Ikwunga Wonodi

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi request reprint Tardive dyskinesia in children treated with atypical antipsychotic medications
    Ikwunga Wonodi
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland 21228, USA
    Mov Disord 22:1777-82. 2007
  2. pmc Downregulated kynurenine 3-monooxygenase gene expression and enzyme activity in schizophrenia and genetic association with schizophrenia endophenotypes
    Ikwunga Wonodi
    Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228
    Arch Gen Psychiatry 68:665-74. 2011
  3. ncbi request reprint Ethnicity and the course of tardive dyskinesia in outpatients presenting to the motor disorders clinic at the Maryland psychiatric research center
    Ikwunga Wonodi
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    J Clin Psychopharmacol 24:592-8. 2004
  4. doi request reprint Dipyridamole monotherapy in schizophrenia: pilot of a novel treatment approach by modulation of purinergic signaling
    Ikwunga Wonodi
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, P O Box 21247, Baltimore, MD 21228, USA
    Psychopharmacology (Berl) 218:341-5. 2011
  5. pmc Cortical kynurenine pathway metabolism: a novel target for cognitive enhancement in Schizophrenia
    Ikwunga Wonodi
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, USA
    Schizophr Bull 36:211-8. 2010
  6. pmc Dopamine transporter polymorphism modulates oculomotor function and DAT1 mRNA expression in schizophrenia
    Ikwunga Wonodi
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, 21228, USA
    Am J Med Genet B Neuropsychiatr Genet 150:282-9. 2009
  7. ncbi request reprint Effects of repeated amphetamine administration on antisaccade in schizophrenia spectrum personality
    Ikwunga Wonodi
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA
    Psychiatry Res 141:237-45. 2006
  8. pmc Effects of moderate-dose treatment with varenicline on neurobiological and cognitive biomarkers in smokers and nonsmokers with schizophrenia or schizoaffective disorder
    L Elliot Hong
    Maryland Psychiatric Research Center, Baltimore, MD 21228, USA
    Arch Gen Psychiatry 68:1195-206. 2011
  9. ncbi request reprint Catechol O-methyltransferase polymorphism and eye tracking in schizophrenia: a preliminary report
    Gunvant K Thaker
    MPRC, PO Box 21247, Baltimore, MD 21228, USA
    Am J Psychiatry 161:2320-2. 2004
  10. ncbi request reprint Dihydropyrimidinase-related protein 2 (DRP-2) gene and association to deficit and nondeficit schizophrenia
    L Elliot Hong
    Department of Psychiatry, Maryland Psychiatric Research Center, School of Medicine, University of Maryland, Baltimore, 21228, USA
    Am J Med Genet B Neuropsychiatr Genet 136:8-11. 2005

Research Grants

Detail Information

Publications27

  1. ncbi request reprint Tardive dyskinesia in children treated with atypical antipsychotic medications
    Ikwunga Wonodi
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland 21228, USA
    Mov Disord 22:1777-82. 2007
    ..Ethnicity might also be a risk factor for dyskinesia in children. Side-effect profile of the atypical antipsychotic drugs in children may be much different than that in adults...
  2. pmc Downregulated kynurenine 3-monooxygenase gene expression and enzyme activity in schizophrenia and genetic association with schizophrenia endophenotypes
    Ikwunga Wonodi
    Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228
    Arch Gen Psychiatry 68:665-74. 2011
    ..The proximal cause may be an impairment of kynurenine 3-monooxygenase (KMO), a rate-limiting enzyme at the branching point of the kynurenine pathway...
  3. ncbi request reprint Ethnicity and the course of tardive dyskinesia in outpatients presenting to the motor disorders clinic at the Maryland psychiatric research center
    Ikwunga Wonodi
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    J Clin Psychopharmacol 24:592-8. 2004
    ..The current study examines the anatomic distribution and course of TD in a cohort of schizophrenia patients of European and African descent with TD who were referred to the Motor Disorders Clinic (MDC)...
  4. doi request reprint Dipyridamole monotherapy in schizophrenia: pilot of a novel treatment approach by modulation of purinergic signaling
    Ikwunga Wonodi
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, P O Box 21247, Baltimore, MD 21228, USA
    Psychopharmacology (Berl) 218:341-5. 2011
    ..One previous clinical trial showed superiority of adjunctive dipyridamole, an adenosine reuptake inhibitor, compared to placebo in ameliorating positive symptoms in schizophrenia patients...
  5. pmc Cortical kynurenine pathway metabolism: a novel target for cognitive enhancement in Schizophrenia
    Ikwunga Wonodi
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, USA
    Schizophr Bull 36:211-8. 2010
    ..The emerging, remarkable confluence of data from humans and animals suggests an opportunity for developing a rational pharmacology by targeting cortical kynurenine pathway metabolism for cognition enhancement in schizophrenia and beyond...
  6. pmc Dopamine transporter polymorphism modulates oculomotor function and DAT1 mRNA expression in schizophrenia
    Ikwunga Wonodi
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, 21228, USA
    Am J Med Genet B Neuropsychiatr Genet 150:282-9. 2009
    ..05), but higher expression in schizophrenia donors. Findings suggest regulatory effects of another gene(s) or etiological factor in schizophrenia, which modulate DAT1 gene function...
  7. ncbi request reprint Effects of repeated amphetamine administration on antisaccade in schizophrenia spectrum personality
    Ikwunga Wonodi
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA
    Psychiatry Res 141:237-45. 2006
    ..Findings from this preliminary study suggest SSP may be more receptive to the beneficial effects of repeated amphetamine on cognition than healthy controls...
  8. pmc Effects of moderate-dose treatment with varenicline on neurobiological and cognitive biomarkers in smokers and nonsmokers with schizophrenia or schizoaffective disorder
    L Elliot Hong
    Maryland Psychiatric Research Center, Baltimore, MD 21228, USA
    Arch Gen Psychiatry 68:1195-206. 2011
    ..It is not yet clear which nicotinic acetylcholine receptor (nAChR) subtype or subtypes are responsible for these seemingly pervasive nicotinic effects in schizophrenia and schizoaffective disorder...
  9. ncbi request reprint Catechol O-methyltransferase polymorphism and eye tracking in schizophrenia: a preliminary report
    Gunvant K Thaker
    MPRC, PO Box 21247, Baltimore, MD 21228, USA
    Am J Psychiatry 161:2320-2. 2004
    ..This study examined associations between functional polymorphism (Val(108/158) Met) in the catechol O-methyltransferase (COMT) gene and eye tracking measures in schizophrenia...
  10. ncbi request reprint Dihydropyrimidinase-related protein 2 (DRP-2) gene and association to deficit and nondeficit schizophrenia
    L Elliot Hong
    Department of Psychiatry, Maryland Psychiatric Research Center, School of Medicine, University of Maryland, Baltimore, 21228, USA
    Am J Med Genet B Neuropsychiatr Genet 136:8-11. 2005
    ..2%, P =0.050) forms of schizophrenia compared to controls (allele frequency 25.0%). We conclude that the DRP-2 *2236 C allele may mark another polymorphism in DRP-2, or in a nearby gene, that may influence susceptibility to schizophrenia...
  11. pmc Refining the predictive pursuit endophenotype in schizophrenia
    L Elliot Hong
    Maryland Psychiatric Research Center, Lions Vision Center, Johns Hopkins School of Medicine, Baltimore, Maryland 21228, USA
    Biol Psychiatry 63:458-64. 2008
    ..Previous work has shown a reduced predictive pursuit response to a briefly masked (i.e., invisible) moving object in schizophrenia. However, the overt awareness of target removal can confound the measurement...
  12. pmc Sensory gating endophenotype based on its neural oscillatory pattern and heritability estimate
    L Elliot Hong
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Arch Gen Psychiatry 65:1008-16. 2008
    ..Frequency-specific sensory gating may be less complex than the P50 response, and therefore closer to the direct genetic effects, and thus a more valid endophenotype...
  13. pmc Evidence of missense mutations on the neuregulin 1 gene affecting function of prepulse inhibition
    L Elliot Hong
    Department of Psychiatry, Maryland Psychiatric Research Center, Baltimore, Maryland 21228, USA
    Biol Psychiatry 63:17-23. 2008
    ..A widely used surrogate measure of psychosis in animal models, PPI is considered a schizophrenia endophenotype. We hypothesized that if NRG1 influences PPI in rodents, then it should have a similar effect on PPI in humans...
  14. pmc Impaired kynurenine pathway metabolism in the prefrontal cortex of individuals with schizophrenia
    Korrapati V Sathyasaikumar
    Maryland Psychiatric Research Center, Baltimore, MD, USA
    Schizophr Bull 37:1147-56. 2011
    ..The present results further support the hypothesis that the normalization of cortical KP metabolism may constitute an effective new treatment strategy in SZ...
  15. pmc Nicotine enhances but does not normalize visual sustained attention and the associated brain network in schizophrenia
    L Elliot Hong
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA
    Schizophr Bull 37:416-25. 2011
    ..These findings provide guidance for developing new treatment strategies for the sustained attention deficit in schizophrenia...
  16. pmc Is motion perception deficit in schizophrenia a consequence of eye-tracking abnormality?
    L Elliot Hong
    Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland 21228, USA
    Biol Psychiatry 65:1079-85. 2009
    ..However, eye movement closely interacts with motion perception. The known eye-tracking difficulties in schizophrenia patients may interact with their motion perception...
  17. ncbi request reprint Specific motion processing pathway deficit during eye tracking in schizophrenia: a performance-matched functional magnetic resonance imaging study
    L Elliot Hong
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore 21228, USA
    Biol Psychiatry 57:726-32. 2005
    ....
  18. ncbi request reprint Nicotine effect on prepulse inhibition and prepulse facilitation in schizophrenia patients
    L Elliot Hong
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Neuropsychopharmacology 33:2167-74. 2008
    ..002). In conclusion, the findings confirmed that nicotine transiently improves acoustic PPI in schizophrenia patients. Additionally, schizophrenia patients with more clinical symptoms may have benefited more from nicotinic effect on PPI...
  19. ncbi request reprint Independent domains of inhibitory gating in schizophrenia and the effect of stimulus interval
    L Elliot Hong
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, P O Box 21247, Baltimore, MD 21228, USA
    Am J Psychiatry 164:61-5. 2007
    ..The authors hypothesized that the relationship of the two measures may vary as a function of interstimulus intervals of stimulus presentations...
  20. ncbi request reprint Naltrexone treatment of tardive dyskinesia in patients with schizophrenia
    Ikwunga Wonodi
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    J Clin Psychopharmacol 24:441-5. 2004
    ..The goal of the current study was to test whether moderately high doses of naltrexone, alone or in combination with a subtherapeutic dose of a gamma aminobutyric acid agonist, improve TD...
  21. ncbi request reprint Deficits on the Continuous Performance Test within the schizophrenia spectrum and the mediating effects of family history of schizophrenia
    Matthew T Avila
    Department of Psychiatry, University of Maryland School of Medicine, Maryland Psychiatric Research Center, Baltimore, MD 21228, USA
    J Abnorm Psychol 115:771-8. 2006
    ..Results suggest that SSPD in the absence of a family history of psychosis may be a phenocopy...
  22. pmc Adjunctive risperidone for partially responsive people with schizophrenia treated with clozapine
    Elaine Weiner
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Neuropsychopharmacology 35:2274-83. 2010
    ..The study results are discussed in the context of previous double-blind studies of adjunctive risperidone. (clinicaltrials.gov, trial number: NCT00056498)...
  23. ncbi request reprint Association between Val108/158 Met polymorphism of the COMT gene and schizophrenia
    Ikwunga Wonodi
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland 21228, USA
    Am J Med Genet B Neuropsychiatr Genet 120:47-50. 2003
    ..These results provide support for a role of this variant in the etiopathophysiology of schizophrenia...
  24. ncbi request reprint Reliability of a portable head-mounted eye tracking instrument for schizophrenia research
    L Elliot Hong
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland, Baltimore, MD 21228, USA
    Behav Res Methods 37:133-8. 2005
    ..96). This result suggests that the portable device is comparable with a lab-based system, which makes possible the collection of eye movement data in community-based and multicenter familial studies of schizophrenia...
  25. ncbi request reprint Psychopathological and cognitive correlates of tardive dyskinesia in patients treated with neuroleptics
    Ikwunga Wonodi
    Maryland Psychiatric Research Center, Motor Disorders Clinic, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Adv Neurol 96:336-49. 2005
    ..No effective treatments for TD are available. This lack of effective therapy is problematic, especially in the few patients in whom the disorder causes functional impairment and other complications, and in whom it may be irreversible...
  26. ncbi request reprint Association between polymorphism of the SNAP29 gene promoter region and schizophrenia
    Ikwunga Wonodi
    Schizophr Res 78:339-41. 2005

Research Grants1

  1. Genetic Polymorphism of a Schizophrenia Endophenotype
    Ikwunga Wonodi; Fiscal Year: 2007
    ..Deciphering the genetic mechanisms of prefrontal dopamine dysfunction in schizophrenia would advance our understanding of the pathophysiology of schizophrenia and may help identify novel treatments. ..