Pak Kin Wong

Summary

Affiliation: University of Arizona
Country: USA

Publications

  1. pmc Statistical metamodeling for revealing synergistic antimicrobial interactions
    Hsiang Chia Chen
    Department of Aerospace and Mechanical Engineering, University of Arizona, Tucson, Arizona, USA
    PLoS ONE 5:e15472. 2010
  2. ncbi request reprint Single cell gene expression analysis in injury-induced collective cell migration
    Reza Riahi
    Department of Aerospace and Mechanical Engineering, The University of Arizona, Tucson, Arizona 85721, USA
    Integr Biol (Camb) 6:192-202. 2014
  3. pmc Closed-loop control of cellular functions using combinatory drugs guided by a stochastic search algorithm
    Pak Kin Wong
    Department of Aerospace and Mechanical Engineering and Bio5 Institute, University of Arizona, N718, 1130 North Mountain Avenue, Tucson, AZ 85721, USA
    Proc Natl Acad Sci U S A 105:5105-10. 2008
  4. pmc System Integration - A Major Step toward Lab on a Chip
    Mandy Ly Sin
    Department of Aerospace and Mechanical Engineering, University of Arizona, Tucson, AZ 85721, USA
    J Biol Eng 5:6. 2011
  5. ncbi request reprint Molecular detection of bacterial pathogens using microparticle enhanced double-stranded DNA probes
    Reza Riahi
    Department of Aerospace and Mechanical Engineering, University of Arizona, Tucson, Arizona 85721, United States
    Anal Chem 83:6349-54. 2011
  6. ncbi request reprint In situ electrokinetic enhancement for self-assembled-monolayer-based electrochemical biosensing
    Mandy L Y Sin
    Department of Aerospace and Mechanical Engineering, University of Arizona, Tucson, Arizona 85721, United States
    Anal Chem 84:2702-7. 2012
  7. ncbi request reprint Single cell antimicrobial susceptibility testing by confined microchannels and electrokinetic loading
    Yi Lu
    Department of Aerospace and Mechanical Engineering, The University of Arizona, Tucson, Arizona 85721, United States
    Anal Chem 85:3971-6. 2013
  8. ncbi request reprint Electrokinetic focusing and separation of mammalian cells in conductive biological fluids
    Jian Gao
    Department of Aerospace and Mechanical Engineering, The University of Arizona, Tucson, Arizona 85721, USA
    Analyst 137:5215-21. 2012
  9. ncbi request reprint Hybrid electrokinetic manipulation in high-conductivity media
    Jian Gao
    Department of Aerospace and Mechanical Engineering, University of Arizona, Tucson, Arizona 85721, USA
    Lab Chip 11:1770-5. 2011
  10. doi request reprint Hybridization kinetics of double-stranded DNA probes for rapid molecular analysis
    Vinay Gidwani
    Department of Biochemistry and Molecular Biophysics, University of Arizona, Tucson, Arizona, USA
    Analyst 134:1675-81. 2009

Collaborators

Detail Information

Publications23

  1. pmc Statistical metamodeling for revealing synergistic antimicrobial interactions
    Hsiang Chia Chen
    Department of Aerospace and Mechanical Engineering, University of Arizona, Tucson, Arizona, USA
    PLoS ONE 5:e15472. 2010
    ..With its effectiveness and simplicity, the MACO scheme possesses the potential to serve as a generic platform for identifying synergistic antimicrobial cocktails toward management of bacterial infection in the future...
  2. ncbi request reprint Single cell gene expression analysis in injury-induced collective cell migration
    Reza Riahi
    Department of Aerospace and Mechanical Engineering, The University of Arizona, Tucson, Arizona 85721, USA
    Integr Biol (Camb) 6:192-202. 2014
    ..Taken together, our single-cell gene expression analyses reveal modular cell responses to mechanical injury, manipulation of which may afford novel strategies for tissue repair and prevention of tumor invasion in the future. ..
  3. pmc Closed-loop control of cellular functions using combinatory drugs guided by a stochastic search algorithm
    Pak Kin Wong
    Department of Aerospace and Mechanical Engineering and Bio5 Institute, University of Arizona, N718, 1130 North Mountain Avenue, Tucson, AZ 85721, USA
    Proc Natl Acad Sci U S A 105:5105-10. 2008
    ..The closed-loop optimization approach possesses the potential of being an effective approach for manipulating a wide class of biological systems...
  4. pmc System Integration - A Major Step toward Lab on a Chip
    Mandy Ly Sin
    Department of Aerospace and Mechanical Engineering, University of Arizona, Tucson, AZ 85721, USA
    J Biol Eng 5:6. 2011
    ..Future advancements of these microfluidic strategies will lead toward translational lab-on-a-chip systems for a wide spectrum of biological engineering applications...
  5. ncbi request reprint Molecular detection of bacterial pathogens using microparticle enhanced double-stranded DNA probes
    Reza Riahi
    Department of Aerospace and Mechanical Engineering, University of Arizona, Tucson, Arizona 85721, United States
    Anal Chem 83:6349-54. 2011
    ..Its applicability toward clinical diagnostics is demonstrated by directly identifying bacterial pathogens in urine samples from patients with urinary tract infections...
  6. ncbi request reprint In situ electrokinetic enhancement for self-assembled-monolayer-based electrochemical biosensing
    Mandy L Y Sin
    Department of Aerospace and Mechanical Engineering, University of Arizona, Tucson, Arizona 85721, United States
    Anal Chem 84:2702-7. 2012
    ....
  7. ncbi request reprint Single cell antimicrobial susceptibility testing by confined microchannels and electrokinetic loading
    Yi Lu
    Department of Aerospace and Mechanical Engineering, The University of Arizona, Tucson, Arizona 85721, United States
    Anal Chem 85:3971-6. 2013
    ..The antibiotic resistance profiles of bacteria can be determined in less than 1 h compared to days in standard culture-based AST techniques...
  8. ncbi request reprint Electrokinetic focusing and separation of mammalian cells in conductive biological fluids
    Jian Gao
    Department of Aerospace and Mechanical Engineering, The University of Arizona, Tucson, Arizona 85721, USA
    Analyst 137:5215-21. 2012
    ....
  9. ncbi request reprint Hybrid electrokinetic manipulation in high-conductivity media
    Jian Gao
    Department of Aerospace and Mechanical Engineering, University of Arizona, Tucson, Arizona 85721, USA
    Lab Chip 11:1770-5. 2011
    ..The device operates directly with biological samples including urine and buffy coats. We show that pathogenic bacteria and biowarfare agents can be concentrated for over 3 orders of magnitude using hybrid electrokinetics...
  10. doi request reprint Hybridization kinetics of double-stranded DNA probes for rapid molecular analysis
    Vinay Gidwani
    Department of Biochemistry and Molecular Biophysics, University of Arizona, Tucson, Arizona, USA
    Analyst 134:1675-81. 2009
    ..The study provides a general guideline for the design of the probes for reducing the total assay time. With an appropriate design of the probes, the assay can be finished within minutes at room temperature...
  11. pmc Antimicrobial susceptibility testing using high surface-to-volume ratio microchannels
    Chia Hsiang Chen
    Department of Aerospace and Mechanical Engineering, P O Box 210119, University of Arizona, 1703 East Mabel Street, Tucson, Arizona 85721, USA
    Anal Chem 82:1012-9. 2010
    ..The antimicrobial resistance pattern can be determined as rapidly as 2 h compared to days in standard clinical procedures facilitating diagnostics at the point of care...
  12. doi request reprint A double-stranded molecular probe for homogeneous nucleic acid analysis
    Daniel Meserve
    Department of Aerospace and Mechanical Engineering, University of Arizona, Tucson, Arizona, USA
    Analyst 133:1013-9. 2008
    ..By proper design of the sequence, the probe discriminates single nucleotide mismatches in a single step without any separation step or measurement of melting profile...
  13. pmc Oridonin confers protection against arsenic-induced toxicity through activation of the Nrf2-mediated defensive response
    Yu Du
    Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona, USA
    Environ Health Perspect 116:1154-61. 2008
    ..Recently, activation of the Nrf2 signaling pathway has been reported to confer protection against arsenic-induced toxicity in a cell culture model...
  14. ncbi request reprint Mapping photothermally induced gene expression in living cells and tissues by nanorod-locked nucleic acid complexes
    Reza Riahi
    Department of Aerospace and Mechanical Engineering, University of Arizona, Tucson, Arizona 85721, United States
    ACS Nano 8:3597-605. 2014
    ..The gold nanorod-locked nucleic acid complex enables mapping of intracellular gene expressions and analyzes the photothermal effects of nanostructures toward various biomedical applications. ..
  15. doi request reprint Advances in wound-healing assays for probing collective cell migration
    Reza Riahi
    Department of Aerospace and Mechanical Engineering, The University of Arizona, Tucson, AZ, USA
    J Lab Autom 17:59-65. 2012
    ..In this review, we provide an overview of advances in wound-healing assays and discuss their advantages and limitations in studying collective cell migration...
  16. pmc Electrokinetic stringency control in self-assembled monolayer-based biosensors for multiplex urinary tract infection diagnosis
    Tingting Liu
    Department of Aerospace and Mechanical Engineering, University of Arizona, Tucson, AZ, USA
    Nanomedicine 10:159-66. 2014
    ..The results demonstrate that electrokinetic stringency control can significantly improve the signal-to-noise ratio of the biosensor for multiplex urinary tract infection diagnosis...
  17. pmc Detection of mRNA in living cells by double-stranded locked nucleic acid probes
    Reza Riahi
    Department of Aerospace and Mechanical Engineering, The University of Arizona, Tucson, AZ 85721 0119, USA
    Analyst 138:4777-85. 2013
    ....
  18. pmc Dual roles of Nrf2 in cancer
    Alexandria Lau
    Department of Pharmacology and Toxicology, University of Arizona, Tucson, AZ 85721, USA
    Pharmacol Res 58:262-70. 2008
    ..This review is primarily focused on the role of Nrf2 in cancer, with emphasis on the recent findings indicating the cancer promoting function of Nrf2 and its role in acquired chemoresistance...
  19. doi request reprint Geometric control of capillary architecture via cell-matrix mechanical interactions
    Jian Sun
    Department of Aerospace and Mechanical Engineering, The University of Arizona, Tucson, AZ 85721, USA
    Biomaterials 35:3273-80. 2014
    ..Collectively, these results reveal a mechanoregulation scheme of endothelial cells to regulate the capillary network architecture via cell-matrix mechanical interactions. ..
  20. pmc Nrf2 promotes neuronal cell differentiation
    Fei Zhao
    Department of Pharmacology and Toxicology, University of Arizona, Tucson, AZ 85721, USA
    Free Radic Biol Med 47:867-79. 2009
    ..Collectively, our data demonstrate a novel role for Nrf2 in promoting neuronal cell differentiation, which will open new perspectives for therapeutic uses of Nrf2 activators in patients with neurodegenerative diseases...
  21. doi request reprint Separation-free detection of nuclear factor kappa B with double-stranded molecular probes
    Zhaohui Wang
    Department of Aerospace and Mechanical Engineering, University of Arizona, Tucson, Arizona, USA
    Analyst 133:998-1000. 2008
    ..This paper reports a simple, rapid molecular binding scheme for the detection and quantification of the transcription factor nuclear factor kappa B and other DNA binding proteins without any separation or immobilization step...
  22. pmc Mechanically induced intercellular calcium communication in confined endothelial structures
    Michael Junkin
    Department of Aerospace and Mechanical Engineering, The University of Arizona, Tucson, AZ 85721, USA
    Biomaterials 34:2049-56. 2013
    ..Our results reveal that calcium signaling provides a robust mechanism for cell-cell communication in networks of endothelial cells despite the diversity of the microenvironmental inputs and complexity of vascular structures...