Research Topics
Species | DAVID T contact WONGSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Salivary biomarkers for periodontal disease diagnosticsOle Brinkmann
University of California at Los Angeles School of Dentistry, Dental Research Institute, 73 017 CHS, Le Conte Avenue, Los Angeles, CA 90095, USA 1 310 206 3048 1 310 825 7609
Expert Opin Med Diagn 5:25-35. 2011..Take home message: Salivary diagnostics has great potential for the detection of oral and systemic diseases. Periodontal disease diagnostics, therapy and prognosis could benefit from this emerging diagnostic field...
SalivaomicsDavid T W Wong
Dental Research Institute, University of California, Los Angeles, School of Dentistry, UCLA, os Angeles, Calif 90095, USA
J Am Dent Assoc 143:19S-24S. 2012..Saliva is an emerging medium to be explored for health and disease surveillance, as well as for personalized medicine. A major mandate is to demonstrate clinicians' ability to use saliva to detect and monitor systemic diseases...
Prevalidation of salivary biomarkers for oral cancer detectionDavid Elashoff
School of Dentistry, University of California at Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
Cancer Epidemiol Biomarkers Prev 21:664-72. 2012....- Transcriptomic dissection of tongue squamous cell carcinomaHui Ye
Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, Chicago, IL, USA
BMC Genomics 9:69. 2008..It is significantly more aggressive than other forms of HNOSCC, in terms of local invasion and spread. In this study, we aim to identify specific transcriptomic signatures that associated with OTSCC... - Saliva Ontology: an ontology-based framework for a Salivaomics Knowledge BaseJiye Ai
University of California at Los Angeles School of Dentistry, University of California, Los Angeles, CA 90095 1668, USA
BMC Bioinformatics 11:302. 2010..SKB is created by aligning (1) the saliva biomarker discovery and validation resources at UCLA with (2) the ontology resources developed by the OBO (Open Biomedical Ontologies) Foundry, including a new Saliva Ontology (SALO)... - A forward-backward fragment assembling algorithm for the identification of genomic amplification and deletion breakpoints using high-density single nucleotide polymorphism (SNP) arrayTianwei Yu
Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, GA, USA
BMC Bioinformatics 8:145. 2007..To accurately identify small segments of CNA from SNP array data, segmentation methods that are sensitive to CNA while resistant to noise are required... - Salivary diagnostics: enhancing disease detection and making medicine betterAlik Segal
University of California Los Angeles, School of Dentistry and Dental Research Institute, Los Angeles, CA 90095, USA
Eur J Dent Educ 12:22-9. 2008..The translational applications and opportunities are enormous. This review presents the translational value of saliva as a credible clinical diagnostic fluid and the scientific rationale for such use... - Saliva: diagnostics and therapeutic perspectivesN Spielmann
School of Dentistry and Dental Research Institute, University of California at Los Angeles, Los Angeles, CA, USA
Oral Dis 17:345-54. 2011.... - Salivary diagnostics powered by nanotechnologies, proteomics and genomicsDavid T Wong
School of Dentistry, Dental Research Institute, University of California, Los Angeles 73 017 CHS, 10833 Le Conte Ave, Los Angeles, Calif 90095, USA
J Am Dent Assoc 137:313-21. 2006..Oral fluid is a perfect medium to be explored for health and disease surveillance... - Salivary proteomics for oral cancer biomarker discoveryShen Hu
Oral Biology and Medicine Division and Dental Research Institute, School of Dentistry, University of California at Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
Clin Cancer Res 14:6246-52. 2008..This study aims to explore the presence of informative protein biomarkers in the human saliva proteome and to evaluate their potential for detection of oral squamous cell carcinoma (OSCC)... - Salivary mRNA targets for cancer diagnosticsBernhard G Zimmermann
UCLA Dental Research Institute, 73 017 Center for Health Sciences, 10833 Le Conte Avenue, Los Angeles, CA 90095 1668, USA
Oral Oncol 44:425-9. 2008..Our group is actively pursuing the assembly of a toolbox for the molecular analysis of oral fluid. Here we present our current status utilizing the salivary transcriptome for oral cancer diagnostics... - Human body fluid proteome analysisShen Hu
School of Dentistry, Division of Oral Biology and Medicine, Dental Research Institute, University of California, Los Angeles, CA 90095, USA
Proteomics 6:6326-53. 2006..With the advances made in proteomics technologies, the impact of HBFP analysis in the search for clinically relevant disease biomarkers would be realized in the future... - Optical protein sensor for detecting cancer markers in salivaWinny Tan
Department of Biomedical Engineering, University of California, 7523 Boelter Hall, Los Angeles, CA 90095 1600, USA
Biosens Bioelectron 24:266-71. 2008..These positive results enable us to proceed to using confocal optical protein sensor to detect other biomarkers, which have much lower concentrations... - Molecular mechanisms of head and neck cancerAmit M Deshpande
School of Dentistry and Dental Research Institute, University of California Los Angeles, CA, USA
Expert Rev Anticancer Ther 8:799-809. 2008..In this article we will briefly outline the current state of diagnostics and treatment and our understanding of the molecular causes of SCCHN... - Salivary transcriptome diagnostics for oral cancer detectionYang Li
School of Dentistry and Dental Research Institute, University of California-Los Angeles, Los Angeles, California, USA
Clin Cancer Res 10:8442-50. 2004..Salivary transcriptome profiling can be applied to evaluate its usefulness for other major disease applications as well as for normal health surveillance... - The proteomes of human parotid and submandibular/sublingual gland salivas collected as the ductal secretionsPaul Denny
School of Dentistry, University of Southern California, Los Angeles, California 90089, USA
J Proteome Res 7:1994-2006. 2008.... - Human saliva proteome analysis and disease biomarker discoveryShen Hu
University of California Los Angeles, School of Dentistry and Dental Research Institute, CA 90095, USA
Expert Rev Proteomics 4:531-8. 2007..With the fast development of mass spectrometry and proteomic technologies, we are enthusiastic that saliva protein biomarkers will be developed for clinical diagnosis and prognosis of human diseases in the future... - Oral cancer proteomicsShen Hu
School of Dentistry, UCLA School of Dentistry, Dental Research Institute, Los Angeles, CA 90095 1668, USA
Curr Opin Mol Ther 9:467-76. 2007..These proteomic applications may collectively facilitate the early detection and successful treatment of this devastating disease in the future... - Cdk2ap1 is required for epigenetic silencing of Oct4 during murine embryonic stem cell differentiationAmit M Deshpande
Dental Research Institute, UCLA School of Dentistry, Los Angeles, California 90025, USA
J Biol Chem 284:6043-7. 2009..Our data support a potential molecular link between the known differentiation promoters, including bone morphogenetic proteins and transforming growth factor signaling, and embryonic stem cell differentiation... - p12(CDK2-AP1) mediates DNA damage responses induced by cisplatinYong Kim
School of Dentistry and Dental Research Institute, University of California Los Angeles, Los Angeles, CA 90095, USA
Oncogene 24:407-18. 2005..These data further suggest p12(CDK2-AP1) is a potential gene therapeutic agent for oral/head and neck cancer in conjunction with DNA-damaging agents such as cisplatin... - Preclinical validation of salivary biomarkers for primary Sjögren's syndromeShen Hu
University of California, Los Angeles, USA
Arthritis Care Res (Hoboken) 62:1633-8. 2010..In the current study, we aimed to verify these candidate biomarkers in independent patient populations and to evaluate their predictive values for primary SS detection... - Cyclin-dependent kinase 2-associating protein 1 commits murine embryonic stem cell differentiation through retinoblastoma protein regulationYong Kim
School of Dentistry and Dental Research Institute, UCLA, Los Angeles, CA 90095, USA
J Biol Chem 284:23405-14. 2009..This sheds light on the role of the establishment of the proper somatic cell type cell cycle regulation for mESCs to enter into the differentiation process... - Discovery and preclinical validation of salivary transcriptomic and proteomic biomarkers for the non-invasive detection of breast cancerLei Zhang
School of Dentistry and Dental Research Institute, University of California Los Angeles, Los Angeles, California, United States of America
PLoS ONE 5:e15573. 2010..In this study, a case-control discovery and independent preclinical validations were conducted to evaluate the performance and translational utilities of salivary transcriptomic and proteomic biomarkers for breast cancer detection... - Current advances in identification of cancer biomarkers in salivaMartha Arellano
School of Dentistry and Dental Research Institute, University of California at Los Angeles, Los Angeles CA 90095, USA
Front Biosci (Schol Ed) 1:296-303. 2009..With the new molecular profiling technologies such as microarray and proteomics, we are expecting to reveal highly discriminatory genomic and proteomic targets that can best detect the disease status... - Mutation of Cys105 inhibits dimerization of p12CDK2-AP1 and its growth suppressor effectYong Kim
School of Dentistry and Dental Research Institute, UCLA, Los Angeles, California 90095, USA
J Biol Chem 280:23273-9. 2005..Taken together, our data suggest that p12 forms a nuclear homodimers in contact inhibited normal diploid cells and dimerization of p12 is a necessary process for the growth inhibition effect by p12... - Salivary biomarkers for clinical applicationsLei Zhang
Dental Research Institute, School of Dentistry, University of California, Los Angeles, California, USA
Mol Diagn Ther 13:245-59. 2009..This review presents current salivary biomarker research and technology developmental efforts for clinical applications... - Salivary proteomic and genomic biomarkers for primary Sjögren's syndromeShen Hu
University of California, Los Angeles, California, USA
Arthritis Rheum 56:3588-600. 2007..To identify a panel of protein and messenger RNA (mRNA) biomarkers in human whole saliva (WS) that may be used in the detection of primary Sjögren's syndrome (SS)... - Electrochemical detection of low-copy number salivary RNA based on specific signal amplification with a hairpin probeFang Wei
Department of Mechanical and Aerospace Engineering, University of California, Los Angeles, CA, USA
Nucleic Acids Res 36:e65. 2008..The resultant process allows a simple setup and by reducing the number of steps it is suited for the point-of-care detection of specific nucleic acid sequences from complex body fluids such as saliva... - Implications of salivary proteomics in drug discovery and development: a focus on cancer drug discoveryShen Hu
UCLA School of Dentistry and Dental Research Institute, UCLA School of Medicine, Los Angeles, CA 90095, USA
Drug Discov Today 12:911-6. 2007..Potential applications of saliva proteomics in anticancer drug discovery and development will also be discussed... - Electrochemical sensor for multiplex biomarkers detectionFang Wei
Department of Mechanical and Aerospace Engineering, University of California, Los Angeles, California, USA
Clin Cancer Res 15:4446-52. 2009..Multiplexing assay of biomarkers at the point-of-care is an elusive goal for molecular diagnostics... - Salivary transcriptomic biomarkers for detection of resectable pancreatic cancerLei Zhang
School of Dentistry and Dental Research Institute, University of California Los Angeles, Los Angeles, California 90095, USA
Gastroenterology 138:949-57.e1-7. 2010.... - Saliva: an emerging biofluid for early detection of diseasesYu Hsiang Lee
UCLA School of Dentistry and Dental Research Institute, 73 017 CHS 10833 Le Conte Ave, Los Angeles, CA 90095, USA
Am J Dent 22:241-8. 2009..This review presents an overview of the value of saliva as a credible diagnostic tool, the discovery of salivary biomarkers, and the development of salivary diagnostics now and in the future... - Systemic disease-induced salivary biomarker profiles in mouse models of melanoma and non-small cell lung cancerKai Gao
School of Dentistry and Dental Research Institute, University of California Los Angeles, Los Angeles, CA, USA
PLoS ONE 4:e5875. 2009..Although the rationale for oral diseases applications (e.g. oral cancer) is intuitive, the rationale and relationship between systemic diseases and saliva biomarkers are unclear... - A universal pre-analytic solution for concurrent stabilization of salivary proteins, RNA and DNA at ambient temperatureJiang Jiang
Dental Research Institute, UCLA School of Dentistry, Los Angeles, CA 90095, USA
Arch Oral Biol 54:268-73. 2009..To maximize this clinical advantage, it is highly desirable to have a global salivary analyte stabilizer for proteins, RNA and DNA at ambient temperature... - Targeted inactivation of p12, CDK2 associating protein 1, leads to early embryonic lethalityYong Kim
Division of Oral Biology and Medicine, Dental Research Institute, School of Dentistry, University of California Los Angeles, Los Angeles, California, United States of America
PLoS ONE 4:e4518. 2009..This study demonstrates that Cdk2ap1 plays an essential role in the early stage of embryogenesis and has a potential role during craniofacial morphogenesis... - Human saliva proteome analysisShen Hu
School of Dentistry and Dental Research Institute, University of California, Los Angeles, California, 90095 1668, USA
Ann N Y Acad Sci 1098:323-9. 2007..The impact of human saliva proteome analysis in the search for clinically relevant disease biomarkers will be realized through advances made using proteomics technologies... - Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometryPrasanna Ramachandran
Department of Chemistry and Biochemistry, University of California-Los Angeles, Los Angeles, California, USA
J Proteome Res 5:1493-503. 2006..Of these, 16 glycoproteins have not been reported previously in saliva. In addition, we identified 44 new sites of N-linked glycosylation on the proteins... - Serum circulating human mRNA profiling and its utility for oral cancer detectionYang Li
School of Dentistry and Dental Research Institute, Division of Head and Neck Surgery/Otolaryngology, David Geffen School of Medicine University of California, Los Angeles, CA 90095, USA
J Clin Oncol 24:1754-60. 2006..CONCLUSION: The utility of serum transcriptome diagnostics is successfully demonstrated for OSCC detection. This novel concept could be developed as an adjunctive tool for disease diagnosis... - Salivary diagnostics for oral cancerDavid T Wong
Division of Oral Biology and Medicine, University of California, Los Angeles, School of Dentistry, USA
J Calif Dent Assoc 34:303-8. 2006.... - Loss of p12CDK2-AP1 expression in human oral squamous cell carcinoma with disrupted transforming growth factor-beta-Smad signaling pathwayHui Peng
Dental Research Institute, School of Dentistry, University of California Los Angeles, Los Angeles, CA 90095, USA
Neoplasia 8:1028-36. 2006.... - Genomic targets in salivaBernhard G Zimmermann
School of Dentistry and Dental Research Institute, University of California, Los Angeles UCLA, Los Angeles, California 90095, USA
Ann N Y Acad Sci 1098:184-91. 2007..Data are also now in place to validate the presence of unique diagnostic panels of salivary mRNAs in subjects with Sjögren's disease... - Discovery of oral fluid biomarkers for human oral cancer by mass spectrometryShen Hu
School of Dentistry and Dental Research Institute, University of California Los Angeles, Los Angeles, CA, USA
Cancer Genomics Proteomics 4:55-64. 2007..Once discovered and validated on a large and independent clinical cohort, oral fluid proteomic biomarkers may be extensively used for future disease diagnosis... - Cyclin G2 dysregulation in human oral cancerYong Kim
School of Dentistry and Dental Research Institute, University of California at Los Angeles, Los Angeles, California, USA
Cancer Res 64:8980-6. 2004.... - Differentially expressed protein markers in human submandibular and sublingual secretionsShen Hu
School of Dentistry, Dental Research Institute, UCLA School of Dentistry, University of California-Los Angeles, Los Angeles, CA 90095, USA
Int J Oncol 25:1423-30. 2004.... - Proteomic analysis of saliva: 2D gel electrophoresis, LC-MS/MS, and Western blottingShen Hu
School of Dentistry, University of California Los Angeles, Los Angeles, CA, USA
Methods Mol Biol 666:31-41. 2010..In this chapter, we describe the protocols for proteomic analysis of saliva using 2D gel electrophoresis, Western blotting, and LC-MS/MS... - In situ and non-invasive detection of specific bacterial species in oral biofilms using fluorescently labeled monoclonal antibodiesFang Gu
School of Dentistry and Dental Research Institute, University of California, 10833 Le Conte Avenue, Los Angeles, CA 90095-1668, United States
J Microbiol Methods 62:145-60. 2005..These studies indicate that MAbs based bacterial detection with CLSM is a versatile tool which permits new insights into the ecology of oral biofilm development... - Salivary diagnosticsDavid T Wong
Division of Oral Biology and Medicine, University of California, Los Angeles, School of Dentistry, USA
J Calif Dent Assoc 34:283-5. 2006 - Structural-mechanical characterization of nanoparticle exosomes in human saliva, using correlative AFM, FESEM, and force spectroscopyShivani Sharma
Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, USA
ACS Nano 4:1921-6. 2010.... - Large-scale identification of proteins in human salivary proteome by liquid chromatography/mass spectrometry and two-dimensional gel electrophoresis-mass spectrometryShen Hu
School of Dentistry and Dental Research Institute, University of California, Los Angeles, CA 90095, USA
Proteomics 5:1714-28. 2005..In total, we cataloged 309 proteins from human whole saliva by using these two proteomic approaches... - Bio/abiotic interface constructed from nanoscale DNA dendrimer and conducting polymer for ultrasensitive biomolecular diagnosisFang Wei
Department of Mechanical and Aerospace Engineering, School of Engineering and Applied Science, UCLA, Los Angeles, CA 90095 1597, USA
Small 5:1784-90. 2009..An LOD of 10 aM is established for IL-8 mRNA. The typical sample volume used in the detection is 4 microL, thus the LOD reaches only 25 target molecules (40 yoctomole)... - Global expression-based classification of lymph node metastasis and extracapsular spread of oral tongue squamous cell carcinomaXiaofeng Zhou
Dental Research Institute, School of Dentistry, University of California at Los Angeles, Los Angeles, CA 90095-1668, USA
Neoplasia 8:925-32. 2006..Leave-one-out cross-validation showed overall accuracy rates of 85% for both pN and ECS prediction models. Our results demonstrated that the pN and the ECS of OTSCCs can be predicted by gene expression analyses of primary tumors... - Systems biology analysis of Sjögren's syndrome and mucosa-associated lymphoid tissue lymphoma in parotid glandsShen Hu
University of California, School of Dentistry, Los Angeles, CA 90095 1668, USA
Arthritis Rheum 60:81-92. 2009.... - Exon-level expression profiling: a comprehensive transcriptome analysis of oral fluidsZhanzhi Hu
Dental Research Institute, 73 017 Center for Health Sciences, University of California, Los Angeles, CA 90095 1668, USA
Clin Chem 54:824-32. 2008..The aim of this study was to provide proof-of-concept data on the combination of a universal mRNA-amplification method with exon arrays for candidate selection and a multiplex preamplification method for easy validation... - Characterization of salivary RNA by cDNA library analysisNoh Jin Park
UCLA Dental Research Institute, Los Angeles, CA 90095, USA
Arch Oral Biol 52:30-5. 2007.... - Characterization of RNA in salivaNoh Jin Park
Dental Research Institute, UCLA School of Dentistry, Johnson Comprehensive Cancer Center, Division of Head and Neck Surgery/Otolaryngology, Henry Samueli School of Engineering, UCLA, Los Angeles, CA 90095, USA
Clin Chem 52:988-94. 2006..CONCLUSIONS: Saliva harbors both full-length and partially degraded forms of mRNA. RNA enters the oral cavity from different sources, and association with macromolecules may protect salivary RNA from degradation... - Confident assignment of intact mass tags to human salivary cystatins using top-down Fourier-transform ion cyclotron resonance mass spectrometryChristopher M Ryan
The Pasarow Mass Spectrometry Laboratory, The NPI Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90024, USA
J Am Soc Mass Spectrom 21:908-17. 2010..With fully characterized cystatin intact mass tags it will now be possible to examine the correlation between the abundance of these molecules and human health and disease... - Progress in concurrent analysis of loss of heterozygosity and comparative genomic hybridization utilizing high density single nucleotide polymorphism arraysXiaofeng Zhou
School of Dentistry, Dental Research Institute, University of California at Los Angeles, CA 90095-1668, USA
Cancer Genet Cytogenet 159:53-7. 2005..This review highlights recent progress on concurrent LOH and CGH analyses utilizing high density SNP arrays and their application in cancer research... - Micro-heterogeneity of human saliva Peptide P-C characterized by high-resolution top-down Fourier-transform mass spectrometryFrederic Halgand
The Pasarow Mass Spectrometry Laboratory, NPI Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
J Am Soc Mass Spectrom 21:868-77. 2010..While the biological significance of such subtle variations in protein structure remains unclear, their importance cannot be assigned without their characterization, as is reported here for one of the major salivary proteins... - Systemic assessments utilizing saliva: part 1 general considerations and current assessmentsMichael D Forde
Division of Prosthodontics, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Int J Prosthodont 19:43-52. 2006..In Part 2, the role of saliva to measure bone turnover with a special emphasis on osteoporosis will be discussed... - Towards a simple, saliva-based test for the detection of oral cancer 'oral fluid (saliva), which is the mirror of the body, is a perfect medium to be explored for health and disease surveillance'David T Wong
Expert Rev Mol Diagn 6:267-72. 2006 - Genomic assessments of the frequent loss of heterozygosity region on 8p21.3-p22 in head and neck squamous cell carcinomaHui Ye
Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, MC860, 801 South Paulina Street, Room 530C, Chicago, IL 60612 7213, USA
Cancer Genet Cytogenet 176:100-6. 2007..Thus, our results suggest that MTUS1 is one of the candidate tumor suppressor genes for HNSCC residing at 8p21.3 approximately p22. The identification of these candidate genes will facilitate the understanding of tumorigenesis of HNSCC... - Cultural, behavioral, social, and psychological perceptions of saliva: relevance to clinical diagnosticsSean Nguyen
University of California Los Angeles School of Dentistry, USA
J Calif Dent Assoc 34:317-22. 2006.... - Salivary transcriptomeDavid T Wong
Clin Cancer Res 13:1350-1; author reply 1351. 2007 - The preferences of adult outpatients in medical or dental care settings for giving saliva, urine or blood for clinical testingSreenivas Koka
Department of Dental Specialties, Mayo Clinic, Rochester, Minn 55905, USA
J Am Dent Assoc 139:735-40. 2008..These preferences, however, are unknown. The authors assessed patients' preferences for the collection of saliva, urine and blood as diagnostic fluids... - Self-reported visual impairment in elderly Canadians and its impact on healthy livingYa Ping Jin
Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada
Can J Ophthalmol 43:407-13. 2008.... - "Ventilator bellow standstill"David T Wong
Can J Anaesth 52:774-5. 2005 - RNAprotect saliva: An optimal room- temperature stabilization reagent for the salivary transcriptomeNoh Jin Park
Clin Chem 52:2303-4. 2006 - Genomic dissection for characterization of cancerous oral epithelium tissues using transcription profilingDaehee Hwang
Department of Chemical Engineering, Room 56-469, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
Oral Oncol 39:259-68. 2003..We identified 45 genes that are strongly correlated with malignancy. Of the 45 genes identified, six have been previously implicated in the disease, and two are uncharacterized clones...
Research Grants
- Genomics and Proteomics of Oral Precancer ProgressionDavid Wong; Fiscal Year: 2009..The outcome of the validated molecular determinants will be utilized for biological mechanistic studies as well as translational research applications, directions that are well in place in our laboratories. ..
- Salivary Biomarkers for Early Oral Cancer DetectionDavid T Wong; Fiscal Year: 2010..PUBLIC HEALTH RELEVANCE: This research project will lead to the discovery of saliva biomarkers that can be used for early detection of oral cancer as well as predicting if an oral precancer will become a cancer. ..
- Systems Approach to Sjogren's Syndrome Pathogenesis (SASSP)DAVID T contact WONG; Fiscal Year: 2010..These key molecular targets will allow development of better diagnostics, therapeutics and prognostics for this major autoimmune disease. ..
- Salivary Proteomic & Genomic Biomarkers for Primary Sjogren's SyndromeDavid T Wong; Fiscal Year: 2010....
- Molecular Determinants of Oral Tongue Cancer MetastasisXiaofeng Zhou; Fiscal Year: 2010....
- Oral Fluid NanoSensor Test (OFNASET)David Wong; Fiscal Year: 2007..For public: This proposal is to achieve the goal of develop, validate and achieve regulatory FDA approval of tools that can be used by dentists and doctors for in-office real time detection of oral cancer using a drop of saliva. ..
- Salivary Proteomic & Genomic Biomarkers for Primary Sjogren's SyndromeDavid Wong; Fiscal Year: 2007....
- Research Infrastructure Improvement for The UCLA SODDavid Wong; Fiscal Year: 2003..abstract_text> ..
- p12CDK2-AP1 in Cell Cycle Control & Oral CarcinogenesisDavid Wong; Fiscal Year: 2004....
- UCLA Collaborative Oral Fluid Diagnostic Research CenterDavid Wong; Fiscal Year: 2005..The translational applications and opportunities are enormous. Significant institutional commitments and corporate sponsorships are in place, fulfilling the research, training, as well as technology transfer missions of NIDCR. ..
- p12CDK2-AP1 in Cell Cycle Control & Oral CarcinogenesisDavid Wong; Fiscal Year: 2006..abstract_text> ..
- Genomics and Proteomics of Oral Precancer ProgressionDavid Wong; Fiscal Year: 2007..The outcome of the validated molecular determinants will be utilized for biological mechanistic studies as well as translational research applications, directions that are well in place in our laboratories. ..
- Human Salivary ProteomeDavid Wong; Fiscal Year: 2007..Our consortium is a multidisciplinary team of biologists, chemists, proteomics leaderships, engineers, computer scientists collectively focusing on the goal to create the periodic table of salivary secretory proteins. ..
- UCLA FUNDAMENTAL CLINICAL RESEARCH TRAINING PROGRAMDavid Wong; Fiscal Year: 2007..abstract_text> ..
- Molecular Determinants of Oral Tongue Cancer MetastasisDavid Wong; Fiscal Year: 2009....