Y Woo

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi Cardiac retransplantation is an efficacious therapy for primary cardiac allograft failure
    Pavan Atluri
    Division of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Cardiothorac Surg 3:26. 2008
  2. ncbi One year transgene expression with adeno-associated virus cardiac gene transfer
    Y Joseph Woo
    University of Pennsylvania Department of Surgery, Philadelphia, PA 19104, United States
    Int J Cardiol 100:421-6. 2005
  3. ncbi Robotic resection of an aortic valve papillary fibroelastoma
    Y Joseph Woo
    Division of Cardiothoracic Surgery, Department of General Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Ann Thorac Surg 80:1100-2. 2005
  4. ncbi Active thermoregulation improves outcome of off-pump coronary artery bypass
    Y Joseph Woo
    Division of Cardiothoracic Surgery, Department of Surgery, University of Pennsylvania School of Medecine, Philadelphia, PA 19104, USA
    Asian Cardiovasc Thorac Ann 13:157-60. 2005
  5. ncbi Minimally invasive valve surgery
    Y Joseph Woo
    Division of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania, Silverstein 6, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Surg Clin North Am 89:923-49, x. 2009
  6. ncbi Stromal cell-derived factor and granulocyte-monocyte colony-stimulating factor form a combined neovasculogenic therapy for ischemic cardiomyopathy
    Y Joseph Woo
    Division of Cardiothoracic Surgery, Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 130:321-9. 2005
  7. ncbi Cardiac surgery in patients on antiplatelet and antithrombotic agents
    Y Joseph Woo
    Minimally Invasive and Robotic Cardiac Surgery Program, Division of Cardiothoracic Surgery, Department of Surgery, University of Pennsylvania, Silverstein 6, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Semin Thorac Cardiovasc Surg 17:66-72. 2005
  8. ncbi Robotic cardiac surgery
    Y Joseph Woo
    Division of Cardiothoracic Surgery, Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Int J Med Robot 2:225-32. 2006
  9. ncbi Transventricular mitral valve operations
    Y Joseph Woo
    Department of Surgery, University of Pennsylvania, Philadelphia, PA, USA
    Ann Thorac Surg 92:1501-3. 2011
  10. ncbi Myocardial regeneration therapy for ischemic cardiomyopathy with cyclin A2
    Y Joseph Woo
    Division of Cardiothoracic Surgery, Division of Cardiology, Department of Medicine, Columbia University School of Medicine, New York, New York, USA
    J Thorac Cardiovasc Surg 133:927-33. 2007

Research Grants

  1. Angiogenesis and Cardiac Growth as Heart Failure Therapy
    Y Woo; Fiscal Year: 2007
  2. Angiogenic tissue engineering to limit post-infarction ventricular remodeling
    Y Joseph Woo; Fiscal Year: 2010

Detail Information

Publications72

  1. ncbi Cardiac retransplantation is an efficacious therapy for primary cardiac allograft failure
    Pavan Atluri
    Division of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Cardiothorac Surg 3:26. 2008
    ..Cardiac retransplantation remains the only viable long-term solution for end-stage cardiac allograft failure. Given the limited number of available donor hearts, the long term results of this treatment option need to be evaluated...
  2. ncbi One year transgene expression with adeno-associated virus cardiac gene transfer
    Y Joseph Woo
    University of Pennsylvania Department of Surgery, Philadelphia, PA 19104, United States
    Int J Cardiol 100:421-6. 2005
    ..This study examined the feasibility of AAV-mediated myocardial gene transfer in mice, the animal which, because of transgenic technology, has become the disease model of choice for cardiovascular research...
  3. ncbi Robotic resection of an aortic valve papillary fibroelastoma
    Y Joseph Woo
    Division of Cardiothoracic Surgery, Department of General Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Ann Thorac Surg 80:1100-2. 2005
    ..The patient underwent robotic minimally invasive resection. The pathologic examination revealed papillary fibroelastoma...
  4. ncbi Active thermoregulation improves outcome of off-pump coronary artery bypass
    Y Joseph Woo
    Division of Cardiothoracic Surgery, Department of Surgery, University of Pennsylvania School of Medecine, Philadelphia, PA 19104, USA
    Asian Cardiovasc Thorac Ann 13:157-60. 2005
    ..4 +/- 0.2 vs. 3.3 +/- 0.7 units), time to extubation (6.8 +/- 0.5 vs. 11.4 +/- 2.3 hours), intensive care unit stay (1.3 +/- 0.1 vs. 2.0 +/- 0.3 days), and hospital stay (4.3 +/- 0.1 vs. 5.1 +/- 0.3 days)...
  5. ncbi Minimally invasive valve surgery
    Y Joseph Woo
    Division of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania, Silverstein 6, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Surg Clin North Am 89:923-49, x. 2009
    ..These operations are proving to be safe, highly effective, and durable, and their use will likely continue to increase and become even more widely applicable...
  6. ncbi Stromal cell-derived factor and granulocyte-monocyte colony-stimulating factor form a combined neovasculogenic therapy for ischemic cardiomyopathy
    Y Joseph Woo
    Division of Cardiothoracic Surgery, Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 130:321-9. 2005
    ....
  7. ncbi Cardiac surgery in patients on antiplatelet and antithrombotic agents
    Y Joseph Woo
    Minimally Invasive and Robotic Cardiac Surgery Program, Division of Cardiothoracic Surgery, Department of Surgery, University of Pennsylvania, Silverstein 6, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Semin Thorac Cardiovasc Surg 17:66-72. 2005
    ..Specific surgical and medical strategies can be employed to attenuate this bleeding. These antithrombotic agents and anti-hemorrhagic measures will be reviewed in depth...
  8. ncbi Robotic cardiac surgery
    Y Joseph Woo
    Division of Cardiothoracic Surgery, Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Int J Med Robot 2:225-32. 2006
    ....
  9. ncbi Transventricular mitral valve operations
    Y Joseph Woo
    Department of Surgery, University of Pennsylvania, Philadelphia, PA, USA
    Ann Thorac Surg 92:1501-3. 2011
    ..These cases demonstrate a feasible, alternative, transventricular approach to mitral valve replacement and repair...
  10. ncbi Myocardial regeneration therapy for ischemic cardiomyopathy with cyclin A2
    Y Joseph Woo
    Division of Cardiothoracic Surgery, Division of Cardiology, Department of Medicine, Columbia University School of Medicine, New York, New York, USA
    J Thorac Cardiovasc Surg 133:927-33. 2007
    ..Our prior studies have demonstrated robust cyclin A2 transgene expression and marked antiphosphorylated histone H3 activity with this strategy, indicating the induction of cardiomyocyte mitosis...
  11. ncbi Minimally invasive, robotic, and off-pump mitral valve surgery
    Y Joseph Woo
    Division of Cardiothoracic Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    Semin Thorac Cardiovasc Surg 18:139-47. 2006
    ..Surgery with videoscopic assistance can be effectively performed without sternotomy. Robotics systems are gaining wider adoption. Implantable devices to repair or replace the mitral valve off-pump and percutaneously are emerging...
  12. ncbi Therapeutic delivery of cyclin A2 induces myocardial regeneration and enhances cardiac function in ischemic heart failure
    Y Joseph Woo
    Division of Cardiothoracic Surgery, Department of Surgery, University of Pennsylvania School of Medicine, 3400 Spruce St, Philadelphia PA 19104, USA
    Circulation 114:I206-13. 2006
    ..Heart failure is a global health concern. As a novel therapeutic strategy, the induction of endogenous myocardial regeneration was investigated by initiating cardiomyocyte mitosis by expressing the cell cycle regulator cyclin A2...
  13. ncbi Off-pump revascularization for significant left ventricular dysfunction
    Y Joseph Woo
    Division of Cardiothoracic Surgery, Department of Surgery, University of Pennsylvania School of Medicine, 6 Silverstein Pavilion 3400 Spruce St, Philadelphia, PA 19104, USA
    Asian Cardiovasc Thorac Ann 14:306-9. 2006
    ..This technique provides an effective means of safely revascularizing patients with significant left ventricular dysfunction, and it may provide a valuable alternative approach in patients with ischemic cardiomyopathy...
  14. ncbi Minimally invasive valve surgery
    Y Joseph Woo
    Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Semin Thorac Cardiovasc Surg 19:289-98. 2007
    ..Finally, unique situations such as pulmonic valve surgery, reoperations, beating heart surgery, and robotics are discussed...
  15. ncbi Implantable ventricular assist device exchange with focused intravascular deairing techniques
    Y Joseph Woo
    Department of Surgery, Division of Cardiovascular Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Ann Thorac Surg 91:306-7. 2011
    ....
  16. ncbi Ethyl pyruvate preserves cardiac function and attenuates oxidative injury after prolonged myocardial ischemia
    Y Joseph Woo
    Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    J Thorac Cardiovasc Surg 127:1262-9. 2004
    ..This study sought to evaluate ethyl pyruvate as a myocardial protective agent in a rat model of ischemia-reperfusion injury...
  17. ncbi Local myocardial overexpression of growth hormone attenuates postinfarction remodeling and preserves cardiac function
    Vasant Jayasankar
    Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Ann Thorac Surg 77:2122-9; discussion 2129. 2004
    ..The induction of localized myocardial hypertrophy presents a novel therapeutic approach for the treatment of ischemic heart failure...
  18. ncbi Targeted overexpression of growth hormone by adenoviral gene transfer preserves myocardial function and ventricular geometry in ischemic cardiomyopathy
    Vasant Jayasankar
    Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    J Mol Cell Cardiol 36:531-8. 2004
    ..The induction of regional hypertrophy is a novel approach to treating heart failure, and may be useful to treat or prevent post-infarction ischemic cardiomyopathy...
  19. ncbi Inhibition of matrix metalloproteinase activity by TIMP-1 gene transfer effectively treats ischemic cardiomyopathy
    Vasant Jayasankar
    Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4283, USA
    Circulation 110:II180-6. 2004
    ..The reduction in myocardial fibrosis may be primarily responsible for the improved diastolic function in treated animals. TIMP-1 overexpression is a promising therapeutic target for continued investigation...
  20. ncbi Apelin has in vivo inotropic effects on normal and failing hearts
    Mark F Berry
    Department of Surgery, Division of Cardiothoracic Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Circulation 110:II187-93. 2004
    ..Apelin may have use as an acute inotropic agent in patients with ischemic heart failure...
  21. ncbi Ethyl pyruvate enhances ATP levels, reduces oxidative stress and preserves cardiac function in a rat model of off-pump coronary bypass
    Matthew D Taylor
    University of Pennsylvania School of Medicine, Division of Cardiothoracic Surgery, Department of Surgery, Silverstein 4, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Heart Lung Circ 14:25-31. 2005
    ..CONCLUSIONS: Ethyl pyruvate enhances myocardial ATP levels, reduces oxidative stress, and preserves myocardial function in a model of transient ischemia/reperfusion injury not subject to myocardial infarction...
  22. ncbi Spliced stromal cell-derived factor-1α analog stimulates endothelial progenitor cell migration and improves cardiac function in a dose-dependent manner after myocardial infarction
    William Hiesinger
    Division of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 140:1174-80. 2010
    ....
  23. ncbi Gene transfer of hepatocyte growth factor attenuates postinfarction heart failure
    Vasant Jayasankar
    Department of Cardiothoracic Surgery, University of Pennsylvania School of Medicine, Pliladelphia, PA 19104, USA
    Circulation 108:II230-6. 2003
    ..This therapy may be useful as an adjunct or alternative to standard revascularization techniques in patients with ischemic heart failure...
  24. ncbi Placental growth factor provides a novel local angiogenic therapy for ischemic cardiomyopathy
    Stephen Kolakowski
    Department of Surgery, Division of Cardiothoracic Surgery, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
    J Card Surg 21:559-64. 2006
    ..This therapy may be useful as an adjunct or alternative to standard revascularization techniques in patients with ischemic heart failure...
  25. ncbi Induction of angiogenesis and inhibition of apoptosis by hepatocyte growth factor effectively treats postischemic heart failure
    Vasant Jayasankar
    Department of Cardiothoracic Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Card Surg 20:93-101. 2005
    ..This technique may be useful to treat or prevent postinfarction heart failure...
  26. ncbi Administration of a tumor necrosis factor inhibitor at the time of myocardial infarction attenuates subsequent ventricular remodeling
    Mark F Berry
    Department of Surgery, Division of Cardiothoracic Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Heart Lung Transplant 23:1061-8. 2004
    ..05) and the relaxation time constant (14.6 +/- 0.6 vs 17.9 +/- 1.2 msec; p < 0.05). CONCLUSIONS: TNF inhibition after infarction reduced leukocyte infiltration and extracellular matrix turnover and preserved cardiac function...
  27. ncbi Fate of the residual distal and proximal aorta after acute type a dissection repair using a contemporary surgical reconstruction algorithm
    Arnar Geirsson
    Division of Cardiothoracic Surgery, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
    Ann Thorac Surg 84:1955-64; discussion 1955-64. 2007
    ..In this study, we evaluated the long-term results of our contemporary, standardized surgical management algorithm for repair of acute type A aortic dissections. Prior reports have analyzed heterogeneous techniques and populations...
  28. ncbi Viral gene transfer of the antiapoptotic factor Bcl-2 protects against chronic postischemic heart failure
    Subhasis Chatterjee
    Division of Cardiothoracic Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Circulation 106:I212-7. 2002
    ..The benefit at 6 weeks is postulated to result from a Bcl-2-mediated reduction in apoptosis and ventricular remodeling. Adeno-Bcl-2 administration offers a potential strategy to protect the heart from late postischemic heart failure...
  29. ncbi Blocking the development of postischemic cardiomyopathy with viral gene transfer of the apoptosis repressor with caspase recruitment domain
    Subhasis Chatterjee
    Division of Cardiothoracic Surgery and Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 125:1461-9. 2003
    ..Adenovirus-apoptosis repressor with caspase recruitment domain administration offers a potential strategy after myocardial ischemia to protect the heart from late postischemic cardiomyopathy...
  30. ncbi Tissue-engineered pro-angiogenic fibroblast scaffold improves myocardial perfusion and function and limits ventricular remodeling after infarction
    J Raymond Fitzpatrick
    Division of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, PA, USA
    J Thorac Cardiovasc Surg 140:667-76. 2010
    ..We hypothesized that a 3-dimensional human fibroblast culture (3DFC) functions as a sustained source of angiogenic cytokines, thereby augmenting native angiogenesis and limiting adverse effects of myocardial ischemia...
  31. ncbi Repair of acute type A aortic dissection associated with temporal arteritis
    Mark F Berry
    Department of Surgery, Division of Cardiothoracic Surgery, University of Pennsylvania School of Medicine, Pennsylvania, Philadelphia, USA
    Ann Thorac Surg 76:1717-8. 2003
    ..The literature concerning the association of aortic dissection and temporal arteritis is reviewed...
  32. ncbi Minimally invasive resection of papillary fibroelastoma in a high-risk patient
    Richard W Kim
    Division of Cardiothoracic Surgery, Department of Surgery, University of Pennsylvania, PA 19104, USA
    J Cardiovasc Med (Hagerstown) 8:639-41. 2007
    ....
  33. ncbi Combined DOR ventriculoplasty and aortic valve replacement in the treatment of post infarction ventricular aneurysm and aortic regurgitation
    Erik E Suarez
    Division of Cardiothoracic Surgery, Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Card Surg 21:486-8. 2006
    ..We present the unique case of a patient suffering from congestive heart failure due to both post-infarct aortic regurgitation and ventricular aneurysm along with his successful surgical treatment...
  34. ncbi Robotic minimally invasive mitral valve reconstruction yields less blood product transfusion and shorter length of stay
    Y Joseph Woo
    Department of Surgery, Division of Cardiothoracic Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Surgery 140:263-7. 2006
    ..CONCLUSION: Patients can undergo mitral valve reconstruction with minimally invasive robotic assistance, avoid a sternotomy, require less blood product transfusion, and experience shorter hospitalization...
  35. ncbi Neovasculogenic therapy to augment perfusion and preserve viability in ischemic cardiomyopathy
    Pavan Atluri
    Division of Cardiothoracic Surgery, Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Ann Thorac Surg 81:1728-36. 2006
    ....
  36. ncbi Fructose 1,6-diphosphate administration attenuates post-ischemic ventricular dysfunction
    Jeffrey E Cohen
    University of Pennsylvania, School of Medicine, Department of Surgery, Philadelphia, PA 19104, USA
    Heart Lung Circ 15:119-23. 2006
    ..0369). CONCLUSIONS: The administration of the glycolytic intermediate, FDP, by intravenous injection, resulted in significantly improved myocardial function after ischemia and improved bioenergetics during ischemia...
  37. ncbi Off-pump, minimally invasive and robotic coronary revascularization yield improved outcomes over traditional on-pump CABG
    Pavan Atluri
    Division of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Int J Med Robot 5:1-12. 2009
    ..Furthermore, for a large number of patients who do not have anatomy amenable to traditional coronary revascularization, adjunctive molecular therapies may provide alternative myocardial micro-revascularization...
  38. ncbi Risk score derived from pre-operative data analysis predicts the need for biventricular mechanical circulatory support
    J Raymond Fitzpatrick
    Division of Cardiovascular Surgery, Hospital of University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Heart Lung Transplant 27:1286-92. 2008
    ..In the era of destination therapy and the total artificial heart, predicting post-LVAD RV failure requiring mechanical support is extremely important...
  39. ncbi Acute myocardial infarction requiring mechanical bridge to transplantation in a patient with undiagnosed anti-phospholipid antibody syndrome
    Clifton C Reade
    Division of Cardiovascular Surgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Heart Lung Transplant 27:682-4. 2008
    ..To our knowledge this is the first reported case of severe acute heart failure due to anti-phospholipid antibody syndrome in which the patient survived through assist device placement and successful transplantation...
  40. ncbi Stromal cell-derived factor-1alpha activation of tissue-engineered endothelial progenitor cell matrix enhances ventricular function after myocardial infarction by inducing neovasculogenesis
    JOHN R FREDERICK
    Division of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Circulation 122:S107-17. 2010
    ....
  41. ncbi Retrograde and antegrade cerebral perfusion: results in short elective arch reconstructive times
    Rita Karianna Milewski
    Division of Cardiovascular Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Ann Thorac Surg 89:1448-57. 2010
    ..The aim of the study was to evaluate perioperative outcomes between antegrade and retrograde cerebral perfusion techniques for elective arch reconstruction times less than 45 minutes...
  42. ncbi Neurologic outcomes from high risk descending thoracic and thoracoabdominal aortic operations in the era of endovascular repair
    Steven R Messe
    Department of Neurology, Hospital of the University of Pennsylvania, University of Pennsylvania Medical Center, 3W Gates Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Neurocrit Care 9:344-51. 2008
    ..However, there are limited data available on outcomes since the advent of thoracic endovascular aortic repair (TEVAR)...
  43. ncbi Plasma levels of receptor for advanced glycation end products, blood transfusion, and risk of primary graft dysfunction
    Jason D Christie
    Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 180:1010-5. 2009
    ..We hypothesized that patients with primary graft dysfunction (PGD) after lung transplantation would have higher RAGE levels in plasma than patients without PGD...
  44. ncbi Antegrade thoracic stent grafting during repair of acute DeBakey I dissection prevents development of thoracoabdominal aortic aneurysms
    Alberto Pochettino
    Division of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4283, USA
    Ann Thorac Surg 88:482-9; discussion 489-90. 2009
    ..This report tests whether antegrade stent-grafting of the proximal descending thoracic aorta during acute DeBakey I dissection decreases future distal aortic aneurysms without an increase in surgical risk...
  45. ncbi Repair of type A aortic dissection in nonagenarian
    Y Joseph Woo
    Division of Cardiothoracic Surgery, Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Asian Cardiovasc Thorac Ann 18:183-4. 2010
    ..We describe successful repair of type A aortic dissection with ascending aortic graft replacement, aortic valve repair, hemiarch reconstruction, and ablation of atrial fibrillation in a 93-year-old man...
  46. ncbi Outcomes using extracorporeal life support for adult respiratory failure due to status asthmaticus
    Mark E Mikkelsen
    Pulmonary, Allergy, and Critical Care Division, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    ASAIO J 55:47-52. 2009
    ....
  47. ncbi Endocarditis with massive aortic root abscess and atrioventricular septal destruction
    Landi M Parish
    Division of Cardiothoracic Surgery, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Interact Cardiovasc Thorac Surg 8:280-2. 2009
    ..Proper planar localization of the aortic root was necessary to avoid left ventricular outflow obstruction and coronary torsion...
  48. ncbi Emergency extracorporeal life support for asphyxic status asthmaticus
    Mark E Mikkelsen
    Division of Pulmonary, Allergy, and Critical Care, Hospital of the University of Pennsylvania, 836 W Gates Pavilion, Philadelphia, PA 19104, USA
    Respir Care 52:1525-9. 2007
    ....
  49. ncbi Minimally invasive video-assisted graft replacement of a descending thoracic aortic aneurysm
    Y Joseph Woo
    Division of Cardiothoracic Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Heart Surg Forum 6:E59-61. 2003
    ..The patient underwent successful minimally invasive video-assisted graft repair of this aneurysm. This report represents the first known clinical application of this operative approach...
  50. ncbi Off-pump coronary artery bypass grafting attenuates postoperative bleeding associated with preoperative clopidogrel administration
    Y Joseph Woo
    Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Heart Surg Forum 6:282-5. 2003
    ..Off-pump coronary artery bypass grafting (OPCAB) may decrease the extent of postoperative bleeding in patients exposed to clopidogrel...
  51. ncbi Targeted overexpression of leukemia inhibitory factor to preserve myocardium in a rat model of postinfarction heart failure
    Mark F Berry
    Department of Surgery, Division of Cardiothoracic Surgery, University of Pennsylvania School of Medicine, 6 Silverstein Pavilion, 3400 Spruce Street, Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 128:866-75. 2004
    ..05). CONCLUSIONS: Myocardial gene transfer of leukemia inhibitory factor preserved cardiac tissue, geometry, and function after myocardial infarction in rats...
  52. ncbi Advances in the treatment of acute type A dissection: an integrated approach
    Joseph E Bavaria
    Division of Cardiothoracic Surgery, University of Pennsylvania Medical Center, Philadelphia 19104 4283, USA
    Ann Thorac Surg 74:S1848-52; discussion S1857-63. 2002
    ..Most series over the past decade have reported a death rate in the range of 15% to 30%. The objective of this study is to examine the effect of an integrated surgical approach on the treatment of acute type A dissections...
  53. ncbi Mesenchymal stem cell injection after myocardial infarction improves myocardial compliance
    Mark F Berry
    Division of Cardiothoracic Surgery, Department of Physiology, University of Pennsylvania School of Medicine, A700 Richards Bldg, 3700 Hamilton Walk, Philadelphia, PA 19104-6085, USA
    Am J Physiol Heart Circ Physiol 290:H2196-203. 2006
    ..Improving scarred heart muscle compliance could be a functional benefit of cellular cardiomyoplasty...
  54. ncbi Techniques for preserving vertebral artery perfusion during thoracic aortic stent grafting requiring aortic arch landing
    Edward Y Woo
    Division of Vascular Surgery, Department of Surgery, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    Vasc Endovascular Surg 40:367-73. 2006
    ..This circumvents the need for potentially hazardous mediastinal dissection and ligation of the proximal left subclavian artery in cases of large proximal aneurysms or unfavorable vertebral artery anatomy...
  55. ncbi Integrity of the cerebral blood-flow response to hyperoxia after cardiopulmonary bypass
    Thomas F Floyd
    Department of Anesthesiology, Penn Presbyterian Hospital, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
    J Cardiothorac Vasc Anesth 21:212-7. 2007
    ..In this study, the hypothesis that cardiopulmonary bypass (CPB) alters the cerebral blood flow (CBF) vasoconstrictive response to hyperoxia was tested...
  56. ncbi Significance of malperfusion syndromes prior to contemporary surgical repair for acute type A dissection: outcomes and need for additional revascularizations
    Arnar Geirsson
    Division of Cardiothoracic Surgery, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104 4283, USA
    Eur J Cardiothorac Surg 32:255-62. 2007
    ..We believe that obliteration of the primary tear site with restoration of flow in the true aortic lumen results in decreased need for revascularization of malperfused organ systems...
  57. ncbi Association between elevated whole blood Epstein-Barr virus (EBV)-encoded RNA EBV polymerase chain reaction and reduced incidence of acute lung allograft rejection
    Vivek N Ahya
    Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Heart Lung Transplant 26:839-44. 2007
    ..We investigated the hypothesis that detection of latent Epstein-Barr virus (EBV) in peripheral blood may be a functional marker for the net effects of administered immunosuppression...
  58. ncbi High-risk repair of ascending aortic aneurysm due to giant cell aortitis
    Pavan Atluri
    Division of Cardiothoracic Surgery, Department of Surgery, University of Pennsylvania School of Medicine, Silverstein 4, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Asian Cardiovasc Thorac Ann 15:252-4. 2007
    ..We report the successful repair of an ascending aortic aneurysm in an 83-year-old woman with a history of treatment for temporal arteritis and pathologic evidence of giant cell aortitis...
  59. ncbi Transmyocardial revascularization to enhance myocardial vasculogenesis and hemodynamic function
    Pavan Atluri
    Division of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 135:283-91, 291.e1; discussion 291. 2008
    ..The molecular mechanisms underlying this therapy, however, are poorly understood. The focus of this study was evaluation of the proposed vasculogenic mechanisms involved in transmyocardial laser revascularization...
  60. ncbi Sex, aging, and preexisting cerebral ischemic disease in patients with aortic stenosis
    Ping Wang
    Department of Radiology, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Ann Thorac Surg 90:1230-5. 2010
    ..We tested the hypotheses that increasing age, female sex, coronary artery disease, and the severity of AS are predictive of the severity of preexisting cerebral ischemic lesions...
  61. ncbi Minimally invasive aortic valve replacement combined with radiofrequency-modified maze procedure
    Stephen Kolakowski
    Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Card Surg 20:164-6. 2005
    ..This is the first reported case of a minimally invasive aortic valve replacement combined with a radiofrequency-modified maze procedure...
  62. ncbi Surgical revision after percutaneous mitral repair with the MitraClip device
    Michael Argenziano
    Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Ann Thorac Surg 89:72-80; discussion p 80. 2010
    ..Preserving conventional surgical options in the event of percutaneous treatment failure is important. We describe surgical treatment at varying intervals after the MitraClip procedure in 32 patients...
  63. ncbi Safety and efficacy of left ventricular assist device support in postmyocardial infarction cardiogenic shock
    Bradley G Leshnower
    Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Ann Thorac Surg 81:1365-70; discussion 1370-1. 2006
    ..CONCLUSIONS: Left ventricular assist device support in patients with CS-AMI is a safe and effective therapy which should be incorporated into the standard treatment paradigm for appropriate patients presenting with this lethal disease...
  64. ncbi Computational protein design to reengineer stromal cell-derived factor-1α generates an effective and translatable angiogenic polypeptide analog
    William Hiesinger
    Division of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Circulation 124:S18-26. 2011
    ..In this study, computational protein design was used to create a more efficient evolution of the native SDF protein...
  65. ncbi Oxygen-dependent quenching of phosphorescence used to characterize improved myocardial oxygenation resulting from vasculogenic cytokine therapy
    William Hiesinger
    Division of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Appl Physiol 110:1460-5. 2011
    ..This effect could potentially mitigate the vicious cycle of myocyte death, myocardial fibrosis, progressive ventricular dilatation, and eventual heart failure seen after acute myocardial infarction...
  66. ncbi Innominate artery transection in the setting of a bovine arch
    Mireille A Moise
    Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia 19104, USA
    J Thorac Cardiovasc Surg 128:632-4. 2004
  67. ncbi Robotic microlaryngeal surgery: a technical feasibility study using the daVinci surgical robot and an airway mannequin
    Neil G Hockstein
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Laryngoscope 115:780-5. 2005
    ..The purpose of this study is to demonstrate the technical feasibility of robot-assisted microlaryngeal surgery...
  68. ncbi Left main coronary embolism
    Victor M Mejia
    Cardiology Department and Cardiothoracic Surgery Department, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Invasive Cardiol 18:296. 2006
    ..Coronary angiography revealed an embolus in the left main artery which was treated with rheolytic thrombectomy. This represents an uncommon cause of acute myocardial infarction...
  69. ncbi Minimal-incision cardiac surgery. Introduction
    Y Joseph Woo
    Semin Thorac Cardiovasc Surg 19:279-80. 2007
  70. ncbi Neurological monitoring and off-pump surgery in a very high-risk stroke patient
    Mark F Berry
    Division of Cardiothoracic Surgery, Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Ann Thorac Surg 80:2372-4. 2005
    ..This management strategy may reduce the stroke risk in similar patients...
  71. ncbi Robot-assisted pharyngeal and laryngeal microsurgery: results of robotic cadaver dissections
    Neil G Hockstein
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Laryngoscope 115:1003-8. 2005
    ..Robotic surgery has significant potential in pharyngeal and microlaryngeal surgery. We demonstrate the use of a surgical robot in pharyngeal and microlaryngeal surgery in a cadaver...
  72. ncbi Intraoperative effects of the coapsys annuloplasty system in a randomized evaluation (RESTOR-MV) of functional ischemic mitral regurgitation
    Eugene A Grossi
    New York University Medical Center, New York, New York 10028, USA
    Ann Thorac Surg 80:1706-11. 2005
    ..Coapsys is a ventricular-annular remodeling device designed to treat functional ischemic MR; it does not require cardiopulmonary bypass. Initial intraoperative results of the RESTOR-MV randomized clinical trial are presented...

Research Grants5

  1. Angiogenesis and Cardiac Growth as Heart Failure Therapy
    Y Woo; Fiscal Year: 2007
    ..The candidate's institution, sponsor, and chairman provide a uniquely supportive, high-caliber, educationally stimulating environment highly conducive to the achievement of these goals. ..
  2. Angiogenic tissue engineering to limit post-infarction ventricular remodeling
    Y Joseph Woo; Fiscal Year: 2010
    ....