J K Wong
Affiliation: University of California
- In vivo compartmentalization of human immunodeficiency virus: evidence from the examination of pol sequences from autopsy tissuesJ K Wong
Department of Medicine, University of California, San Diego, School of Medicine, La Jolla 92093 0679, USA
J Virol 71:2059-71. 1997..These observations support the concept of anatomically distinct, independently evolving quasispecies (virodemes)...
- Reduction of HIV-1 in blood and lymph nodes following potent antiretroviral therapy and the virologic correlates of treatment failureJ K Wong
Department of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 94:12574-9. 1997..Conversely, the persistence of even modest levels of plasma virus after 1 year of treatment reflects ongoing viral replication, the emergence of drug resistance, and the maintenance of high burdens of virus in the lymph nodes...
- Human immunodeficiency virus replication and genotypic resistance in blood and lymph nodes after a year of potent antiretroviral therapyH F Gunthard
Department of Pathology, School of Medicine, University of California San Diego, La Jolla 92093 0679, USA
J Virol 72:2422-8. 1998..These findings argue that HIV replication differs significantly between patients on potent antiretroviral therapy with low but detectable viral loads and those with undetectable viral loads...
- Prevalence and predictive value of intermittent viremia with combination hiv therapyD V Havlir
University of California, San Diego, 150 W Washington, Suite 100, San Diego, CA 92103, USA
JAMA 286:171-9. 2001....
- Effect of influenza vaccination on viral replication and immune response in persons infected with human immunodeficiency virus receiving potent antiretroviral therapyH F Gunthard
Department of Pathology, University of California San Diego, School of Medicine, La Jolla, California, USA
J Infect Dis 181:522-31. 2000....
- Genetic composition of human immunodeficiency virus type 1 in cerebrospinal fluid and blood without treatment and during failing antiretroviral therapyM C Strain
University of California, San Diego, La Jolla, CA, USA
J Virol 79:1772-88. 2005....
- Heterogeneous clearance rates of long-lived lymphocytes infected with HIV: intrinsic stability predicts lifelong persistenceM C Strain
Department of Medicine and Pathology, University of California at San Diego, La Jolla, CA 90293, USA
Proc Natl Acad Sci U S A 100:4819-24. 2003..Eradication will not be achieved with complete inhibition of viral replication alone...
- Estimating selection pressures on HIV-1 using phylogenetic likelihood modelsS L Kosakovsky Pond
Department of Pathology, University of California, San Diego, CA 92093, USA
Stat Med 27:4779-89. 2008..To illustrate our methods, we present an analysis of compartment-specific evolution of HIV-1 env in blood and cerebrospinal fluid and of site-to-site variation in the gag gene of subtype C HIV-1...
- Higher selection pressure from antiretroviral drugs in vivo results in increased evolutionary distance in HIV-1 polH F Gunthard
Department of Pathology, University of California, San Diego, USA
Virology 259:154-65. 1999..A disproportionally high number of synonymous substitutions accounted for the observed divergence and indicated that such genetic changes may not be completely silent...
- Spatiotemporal dynamics of HIV propagationM C Strain
Physics Department, University of California San Diego, 9500 Gilman Drive UH 220, La Jolla, CA 92093 0319, USA
J Theor Biol 218:85-96. 2002..The geometry-limited regime can be modulated by downregulation of CD4. These different properties are analysed quantitatively and compared with previous experimental results...