Research Topics
| BRIAN contact WONGSummaryAffiliation: University of California Country: USA Publications
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Publications
Long-term viability and mechanical behavior following laser cartilage reshapingAmir M Karam
Beckman Laser Institute, University of California, Irvine 92612, USA
Arch Facial Plast Surg 8:105-16. 2006..CONCLUSION: The loss of structural integrity and chondrocyte viability observed across a broad dosimetry range underscores the importance of spatially selective heating methods prior to initiating application in human subjects...
The future of medical diagnostics: review paperWaseem K Jerjes
Head and Neck Optical Diagnostics Society Council, International Society of Minimally Invasive Diagnostics, University College London, London, UK
Head Neck Oncol 3:38. 2011..The meeting included 2 sections: oral communication sessions running in parallel to the IPA programme and poster presentation sessions combined with the IPA and EPPM posters sessions...- At the frontiers of surgery: reviewTahwinder Upile
The Head and Neck Optical Diagnostics Society Council, Head and Neck Centre, University College Hospital, 250 Euston Road, London, NW1 2PG, UK
Head Neck Oncol 3:7. 2011..We review the salient advances in the field and propose further directions of investigation... - Head & neck optical diagnostics: vision of the future of surgeryTahwinder Upile
The Head and Neck Optical Diagnostics Society Council, Head and Neck Centre, University College Hospital, 250 Euston Road, London, NW1 2PG, UK
Head Neck Oncol 1:25. 2009..We are fortunate that this is indeed a possibility and may fundamentally change current clinical and surgical practice to improve our patients' lives... - Needle electrode-based electromechanical reshaping of cartilageCyrus T Manuel
Beckman Laser Institute, University of California Irvine, Irvine, CA 92612, USA
Ann Biomed Eng 38:3389-97. 2010..5 V. In conclusion, electromechanical reshaping of cartilage grafts and intact ears can be effectively performed with negligible temperature elevation and spatially limited cell injury using needle electrodes... - Identification of chondrocyte proliferation following laser irradiation, thermal injury, and mechanical traumaBrian J F Wong
Beckman Laser Institute and Medical Clinic, University of California Irvine, 1002 Health Sciences Road East, Irvine, CA 92612, USA
Lasers Surg Med 37:89-96. 2005.... 
Evolving attractive faces using morphing technology and a genetic algorithm: a new approach to determining ideal facial aestheticsBrian J F Wong
Department of Otolaryngology Head and Neck Surgery, University of California Irvine, Orange, California 92812, USA
Laryngoscope 118:962-74. 2008....- In vivo optical coherence tomography of the human larynx: normative and benign pathology in 82 patientsBrian J F Wong
Department of Otolaryngology Head and Neck Surgery, University of California Irvine, Orange, California, USA
Laryngoscope 115:1904-11. 2005..Patients undergoing surgical head and neck endoscopy were examined using a fiberoptic OCT imaging probe to study and characterize microstructural anatomy and features of the larynx and benign laryngeal pathology in vivo... - Noninvasive measurement of ablation crater size and thermal injury after CO2 laser in the vocal cord with optical coherence tomographyBehrooz A Torkian
Department of Otolaryngology-Head and Neck Surgery, Beckman Laser Institute, University of California-Irvine, 1002 Health Sciences Road, Irvine, CA 92612, USA
Otolaryngol Head Neck Surg 134:86-91. 2006..OCT may be a useful diagnostic and monitoring tool in an otolaryngology practice... - Survival of chondrocytes in rabbit septal cartilage after electromechanical reshapingDmitry E Protsenko
Beckman Laser Institute, University of California Irvine, Irvine, CA, USA
Ann Biomed Eng 39:66-74. 2011..Approximately 20% of original chondrocytes remained viable after reshaping with optimal voltage and application time parameters and compared favorably with conventional surgical shape change techniques such as morselization... - Stress relaxation in porcine septal cartilage during electromechanical reshaping: mechanical and electrical responsesDmitriy E Protsenko
Beckman Laser Institute, University of California Irvine, 1002 Health Sciences Road East, Irvine, CA 92612, USA
Ann Biomed Eng 34:455-64. 2006..Close correlation between alteration of cartilage mechanical state and change in its electrical properties suggest that an electro-chemical reaction is the dominant mechanism behind EMR... - Optical coherence tomography of laryngeal cancerWilliam B Armstrong
Department of Otolaryngology Head and Neck Surgery, University of California Irvine, Orange, California 92868, USA
Laryngoscope 116:1107-13. 2006..This prospective study evaluated the ability of OCT to identify the characteristics of laryngeal cancer and measure changes in the basement membrane, tissue microstructure, and the transition zone at the edge of tumors... - Laser-assisted straightening of deformed cartilage: numerical modelDmitriy E Protsenko
Beckman Laser Institute, University of California Irvine, Irvine, California 92612, USA
Lasers Surg Med 39:245-55. 2007.... - Optical coherence tomography of the newborn airwayJames M Ridgway
Department of Otolaryngology Head and Neck Surgery, University of California Irvine, Irvine, California, USA
Ann Otol Rhinol Laryngol 117:327-34. 2008..We examined the ability of this noninvasive technique to characterize the newborn airway in a prospective clinical trial... - Time and frequency resolved XeCl laser-induced mechanical transients in otic capsule boneRyan G McCaughey
Beckman Laser Institute and Medical Clinic, University of California Irvine, Irvine, California 92715, USA
Photomed Laser Surg 26:31-6. 2008..This study identifies the presence of photoacoustic waves during excimer laser treatment of porcine otic capsule bone... - Optical coherence tomography of the larynx in the awake patientAli Sepehr
Department of Otolaryngology Head and Neck Surgery, University of California, Irvine, CA, USA
Otolaryngol Head Neck Surg 138:425-9. 2008..To demonstrate the feasibility of performing optical coherence tomography of the human larynx on the awake patient with a novel flexible fiberoptic delivery system... - Optical coherence tomography of cholesteatomaHamid R Djalilian
Department of Otolaryngology Head and Neck Surgery, University of California Irvine, Irvine, California 92868, USA
Otol Neurotol 31:932-5. 2010..OCT relies on intrinsic differences in tissue optical properties for image contrast... - Thermoforming of tracheal cartilage: viability, shape change, and mechanical behaviorYongSeok Chae
The Beckman Laser Institute, 1002 Health Sciences Rd East, Irvine, California 92697, USA
Lasers Surg Med 40:550-61. 2008.... - Imaging the human tympanic membrane using optical coherence tomography in vivoHamid R Djalilian
Department of Otolaryngology Head and Neck Surgery, University of California Irvine, Orange, CA 92868, USA
Otol Neurotol 29:1091-4. 2008..Using this technology, we have imaged in vivo the human tympanic membrane (TM) in the office clinic setting and characterized TM microstructure in normal and pathologic conditions... - The effects of laser irradiation of cartilage on chondrocyte gene expression and the collagen matrixPaul K Holden
Department of Otolaryngology Head and Neck Surgery, University of California, Irvine, California 92612, USA
Lasers Surg Med 41:487-91. 2009..The aim of the study was to determine if collagen I and II gene expression occurs within laser irradiated rabbit septal cartilage... - The use of preserved autogenous septal cartilage in "touch-up" rhinoplastyBrian J F Wong
Division of Facial Plastic Surgery, Department of Otolaryngology Head and Neck Surgery, and The Beckman Laser Institute, University of California, Irvine 92612, USA
Arch Facial Plast Surg 5:349-53. 2003..Office-based techniques for preserving cartilage are reviewed... - Characterization of temperature dependent mechanical behavior of cartilageYongSeok Chae
Department of Chemical Engineering and Materials Science, The Henry Samueli School of Engineering, University of California, Irvine, California 92697-2575, USA
Lasers Surg Med 32:271-8. 2003..Further investigation of the molecular changes, which occur during laser irradiation, may assist in understanding the thermal and mechanical behavior of cartilage and how the reshaping process might to be optimized... - Imaging the internal structure of the rat cochlea using optical coherence tomography at 0.827 microm and 1.3 micromBrian J F Wong
Beckman Laser Institute and Medical Clinic, University of California, Irvine, CA 92612, USA
Otolaryngol Head Neck Surg 130:334-8. 2004..The purpose of this study was to use high-speed optical coherence tomography (OCT) to obtain cross-sectional images of the rat cochlea... - Long-term in vivo stability of rabbit nasal septal cartilage following laser cartilage reshaping: a pilot investigationAmir M Karamzadeh
Department of Otolaryngology-Head and Neck Surgery, University of California, Irvine Medical Center 101, The City Drive South, Bldg. 25, Rt. 81, Orange, California 92868-3201, USA
Lasers Surg Med 36:147-54. 2005..Study results underscore the importance of elucidating the optimal laser dosimetry required to initiate permanent shape change while minimizing thermal damage... - Femtosecond laser ablation of the stapesRyan G McCaughey
University of California, Irvine, Beckman Laser Institute and Medical Clinic, 1002 Health Sciences Road, Irvine, Calfornia 92612, USA
J Biomed Opt 14:024040. 2009..Ultra-short-pulsed lasers offer a precise and efficient ablation of the stapes, with minimal thermal and negligible mechanical and acoustic damage. They are, therefore, ideal for stapedotomy operations... - Chondrocyte repopulation of allograft cartilage: a preliminary investigation and strategy for developing cartilage matrices for reconstructionTimothy F Kelley
Division of Facial Plastic Surgery, Beckman Laser Institute and Medical Clinic, Irvine, CA, USA
Otolaryngol Head Neck Surg 127:265-70. 2002..To evaluate the ability of devitalized cartilage to sustain repopulation by allogenic chondrocytes and to use 2-photon microscopy to assess cultured chondrocyte viability... - A novel laryngoscope instrument stabilizer for operative microlaryngoscopyWilliam B Armstrong
Department of Otolaryngology Head and Neck Surgery, University of California, Irvine, USA
Otolaryngol Head Neck Surg 132:471-7. 2005..To evaluate and optimize the design of a removable and inexpensive internal stabilization device to reduce the effect of intention tremor during laryngeal microsurgery... - Depth-resolved phase retardation measurements for laser-assisted non-ablative cartilage reshapingJong In Youn
Beckman Laser Institute and Medical Clinic, The University of California, Irvine, CA 92612, USA
Phys Med Biol 50:1937-50. 2005.... - Characterization of submucosal lesions using optical coherence tomography in the rabbit subglottisAmir M Karamzadeh
Department of Otolaryngology-Head and Neck Surgery, University of California, Irvine Medical Center, Orange, USA
Arch Otolaryngol Head Neck Surg 131:499-504. 2005..CONCLUSION: Optical coherence tomography successfully identifies the microstructure layers of the subglottis and can differentiate between edema and increased collagen deposition in the rabbit model... - Office-based optical coherence tomographic imaging of human vocal cordsShuguang Guo
University of California, Irvine, Department of Biomedical Engineering and Beckman Laser Institute, 92697, USA
J Biomed Opt 11:30501. 2006..Office-based OCT has the potential to guide surgical biopsies, direct therapy, and monitor disease. This is a promising imaging modality to study the larynx... - Measurement of morphologic changes induced by trauma with the use of coherence tomography in porcine vocal cordsNader A Nassif
Department of Physics and Astronomy, University of California, Irvine, Orange, CA 92868-3201, USA
Otolaryngol Head Neck Surg 133:845-50. 2005..The OCT image corresponded closely with histology. CONCLUSION: OCT is a powerful imaging tool with the potential for use in real time and has potential for multiple clinical applications in the larynx... - Rate process analysis of thermal damage in cartilageSergio H Díaz
Beckman Laser Institute and Medical Clinic, University of California, Irvine, CA 92612, USA
Phys Med Biol 48:19-29. 2003..As a result, a damage kinetic model was obtained that can be used to predict the onset, extent and severity of cellular injury to thermal exposure... - Office-based dynamic imaging of vocal cords in awake patients with swept-source optical coherence tomographyLingfeng Yu
University of California, Irvine, Department of Biomedical Engineering, Irvine, California 92697, USA
J Biomed Opt 14:064020. 2009..Office-based OCT is a promising imaging modality to study the larynx for physicians in otolaryngology... - Optical coherence tomography of the larynx using the Niris systemMarc Rubinstein
Department of Otolaryngology Head and Neck Surgery and Beckman Laser Institute and Medical Clinic, University of California Irvine, Irvine, California, USA
J Otolaryngol Head Neck Surg 39:150-6. 2010.... - Gradient-index lens rod based probe for office-based optical coherence tomography of the human larynxShuguang Guo
University of California, Irvine, Department of Biomedical Engineering, Irvine, California 92697, USA
J Biomed Opt 14:014017. 2009..In-vivo OCT imaging of the human larynx is demonstrated. Office-based OCT is a promising imaging modality for early laryngeal cancer diagnosis... - Quantitative assessment of chondrocyte viability after laser mediated reshaping: a novel application of flow cytometryAlexandre Rasouli
Beckman Laser Institute and Medical Clinic, University of California Irvine, 1002 Health Sciences Road East, Irvine, California 92612, USA
Lasers Surg Med 32:3-9. 2003..CONCLUSIONS: Functional fluorescent dyes combined with flow cytometric analysis successfully determines the effect of laser irradiation on the viability of reshaped cartilage... - Optical coherence tomography of the cochlea in the porcine modelAli Sepehr
Beckman Laser Institute and Medical Clinic, University of California Irvine, USA
Laryngoscope 118:1449-51. 2008..To demonstrate the feasibility of optical coherence tomography in microstructural imaging of the porcine cochlea... - Measurement of the elastic modulus of rabbit nasal septal cartilage during Nd:YAG (lambda = 1.32 microm) laser irradiationKenneth K H Chao
Beckman Laser Institute and Medical Clinic, University of California Irvine, 1002 Health Sciences Road East, Irvine, California 92612, USA
Lasers Surg Med 32:377-83. 2003..Measurement of the elastic modulus is an effective means of characterizing alterations in cartilage mechanical behavior during and after laser heating... - Model for estimating the threshold mechanical stability of structural cartilage grafts used in rhinoplastyAllison Zemek
Department of Otolaryngology Head and Neck Surgery, Division of Facial Plastic Surgery, University of California Irvine, Irvine, California, USA
Laryngoscope 120:1089-93. 2010..The aim of this study is to quantitatively identify the threshold mechanical stability (e.g., Young's modulus) of columellar, L-strut, and alar cartilage replacement grafts... - A web-based method for rating facial attractivenessZlatko Devcic
Division of Facial Plastic Surgery, Department of Otolaryngology Head and Neck Surgery, University of California Irvine, Irvine, California, USA
Laryngoscope 120:902-6. 2010.... - Optical coherence tomography-enhanced microlaryngoscopy: preliminary report of a noncontact optical coherence tomography system integrated with a surgical microscopeDavid E Vokes
Department of Otolaryngology Head and Neck Surgery, University of California, Irvine Medical Center, Orange, California, USA
Ann Otol Rhinol Laryngol 117:538-47. 2008..This aim of this study was to develop and evaluate a novel OCT system integrated with a surgical microscope to allow hands-free OCT imaging of the VFs, which could be performed simultaneously with microscopic visualization... - Electromechanical reshaping of septal cartilageKi-Hong Kevin Ho
Beckman Laser Institute and Medical Clinic, Department of Biomedical Engineering, University of California, Irvine 92612, USA
Laryngoscope 113:1916-21. 2003..CONCLUSIONS: These findings demonstrate that cartilage can be reshaped through the process we have described as "electroforming" by generating intrinsic differences in charge separation with negligible heat production... - Low-voltage polymer-based scanning cantilever for in vivo optical coherence tomographyYuli Wang
Department of Electrical Engineering and Computer Science, University of California, Irvine, Irvine, California 92697, USA
Opt Lett 30:53-5. 2005..Low driving voltage ensures safety. Two different optical designs achieve both forward and sidewise scanning and make it possible to image everywhere within the human oral cavity. In vivo OCT imaging of the human tongue is demonstrated... - Temperature dependent change in equilibrium elastic modulus after thermally induced stress relaxation in porcine septal cartilageDmitriy E Protsenko
Beckman Laser Institute, University of California Irvine, 1002 Health Sciences Road East, Irvine, California 92612, USA
Lasers Surg Med 40:202-10. 2008.... - Radiofrequency cartilage reshaping: efficacy, biophysical measurements, and tissue viabilityMichael W Keefe
Beckman Laser Institute, University of California-Irvine, 1002 Health Sciences Rd E, Irvine, CA 92612, USA
Arch Facial Plast Surg 5:46-52. 2003..CONCLUSIONS: Radiofrequency heating has been shown to effectively reshape cartilage while maintaining cellular viability, illustrating a novel application for a widely used technology... - Human nasal cartilage ultrastructure: characteristics and comparison using scanning electron microscopyPaul K Holden
Department of Otolaryngology Head and Neck Surgery, University of California, Irvine Medical Center, Orange, California 92868, USA
Laryngoscope 118:1153-6. 2008..We hypothesized that important differences exist between the nasal septal cartilage and lower lateral cartilage (LLC) ultrastructures. Such differences would be important in the field of cartilage engineering... - Bipolar radiofrequency plasma-mediated ablation of porcine nasal septal cartilage: a pilot investigationMichael C Chao
University of California-San Francisco, California, USA
Am J Rhinol 19:488-94. 2005..CONCLUSION: PMA effectively ablates nasal septal cartilage and may be able to reduce or contour cartilaginous deformities and framework structures in the head and neck... - Lasers and optical technologies in facial plastic surgeryEdward C Wu
Beckman Laser Institute and Medical Clinic, University of California, Irvine, 1002 Health Sciences Rd E, Irvine, CA 92612, USA
Arch Facial Plast Surg 10:381-90. 2008..In the future, therapies will be based on individualized, maximum, safe radiant exposure to deliver optimal dosimetry. Lasers and optical technologies are headed toward safer, easier, more quantifiable, and more individualized therapy... - Practical device for precise cutting of costal cartilage grafts to uniform thicknessAllen Foulad
Beckman Laser Institute and Medical Clinic, University of California Irvine, 1002 Health Sciences Road E, Irvine, CA 92612, USA
Arch Facial Plast Surg 13:259-65. 2011..We describe a simple costal cartilage slicing device that facilitates the production of sections having uniform, user-defined thicknesses... - Minimally invasive ear reshaping with a 1450-nm diode laser using cryogen spray cooling in New Zealand white rabbitsPaul K Holden
Department of Otolaryngology Head and Neck Surgery, University of California, Irvine Medical Center, 101 The City Drive, Bldg 56, Ste 500, Orange, CA 92868, USA
Arch Facial Plast Surg 11:399-404. 2009..This study investigates the use of laser irradiation combined with cryogen skin cooling and stenting to reshape cartilage in the ears of New Zealand white rabbits... - A cost-benefit analysis and method of creating high-quality posters for a low costAmir M Karamzadeh
Department of Otolaryngology-Head and Neck Surgery, University of California-Irvine, 1002 Health Sciences Road E, Irvine, CA 92612-30102, USA
Laryngoscope 112:21-2. 2002.... - Design of a low-cost, USB-compatible, otoscope image-capture systemJon-Paul Pepper
University of California Irvine School of Medicine, Irvine, California, USA
Laryngoscope 116:2224-6. 2006 - Lasers in pediatric airway surgery: current and future clinical applicationsAmir M Karamzadeh
Department of Otolaryngology-Head and Neck Surgery, University of California, Irvine Medical Center, Orange, California, USA
Lasers Surg Med 35:128-34. 2004..CONCLUSIONS: In this review, we will discuss the clinical applications of lasers in pediatric airway surgery, the current state of the art, where the current technology is deficient, and the potential applications of novel laser systems... - Novel wavelengths for laser nerve stimulationRyan G McCaughey
Beckman Laser Institute and Medical Clinic, University of California, Irvine, California 92612, USA
Lasers Surg Med 42:69-75. 2010..Laser light is known to stimulate nerves. This study investigated alternative wavelengths for nerve stimulation... - Cavernous carotid injury during functional endoscopic sinus surgery: case presentations and guidelines for optimal managementJon Paul Pepper
Department of Otolaryngology Head and Neck Surgery, University of California, Irvine Medical Center Pavillion II, Orange, California, USA
Am J Rhinol 21:105-9. 2007..Normal anatomic variations and pathological changes can lead to disastrous outcomes including carotid artery injury... - Engineering of a straighter septum: numerical model of mechanical stress relaxation in laser-heated septal cartilageDmitriy E Protsenko
Conf Proc IEEE Eng Med Biol Soc 2007:5399-402. 2007..The model shows highly non-homogeneous stress distributions before and after laser treatment. The model predicts that sufficiently high reduction of reaction force can be obtained with a localized laser treatment... - The effect of optical design on micromanipulator spot size using CO2 laser irradiationKenneth K H Chao
School of Medicine, University of Texas Health Science Center at San Antonio, USA
Otolaryngol Head Neck Surg 126:593-7. 2002..CONCLUSIONS: Micromanipulator optical design can result in significant differences in laser spot size. The reflective device used in this study demonstrated less sensitivity to increasing laser power... - A role for fibroblasts in mediating the effects of tobacco-induced epithelial cell growth and invasionJean Philippe Coppe
California Pacific Medical Center, Research Institute, San Francisco, CA 94107, USA
Mol Cancer Res 6:1085-98. 2008..Thus, tobacco may not only initiate mutagenic changes in epithelial cells but also promote the growth and invasion of mutant cells by creating a procarcinogenic stromal environment...
Research Grants
- OPTIMIZATION OF LASER MEDIATED CARTILAGE RESHAPINGBrian Wong; Fiscal Year: 2003..The MCSDA will provide the applicant with the fundamental skills needed to become an independent investigator in biomedical optics, and allow further development as a basic scientist. ..
- NonInvasive Optical Imaging of Vocal Cord MicrostructureBrian Wong; Fiscal Year: 2004..Application of OCT to microlaryngeal surgery may reduce iatrogenic phonatory disability by reducing trauma to delicate structures that accompanies conventional techniques. ..
- Analysis of thermoviscoelastic behavior in cartilageBrian Wong; Fiscal Year: 2005....
- Diagnosis of Subglottic Stenosis and Edema in Neonates Using OCTBrian Wong; Fiscal Year: 2010..Development of an office-based treatment technology to diagnosis subglottic stenosis or monitor its development would reduce the need for morbidity and decrease health care costs. ..
- Modeling The Pediatric Upper Airway Using Anatomic Optical Coherence Tomography aBRIAN contact WONG; Fiscal Year: 2010..Development of an office-based treatment technology to image the upper airway in awake children, and then compute airflow accurate would decrease morbidity and reduce health care costs. (End of Abstrct) ..