Research Topics
Genomes and Genes | Ma Li WongSummaryAffiliation: University of Miami Country: USA Publications
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Publications
Phosphodiesterase genes are associated with susceptibility to major depression and antidepressant treatment responseMa Li Wong
Center on Pharmacogenomics, Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
Proc Natl Acad Sci U S A 103:15124-9. 2006..This study identifies a potential CNS role for the PDE11 family. The hypothesis that drugs affecting PDE function, particularly cGMP-related PDEs, represent a treatment strategy for major depression should therefore be tested...- Elevated stress-hemoconcentration in major depression is normalized by antidepressant treatment: secondary analysis from a randomized, double-blind clinical trial and relevance to cardiovascular disease riskMa Li Wong
Department of Psychiatry and Behavioral Sciences, Leonard M Miller School of Medicine, University of Miami, Miami, Florida, USA
PLoS ONE 3:e2350. 2008..Stress-hemoconcentration, a result of psychological stress that might be a risk factor for the pathogenesis of CVD, has been studied in stress-challenge paradigms but has not been systematically studied in MDD... 
Novel sequence variations in the brain-derived neurotrophic factor gene and association with major depression and antidepressant treatment responseJulio Licinio
Center on Pharmacogenomics, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
Arch Gen Psychiatry 66:488-97. 2009..Variations in the brain-derived neurotrophic factor gene (BDNF) have been associated with psychiatric disorders. Deep sequencing of the BDNF gene may identify new variations and bring further insight into psychiatric genetics...- The brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism and depression in Mexican-AmericansLuciana Ribeiro
Department of Psychiatry and Behavioral Sciences, Center on Pharmacogenomics, University of Miami Miller School of Medicine, Miami, Florida 33136 1013, USA
Neuroreport 18:1291-3. 2007..7 95% CI 1.17-2.47). Our findings support the association of BDNF single nucleotide polymorphism rs6265 and depression, suggesting that this polymorphism may increase susceptibility to major depression in Mexican-Americans... - Effects of leptin on intake of specific micro- and macronutrients in a woman with leptin gene deficiency studied off and on leptin at stable body weightJulio Licinio
Department of Psychiatry and Behavioral Sciences D 28, University of Miami, Miller School of Medicine, 1695 NW 9th Avenue, Suite 3100, Miami, FL 33136, USA
Appetite 49:594-9. 2007..The nutritional data from this study indicates a direct link between the effects of leptin and ingestion of several specific micronutrients. The mechanisms underlying these effects warrant further investigation and study... - Repeated antidepressant therapy increases cyclic GMP signaling in rat hippocampusGillian W Reierson
Center on Pharmacogenomics, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, 1580 NW 10th Avenue, Miami, FL 33136, USA
Neurosci Lett 466:149-53. 2009..Immunoassay results showed unchanged cAMP levels. We conclude that increased cGMP signaling might underlie the efficacy of chronic antidepressant treatment... - Phosphodiesterase genes and antidepressant treatment response: a reviewKarin Esposito
Center on Pharmacogenomics, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, 1580 NW 10th Avenue, Miami, FL 33136, USA
Ann Med 41:177-85. 2009..Recent data from animal and human studies indicate that PDEs may play a role in depression and in related stress conditions. PDE genes have been linked directly to depression and to other genes associated with psychiatric disorders... - Changes in insulin sensitivity during leptin replacement therapy in leptin-deficient patientsGilberto Paz-Filho
Dept of Psychiatry and Behavioral Sciences, Univ of Miami Miller School of Medicine, Miami, FL 33136, USA
Am J Physiol Endocrinol Metab 295:E1401-8. 2008..Our results suggest that hyperleptinemia may contribute to mediate the increased insulin resistance of obesity... - Association of PDE11A global haplotype with major depression and antidepressant drug responseHuai Rong Luo
Center on Pharmacogenomics, Department of Psychiatry and Behavioral Science, University of Miami Miller School of Medicine, Miami, FL, USA
Neuropsychiatr Dis Treat 5:163-70. 2009..Thus, our data suggest that the PDE11A global haplotype is associated with both MDD and antidepressant drug response... - Caspase 1 deficiency reduces inflammation-induced brain transcriptionClaudio Mastronardi
Center on Pharmacogenomics, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL 33136, USA
Proc Natl Acad Sci U S A 104:7205-10. 2007..Our results indicate that those genes may also play a role in several neuropsychiatric conditions in which inflammation has been implicated and indicate that casp1 might be a potential therapeutic target for such disorders... - cGMP Signaling, Phosphodiesterases and Major Depressive DisorderGillian W Reierson
University of Miami Miller School of Medicine, Miami, FL, USA
Curr Neuropharmacol 9:715-27. 2011..Here we review a growing body of evidence suggesting that the cGMP signaling cascade warrants further investigation for its involvement in MDD and antidepressant action... - Chronic fluoxetine treatment increases daytime melatonin synthesis in the rodentGillian W Reierson
Center on Pharmacogenomics, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USA
Clin Pharmacol 1:1-6. 2009..We conclude that chronic fluoxetine treatment increases daytime plasma melatonin and pineal AA-NAT gene expression despite downregulated pineal cAMP signaling in the rodent... - Leptin replacement improves cognitive developmentGilberto J Paz-Filho
Department of Psychiatry and Behavioral Sciences, Center for Pharmacogenomics, University of Miami Miller School of Medicine, Miami, Florida, USA
PLoS ONE 3:e3098. 2008..Leptin changes brain structure, neuron excitability and synaptic plasticity. It also regulates the development and function of feeding circuits. However, the effects of leptin on neurocognitive development are unknown... 
Hypothalamic-pituitary-end organ function in women with bipolar depressionNatalie L Rasgon
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305 5723, USA
Psychoneuroendocrinology 32:279-86. 2007..The results are preliminary, and require replication in larger samples...- Pharmacogenomics of neuroimmune interactions in human psychiatric disordersJulio Licinio
Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL 33136, USA
Exp Physiol 92:807-11. 2007.... - Chronic imipramine downregulates cyclic AMP signaling in rat hippocampusGillian W Reierson
Department of Psychiatry and Behavioral Sciences, Center on Pharmacogenomics, University of Miami Miller School of Medicine, Miami, FL 33136, USA
Neuroreport 20:307-11. 2009..We conclude that in contrast with the assumption of antidepressant-mediated increases in cAMP levels, longterm imipramine treatment may have the opposite effect, namely decreased hippocampal cAMP... - Effects of leptin replacement on macro- and micronutrient preferencesJ Licinio
Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL 33136, USA
Int J Obes (Lond) 31:1859-63. 2007..The mechanisms underlying food choices are complex and involve neuroendocrine and biochemical signaling. Among neuroendocrine signals, leptin may play a prominent role in food preference... - Clinical implications of genetic polymorphism of CYP2D6 in Mexican AmericansDeborah L Flores
Ann Intern Med 140:W71. 2004 - Association study of the serotonin transporter promoter polymorphism and mirtazapine antidepressant response in major depressive disorderRhee Hun Kang
Depression Center, Korea University, Seoul, Republic of Korea
Prog Neuropsychopharmacol Biol Psychiatry 31:1317-21. 2007..These results support our hypothesis that the response to noradrenergic and specific serotonergic antidepressants is significantly associated with the 5-HTTLPR polymorphism... - Suicidality scores during double-blind fluoxetine and desipramine treatment in Mexican AmericansAnil Sharma
J Clin Psychopharmacol 27:99-101. 2007 - Simultaneous and continuous 24-hour plasma and cerebrospinal fluid leptin measurements: dissociation of concentrations in central and peripheral compartmentsMa Li Wong
Center for Pharmacogenomics and Interdepartmental Clinical Pharmacology Center, Neuropsychiatric Institute and David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90095, USA
J Clin Endocrinol Metab 89:258-65. 2004.... - Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adultsJulio Licinio
Center for Pharmacogenomics, Neuropsychiatric Institute, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1761, USA
Proc Natl Acad Sci U S A 101:4531-6. 2004..These results highlight the role of the leptin pathway in adults with key effects on the regulation of body weight, gonadal function, and behavior... - From monoamines to genomic targets: a paradigm shift for drug discovery in depressionMa Li Wong
Center for Pharmacogenomics, Neuropsychiatric Institute and David Geffen School of Medicine at UCLA, 695 Charles Young Drive South, Los Angeles, California 90095 1761, USA
Nat Rev Drug Discov 3:136-51. 2004..Yet such a drug is not on the horizon. Here, we cover the different phases of antidepressant drug discovery in the past, present and future, and comment on the challenges and opportunities for antidepressant research... - Alterations in the dynamics of circulating ghrelin, adiponectin, and leptin in human obesityBulent O Yildiz
Center for Pharmacogenomics and Clinical Pharmacology, Neuropsychiatric Institute, Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1761, USA
Proc Natl Acad Sci U S A 101:10434-9. 2004..We suggest that the blunting of the nocturnal rise of ghrelin is a biological feature of human obesity... - Depression, antidepressants and suicidality: a critical appraisalJulio Licinio
Center for Pharmacogenomics and Clinical Pharmacology, Neuropsychiatric Institute and David Geffen School of Medicine, University of California, Los Angeles, USA
Nat Rev Drug Discov 4:165-71. 2005.... - Modeling of the temporal patterns of fluoxetine prescriptions and suicide rates in the United StatesMichael S Milane
Center for Pharmacogenomics and Clinical Pharmacology, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, California, USA
PLoS Med 3:e190. 2006.... - Leptin replacement alters brain response to food cues in genetically leptin-deficient adultsKate Baicy
Department of Psychiatry and Biobehavioral Sciences and Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90024, USA
Proc Natl Acad Sci U S A 104:18276-9. 2007..Leptin appears to modulate feeding behavior through these circuits, suggesting therapeutic targets for human obesity... - Effect of leptin replacement on brain structure in genetically leptin-deficient adultsJohn A Matochik
Neuroimaging Research Branch, National Institute on Drug Abuse, Department of Health and Human Services/National Institutes of Health, Baltimore, Maryland 21224, USA
J Clin Endocrinol Metab 90:2851-4. 2005..Our findings suggest that leptin can have sustained effects on tissue composition in the human brain and broaden the potential spectrum of leptin's influence beyond feeding behavior and endocrine function... - Microanalysis of eating behavior of three leptin deficient adults treated with leptin therapyDonald A Williamson
Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
Appetite 45:75-80. 2005..These results are discussed in the context of the scientific literature pertaining to leptin and its effects on appetite and obesity... - Development of a PCR-based strategy for CYP2D6 genotyping including gene multiplication of worldwide potential usePedro Dorado
University of Beira Interior, Covilh, Portugal
Biotechniques 39:571-4. 2005.... - Ritanserin antagonism of m-chlorophenylpiperazine effects in neuroleptic-free schizophrenics patients: support for serotonin-2 receptor modulation of schizophrenia symptomsWalid Abi-Saab
Department of Psychiatry, Yale University School of Medicine, New Haven, Conn. 06519, USA
Psychopharmacology (Berl) 162:55-62. 2002..CONCLUSIONS: These data support a contribution of 5-HT(2) receptor stimulation to symptom exacerbation in schizophrenic patients and a role for 5-HT(2) receptor antagonism in the prevention of this effect...
Research Grants
- Depression/Metabolic Syndrome in Mexican-American Women.Ma Li Wong; Fiscal Year: 2006..This work will address this important area by the study of an population group who is markedly under represented in patient-oriented investigation. ..
- CNS transcription modulation in peripheral inflammationMa Li Wong; Fiscal Year: 2002..The proposed studies will result in new data that will be needed for us to generate novel testable hypotheses, which will provide the framework for future R0l applications. ..
- Pharmacogenetics of Antidepressant DrugsMa Li Wong; Fiscal Year: 2007..This K-24 award will make possible for the P.I. to significantly increase her time allocation for patient-oriented research and for mentoring of junior trainees and fellows in clinical research. ..