearance T-tropic, syncytia-inducing viruses...
  51. ncbi request reprint Dichotomy in cross-clade reactivity and neutralization by HIV-1 sera: Implications for active and passive immunotherapy
    Lisa A Cavacini
    Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Med Virol 76:146-52. 2005
    ..Understanding antibody responses to native virions after Clade C infection and cross clade antibody behavior has implications for understanding pathogenesis and vaccine development...
  52. pmc Human immunodeficiency virus type 1 pathobiology studied in humanized BALB/c-Rag2-/-gammac-/- mice
    Santhi Gorantla
    Centere for Neurovirology and Neurodegenerative Disorders, Department of Pharmacology, University of Nebraska Medical Center, 985880 Nebraska Medical Center, Omaha, NE 68198 5880, USA
    J Virol 81:2700-12. 2007
    ..We conclude that humanized BALB/c-Rag2(-/-)gamma(c)(-/-) mice represent a unique and valuable resource for HIV-1 pathobiology studies...
  53. ncbi request reprint Traditional practices and exposure to bodily fluids in Lusaka, Zambia
    Janet M Wojcicki
    Department of Pediatrics, University of California, San Francisco, CA 94134, USA
    Trop Med Int Health 12:150-5. 2007
    ..To ascertain if there are specific sociocultural and behavioural practices associated with the exposure to saliva, semen and vaginal fluids, particularly through child-rearing practices and the use of traditional medicine in Lusaka, Zambia...
  54. ncbi request reprint Construction and characterization of a chimeric virus (BIV/HIV-1) carrying the bovine immunodeficiency virus gag-pol gene
    Guomin Chen
    Department of Tumor Virus and HIV, Institute of Virology, CAPM, Beijing, China
    AIDS 16:123-5. 2002
    ..The results firstly demonstrated that it is possible to generate a new type of the BIV/HIV-1 chimeric virus containing BIV gag-pol gene...
  55. ncbi request reprint Localization of human herpesvirus type 8 in human sperms by in situ PCR
    Omar Bagasra
    South Carolina Center for Biotechnology, Department of Biology, Claflin University, 400 Magnolia Street, Orangeburg, SC 29115, USA
    J Mol Histol 36:401-12. 2005
    ..In our studies, we sought to assess the cellular reservoirs of HHV-8 DNA in the semen of HIV-1-infected men and the potential role of HHV-8 infected spermatozoa in horizontal transmission...
  56. pmc Mortality among HIV-1- and human herpesvirus type 8-affected mother-infant pairs in Zambia
    Janet Wojcicki
    Department of Pediatrics, School of Medicine, University of California, San Francisco, CA 94134 0136, USA
    Cancer Epidemiol Biomarkers Prev 17:2238-43. 2008
    ..To determine the respective trends in mortality of Zambian mother-infant pairs based on maternal infection with HIV-1 and human herpesvirus type 8 (HHV-8)...
  57. pmc Infectious molecular clone of a recently transmitted pediatric human immunodeficiency virus clade C isolate from Africa: evidence of intraclade recombination
    Ricky D Grisson
    Department of Cancer, Immunology and AIDS, Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115 6084, USA
    J Virol 78:14066-9. 2004
    ..As a recently transmitted clade C strain, HIV1084i will be a useful vaccine development tool...

Research Grants42

  1. Kaposi's sarcoma and human herpesvirus in Africa
    Charles Wood; Fiscal Year: 2010
    ..Our study will lead to a better understanding of the relative effects of ARV treatment on HHV-8 replication, and it may also lead to more effective KS treatment and prevention guidelines in HIV-infected children. ..
  2. Research and Training on HIV/AIDS Neuropathogenesis in Zambia
    Charles Wood; Fiscal Year: 2007
    ..The preliminary data collected as part of this effort will serve as the basis for a follow-up R01 application. ..
  3. Research Training in Comparative Viral Pathogenesis
    Charles Wood; Fiscal Year: 2007
    ..abstract_text> ..
  4. Kaposi's sarcoma and human herpesvirus in Africa
    Charles Wood; Fiscal Year: 2007
    ..Moreover, it is anticipated that the information generated will be useful in the development of future intervention strategies. ..
  5. Nebraska Center for Virology
    Charles Wood; Fiscal Year: 2006
    ..abstract_text> ..
  6. Kaposi's sarcoma and human herpesvirus in Africa
    Charles Wood; Fiscal Year: 2006
    ..Moreover, it is anticipated that the information generated will be useful in the development of future intervention strategies. ..
  7. Nebraska Center for Virology
    Charles Wood; Fiscal Year: 2005
    ....
  8. Kaposi's sarcoma and human herpesvirus in Africa
    Charles Wood; Fiscal Year: 2010
    ..Our study will lead to a better understanding of the relative effects of ARV treatment on HHV-8 replication, and it may also lead to more effective KS treatment and prevention guidelines in HIV-infected children. ..
  9. Kaposi's sarcoma and human herpesvirus in Africa
    Charles Wood; Fiscal Year: 2009
    ..Moreover, it is anticipated that the information generated will be useful in the development of future intervention strategies. ..
  10. Kaposi's sarcoma and human herpesvirus in Africa
    Charles Wood; Fiscal Year: 2009
    ..Moreover, it is anticipated that the information generated will be useful in the development of future intervention strategies. ..
  11. Nebraska Center for Virology
    Charles Wood; Fiscal Year: 2009
    ..For research to address the effect of anti-HIV drugs on the transmission of a human cancer virus in a setting where infection by both viruses is prevalent. ..
  12. Nebraska Center for Virology
    Charles Wood; Fiscal Year: 2009
    ..For a pilot project to study the subtype-associated effect of RT on the reverse transcription parameters and replicative capacities of HIV-1 viruses. ..
  13. Kaposi's sarcoma and human herpesvirus in Africa
    Charles Wood; Fiscal Year: 2005
    ..Moreover, it is anticipated that the information generated will be useful in the development of future intervention strategies. ..
  14. Evolution of Clade C HIV-1 in Infected Children
    Charles Wood; Fiscal Year: 2005
    ..This study will generate important information about the evolution of Clade C strains in Zambia. ..
  15. NEBRASKA CENTER FOR VIRAL PATHOGENESIS
    Charles Wood; Fiscal Year: 2001
    ..abstract_text> ..
  16. KAPOSIS SARCOMA AND HUMAN HERPESVIRUS IN AFRICA
    Charles Wood; Fiscal Year: 2001
    ..His long-term objective is to understand the roles played by HHV-8 in KS. ..
  17. INTERACTIONS BETWEEN HIV AND KSHV
    Charles Wood; Fiscal Year: 2001
    ..This study should lead to a better understanding of the roles that HIV and KSHV played in KS, the viral and cellular genes involved in HIV-KSHV interaction, and how this interaction affects their disease pathogenesis. ..
  18. KAPOSIS SARCOMA AND HUMAN HERPESVIRUS IN AFRICA
    Charles Wood; Fiscal Year: 2000
    ..His long-term objective is to understand the roles played by HHV-8 in KS. ..
  19. INTERACTIONS BETWEEN HIV AND KSHV
    Charles Wood; Fiscal Year: 2000
    ..This study should lead to a better understanding of the roles that HIV and KSHV played in KS, the viral and cellular genes involved in HIV-KSHV interaction, and how this interaction affects their disease pathogenesis. ..
  20. KAPOSIS SARCOMA AND HUMAN HERPESVIRUS IN AFRICA
    Charles Wood; Fiscal Year: 1999
    ..His long-term objective is to understand the roles played by HHV-8 in KS. ..
  21. INTERACTIONS BETWEEN HIV AND KSHV
    Charles Wood; Fiscal Year: 1999
    ..This study should lead to a better understanding of the roles that HIV and KSHV played in KS, the viral and cellular genes involved in HIV-KSHV interaction, and how this interaction affects their disease pathogenesis. ..
  22. Evolution of Clade C HIV-1 in Infected Children
    Charles Wood; Fiscal Year: 2001
    ..This study will generate important information about the evolution of Clade C strains in Zambia. ..
  23. KAPOSIS SARCOMA AND HUMAN HERPESVIRUS IN AFRICA
    Charles Wood; Fiscal Year: 2002
    ..His long-term objective is to understand the roles played by HHV-8 in KS. ..
  24. Evolution of Clade C HIV-1 in Infected Children
    Charles Wood; Fiscal Year: 2002
    ..This study will generate important information about the evolution of Clade C strains in Zambia. ..
  25. Kaposi's sarcoma and human herpesvirus in Africa
    Charles Wood; Fiscal Year: 2004
    ..Moreover, it is anticipated that the information generated will be useful in the development of future intervention strategies. ..
  26. NEBRASKA CENTER FOR VIRAL PATHOGENESIS
    Charles Wood; Fiscal Year: 2004
    ..abstract_text> ..
  27. Evolution of Clade C HIV-1 in Infected Children
    Charles Wood; Fiscal Year: 2004
    ..This study will generate important information about the evolution of Clade C strains in Zambia. ..
  28. Kaposi's sarcoma and human herpesvirus in Africa
    Charles Wood; Fiscal Year: 2003
    ..Moreover, it is anticipated that the information generated will be useful in the development of future intervention strategies. ..
  29. Equipment Enhancement for NCV: P20RR 15635
    Charles Wood; Fiscal Year: 2003
    ..Support for this revised application will ensure that the synergy that has resulted from the formation of the Nebraska Center for Virology will continue to elevate Nebraska biomedical research to the next level of excellence. ..
  30. NEBRASKA CENTER FOR VIRAL PATHOGENESIS
    Charles Wood; Fiscal Year: 2003
    ..abstract_text> ..
  31. Evolution of Clade C HIV-1 in Infected Children
    Charles Wood; Fiscal Year: 2003
    ..This study will generate important information about the evolution of Clade C strains in Zambia. ..
  32. NEBRASKA CENTER FOR VIRAL PATHOGENESIS
    Charles Wood; Fiscal Year: 2002
    ..abstract_text> ..