DAVID T contact WONG

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Salivary diagnostics powered by nanotechnologies, proteomics and genomics
    David T Wong
    School of Dentistry, Dental Research Institute, University of California, Los Angeles 73 017 CHS, 10833 Le Conte Ave, Los Angeles, Calif 90095, USA
    J Am Dent Assoc 137:313-21. 2006
  2. ncbi request reprint The emerging landscape of salivary diagnostics
    Yong Zhang
    University of California at Los Angeles School of Dentistry, 73 017 CHS, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA, Tel 310 206 3048 Fax 310 825 7609 e mail
    Oral Health Dent Manag 13:200-10. 2014
  3. pmc Systemic disease-induced salivary biomarker profiles in mouse models of melanoma and non-small cell lung cancer
    Kai Gao
    School of Dentistry and Dental Research Institute, University of California Los Angeles, Los Angeles, CA, USA
    PLoS ONE 4:e5875. 2009
  4. pmc Breast cancer exosome-like microvesicles and salivary gland cells interplay alters salivary gland cell-derived exosome-like microvesicles in vitro
    Chang S Lau
    University of California Los Angeles School of Dentistry and Dental Research Institute, Los Angeles, California, United States of America
    PLoS ONE 7:e33037. 2012
  5. pmc Bioinformatics advances in saliva diagnostics
    Ji Ye Ai
    University of California, Los Angeles, CA, USA
    Int J Oral Sci 4:85-7. 2012
  6. pmc Text-mining applied to autoimmune disease research: the Sjögren's syndrome knowledge base
    Sven Ulrik Gorr
    Department of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, Minneapolis, MN 55455, USA
    BMC Musculoskelet Disord 13:119. 2012
  7. ncbi request reprint Salivary diagnostics
    D T W Wong
    University of California, Los Angeles, School of Dentistry, Los Angeles, CA, USA
    Oper Dent 37:562-70. 2012
  8. doi request reprint Salivary biomarkers for periodontal disease diagnostics
    Ole Brinkmann
    University of California at Los Angeles School of Dentistry, Dental Research Institute, 73 017 CHS, Le Conte Avenue, Los Angeles, CA 90095, USA 1 310 206 3048 1 310 825 7609
    Expert Opin Med Diagn 5:25-35. 2011
  9. ncbi request reprint Salivaomics
    David T W Wong
    Dental Research Institute, University of California, Los Angeles, School of Dentistry, UCLA, os Angeles, Calif 90095, USA
    J Am Dent Assoc 143:19S-24S. 2012
  10. pmc Prevalidation of salivary biomarkers for oral cancer detection
    David Elashoff
    School of Dentistry, University of California at Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    Cancer Epidemiol Biomarkers Prev 21:664-72. 2012

Collaborators

Detail Information

Publications74

  1. ncbi request reprint Salivary diagnostics powered by nanotechnologies, proteomics and genomics
    David T Wong
    School of Dentistry, Dental Research Institute, University of California, Los Angeles 73 017 CHS, 10833 Le Conte Ave, Los Angeles, Calif 90095, USA
    J Am Dent Assoc 137:313-21. 2006
    ..Oral fluid is a perfect medium to be explored for health and disease surveillance...
  2. ncbi request reprint The emerging landscape of salivary diagnostics
    Yong Zhang
    University of California at Los Angeles School of Dentistry, 73 017 CHS, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA, Tel 310 206 3048 Fax 310 825 7609 e mail
    Oral Health Dent Manag 13:200-10. 2014
    ..Here we review recent developments in salivary diagnostics that have been accomplished using salivaomics, the mechanisms of saliva diagnostics, as well as the translational and clinical application of saliva biomarkers. ..
  3. pmc Systemic disease-induced salivary biomarker profiles in mouse models of melanoma and non-small cell lung cancer
    Kai Gao
    School of Dentistry and Dental Research Institute, University of California Los Angeles, Los Angeles, CA, USA
    PLoS ONE 4:e5875. 2009
    ..Although the rationale for oral diseases applications (e.g. oral cancer) is intuitive, the rationale and relationship between systemic diseases and saliva biomarkers are unclear...
  4. pmc Breast cancer exosome-like microvesicles and salivary gland cells interplay alters salivary gland cell-derived exosome-like microvesicles in vitro
    Chang S Lau
    University of California Los Angeles School of Dentistry and Dental Research Institute, Los Angeles, California, United States of America
    PLoS ONE 7:e33037. 2012
    ..Thus, the interaction altered the composition of the salivary gland cell-derived exosome-like microvesicles on both the transcriptomically and proteomically...
  5. pmc Bioinformatics advances in saliva diagnostics
    Ji Ye Ai
    University of California, Los Angeles, CA, USA
    Int J Oral Sci 4:85-7. 2012
    ..This article reviews the informatics advances in saliva diagnostics made possible by the Saliva Ontology and SDxMart...
  6. pmc Text-mining applied to autoimmune disease research: the Sjögren's syndrome knowledge base
    Sven Ulrik Gorr
    Department of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, Minneapolis, MN 55455, USA
    BMC Musculoskelet Disord 13:119. 2012
    ..The goal of this study was to develop a database that collects and organizes gene and protein expression data from the existing literature for comparative analysis with future gene expression and proteomic studies of Sjögren's syndrome...
  7. ncbi request reprint Salivary diagnostics
    D T W Wong
    University of California, Los Angeles, School of Dentistry, Los Angeles, CA, USA
    Oper Dent 37:562-70. 2012
    ..This paper will discuss development of salivary biomarkers for the detection of oral and systemic diseases and the translational application of these markers for clinical applications...
  8. doi request reprint Salivary biomarkers for periodontal disease diagnostics
    Ole Brinkmann
    University of California at Los Angeles School of Dentistry, Dental Research Institute, 73 017 CHS, Le Conte Avenue, Los Angeles, CA 90095, USA 1 310 206 3048 1 310 825 7609
    Expert Opin Med Diagn 5:25-35. 2011
    ..Take home message: Salivary diagnostics has great potential for the detection of oral and systemic diseases. Periodontal disease diagnostics, therapy and prognosis could benefit from this emerging diagnostic field...
  9. ncbi request reprint Salivaomics
    David T W Wong
    Dental Research Institute, University of California, Los Angeles, School of Dentistry, UCLA, os Angeles, Calif 90095, USA
    J Am Dent Assoc 143:19S-24S. 2012
    ..Saliva is an emerging medium to be explored for health and disease surveillance, as well as for personalized medicine. A major mandate is to demonstrate clinicians' ability to use saliva to detect and monitor systemic diseases...
  10. pmc Prevalidation of salivary biomarkers for oral cancer detection
    David Elashoff
    School of Dentistry, University of California at Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    Cancer Epidemiol Biomarkers Prev 21:664-72. 2012
    ....
  11. pmc Transcriptomic dissection of tongue squamous cell carcinoma
    Hui Ye
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, Chicago, IL, USA
    BMC Genomics 9:69. 2008
    ..It is significantly more aggressive than other forms of HNOSCC, in terms of local invasion and spread. In this study, we aim to identify specific transcriptomic signatures that associated with OTSCC...
  12. pmc Saliva Ontology: an ontology-based framework for a Salivaomics Knowledge Base
    Jiye Ai
    University of California at Los Angeles School of Dentistry, University of California, Los Angeles, CA 90095 1668, USA
    BMC Bioinformatics 11:302. 2010
    ..SKB is created by aligning (1) the saliva biomarker discovery and validation resources at UCLA with (2) the ontology resources developed by the OBO (Open Biomedical Ontologies) Foundry, including a new Saliva Ontology (SALO)...
  13. pmc A forward-backward fragment assembling algorithm for the identification of genomic amplification and deletion breakpoints using high-density single nucleotide polymorphism (SNP) array
    Tianwei Yu
    Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, GA, USA
    BMC Bioinformatics 8:145. 2007
    ..To accurately identify small segments of CNA from SNP array data, segmentation methods that are sensitive to CNA while resistant to noise are required...
  14. pmc Salivary diagnostics: enhancing disease detection and making medicine better
    Alik Segal
    University of California Los Angeles, School of Dentistry and Dental Research Institute, Los Angeles, CA 90095, USA
    Eur J Dent Educ 12:22-9. 2008
    ..The translational applications and opportunities are enormous. This review presents the translational value of saliva as a credible clinical diagnostic fluid and the scientific rationale for such use...
  15. pmc Saliva: diagnostics and therapeutic perspectives
    N Spielmann
    School of Dentistry and Dental Research Institute, University of California at Los Angeles, Los Angeles, CA, USA
    Oral Dis 17:345-54. 2011
    ....
  16. pmc Salivary proteomics for oral cancer biomarker discovery
    Shen Hu
    Oral Biology and Medicine Division and Dental Research Institute, School of Dentistry, University of California at Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    Clin Cancer Res 14:6246-52. 2008
    ..This study aims to explore the presence of informative protein biomarkers in the human saliva proteome and to evaluate their potential for detection of oral squamous cell carcinoma (OSCC)...
  17. pmc Salivary mRNA targets for cancer diagnostics
    Bernhard G Zimmermann
    UCLA Dental Research Institute, 73 017 Center for Health Sciences, 10833 Le Conte Avenue, Los Angeles, CA 90095 1668, USA
    Oral Oncol 44:425-9. 2008
    ..Our group is actively pursuing the assembly of a toolbox for the molecular analysis of oral fluid. Here we present our current status utilizing the salivary transcriptome for oral cancer diagnostics...
  18. ncbi request reprint p12(CDK2-AP1) mediates DNA damage responses induced by cisplatin
    Yong Kim
    School of Dentistry and Dental Research Institute, University of California Los Angeles, Los Angeles, CA 90095, USA
    Oncogene 24:407-18. 2005
    ..These data further suggest p12(CDK2-AP1) is a potential gene therapeutic agent for oral/head and neck cancer in conjunction with DNA-damaging agents such as cisplatin...
  19. ncbi request reprint Salivary transcriptome diagnostics for oral cancer detection
    Yang Li
    School of Dentistry and Dental Research Institute, University of California Los Angeles, Los Angeles, California, USA
    Clin Cancer Res 10:8442-50. 2004
    ..The purpose of this study is to evaluate the diagnostic value of this new approach by using oral squamous cell carcinoma (OSCC) as the proof-of-principle disease...
  20. ncbi request reprint Oral cancer proteomics
    Shen Hu
    School of Dentistry, UCLA School of Dentistry, Dental Research Institute, Los Angeles, CA 90095 1668, USA
    Curr Opin Mol Ther 9:467-76. 2007
    ..These proteomic applications may collectively facilitate the early detection and successful treatment of this devastating disease in the future...
  21. ncbi request reprint Human saliva proteome analysis and disease biomarker discovery
    Shen Hu
    University of California Los Angeles, School of Dentistry and Dental Research Institute, CA 90095, USA
    Expert Rev Proteomics 4:531-8. 2007
    ..With the fast development of mass spectrometry and proteomic technologies, we are enthusiastic that saliva protein biomarkers will be developed for clinical diagnosis and prognosis of human diseases in the future...
  22. pmc The proteomes of human parotid and submandibular/sublingual gland salivas collected as the ductal secretions
    Paul Denny
    School of Dentistry, University of Southern California, Los Angeles, California 90089, USA
    J Proteome Res 7:1994-2006. 2008
    ....
  23. pmc Molecular mechanisms of head and neck cancer
    Amit M Deshpande
    School of Dentistry and Dental Research Institute, University of California Los Angeles, CA, USA
    Expert Rev Anticancer Ther 8:799-809. 2008
    ..In this article we will briefly outline the current state of diagnostics and treatment and our understanding of the molecular causes of SCCHN...
  24. pmc Optical protein sensor for detecting cancer markers in saliva
    Winny Tan
    Department of Biomedical Engineering, University of California, 7523 Boelter Hall, Los Angeles, CA 90095 1600, USA
    Biosens Bioelectron 24:266-71. 2008
    ..These positive results enable us to proceed to using confocal optical protein sensor to detect other biomarkers, which have much lower concentrations...
  25. pmc Cyclin-dependent kinase 2-associating protein 1 commits murine embryonic stem cell differentiation through retinoblastoma protein regulation
    Yong Kim
    School of Dentistry and Dental Research Institute, UCLA, Los Angeles, CA 90095, USA
    J Biol Chem 284:23405-14. 2009
    ..This sheds light on the role of the establishment of the proper somatic cell type cell cycle regulation for mESCs to enter into the differentiation process...
  26. pmc Cdk2ap1 is required for epigenetic silencing of Oct4 during murine embryonic stem cell differentiation
    Amit M Deshpande
    Dental Research Institute, UCLA School of Dentistry, Los Angeles, California 90025, USA
    J Biol Chem 284:6043-7. 2009
    ..Our data support a potential molecular link between the known differentiation promoters, including bone morphogenetic proteins and transforming growth factor signaling, and embryonic stem cell differentiation...
  27. pmc Human body fluid proteome analysis
    Shen Hu
    School of Dentistry, Division of Oral Biology and Medicine, Dental Research Institute, University of California, Los Angeles, CA 90095, USA
    Proteomics 6:6326-53. 2006
    ..With the advances made in proteomics technologies, the impact of HBFP analysis in the search for clinically relevant disease biomarkers would be realized in the future...
  28. pmc Preclinical validation of salivary biomarkers for primary Sjögren's syndrome
    Shen Hu
    University of California, Los Angeles, USA
    Arthritis Care Res (Hoboken) 62:1633-8. 2010
    ..In the current study, we aimed to verify these candidate biomarkers in independent patient populations and to evaluate their predictive values for primary SS detection...
  29. pmc Discovery and preclinical validation of salivary transcriptomic and proteomic biomarkers for the non-invasive detection of breast cancer
    Lei Zhang
    School of Dentistry and Dental Research Institute, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 5:e15573. 2010
    ..In this study, a case-control discovery and independent preclinical validations were conducted to evaluate the performance and translational utilities of salivary transcriptomic and proteomic biomarkers for breast cancer detection...
  30. pmc Electrochemical detection of low-copy number salivary RNA based on specific signal amplification with a hairpin probe
    Fang Wei
    Department of Mechanical and Aerospace Engineering, University of California, Los Angeles, CA, USA
    Nucleic Acids Res 36:e65. 2008
    ..The resultant process allows a simple setup and by reducing the number of steps it is suited for the point-of-care detection of specific nucleic acid sequences from complex body fluids such as saliva...
  31. ncbi request reprint Current advances in identification of cancer biomarkers in saliva
    Martha Arellano
    School of Dentistry and Dental Research Institute, University of California at Los Angeles, Los Angeles CA 90095, USA
    Front Biosci (Schol Ed) 1:296-303. 2009
    ..With the new molecular profiling technologies such as microarray and proteomics, we are expecting to reveal highly discriminatory genomic and proteomic targets that can best detect the disease status...
  32. doi request reprint Salivary biomarkers for clinical applications
    Lei Zhang
    Dental Research Institute, School of Dentistry, University of California, Los Angeles, California, USA
    Mol Diagn Ther 13:245-59. 2009
    ..This review presents current salivary biomarker research and technology developmental efforts for clinical applications...
  33. pmc Electrochemical sensor for multiplex biomarkers detection
    Fang Wei
    Department of Mechanical and Aerospace Engineering, University of California, Los Angeles, California, USA
    Clin Cancer Res 15:4446-52. 2009
    ..Multiplexing assay of biomarkers at the point-of-care is an elusive goal for molecular diagnostics...
  34. ncbi request reprint Implications of salivary proteomics in drug discovery and development: a focus on cancer drug discovery
    Shen Hu
    UCLA School of Dentistry and Dental Research Institute, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Drug Discov Today 12:911-6. 2007
    ..Potential applications of saliva proteomics in anticancer drug discovery and development will also be discussed...
  35. pmc Salivary proteomic and genomic biomarkers for primary Sjögren's syndrome
    Shen Hu
    University of California, Los Angeles, California, USA
    Arthritis Rheum 56:3588-600. 2007
    ..To identify a panel of protein and messenger RNA (mRNA) biomarkers in human whole saliva (WS) that may be used in the detection of primary Sjögren's syndrome (SS)...
  36. ncbi request reprint Mutation of Cys105 inhibits dimerization of p12CDK2-AP1 and its growth suppressor effect
    Yong Kim
    School of Dentistry and Dental Research Institute, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 280:23273-9. 2005
    ..Taken together, our data suggest that p12 forms a nuclear homodimers in contact inhibited normal diploid cells and dimerization of p12 is a necessary process for the growth inhibition effect by p12...
  37. pmc Targeted inactivation of p12, CDK2 associating protein 1, leads to early embryonic lethality
    Yong Kim
    Division of Oral Biology and Medicine, Dental Research Institute, School of Dentistry, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 4:e4518. 2009
    ..This study demonstrates that Cdk2ap1 plays an essential role in the early stage of embryogenesis and has a potential role during craniofacial morphogenesis...
  38. pmc Saliva: an emerging biofluid for early detection of diseases
    Yu Hsiang Lee
    UCLA School of Dentistry and Dental Research Institute, 73 017 CHS 10833 Le Conte Ave, Los Angeles, CA 90095, USA
    Am J Dent 22:241-8. 2009
    ..This review presents an overview of the value of saliva as a credible diagnostic tool, the discovery of salivary biomarkers, and the development of salivary diagnostics now and in the future...
  39. ncbi request reprint Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry
    Prasanna Ramachandran
    Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, California, USA
    J Proteome Res 5:1493-503. 2006
    ..Of these, 16 glycoproteins have not been reported previously in saliva. In addition, we identified 44 new sites of N-linked glycosylation on the proteins...
  40. pmc A universal pre-analytic solution for concurrent stabilization of salivary proteins, RNA and DNA at ambient temperature
    Jiang Jiang
    Dental Research Institute, UCLA School of Dentistry, Los Angeles, CA 90095, USA
    Arch Oral Biol 54:268-73. 2009
    ..To maximize this clinical advantage, it is highly desirable to have a global salivary analyte stabilizer for proteins, RNA and DNA at ambient temperature...
  41. ncbi request reprint Salivary diagnostics for oral cancer
    David T Wong
    Division of Oral Biology and Medicine, University of California, Los Angeles, School of Dentistry, USA
    J Calif Dent Assoc 34:303-8. 2006
    ....
  42. ncbi request reprint Serum circulating human mRNA profiling and its utility for oral cancer detection
    Yang Li
    School of Dentistry and Dental Research Institute, Division of Head and Neck Surgery Otolaryngology, David Geffen School of Medicine University of California, Los Angeles, CA 90095, USA
    J Clin Oncol 24:1754-60. 2006
    ..Oral squamous cell carcinoma (OSCC) was selected as the proof-of-concept disease...
  43. pmc Loss of p12CDK2-AP1 expression in human oral squamous cell carcinoma with disrupted transforming growth factor-beta-Smad signaling pathway
    Hui Peng
    Dental Research Institute, School of Dentistry, University of California Los Angeles, Los Angeles, CA 90095, USA
    Neoplasia 8:1028-36. 2006
    ....
  44. pmc Salivary transcriptomic biomarkers for detection of resectable pancreatic cancer
    Lei Zhang
    School of Dentistry and Dental Research Institute, University of California Los Angeles, Los Angeles, California 90095, USA
    Gastroenterology 138:949-57.e1-7. 2010
    ....
  45. ncbi request reprint Human saliva proteome analysis
    Shen Hu
    School of Dentistry and Dental Research Institute, University of California, Los Angeles, California, 90095 1668, USA
    Ann N Y Acad Sci 1098:323-9. 2007
    ..The impact of human saliva proteome analysis in the search for clinically relevant disease biomarkers will be realized through advances made using proteomics technologies...
  46. ncbi request reprint Discovery of oral fluid biomarkers for human oral cancer by mass spectrometry
    Shen Hu
    School of Dentistry and Dental Research Institute, University of California Los Angeles, Los Angeles, CA, USA
    Cancer Genomics Proteomics 4:55-64. 2007
    ..Once discovered and validated on a large and independent clinical cohort, oral fluid proteomic biomarkers may be extensively used for future disease diagnosis...
  47. pmc Genomic targets in saliva
    Bernhard G Zimmermann
    School of Dentistry and Dental Research Institute, University of California, Los Angeles UCLA, Los Angeles, California 90095, USA
    Ann N Y Acad Sci 1098:184-91. 2007
    ..Data are also now in place to validate the presence of unique diagnostic panels of salivary mRNAs in subjects with Sjögren's disease...
  48. pmc Proteomic analysis of saliva: 2D gel electrophoresis, LC-MS/MS, and Western blotting
    Shen Hu
    School of Dentistry, University of California Los Angeles, Los Angeles, CA, USA
    Methods Mol Biol 666:31-41. 2010
    ..In this chapter, we describe the protocols for proteomic analysis of saliva using 2D gel electrophoresis, Western blotting, and LC-MS/MS...
  49. pmc Structural-mechanical characterization of nanoparticle exosomes in human saliva, using correlative AFM, FESEM, and force spectroscopy
    Shivani Sharma
    Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, USA
    ACS Nano 4:1921-6. 2010
    ....
  50. pmc Bio/abiotic interface constructed from nanoscale DNA dendrimer and conducting polymer for ultrasensitive biomolecular diagnosis
    Fang Wei
    Department of Mechanical and Aerospace Engineering, School of Engineering and Applied Science, UCLA, Los Angeles, CA 90095 1597, USA
    Small 5:1784-90. 2009
    ..An LOD of 10 aM is established for IL-8 mRNA. The typical sample volume used in the detection is 4 microL, thus the LOD reaches only 25 target molecules (40 yoctomole)...
  51. ncbi request reprint In situ and non-invasive detection of specific bacterial species in oral biofilms using fluorescently labeled monoclonal antibodies
    Fang Gu
    School of Dentistry and Dental Research Institute, University of California, 10833 Le Conte Avenue, Los Angeles, CA 90095 1668, United States
    J Microbiol Methods 62:145-60. 2005
    ..These studies indicate that MAbs based bacterial detection with CLSM is a versatile tool which permits new insights into the ecology of oral biofilm development...
  52. ncbi request reprint Large-scale identification of proteins in human salivary proteome by liquid chromatography/mass spectrometry and two-dimensional gel electrophoresis-mass spectrometry
    Shen Hu
    School of Dentistry and Dental Research Institute, University of California, Los Angeles, CA 90095, USA
    Proteomics 5:1714-28. 2005
    ..In total, we cataloged 309 proteins from human whole saliva by using these two proteomic approaches...
  53. pmc Systems biology analysis of Sjögren's syndrome and mucosa-associated lymphoid tissue lymphoma in parotid glands
    Shen Hu
    University of California, School of Dentistry, Los Angeles, CA 90095 1668, USA
    Arthritis Rheum 60:81-92. 2009
    ....
  54. pmc Exon-level expression profiling: a comprehensive transcriptome analysis of oral fluids
    Zhanzhi Hu
    Dental Research Institute, 73 017 Center for Health Sciences, University of California, Los Angeles, CA 90095 1668, USA
    Clin Chem 54:824-32. 2008
    ..The aim of this study was to provide proof-of-concept data on the combination of a universal mRNA-amplification method with exon arrays for candidate selection and a multiplex preamplification method for easy validation...
  55. ncbi request reprint Cyclin G2 dysregulation in human oral cancer
    Yong Kim
    School of Dentistry and Dental Research Institute, University of California at Los Angeles, Los Angeles, California, USA
    Cancer Res 64:8980-6. 2004
    ....
  56. ncbi request reprint Differentially expressed protein markers in human submandibular and sublingual secretions
    Shen Hu
    School of Dentistry, Dental Research Institute, UCLA School of Dentistry, University of California Los Angeles, Los Angeles, CA 90095, USA
    Int J Oncol 25:1423-30. 2004
    ....
  57. ncbi request reprint Salivary diagnostics
    David T Wong
    Division of Oral Biology and Medicine, University of California, Los Angeles, School of Dentistry, USA
    J Calif Dent Assoc 34:283-5. 2006
  58. pmc Global expression-based classification of lymph node metastasis and extracapsular spread of oral tongue squamous cell carcinoma
    Xiaofeng Zhou
    Dental Research Institute, School of Dentistry, University of California at Los Angeles, Los Angeles, CA 90095 1668, USA
    Neoplasia 8:925-32. 2006
    ..Leave-one-out cross-validation showed overall accuracy rates of 85% for both pN and ECS prediction models. Our results demonstrated that the pN and the ECS of OTSCCs can be predicted by gene expression analyses of primary tumors...
  59. pmc Characterization of salivary RNA by cDNA library analysis
    Noh Jin Park
    UCLA Dental Research Institute, Los Angeles, CA 90095, USA
    Arch Oral Biol 52:30-5. 2007
    ....
  60. ncbi request reprint Progress in concurrent analysis of loss of heterozygosity and comparative genomic hybridization utilizing high density single nucleotide polymorphism arrays
    Xiaofeng Zhou
    School of Dentistry, Dental Research Institute, University of California at Los Angeles, CA 90095 1668, USA
    Cancer Genet Cytogenet 159:53-7. 2005
    ..This review highlights recent progress on concurrent LOH and CGH analyses utilizing high density SNP arrays and their application in cancer research...
  61. pmc Confident assignment of intact mass tags to human salivary cystatins using top-down Fourier-transform ion cyclotron resonance mass spectrometry
    Christopher M Ryan
    The Pasarow Mass Spectrometry Laboratory, The NPI Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90024, USA
    J Am Soc Mass Spectrom 21:908-17. 2010
    ..With fully characterized cystatin intact mass tags it will now be possible to examine the correlation between the abundance of these molecules and human health and disease...
  62. doi request reprint Micro-heterogeneity of human saliva Peptide P-C characterized by high-resolution top-down Fourier-transform mass spectrometry
    Frederic Halgand
    The Pasarow Mass Spectrometry Laboratory, NPI Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
    J Am Soc Mass Spectrom 21:868-77. 2010
    ..While the biological significance of such subtle variations in protein structure remains unclear, their importance cannot be assigned without their characterization, as is reported here for one of the major salivary proteins...
  63. ncbi request reprint Characterization of RNA in saliva
    Noh Jin Park
    Dental Research Institute, UCLA School of Dentistry, Johnson Comprehensive Cancer Center, Division of Head and Neck Surgery Otolaryngology, Henry Samueli School of Engineering, UCLA, Los Angeles, CA 90095, USA
    Clin Chem 52:988-94. 2006
    ..We have previously shown that human mRNAs are present in saliva and can be used as biomarkers of oral cancer. In this study, we analyzed the integrity, sources, and stability of salivary RNA...
  64. pmc Genomic assessments of the frequent loss of heterozygosity region on 8p21.3-p22 in head and neck squamous cell carcinoma
    Hui Ye
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, MC860, 801 South Paulina Street, Room 530C, Chicago, IL 60612 7213, USA
    Cancer Genet Cytogenet 176:100-6. 2007
    ..Thus, our results suggest that MTUS1 is one of the candidate tumor suppressor genes for HNSCC residing at 8p21.3 approximately p22. The identification of these candidate genes will facilitate the understanding of tumorigenesis of HNSCC...
  65. ncbi request reprint Systemic assessments utilizing saliva: part 1 general considerations and current assessments
    Michael D Forde
    Division of Prosthodontics, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Int J Prosthodont 19:43-52. 2006
    ..In Part 2, the role of saliva to measure bone turnover with a special emphasis on osteoporosis will be discussed...
  66. ncbi request reprint Towards a simple, saliva-based test for the detection of oral cancer 'oral fluid (saliva), which is the mirror of the body, is a perfect medium to be explored for health and disease surveillance'
    David T Wong
    Expert Rev Mol Diagn 6:267-72. 2006
  67. ncbi request reprint "Ventilator bellow standstill"
    David T Wong
    Can J Anaesth 52:774-5. 2005
  68. ncbi request reprint Cultural, behavioral, social, and psychological perceptions of saliva: relevance to clinical diagnostics
    Sean Nguyen
    University of California Los Angeles School of Dentistry, USA
    J Calif Dent Assoc 34:317-22. 2006
    ....
  69. ncbi request reprint RNAprotect saliva: An optimal room- temperature stabilization reagent for the salivary transcriptome
    Noh Jin Park
    Clin Chem 52:2303-4. 2006
  70. ncbi request reprint Salivary transcriptome
    David T Wong
    Clin Cancer Res 13:1350-1; author reply 1351. 2007
  71. pmc The preferences of adult outpatients in medical or dental care settings for giving saliva, urine or blood for clinical testing
    Sreenivas Koka
    Department of Dental Specialties, Mayo Clinic, Rochester, Minn 55905, USA
    J Am Dent Assoc 139:735-40. 2008
    ..These preferences, however, are unknown. The authors assessed patients' preferences for the collection of saliva, urine and blood as diagnostic fluids...
  72. ncbi request reprint Self-reported visual impairment in elderly Canadians and its impact on healthy living
    Ya Ping Jin
    Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada
    Can J Ophthalmol 43:407-13. 2008
    ....
  73. ncbi request reprint Genomic dissection for characterization of cancerous oral epithelium tissues using transcription profiling
    Daehee Hwang
    Department of Chemical Engineering, Room 56 469, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Oral Oncol 39:259-68. 2003
    ..We identified 45 genes that are strongly correlated with malignancy. Of the 45 genes identified, six have been previously implicated in the disease, and two are uncharacterized clones...

Research Grants33

  1. Oral Fluid NanoSensor Test (OFNASET)
    David Wong; Fiscal Year: 2007
    ..For public: This proposal is to achieve the goal of develop, validate and achieve regulatory FDA approval of tools that can be used by dentists and doctors for in-office real time detection of oral cancer using a drop of saliva. ..
  2. Genomics and Proteomics of Oral Precancer Progression
    David Wong; Fiscal Year: 2009
    ..The outcome of the validated molecular determinants will be utilized for biological mechanistic studies as well as translational research applications, directions that are well in place in our laboratories. ..
  3. Salivary Biomarkers for Early Oral Cancer Detection
    David T Wong; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: This research project will lead to the discovery of saliva biomarkers that can be used for early detection of oral cancer as well as predicting if an oral precancer will become a cancer. ..
  4. p12CDK2-AP1 in Cell Cycle Control & Oral Carcinogenesis
    David Wong; Fiscal Year: 2003
    ..abstract_text> ..
  5. Systems Approach to Sjogren's Syndrome Pathogenesis (SASSP)
    David Wong; Fiscal Year: 2009
    ..These key molecular targets will allow development of better diagnostics, therapeutics and prognostics for this major autoimmune disease. ..
  6. Salivary Biomarkers for Early Oral Cancer Detection
    David Wong; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: This research project will lead to the discovery of saliva biomarkers that can be used for early detection of oral cancer as well as predicting if an oral precancer will become a cancer. ..
  7. Salivary Proteomic & Genomic Biomarkers for Primary Sjogren's Syndrome
    David Wong; Fiscal Year: 2009
    ....
  8. Molecular Determinants of Oral Tongue Cancer Metastasis
    David Wong; Fiscal Year: 2009
    ....
  9. Systems Approach to Sjogren's Syndrome Pathogenesis (SASSP)
    DAVID T contact WONG; Fiscal Year: 2010
    ..These key molecular targets will allow development of better diagnostics, therapeutics and prognostics for this major autoimmune disease. ..
  10. Salivary Proteomic & Genomic Biomarkers for Primary Sjogren's Syndrome
    David T Wong; Fiscal Year: 2010
    ....
  11. Molecular Determinants of Oral Tongue Cancer Metastasis
    Xiaofeng Zhou; Fiscal Year: 2010
    ....
  12. Salivary Proteomic & Genomic Biomarkers for Primary Sjogren's Syndrome
    David Wong; Fiscal Year: 2007
    ....
  13. Research Infrastructure Improvement for The UCLA SOD
    David Wong; Fiscal Year: 2003
    ..abstract_text> ..
  14. p12CDK2-AP1 in Cell Cycle Control & Oral Carcinogenesis
    David Wong; Fiscal Year: 2004
    ..abstract_text> ..
  15. Genomics and Proteomics of Oral Precancer Progression
    David Wong; Fiscal Year: 2004
    ..The outcome of the validated molecular determinants will be utilized for biological mechanistic studies as well as translational research applications, directions that are well in place in our laboratories. ..
  16. p12CDK2-AP1 in Cell Cycle Control & Oral Carcinogenesis
    David Wong; Fiscal Year: 2004
    ....
  17. p12CDK2-AP1 in Cell Cycle Control & Oral Carcinogenesis
    David Wong; Fiscal Year: 2005
    ..abstract_text> ..
  18. Genomics and Proteomics of Oral Precancer Progression
    David Wong; Fiscal Year: 2005
    ..The outcome of the validated molecular determinants will be utilized for biological mechanistic studies as well as translational research applications, directions that are well in place in our laboratories. ..
  19. UCLA Collaborative Oral Fluid Diagnostic Research Center
    David Wong; Fiscal Year: 2005
    ..The translational applications and opportunities are enormous. Significant institutional commitments and corporate sponsorships are in place, fulfilling the research, training, as well as technology transfer missions of NIDCR. ..
  20. Genomics and Proteomics of Oral Precancer Progression
    David Wong; Fiscal Year: 2006
    ..The outcome of the validated molecular determinants will be utilized for biological mechanistic studies as well as translational research applications, directions that are well in place in our laboratories. ..
  21. p12CDK2-AP1 in Cell Cycle Control & Oral Carcinogenesis
    David Wong; Fiscal Year: 2006
    ..abstract_text> ..
  22. Salivary Proteomic & Genomic Biomarkers for Primary Sjogren's Syndrome
    David Wong; Fiscal Year: 2006
    ....
  23. Genomics and Proteomics of Oral Precancer Progression
    David Wong; Fiscal Year: 2007
    ..The outcome of the validated molecular determinants will be utilized for biological mechanistic studies as well as translational research applications, directions that are well in place in our laboratories. ..
  24. Human Salivary Proteome
    David Wong; Fiscal Year: 2007
    ..Our consortium is a multidisciplinary team of biologists, chemists, proteomics leaderships, engineers, computer scientists collectively focusing on the goal to create the periodic table of salivary secretory proteins. ..
  25. UCLA FUNDAMENTAL CLINICAL RESEARCH TRAINING PROGRAM
    David Wong; Fiscal Year: 2007
    ..abstract_text> ..
  26. Molecular Determinants of Oral Tongue Cancer Metastasis
    David Wong; Fiscal Year: 2009
    ....