Georg Thomas Wondrak

Summary

Affiliation: University of Arizona
Country: USA

Publications

  1. ncbi request reprint Identification of alpha-dicarbonyl scavengers for cellular protection against carbonyl stress
    Georg T Wondrak
    Department of Pharmacology and Toxicology, College of Pharmacy, Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, USA
    Biochem Pharmacol 63:361-73. 2002
  2. ncbi request reprint Reactivity-based drug discovery using vitamin B(6)-derived pharmacophores
    Georg T Wondrak
    Department of Pharmacology and Toxicology, Division of Medicinal Chemistry, University of Arizona, Arizona Cancer Center, 1515 North Campbell Avenue, Tucson, AZ 85724, USA
    Mini Rev Med Chem 8:519-28. 2008
  3. pmc Phenotypic identification of the redox dye methylene blue as an antagonist of heat shock response gene expression in metastatic melanoma cells
    Angela L Davis
    Pharmacology and Toxicology, College of Pharmacy, Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, USA
    Int J Mol Sci 14:4185-202. 2013
  4. doi request reprint Vitamin b6: beyond coenzyme functions
    Georg T Wondrak
    Department of Pharmacology and Toxicology, College of Pharmacy and Arizona Cancer Center, University of Arizona, Tucson, AZ, USA
    Subcell Biochem 56:291-300. 2012
  5. doi request reprint Autophagic-lysosomal dysregulation downstream of cathepsin B inactivation in human skin fibroblasts exposed to UVA
    Sarah D Lamore
    Department of Pharmacology and Toxicology, College of Pharmacy and University of Arizona, Arizona Cancer Center, 1515 North Campbell Avenue, Tucson, AZ 85724, USA
    Photochem Photobiol Sci 11:163-72. 2012
  6. pmc The cinnamon-derived dietary factor cinnamic aldehyde activates the Nrf2-dependent antioxidant response in human epithelial colon cells
    Georg Thomas Wondrak
    Department of Pharmacology and Toxicology, College of Pharmacy, Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, USA
    Molecules 15:3338-55. 2010
  7. pmc Cinnamoyl-based Nrf2-activators targeting human skin cell photo-oxidative stress
    Georg T Wondrak
    Department of Pharmacology and Toxicology, College of Pharmacy, Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, USA
    Free Radic Biol Med 45:385-95. 2008
  8. pmc NQO1-activated phenothiazinium redox cyclers for the targeted bioreductive induction of cancer cell apoptosis
    Georg T Wondrak
    Department of Pharmacology and Toxicology, College of Pharmacy, Arizona Cancer Center, University of Arizona, 1515 North Campbell Avenue, Tucson, AZ 85724, USA
    Free Radic Biol Med 43:178-90. 2007
  9. ncbi request reprint Let the sun shine in: mechanisms and potential for therapeutics in skin photodamage
    Georg T Wondrak
    Arizona Cancer Center, University of Arizona, Department of Pharmacology and Toxicology, College of Pharmacy, 1515 North Campbell Avenue, Tucson, AZ 85724, USA
    Curr Opin Investig Drugs 8:390-400. 2007
  10. ncbi request reprint Antimelanoma activity of apoptogenic carbonyl scavengers
    Georg T Wondrak
    Department of Pharmacology and Toxicology, College of Pharmacy, Arizona Cancer Center, University of Arizona, Tucson, USA
    J Pharmacol Exp Ther 316:805-14. 2006

Research Grants

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Identification of alpha-dicarbonyl scavengers for cellular protection against carbonyl stress
    Georg T Wondrak
    Department of Pharmacology and Toxicology, College of Pharmacy, Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, USA
    Biochem Pharmacol 63:361-73. 2002
    ..Our research qualifies alpha-amino-beta-mercapto-beta,beta-dimethyl-ethane as a promising pharmacophore for the development of related alpha-dicarbonyl scavengers as therapeutic agents to protect cells against carbonyl stress...
  2. ncbi request reprint Reactivity-based drug discovery using vitamin B(6)-derived pharmacophores
    Georg T Wondrak
    Department of Pharmacology and Toxicology, Division of Medicinal Chemistry, University of Arizona, Arizona Cancer Center, 1515 North Campbell Avenue, Tucson, AZ 85724, USA
    Mini Rev Med Chem 8:519-28. 2008
    ..Based on the fascinating chemical versatility of B(6)-derived pharmacophores, B(6)-vitamers are therefore promising lead compounds for reactivity-based drug design...
  3. pmc Phenotypic identification of the redox dye methylene blue as an antagonist of heat shock response gene expression in metastatic melanoma cells
    Angela L Davis
    Pharmacology and Toxicology, College of Pharmacy, Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, USA
    Int J Mol Sci 14:4185-202. 2013
    ..Taken together, these data suggest feasibility of repurposing the non-oncological redox drug MB as a therapeutic heat shock response antagonist for cancer cell chemosensitization...
  4. doi request reprint Vitamin b6: beyond coenzyme functions
    Georg T Wondrak
    Department of Pharmacology and Toxicology, College of Pharmacy and Arizona Cancer Center, University of Arizona, Tucson, AZ, USA
    Subcell Biochem 56:291-300. 2012
    ..In this chapter, the structural basis of vitamin B6 activity as a potent antioxidant, metal chelator, carbonyl scavenger, and photosensitizer is presented and the physiological relevance is discussed...
  5. doi request reprint Autophagic-lysosomal dysregulation downstream of cathepsin B inactivation in human skin fibroblasts exposed to UVA
    Sarah D Lamore
    Department of Pharmacology and Toxicology, College of Pharmacy and University of Arizona, Arizona Cancer Center, 1515 North Campbell Avenue, Tucson, AZ 85724, USA
    Photochem Photobiol Sci 11:163-72. 2012
    ....
  6. pmc The cinnamon-derived dietary factor cinnamic aldehyde activates the Nrf2-dependent antioxidant response in human epithelial colon cells
    Georg Thomas Wondrak
    Department of Pharmacology and Toxicology, College of Pharmacy, Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, USA
    Molecules 15:3338-55. 2010
    ..CA may therefore represent an underappreciated chemopreventive dietary factor targeting colorectal carcinogenesis...
  7. pmc Cinnamoyl-based Nrf2-activators targeting human skin cell photo-oxidative stress
    Georg T Wondrak
    Department of Pharmacology and Toxicology, College of Pharmacy, Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, USA
    Free Radic Biol Med 45:385-95. 2008
    ..Our pilot studies suggest feasibility of developing cinnamoyl-based Nrf2-activators as novel photo-chemopreventive agents targeting skin cell photo-oxidative stress...
  8. pmc NQO1-activated phenothiazinium redox cyclers for the targeted bioreductive induction of cancer cell apoptosis
    Georg T Wondrak
    Department of Pharmacology and Toxicology, College of Pharmacy, Arizona Cancer Center, University of Arizona, 1515 North Campbell Avenue, Tucson, AZ 85724, USA
    Free Radic Biol Med 43:178-90. 2007
    ..Based on the known overexpression of NQO1 in various tumors these findings suggest the feasibility of developing PRC lead compounds into tumor-selective bioreductive chemotherapeutics...
  9. ncbi request reprint Let the sun shine in: mechanisms and potential for therapeutics in skin photodamage
    Georg T Wondrak
    Arizona Cancer Center, University of Arizona, Department of Pharmacology and Toxicology, College of Pharmacy, 1515 North Campbell Avenue, Tucson, AZ 85724, USA
    Curr Opin Investig Drugs 8:390-400. 2007
    ....
  10. ncbi request reprint Antimelanoma activity of apoptogenic carbonyl scavengers
    Georg T Wondrak
    Department of Pharmacology and Toxicology, College of Pharmacy, Arizona Cancer Center, University of Arizona, Tucson, USA
    J Pharmacol Exp Ther 316:805-14. 2006
    ..Our results suggest that carbonyl scavengers acting as direct molecular antagonists of RCS are promising apoptogenic prototype agents for antimelanoma drug design...
  11. ncbi request reprint 3-hydroxypyridine chromophores are endogenous sensitizers of photooxidative stress in human skin cells
    Georg T Wondrak
    Department of Pharmacology and Toxicology, College of Pharmacy, Arizona Cancer Center, University of Arizona, Tucson, Arizona 85724, USA
    J Biol Chem 279:30009-20. 2004
    ....
  12. pmc Antimelanoma activity of the redox dye DCPIP (2,6-dichlorophenolindophenol) is antagonized by NQO1
    Christopher M Cabello
    Department of Pharmacology and Toxicology, College of Pharmacy, Arizona Cancer Center, University of Arizona, 1515 North Campbell Avenue, Tucson, AZ 85724, USA
    Biochem Pharmacol 78:344-54. 2009
    ..Systemic administration of DCPIP displayed significant antimelanoma activity in the A375 murine xenograft model. These findings suggest feasibility of targeting tumors that display low NQO1 enzymatic activity using DCPIP...
  13. ncbi request reprint Identification of quenchers of photoexcited States as novel agents for skin photoprotection
    Georg T Wondrak
    University of Arizona, Arizona Cancer Center, 1515 North Campbell Ave, Tucson, AZ 85724, USA
    J Pharmacol Exp Ther 312:482-91. 2005
    ..Furthermore, QPES photoprotection of reconstructed full thickness human skin exposed to solar simulated light has been demonstrated...
  14. ncbi request reprint Experimental therapeutics: targeting the redox Achilles heel of cancer
    Christopher M Cabello
    University of Arizona, Department of Pharmacology and Toxicology, College of Pharmacy, Arizona Cancer Center, 1515 North Campbell Avenue, Tucson, AZ 85721, USA
    Curr Opin Investig Drugs 8:1022-37. 2007
    ..Based on ongoing redox biomarker discovery and validation, future redox phenotyping and genotyping may guide the selection of novel redox chemotherapeutics that efficiently target the redox Achilles heel of the individual tumor...
  15. ncbi request reprint Photosensitized growth inhibition of cultured human skin cells: mechanism and suppression of oxidative stress from solar irradiation of glycated proteins
    Georg T Wondrak
    Department of Pharmacology and Toxicology, College of Pharmacy, Arizona Cancer Center, University of Arizona, Tucson, Arizona 85724, USA
    J Invest Dermatol 119:489-98. 2002
    ....
  16. ncbi request reprint Proteins of the extracellular matrix are sensitizers of photo-oxidative stress in human skin cells
    Georg T Wondrak
    Department of Pharmacology and Toxicology, College of Pharmacy, Arizona Cancer Center, University of Arizona, 1515 North Campbell Avenue, Tucson, AZ 85724, USA
    J Invest Dermatol 121:578-86. 2003
    ..Our results support the hypothesis that extracellular matrix proteins play a functional role in skin photoaging and carcinogenesis by sensitization of photo-oxidative damage...
  17. ncbi request reprint Photosensitization of DNA damage by glycated proteins
    Georg T Wondrak
    Department of Pharmacology and Toxicology, College of Pharmacy, Arizona Cancer Center, University, of Arizona, Tucson, AZ, USA
    Photochem Photobiol Sci 1:355-63. 2002
    ..Glycated proteins in skin may equally function as potent photosensitizers of DNA damage with implications for photoaging and photocarcinogenesis...
  18. pmc The topical antimicrobial zinc pyrithione is a heat shock response inducer that causes DNA damage and PARP-dependent energy crisis in human skin cells
    Sarah D Lamore
    Department of Pharmacology and Toxicology, College of Pharmacy, Arizona Cancer Center, University of Arizona, Tucson, AZ, USA
    Cell Stress Chaperones 15:309-22. 2010
    ....
  19. pmc The cinnamon-derived Michael acceptor cinnamic aldehyde impairs melanoma cell proliferation, invasiveness, and tumor growth
    Christopher M Cabello
    Department of Pharmacology and Toxicology, College of Pharmacy, Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, USA
    Free Radic Biol Med 46:220-31. 2009
    ..These findings support a previously unrecognized role of CA as a dietary Michael acceptor with potential anti-cancer activity...
  20. ncbi request reprint Endogenous UVA-photosensitizers: mediators of skin photodamage and novel targets for skin photoprotection
    Georg T Wondrak
    Department of Pharmacology and Toxicology, College of Pharmacy, Arizona Cancer Center, University of Arizona, 1515 North Campbell Avenue, Tucson, AZ, USA
    Photochem Photobiol Sci 5:215-37. 2006
    ....
  21. pmc The experimental chemotherapeutic N6-furfuryladenosine (kinetin-riboside) induces rapid ATP depletion, genotoxic stress, and CDKN1A(p21) upregulation in human cancer cell lines
    Christopher M Cabello
    Department of Pharmacology and Toxicology, Arizona Cancer Center, University of Arizona, Tucson, 85724, USA
    Biochem Pharmacol 77:1125-38. 2009
    ..Taken together our data suggest that early induction of genotoxicity and energy crisis are important causative factors involved in FAdo cytotoxicity...
  22. pmc Redox-directed cancer therapeutics: molecular mechanisms and opportunities
    Georg T Wondrak
    Department of Pharmacology and Toxicology, College of Pharmacy, Arizona Cancer Center, University of Arizona, Tucson, Arizona, USA
    Antioxid Redox Signal 11:3013-69. 2009
    ..The impressive number of ongoing clinical trials that examine therapeutic performance of novel redox drugs in cancer patients demonstrates that redox chemotherapy has made the crucial transition from bench to bedside...
  23. ncbi request reprint DNA damage by carbonyl stress in human skin cells
    Michael J Roberts
    Department of Pharmacology and Toxicology, College of Pharmacy, Arizona Cancer Center, University of Arizona, 1515 North Campbell Avenue, Tucson, AZ 85724, USA
    Mutat Res 522:45-56. 2003
    ..The genotoxic potential of RCS in cultured skin cells and its suppression by a carbonyl scavenger as described in this study have implications for skin damage and carcinogenesis and its prevention by agents selective for carbonyl stress...
  24. pmc Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2
    Xiao Jun Wang
    Department of Pharmacology and Toxicology, University of Arizona, Tucson, AZ 85721, USA
    Carcinogenesis 29:1235-43. 2008
    ....
  25. pmc GLO1 overexpression in human malignant melanoma
    Warner B Bair
    Department of Pharmacology and Toxicology, College of Pharmacy and Arizona Cancer Center, University of Arizona, Tucson, USA
    Melanoma Res 20:85-96. 2010
    ..Taken together, our data suggest a function of GLO1 in the regulation of detoxification and target adduction by the glycolytic byproduct methylglyoxal in malignant melanoma...
  26. pmc Resveratrol prevents epigenetic silencing of BRCA-1 by the aromatic hydrocarbon receptor in human breast cancer cells
    Andreas J Papoutsis
    Department of Nutritional Sciences, The University of Arizona, Tucson, AZ 85721, USA
    J Nutr 140:1607-14. 2010
    ..These results support the hypothesis that epigenetic silencing of the BRCA-1 gene by the AhR is preventable with Res and provide the molecular basis for the development of dietary strategies based on natural AhR antagonists...

Research Grants5

  1. Targeting Glycolytic Control of Melanoma Cell Survival
    Georg T Wondrak; Fiscal Year: 2010
    ..The proposed research aims to elucidate the molecular mechanism that regulates melanoma cell survival by methylglyoxal and to test antagonists of methylglyoxal as novel anti-melanoma therapeutics. ..
  2. Targeting Glycolytic Control of Melanoma Cell Survival
    GEORG WONDRAK; Fiscal Year: 2009
    ..The proposed research aims to elucidate the molecular mechanism that regulates melanoma cell survival by methylglyoxal and to test antagonists of methylglyoxal as novel anti-melanoma therapeutics. ..