OWEN M contact WOLKOWITZ
Affiliation: University of California
- The "steroid dementia syndrome": a possible model of human glucocorticoid neurotoxicityOwen M Wolkowitz
Department of Psychiatry, Medical Center, University of California, San Francisco, San Francisco, CA, USA
Neurocase 13:189-200. 2007..Although this syndrome is uncommon, it is consistent with evolving theories of the neurotoxic or neuroendangering potential of glucocorticoids in some situations...
- Resting leukocyte telomerase activity is elevated in major depression and predicts treatment responseO M Wolkowitz
Department of Psychiatry, School of Medicine, University of California, San Francisco UCSF, San Francisco, CA 94143 0984, USA
Mol Psychiatry 17:164-72. 2012..PBMC telomerase activity might reflect a novel aspect of depressive pathophysiology and might represent a novel biomarker of antidepressant responsiveness...
- Serum BDNF levels before treatment predict SSRI response in depressionOwen M Wolkowitz
Department of Psychiatry, University of California, San Francisco School of Medicine, San Francisco, CA 94143, United States
Prog Neuropsychopharmacol Biol Psychiatry 35:1623-30. 2011..It is also unknown whether pre-treatment serum BDNF levels predict antidepressant response...
- Depression gets old fast: do stress and depression accelerate cell aging?Owen M Wolkowitz
Department of Psychiatry, University of California School of Medicine, San Francisco, California, USA
Depress Anxiety 27:327-38. 2010....
- Glucocorticoids. Mood, memory, and mechanismsOwen M Wolkowitz
Department of Psychiatry, University of California San Francisco UCSF School of Medicine, San Francisco, California, USA
Ann N Y Acad Sci 1179:19-40. 2009..The article concludes with a conceptual model of glucocorticoid actions in the brain that may lead to novel therapeutic opportunities...
- Leukocyte telomere length in major depression: correlations with chronicity, inflammation and oxidative stress--preliminary findingsOwen M Wolkowitz
Department of Psychiatry, University of California San Francisco School of Medicine, San Francisco, California, United States of America
PLoS ONE 6:e17837. 2011..We sought to determine if leukocyte telomeres are shortened in Major Depressive Disorder (MDD), whether this is a function of lifetime depression exposure and whether this is related to putative mediators, oxidation and inflammation...
- Of sound mind and body: depression, disease, and accelerated agingOwen M Wolkowitz
Department of Psychiatry, School of Medicine, University of California, San Francisco, California, USA
Dialogues Clin Neurosci 13:25-39. 2011..These factors interact in increasing the likelihood of physical disease and of accelerated aging at the cellular level. We conclude with suggestions for novel mechanism-based therapeutics based on these mediators...
- Repeated psychological stress testing in stimulant-dependent patientsDebra S Harris
Drug Dependence Research Center, Langley Porter Psychiatric Institute, Department of Psychiatry, University of California, San Francisco, CA, USA
Prog Neuropsychopharmacol Biol Psychiatry 29:669-77. 2005..Although less convincing because of the heterogeneity of the subjects, they also suggest that HPA axis responsivity is not clearly linked to acute stress-induced stimulant craving or affective response...
- Chronic pregnenolone effects in normal humans: attenuation of benzodiazepine-induced sedationSharon E Meieran
University of California, San Francisco School of Medicine, San Francisco, CA, USA
Psychoneuroendocrinology 29:486-500. 2004..Further larger-scale studies, utilizing a broader range of doses and experimental conditions, are warranted...
- Cell aging in relation to stress arousal and cardiovascular disease risk factorsElissa S Epel
UCSF Department of Psychiatry, San Francisco, CA, USA
Psychoneuroendocrinology 31:277-87. 2006..These findings may implicate telomerase as a novel and important mediator of the effects of psychological stress on physical health and disease...
- Altering cortisol level does not change the pleasurable effects of methamphetamine in humansDebra S Harris
Drug Dependence Research Center, Langley Porter Psychiatric Institute, Department of Psychiatry, University of California, San Francisco, CA 94143 0984, USA
Neuropsychopharmacology 28:1677-84. 2003..Metyrapone was associated with significant premature ventricular complexes in two subjects during methamphetamine administration and may not be safe for those who use methamphetamine...
- Dynamics of telomerase activity in response to acute psychological stressElissa S Epel
Department of Psychiatry, University of California, San Francisco, 3333 Calif St, Suite 465, San Francisco, CA 94143, USA
Brain Behav Immun 24:531-9. 2010....
- The "steroid dementia syndrome": an unrecognized complication of glucocorticoid treatmentOwen M Wolkowitz
University of California, San Francisco, School of Medicine, 401 Parnassus Ave, Box F 0984, San Francisco, CA 94143 0984, USA
Ann N Y Acad Sci 1032:191-4. 2004..Several clinical cases of this syndrome, with shared phenomenological and neuropsychological features, are presented here...
- Double-blind antiglucocorticoid treatment in schizophrenia and schizoaffective disorder: a pilot studyElysa J Marco
University of California, Langley Porter Psychiatric Institute, San Francisco, USA
World J Biol Psychiatry 3:156-61. 2002....
- Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS)Nicole Maninger
Department of Psychiatry, University of California San Francisco, School of Medicine, San Francisco 94143, USA
Front Neuroendocrinol 30:65-91. 2009..Accumulating data suggest abnormal DHEA and/or DHEAS concentrations in several neuropsychiatric conditions. The evidence that DHEA and DHEAS may be fruitful targets for pharmacotherapy in some conditions is reviewed...
- Serum brain-derived neurotrophic factor predicts responses to escitalopram in chronic posttraumatic stress disorderWilliam Berger
Department of Psychiatry, University of California, San Francisco, CA, USA
Prog Neuropsychopharmacol Biol Psychiatry 34:1279-84. 2010..Some studies have found that antidepressants increase serum brain-derived neurotrophic factor (BDNF) levels in patients with major depression and the expression of BDNF mRNA in limbic structures of rats...
- Low serum IL-10 concentrations and loss of regulatory association between IL-6 and IL-10 in adults with major depressionFirdaus S Dhabhar
Department of Psychiatry and Behavioral Sciences, Stanford University, School of Medicine, Stanford, CA 94305, USA
J Psychiatr Res 43:962-9. 2009....
- When blue turns to grey: do stress and depression accelerate cell aging?Owen M Wolkowitz
World J Biol Psychiatry 9:2-5. 2008
- Behavioral implications of lowering cholesterol levels: a double-blind pilot studyTom Ormiston
Santa Clara Valley Medical Center, San Jose, CA 95128, USA
Psychosomatics 44:412-4. 2003..This pilot study, although limited in size, raises the possibility that cholesterol-lowering drugs are associated with mild, time-limited increases in impulsivity and with mild, time-delayed improvements in depression ratings...
- Neurotransmitters, neurosteroids and neurotrophins: new models of the pathophysiology and treatment of depressionOwen M Wolkowitz
World J Biol Psychiatry 4:98-102. 2003
- Benzodiazepines in schizophrenia: prefrontal cortex atrophy predicts clinical response to alprazolam augmentationWilliam W Seeley
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, USA
World J Biol Psychiatry 3:221-4. 2002..Mechanistic considerations and suggestions for future research are discussed...