E C Wong

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint New developments in arterial spin labeling pulse sequences
    Eric C Wong
    UCSD Center for Functional MRI, La Jolla, CA, USA
    NMR Biomed 26:887-91. 2013
  2. doi request reprint Local head gradient coils: window(s) of opportunity
    Eric C Wong
    Department of Radiology and Psychiatry, University of California, San Diego, CA, USA
    Neuroimage 62:660-4. 2012
  3. doi request reprint Blind detection of vascular sources and territories using random vessel encoded arterial spin labeling
    Eric C Wong
    Department of Radiology, UCSD Center for Functional MRI, 9500 Gilman Drive, MC 0677, La Jolla, CA 92093 0677, USA
    MAGMA 25:95-101. 2012
  4. ncbi request reprint Implementation of quantitative perfusion imaging techniques for functional brain mapping using pulsed arterial spin labeling
    E C Wong
    Department of Radiology, University of California, San Diego, La Jolla 92037 7756, USA
    NMR Biomed 10:237-49. 1997
  5. ncbi request reprint Quantifying CBF with pulsed ASL: technical and pulse sequence factors
    Eric C Wong
    University of California, San Diego, La Jolla, California CA 92093 0677, USA
    J Magn Reson Imaging 22:727-31. 2005
  6. ncbi request reprint Velocity-selective arterial spin labeling
    Eric C Wong
    Department of Radiology, University of California San Diego, La Jolla, 92093, USA
    Magn Reson Med 55:1334-41. 2006
  7. ncbi request reprint T(1) and T(2) selective method for improved SNR in CSF-attenuated imaging: T(2)-FLAIR
    E C Wong
    University of California, San Diego, San Diego, California, USA
    Magn Reson Med 45:529-32. 2001
  8. ncbi request reprint Turbo ASL: arterial spin labeling with higher SNR and temporal resolution
    E C Wong
    University of California, San Diego, San Diego, California, USA
    Magn Reson Med 44:511-5. 2000
  9. ncbi request reprint Vessel-encoded arterial spin-labeling using pseudocontinuous tagging
    Eric C Wong
    Department of Radiology, University of California, San Diego, La Jolla, CA, USA
    Magn Reson Med 58:1086-91. 2007
  10. ncbi request reprint Quantitative perfusion imaging using arterial spin labeling
    E C Wong
    Department of Radiology, University of California, San Diego, San Diego, California 92037, USA
    Neuroimaging Clin N Am 9:333-42. 1999

Detail Information

Publications41

  1. doi request reprint New developments in arterial spin labeling pulse sequences
    Eric C Wong
    UCSD Center for Functional MRI, La Jolla, CA, USA
    NMR Biomed 26:887-91. 2013
    ..Some of these recent advances are reviewed here...
  2. doi request reprint Local head gradient coils: window(s) of opportunity
    Eric C Wong
    Department of Radiology and Psychiatry, University of California, San Diego, CA, USA
    Neuroimage 62:660-4. 2012
    ..This article describes the development of local gradient coil technology at MCW, and a historical perspective on local head gradient coils in general...
  3. doi request reprint Blind detection of vascular sources and territories using random vessel encoded arterial spin labeling
    Eric C Wong
    Department of Radiology, UCSD Center for Functional MRI, 9500 Gilman Drive, MC 0677, La Jolla, CA 92093 0677, USA
    MAGMA 25:95-101. 2012
    ..The goal of this work is to use vessel encoded arterial spin labeling (VEASL) methods to detect feeding arteries without prior knowledge of their positions, and map the vascular territory of each...
  4. ncbi request reprint Implementation of quantitative perfusion imaging techniques for functional brain mapping using pulsed arterial spin labeling
    E C Wong
    Department of Radiology, University of California, San Diego, La Jolla 92037 7756, USA
    NMR Biomed 10:237-49. 1997
    ....
  5. ncbi request reprint Quantifying CBF with pulsed ASL: technical and pulse sequence factors
    Eric C Wong
    University of California, San Diego, La Jolla, California CA 92093 0677, USA
    J Magn Reson Imaging 22:727-31. 2005
    ..In principle, this technique may allow ASL measurement of cerebral blood flow (CBF) that is insensitive to transit delays...
  6. ncbi request reprint Velocity-selective arterial spin labeling
    Eric C Wong
    Department of Radiology, University of California San Diego, La Jolla, 92093, USA
    Magn Reson Med 55:1334-41. 2006
    ..The technical considerations described here include the design of VS pulses, background suppression, anisotropy with respect to velocity-encoding directions, and CBF quantitation issues...
  7. ncbi request reprint T(1) and T(2) selective method for improved SNR in CSF-attenuated imaging: T(2)-FLAIR
    E C Wong
    University of California, San Diego, San Diego, California, USA
    Magn Reson Med 45:529-32. 2001
    ..This allows the tissue magnetization to recover more rapidly, allows for the use of shorter TR values, and reduces T(1) weighting. Magn Reson Med 45:529-532, 2001...
  8. ncbi request reprint Turbo ASL: arterial spin labeling with higher SNR and temporal resolution
    E C Wong
    University of California, San Diego, San Diego, California, USA
    Magn Reson Med 44:511-5. 2000
    ..This improves both the temporal resolution and the sensitivity of ASL for functional brain mapping...
  9. ncbi request reprint Vessel-encoded arterial spin-labeling using pseudocontinuous tagging
    Eric C Wong
    Department of Radiology, University of California, San Diego, La Jolla, CA, USA
    Magn Reson Med 58:1086-91. 2007
    ..High SNR maps of left carotid, right carotid, and basilar territories are generated in 6 min of scan time...
  10. ncbi request reprint Quantitative perfusion imaging using arterial spin labeling
    E C Wong
    Department of Radiology, University of California, San Diego, San Diego, California 92037, USA
    Neuroimaging Clin N Am 9:333-42. 1999
    ..The one major technical challenge that currently prevents more general application in the brain is the sensitivity to abnormally long transit delays...
  11. ncbi request reprint Quantification of regional pulmonary blood flow using ASL-FAIRER
    D S Bolar
    Department of Radiology, University of California San Diego, 92103, USA
    Magn Reson Med 55:1308-17. 2006
    ..The advantages and drawbacks of the single- vs. multiple-subtraction approaches are considered within a theoretical framework tailored to PBF...
  12. ncbi request reprint Nonlinear temporal dynamics of the cerebral blood flow response
    K L Miller
    Department of Electrical Engineering, Stanford University, Stanford, California, USA
    Hum Brain Mapp 13:1-12. 2001
    ..The observed nonlinearities are consistent with a model with a nonlinear step from stimulus to neural activity, a linear step from neural activity to CBF change, and a nonlinear step from CBF change to BOLD signal change...
  13. ncbi request reprint A general kinetic model for quantitative perfusion imaging with arterial spin labeling
    R B Buxton
    Department of Radiology, University of San Diego, California, USA
    Magn Reson Med 40:383-96. 1998
    ..In preliminary experiments with a human subject, the model provided a good description of pulsed ASL data during a simple sensorimotor activation task...
  14. ncbi request reprint The effects of flow dispersion and cardiac pulsation in arterial spin labeling
    Wen Chau Wu
    Department of University of California, San Diego, La Jolla, CA 92093, USA
    IEEE Trans Med Imaging 26:84-92. 2007
    ..We conclude that both flow dispersion and fluctuations in the ASL signal due to cardiac pulsations are significant...
  15. ncbi request reprint Discrepancies between BOLD and flow dynamics in primary and supplementary motor areas: application of the balloon model to the interpretation of BOLD transients
    Takayuki Obata
    Department of Radiology, University of California at San Diego, 92039 0677, La Jolla, CA, USA
    Neuroimage 21:144-53. 2004
    ..This study illustrates the utility and the limitations of using theoretical models combined with ASL techniques to understand the dynamics of the BOLD response...
  16. ncbi request reprint Dynamic imaging of perfusion in human skeletal muscle during exercise with arterial spin labeling
    L R Frank
    Department of Radiology, University of California at San Diego, San Diego, California, USA
    Magn Reson Med 42:258-67. 1999
    ..These results are interpreted in terms of a quantitative model for the perfusion signal in muscle. This method can provide a useful tool in the study of muscle physiology. Magn Reson Med 42:258-267, 1999. Published 1999 Wiley-Liss, Inc...
  17. ncbi request reprint Detection power, estimation efficiency, and predictability in event-related fMRI
    T T Liu
    Department of Radiology, University of California, San Diego, La Jolla, California 92037, USA
    Neuroimage 13:759-73. 2001
    ....
  18. ncbi request reprint Vascular space occupancy weighted imaging with control of residual blood signal and higher contrast-to-noise ratio
    Wen Chau Wu
    Department of Radiology, University of California at San Diego, La Jolla, CA 92093, USA
    IEEE Trans Med Imaging 26:1319-27. 2007
    ..Results also demonstrated its advantages of 1.6-fold higher CNR and insensitivity to variant tissue/blood T1 as well as inversion efficiency...
  19. ncbi request reprint Feasibility of velocity selective arterial spin labeling in functional MRI
    Wen Chau Wu
    Department of Radiology, University of California, San Diego, La Jolla, California 92093, USA
    J Cereb Blood Flow Metab 27:831-8. 2007
    ..Velocity selective imaging can remove intravascular signal from the vessels where the flow velocity is above Vc...
  20. ncbi request reprint Brain activation and pupil response during covert performance of the Stroop Color Word task
    G G Brown
    Psychiatry Department, University of California San Diego, USA
    J Int Neuropsychol Soc 5:308-19. 1999
    ..Rather, a network of brain regions is implicated, with separate regions within this system supporting distinct functions...
  21. ncbi request reprint Comparison of simultaneously measured perfusion and BOLD signal increases during brain activation with T(1)-based tissue identification
    W M Luh
    Biophysics Research Institute, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Magn Reson Med 44:137-43. 2000
    ..Perfusion activation maps will likely represent the sites of neuronal activity better than do BOLD activation maps. Magn Reson Med 44:137-143, 2000...
  22. ncbi request reprint Imaging periodic currents using alternating balanced steady-state free precession
    Giedrius T Buracas
    Department of Radiology, UCSD Center for Functional MRI, La Jolla, California 92037, USA
    Magn Reson Med 59:140-8. 2008
    ..Current phantom experiments employing ABSS imaging resulted in detection of magnetic field variations as small as 0.15nT in scans lasting for 36 sec, which is more sensitive than using gradient-recalled echo imaging...
  23. doi request reprint Longitudinal MRI studies in the isoflurane-anesthetized rat: long-term effects of a short hypoxic episode on regulation of cerebral blood flow as assessed by pulsed arterial spin labelling
    Susanne Wegener
    Department of Radiology, University of California at San Diego, San Diego, CA 92103, USA
    NMR Biomed 21:696-703. 2008
    ..These findings indicate that, in isoflurane-anesthetized rats, even a short hypoxic episode can have long-lasting effects on cerebrovascular regulation...
  24. doi request reprint Quantitative assessment of mixed cerebral vascular territory supply with vessel encoded arterial spin labeling MRI
    Akash P Kansagra
    School of Medicine, University of California, San Diego, La Jolla, CA 92093 0677, USA
    Stroke 39:2980-5. 2008
    ..In the present study, we quantitatively assess mixing of internal carotid and basilar artery blood through cerebrovascular anastomoses using vessel-encoded arterial spin labeling and a new postprocessing method...
  25. doi request reprint Mapping of vertebral artery perfusion territories using arterial spin labeling MRI
    Akash P Kansagra
    School of Medicine, University of California, San Diego, California, USA
    J Magn Reson Imaging 28:762-6. 2008
    ..To demonstrate the use of a noninvasive arterial spin labeling (ASL) MRI technique and evaluate vertebral artery (VA) territories in the brain...
  26. ncbi request reprint Intravascular effect in velocity-selective arterial spin labeling: the choice of inflow time and cutoff velocity
    Wen Chau Wu
    Center for Functional MRI, Department of Radiology, University of California San Diego, 9500 Gilman Drive 0677, La Jolla, CA 92093, USA
    Neuroimage 32:122-8. 2006
    ..In field strength of 3 T, numerical simulation shows that optimal signal-to-noise ratio efficiency can be achieved with TR/TI = 2092 ms/1664 ms for single slice and 4493 ms/1404 ms for slab imaging...
  27. pmc High efficiency, low distortion 3D diffusion tensor imaging with variable density spiral fast spin echoes (3D DW VDS RARE)
    Lawrence R Frank
    Center for Scientific Computation in Imaging, San Diego, CA 92103, USA
    Neuroimage 49:1510-23. 2010
    ..In addition, a novel method for fast and accurate reconstruction of the non-Cartesian data is employed. Results are demonstrated in the brains of normal human volunteers...
  28. doi request reprint Multiphase pseudocontinuous arterial spin labeling (MP-PCASL) for robust quantification of cerebral blood flow
    Youngkyoo Jung
    Center for Functional MRI and Department of Radiology, University of California San Diego, La Jolla, California 92093, USA
    Magn Reson Med 64:799-810. 2010
    ..Our results show that multiple phase offset PCASL provides robust cerebral blood flow quantification while retaining much of the sensitivity advantage of PCASL...
  29. doi request reprint Perfusion tensor imaging
    Lawrence R Frank
    Center for Scientific Computation in Imaging, UCSD, La Jolla, California 92093 0854, USA
    Magn Reson Med 60:1284-91. 2008
    ..We demonstrate this new method, Perfusion Tensor Imaging (PTI), in both the brain and skeletal muscle of normal human volunteers and discuss possible applications...
  30. ncbi request reprint Quantification of rodent cerebral blood flow (CBF) in normal and high flow states using pulsed arterial spin labeling magnetic resonance imaging
    Susanne Wegener
    Department of Radiology, University of California San Diego, San Diego, California, USA
    J Magn Reson Imaging 26:855-62. 2007
    ....
  31. ncbi request reprint Analysis and design of perfusion-based event-related fMRI experiments
    Thomas T Liu
    Department of Radiology, University of California at San Diego, La Jolla, California, 92093, USA
    Neuroimage 16:269-82. 2002
    ..Numerical simulations and results from ASL experiments are used to support the theoretical findings...
  32. ncbi request reprint A signal processing model for arterial spin labeling functional MRI
    Thomas T Liu
    Center for Functional Magnetic Resonance Imaging and Department of Radiology, University of California San Diego, La Jolla, CA 92093 0677, USA
    Neuroimage 24:207-15. 2005
    ..The formation of BOLD estimates from the ASL data is also considered and perfusion weighting of the estimates is examined using the signal model...
  33. ncbi request reprint Alternative brain organization after prenatal cerebral injury: convergent fMRI and cognitive data
    Joan Stiles
    Department of Cognitive Science, University of California, San Diego 92093 0515, USA
    J Int Neuropsychol Soc 9:604-22. 2003
    ..In addition, the coupling of the activation with the behavioral data allows us to go beyond the simple mapping of functional sites, to ask questions about how those sites may have come to mediate the spatial functions...
  34. ncbi request reprint Increased diffusion sensitivity with hyperechos
    Lawrence R Frank
    UCSD Center for Functional MR1, San Diego, California 92093, USA
    Magn Reson Med 49:1098-105. 2003
    ..The advantages of the two-pulse diffusion weighted hyperecho sequence are demonstrated theoretically. Experimental results are shown in the application to high angular resolution diffusion encoding (HARD) in normal human brain...
  35. ncbi request reprint Mapping the physiological parameters of articular cartilage with magnetic resonance imaging
    L R Frank
    Department of Radiology, University of California at San Diego, USA
    Top Magn Reson Imaging 10:153-79. 1999
    ..In this article we review the current status of this research and pose some questions concerning the future directions of articular cartilage research and clinical applications...
  36. ncbi request reprint T1-selective diffusion weighted fMRI at 1.5T
    C A Popp Weingarten
    Department of Radiology, Emory University, Atlanta, GA 30322, USA
    NMR Biomed 11:405-13. 1998
    ..The results are consistent with an intravascular contribution to the functional signal and to its large ADC...
  37. ncbi request reprint Estimation of respiration-induced noise fluctuations from undersampled multislice fMRI data
    L R Frank
    Department of Radiology, University of California at San Diego, San Diego, California, USA
    Magn Reson Med 45:635-44. 2001
    ..Magn Reson Med 45:635-644, 2001. Published 2001 Wiley-Liss, Inc...
  38. ncbi request reprint BOLD and perfusion response to finger-thumb apposition after acetazolamide administration: differential relationship to global perfusion
    Gregory G Brown
    VA San Diego Healthcare System, San Diego, California 92161, USA
    J Cereb Blood Flow Metab 23:829-37. 2003
    ....
  39. ncbi request reprint Functional MRI of global and local processing in children
    Pamela Moses
    Department of Cognitive Science, University of California of San Diego, La Jolla, California 92093, USA
    Neuroimage 16:415-24. 2002
    ..Importantly these patterns of functional activation mirror the profiles of RT performance. Together they demonstrate a shift from undifferentiated, bilateral processing toward hemispheric lateralization...
  40. ncbi request reprint Comparing the brain areas supporting nondeclarative categorization and recognition memory
    Paul J Reber
    Department of Psychology, 102 Swift Hall, Northwestern University, 2029 Sheridan Road, Evanston, IL 60201, USA
    Brain Res Cogn Brain Res 14:245-57. 2002
    ..The current findings support those results and additionally identify brain areas active during categorization that are involved in expressing this category knowledge...
  41. ncbi request reprint Encoding activity in the medial temporal lobe examined with anatomically constrained fMRI analysis
    Paul J Reber
    Department of Psychology, Northwestern University, Evanston, Illinois 60201, USA
    Hippocampus 12:363-76. 2002
    ..The anatomically driven methodology is shown to provide detailed comparison of levels of activity change across specific brain areas and to provide increased sensitivity to functional change in each region of the MTL...

Research Grants8

  1. Arterial Spin Labeling for fMRI
    Eric Wong; Fiscal Year: 2004
    ....
  2. Development of Arterial Spin Labeling for Clinical Applications
    Eric Wong; Fiscal Year: 2007
    ..The result of this work will be robust methods for measuring not only the amount of perfusion, but also the vascular source from which that perfusion was derived. ..
  3. Development of Arterial Spin Labeling for Clinical Applications
    Eric Wong; Fiscal Year: 2009
    ..The result of this work will be robust methods for measuring not only the amount of perfusion, but also the vascular source from which that perfusion was derived. ..