J K Wong

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc In vivo compartmentalization of human immunodeficiency virus: evidence from the examination of pol sequences from autopsy tissues
    J K Wong
    Department of Medicine, University of California, San Diego, School of Medicine, La Jolla 92093 0679, USA
    J Virol 71:2059-71. 1997
  2. pmc Reduction of HIV-1 in blood and lymph nodes following potent antiretroviral therapy and the virologic correlates of treatment failure
    J K Wong
    Department of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 94:12574-9. 1997
  3. pmc Human immunodeficiency virus replication and genotypic resistance in blood and lymph nodes after a year of potent antiretroviral therapy
    H F Gunthard
    Department of Pathology, School of Medicine, University of California San Diego, La Jolla 92093 0679, USA
    J Virol 72:2422-8. 1998
  4. ncbi request reprint Prevalence and predictive value of intermittent viremia with combination hiv therapy
    D V Havlir
    University of California, San Diego, 150 W Washington, Suite 100, San Diego, CA 92103, USA
    JAMA 286:171-9. 2001
  5. ncbi request reprint Effect of influenza vaccination on viral replication and immune response in persons infected with human immunodeficiency virus receiving potent antiretroviral therapy
    H F Gunthard
    Department of Pathology, University of California San Diego, School of Medicine, La Jolla, California, USA
    J Infect Dis 181:522-31. 2000
  6. pmc Genetic composition of human immunodeficiency virus type 1 in cerebrospinal fluid and blood without treatment and during failing antiretroviral therapy
    M C Strain
    University of California, San Diego, La Jolla, CA, USA
    J Virol 79:1772-88. 2005
  7. pmc Heterogeneous clearance rates of long-lived lymphocytes infected with HIV: intrinsic stability predicts lifelong persistence
    M C Strain
    Department of Medicine and Pathology, University of California at San Diego, La Jolla, CA 90293, USA
    Proc Natl Acad Sci U S A 100:4819-24. 2003
  8. pmc Estimating selection pressures on HIV-1 using phylogenetic likelihood models
    S L Kosakovsky Pond
    Department of Pathology, University of California, San Diego, CA 92093, USA
    Stat Med 27:4779-89. 2008
  9. ncbi request reprint Higher selection pressure from antiretroviral drugs in vivo results in increased evolutionary distance in HIV-1 pol
    H F Gunthard
    Department of Pathology, University of California, San Diego, USA
    Virology 259:154-65. 1999
  10. ncbi request reprint Spatiotemporal dynamics of HIV propagation
    M C Strain
    Physics Department, University of California San Diego, 9500 Gilman Drive UH 220, La Jolla, CA 92093 0319, USA
    J Theor Biol 218:85-96. 2002

Detail Information

Publications10

  1. pmc In vivo compartmentalization of human immunodeficiency virus: evidence from the examination of pol sequences from autopsy tissues
    J K Wong
    Department of Medicine, University of California, San Diego, School of Medicine, La Jolla 92093 0679, USA
    J Virol 71:2059-71. 1997
    ..These observations support the concept of anatomically distinct, independently evolving quasispecies (virodemes)...
  2. pmc Reduction of HIV-1 in blood and lymph nodes following potent antiretroviral therapy and the virologic correlates of treatment failure
    J K Wong
    Department of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 94:12574-9. 1997
    ..Conversely, the persistence of even modest levels of plasma virus after 1 year of treatment reflects ongoing viral replication, the emergence of drug resistance, and the maintenance of high burdens of virus in the lymph nodes...
  3. pmc Human immunodeficiency virus replication and genotypic resistance in blood and lymph nodes after a year of potent antiretroviral therapy
    H F Gunthard
    Department of Pathology, School of Medicine, University of California San Diego, La Jolla 92093 0679, USA
    J Virol 72:2422-8. 1998
    ..These findings argue that HIV replication differs significantly between patients on potent antiretroviral therapy with low but detectable viral loads and those with undetectable viral loads...
  4. ncbi request reprint Prevalence and predictive value of intermittent viremia with combination hiv therapy
    D V Havlir
    University of California, San Diego, 150 W Washington, Suite 100, San Diego, CA 92103, USA
    JAMA 286:171-9. 2001
    ....
  5. ncbi request reprint Effect of influenza vaccination on viral replication and immune response in persons infected with human immunodeficiency virus receiving potent antiretroviral therapy
    H F Gunthard
    Department of Pathology, University of California San Diego, School of Medicine, La Jolla, California, USA
    J Infect Dis 181:522-31. 2000
    ....
  6. pmc Genetic composition of human immunodeficiency virus type 1 in cerebrospinal fluid and blood without treatment and during failing antiretroviral therapy
    M C Strain
    University of California, San Diego, La Jolla, CA, USA
    J Virol 79:1772-88. 2005
    ....
  7. pmc Heterogeneous clearance rates of long-lived lymphocytes infected with HIV: intrinsic stability predicts lifelong persistence
    M C Strain
    Department of Medicine and Pathology, University of California at San Diego, La Jolla, CA 90293, USA
    Proc Natl Acad Sci U S A 100:4819-24. 2003
    ..Eradication will not be achieved with complete inhibition of viral replication alone...
  8. pmc Estimating selection pressures on HIV-1 using phylogenetic likelihood models
    S L Kosakovsky Pond
    Department of Pathology, University of California, San Diego, CA 92093, USA
    Stat Med 27:4779-89. 2008
    ..To illustrate our methods, we present an analysis of compartment-specific evolution of HIV-1 env in blood and cerebrospinal fluid and of site-to-site variation in the gag gene of subtype C HIV-1...
  9. ncbi request reprint Higher selection pressure from antiretroviral drugs in vivo results in increased evolutionary distance in HIV-1 pol
    H F Gunthard
    Department of Pathology, University of California, San Diego, USA
    Virology 259:154-65. 1999
    ..A disproportionally high number of synonymous substitutions accounted for the observed divergence and indicated that such genetic changes may not be completely silent...
  10. ncbi request reprint Spatiotemporal dynamics of HIV propagation
    M C Strain
    Physics Department, University of California San Diego, 9500 Gilman Drive UH 220, La Jolla, CA 92093 0319, USA
    J Theor Biol 218:85-96. 2002
    ..The geometry-limited regime can be modulated by downregulation of CD4. These different properties are analysed quantitatively and compared with previous experimental results...