Kwoon Y Wong
Affiliation: University of Michigan
Pack W, Hill D, Wong K. Melatonin modulates M4-type ganglion-cell photoreceptors. Neuroscience. 2015;303:178-88 pubmed publisher
..This is the first report of a circadian variation in ipRGCs' resting properties and synaptic input, and of melatoninergic modulation of ipRGCs. ..
Reifler A, Chervenak A, Dolikian M, Benenati B, Meyers B, Demertzis Z, et al
. The rat retina has five types of ganglion-cell photoreceptors. Exp Eye Res. 2015;130:17-28 pubmed publisher
..This correlation of spiking photoresponses with cell types will help researchers classify ipRGCs in multielectrode-array (MEA) spike recordings. ..
Vartanian G, Li B, Chervenak A, Walch O, Pack W, Ala Laurila P, et al
. Melatonin Suppression by Light in Humans Is More Sensitive Than Previously Reported. J Biol Rhythms. 2015;30:351-4 pubmed publisher
..This finding has far-reaching implications since there is mounting evidence that nocturnal activation of the circadian system can be harmful. ..
Zhao X, Stafford B, Godin A, King W, Wong K. Photoresponse diversity among the five types of intrinsically photosensitive retinal ganglion cells. J Physiol. 2014;592:1619-36 pubmed publisher
Zhao X, Pack W, Khan N, Wong K. Prolonged Inner Retinal Photoreception Depends on the Visual Retinoid Cycle. J Neurosci. 2016;36:4209-17 pubmed publisher
..Here, we present electrophysiological and behavioral evidence that ipRGCs depend on the RPE to continuously regenerate melanopsin during intense prolonged photostimulation. ..
Walch O, Zhang L, Reifler A, Dolikian M, Forger D, Wong K. Characterizing and modeling the intrinsic light response of rat ganglion-cell photoreceptors. J Neurophysiol. 2015;114:2955-66 pubmed publisher
..These mathematical models will help predict how each ipRGC cluster might respond to stimuli of any waveform and could inform the invention of lighting technologies that promote health through melanopsin stimulation. ..
Reifler A, Chervenak A, Dolikian M, Benenati B, Li B, Wachter R, et al
. All spiking, sustained ON displaced amacrine cells receive gap-junction input from melanopsin ganglion cells. Curr Biol. 2015;25:2763-2773 pubmed publisher
..These results demonstrate that ipRGCs are a major source of tonic visual information within the retina and exert widespread intraretinal influence. They also add to recent evidence that ganglion cells signal not only to the brain. ..
Wong K. A retinal ganglion cell that can signal irradiance continuously for 10 hours. J Neurosci. 2012;32:11478-85 pubmed publisher
..These results further suggest that the photoreceptors and ON bipolar cells presynaptic to ipRGCs may be able to respond to light continuously for 10 h. ..
Zhao X, Reifler A, Schroeder M, Jaeckel E, Chervenak A, Wong K. Mechanisms creating transient and sustained photoresponses in mammalian retinal ganglion cells. J Gen Physiol. 2017;149:335-353 pubmed publisher
..Parenthetically, we find evidence in both mice and rats that the kinetics of light-induced mGluR6 deactivation determines whether an ON bipolar cell responds tonically or transiently to light. ..