David A Wolk

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Amyloid imaging in atypical presentations of Alzheimer's disease
    David A Wolk
    Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA
    Curr Neurol Neurosci Rep 13:412. 2013
  2. pmc Familiarity-based memory as an early cognitive marker of preclinical and prodromal AD
    David A Wolk
    Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Neuropsychologia 51:1094-102. 2013
  3. pmc Amyloid imaging in dementias with atypical presentation
    David A Wolk
    Department of Neurology, University of Pennsylvania, Philadelphia, USA
    Alzheimers Dement 8:389-98. 2012
  4. pmc Arterial spin labeling MRI: an emerging biomarker for Alzheimer's disease and other neurodegenerative conditions
    David A Wolk
    Department of Neurology, Penn Memory Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Curr Opin Neurol 25:421-8. 2012
  5. doi Amyloid imaging in Alzheimer's disease: comparison of florbetapir and Pittsburgh compound-B positron emission tomography
    David A Wolk
    Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
    J Neurol Neurosurg Psychiatry 83:923-6. 2012
  6. doi Association between in vivo fluorine 18-labeled flutemetamol amyloid positron emission tomography imaging and in vivo cerebral cortical histopathology
    David A Wolk
    Penn Memory Center, 3615 Chestnut St, Philadelphia, PA 19104, USA
    Arch Neurol 68:1398-403. 2011
  7. pmc Fractionating verbal episodic memory in Alzheimer's disease
    David A Wolk
    Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA
    Neuroimage 54:1530-9. 2011
  8. pmc Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's disease
    David A Wolk
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 107:10256-61. 2010
  9. pmc A medial temporal lobe division of labor: insights from memory in aging and early Alzheimer disease
    David A Wolk
    Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Hippocampus 21:461-6. 2011
  10. pmc Update on amyloid imaging: from healthy aging to Alzheimer's disease
    David A Wolk
    Department of Neurology, Penn Memory Center, University of Pennsylvania, Ralston House, 3615 Chestnut Street, Philadelphia, PA 19104, USA
    Curr Neurol Neurosci Rep 9:345-52. 2009

Detail Information

Publications51

  1. pmc Amyloid imaging in atypical presentations of Alzheimer's disease
    David A Wolk
    Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA
    Curr Neurol Neurosci Rep 13:412. 2013
    ..This article reviews several amyloid imaging studies of these populations which support autopsy case series and reveal a dissociation between the spatial distribution of amyloid plaques and clinical phenotype. ..
  2. pmc Familiarity-based memory as an early cognitive marker of preclinical and prodromal AD
    David A Wolk
    Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Neuropsychologia 51:1094-102. 2013
    ....
  3. pmc Amyloid imaging in dementias with atypical presentation
    David A Wolk
    Department of Neurology, University of Pennsylvania, Philadelphia, USA
    Alzheimers Dement 8:389-98. 2012
    ..We explored the potential value of amyloid imaging in patients with atypical presentations of dementia...
  4. pmc Arterial spin labeling MRI: an emerging biomarker for Alzheimer's disease and other neurodegenerative conditions
    David A Wolk
    Department of Neurology, Penn Memory Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Curr Opin Neurol 25:421-8. 2012
    ....
  5. doi Amyloid imaging in Alzheimer's disease: comparison of florbetapir and Pittsburgh compound-B positron emission tomography
    David A Wolk
    Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
    J Neurol Neurosurg Psychiatry 83:923-6. 2012
    ..Florbetapir-F18 recently demonstrated in vivo correlation with postmortem Aβ histopathology, but has not been directly compared with PiB-C11...
  6. doi Association between in vivo fluorine 18-labeled flutemetamol amyloid positron emission tomography imaging and in vivo cerebral cortical histopathology
    David A Wolk
    Penn Memory Center, 3615 Chestnut St, Philadelphia, PA 19104, USA
    Arch Neurol 68:1398-403. 2011
    ..To determine the correspondence of in vivo quantitative estimates of brain uptake of fluorine 18-labeled flutemetamol with immunohistochemical estimates of amyloid levels in patients who underwent previous biopsy...
  7. pmc Fractionating verbal episodic memory in Alzheimer's disease
    David A Wolk
    Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA
    Neuroimage 54:1530-9. 2011
    ....
  8. pmc Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's disease
    David A Wolk
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 107:10256-61. 2010
    ....
  9. pmc A medial temporal lobe division of labor: insights from memory in aging and early Alzheimer disease
    David A Wolk
    Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Hippocampus 21:461-6. 2011
    ..These results are consistent with a division of labor in the MTL and the dual process model...
  10. pmc Update on amyloid imaging: from healthy aging to Alzheimer's disease
    David A Wolk
    Department of Neurology, Penn Memory Center, University of Pennsylvania, Ralston House, 3615 Chestnut Street, Philadelphia, PA 19104, USA
    Curr Neurol Neurosci Rep 9:345-52. 2009
    ..Given the considerable clinical experience compared with other tracers, this review focuses on the literature involving Pittsburgh compound B positron emission tomography...
  11. pmc Discrimination and reliance on conceptual fluency cues are inversely related in patients with mild Alzheimer's disease
    David A Wolk
    Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA
    Neuropsychologia 47:1865-72. 2009
    ..In addition, these findings suggest that discrimination and reliance on fluency cues may be inversely related in both AD patients and older adult controls...
  12. pmc Amyloid imaging in mild cognitive impairment subtypes
    David A Wolk
    Alzheimer s Disease Research Center, University of Pittsburgh, Pittsburgh, PA 19104, USA
    Ann Neurol 65:557-68. 2009
    ....
  13. ncbi ERP correlates of Remember/Know decisions: association with the late posterior negativity
    David A Wolk
    Alzheimer s Disease Research Center, Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA
    Biol Psychol 75:131-5. 2007
    ..Previous work has described a late posterior negativity which appears to be related to the search for and recapitulation of study details. Such processing may be critical in making Remember/Know determinations...
  14. pmc Alzheimer's disease pattern of brain atrophy predicts cognitive decline in Parkinson's disease
    Daniel Weintraub
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104 3339, USA
    Brain 135:170-80. 2012
    ..In addition, an Alzheimer's disease pattern of brain atrophy may be a preclinical biomarker of cognitive decline in Parkinson's disease...
  15. pmc Cognitive status impacts age-related changes in attention to novel and target events in normal adults
    Kirk R Daffner
    Brigham Behavioral Neurology Group, Division of Cognitive and Behavioral Neurology, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neuropsychology 21:291-300. 2007
    ..Moreover, the results support the notion of there being different patterns of normal cognitive aging and the need to identify the factors that influence them...
  16. pmc Basal cerebral metabolism may modulate the cognitive effects of Abeta in mild cognitive impairment: an example of brain reserve
    Ann D Cohen
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 29:14770-8. 2009
    ....
  17. pmc Cerebrovascular atherosclerosis correlates with Alzheimer pathology in neurodegenerative dementias
    Mark Yarchoan
    3615 Chestnut Street, Philadelphia, PA 19104, USA
    Brain 135:3749-56. 2012
    ....
  18. pmc ERP correlates of item recognition memory: effects of age and performance
    David A Wolk
    Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15217, USA
    Brain Res 1250:218-31. 2009
    ..These findings suggest that weak memory retrieval supported by earlier ERP modulations, may lead to an enhanced LFE in the service of additional retrieval attempts...
  19. ncbi Resilient brain aging: characterization of discordance between Alzheimer's disease pathology and cognition
    Selam Negash
    Penn Memory Center, 3615 Chestnut Street, University of Pennsylvania, Philadelphia, PA 19104, USA
    Curr Alzheimer Res 10:844-51. 2013
    ....
  20. pmc Cognitive and functional resilience despite molecular evidence of Alzheimer's disease pathology
    Selam Negash
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
    Alzheimers Dement 9:e89-95. 2013
    ..The aim of the present study was to examine cognitive and cerebral reserve factors associated with resilient functioning in the setting of AD pathology...
  21. pmc Compensatory neural activity distinguishes different patterns of normal cognitive aging
    Jenna L Riis
    Brigham Behavioral Neurology Group, Division of Cognitive and Behavioral Neurology, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
    Neuroimage 39:441-54. 2008
    ..These findings provide strong evidence for different patterns of age-related changes in the processing of salient environmental stimuli, with cognitive status serving as a key mediating variable...
  22. pmc Relationship between plasma analytes and SPARE-AD defined brain atrophy patterns in ADNI
    Jon B Toledo
    Department of Pathology and Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    PLoS ONE 8:e55531. 2013
    ....
  23. pmc Can MRI screen for CSF biomarkers in neurodegenerative disease?
    Corey T McMillan
    Department of Neurology, University of Pennsylvania, Philadelphia, USA
    Neurology 80:132-8. 2013
    ..In this study, we evaluate the utility of MRI as a noninvasive screening procedure for the differential diagnosis of AD and FTLD...
  24. pmc Recollection and familiarity in amnestic mild cognitive impairment: a global decline in recognition memory
    David A Wolk
    Alzheimer s Disease Research Center, University of Pittsburgh, Pittsburgh, PA 15213 2582, USA
    Neuropsychologia 46:1965-78. 2008
    ..As familiarity is thought to be spared in normal aging, its measurement may provide a relatively specific marker for the early pathological changes of Alzheimer's disease...
  25. pmc Effects of task-set adoption on ERP correlates of controlled and automatic recognition memory
    Kristine A Wilckens
    Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA
    Neuroimage 55:1384-92. 2011
    ..We conclude that adopting a retrieval task-set impacts recollection memory but not familiarity. These data indicate that attentional state immediately prior to retrieval can influence objective measures of recollection memory...
  26. pmc Increased functional connectivity within medial temporal lobe in mild cognitive impairment
    Sandhitsu R Das
    Penn Image Computing and Science Laboratory PICSL, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Hippocampus 23:1-6. 2013
    ..This dissociation of changes in functional connectivity within the MTL versus the MTL's connection with other neocortical structures can help enrich the characterization of early stages of disease progression in AD...
  27. ncbi CSF Apo-E levels associate with cognitive decline and MRI changes
    Jon B Toledo
    Department of Pathology and Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, HUP, Maloney 3rd, 36th and Spruce Streets, Philadelphia, PA, 19104 4283, USA
    Acta Neuropathol 127:621-32. 2014
    ....
  28. pmc Parietal influence on temporal encoding indexed by simultaneous transcranial magnetic stimulation and electroencephalography
    Martin Wiener
    Department of Neurology, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 32:12258-67. 2012
    ..These results suggest that a feedforward mechanism from parietal to prefrontal regions mediates temporal encoding and demonstrate a dissociation between early and late phases of encoding processes...
  29. ncbi Comparative accuracies of two common screening instruments for classification of Alzheimer's disease, mild cognitive impairment, and healthy aging
    David R Roalf
    Department of Psychiatry, Neuropsychiatry, University of Pennsylvania, Philadelphia, PA, USA
    Alzheimers Dement 9:529-37. 2013
    ....
  30. pmc Comparative survey of the topographical distribution of signature molecular lesions in major neurodegenerative diseases
    Steven E Arnold
    Penn Memory Center, Departments of Psychiatry and Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, 19104
    J Comp Neurol 521:4339-55. 2013
    ....
  31. pmc Association of plasma C-reactive protein levels with the diagnosis of Alzheimer's disease
    Mark Yarchoan
    Department of Internal Medicine, University of Pennsylvania, Philadelphia, PA, United States
    J Neurol Sci 333:9-12. 2013
    ..Our results support previous reports of reduced levels of plasma CRP in AD and indicate its potential utility as a biomarker for the diagnosis of AD. ..
  32. pmc Microvascular perfusion based on arterial spin labeled perfusion MRI as a measure of vascular risk in Alzheimer's disease
    Quan Zhang
    Center for Functional Neuroimaging, University of Pennsylvania, Philadelphia, PA, USA Department of Radiology, Tianjin Medical University General Hospital, Tianjin, China
    J Alzheimers Dis 32:677-87. 2012
    ..Future prospective studies in larger cohorts with optimized ASL MRI protocols will be needed to validate these observations...
  33. pmc Frequency and clinicopathological characteristics of presenilin 1 Gly206Ala mutation in Puerto Rican Hispanics with dementia
    Steven E Arnold
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Alzheimers Dis 33:1089-95. 2013
    ..Considered together with the increased prevalence and mortality of AD reported in Puerto Rico, these high rates may reflect hereditary risk concentrated in the island which warrants further study...
  34. pmc Direct comparison of fluorodeoxyglucose positron emission tomography and arterial spin labeling magnetic resonance imaging in Alzheimer's disease
    Erik S Musiek
    Department of Neurology, University of Pennsylvania, Philadelphia, USA
    Alzheimers Dement 8:51-9. 2012
    ..Recently, measurement of cerebral blood flow using arterial spin labeling magnetic resonance imaging (ASL-MRI) has shown diagnostic potential in AD, although it has never been directly compared with FDG-PET...
  35. pmc Neurodegeneration across stages of cognitive decline in Parkinson disease
    Daniel Weintraub
    Department of Psychiatry, University of Pennsylvania, 3615 Chestnut St, Ste 330, Philadelphia, PA 19104, USA
    Arch Neurol 68:1562-8. 2011
    ..To assess regions and patterns of brain atrophy in patients with Parkinson disease (PD) with normal cognition (PD-NC), mild cognitive impairment (PD-MCI), and dementia-level cognitive deficits (PDD)...
  36. doi Improved proper name recall by electrical stimulation of the anterior temporal lobes
    Lars A Ross
    Department of Psychology, Temple University, Philadelphia, PA 19112, USA
    Neuropsychologia 48:3671-4. 2010
    ..These findings are consistent with the notion that the anterior temporal lobes are critically involved in the retrieval of people's names...
  37. ncbi Age-related differences in attention to novelty among cognitively high performing adults
    Kirk R Daffner
    Brigham Behavioral Neurology Group, Division of Cognitive and Behavioral Neurology, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
    Biol Psychol 72:67-77. 2006
    ..We hypothesise that cognitively high performing old individuals successfully manage the task by relying on additional neural resources and perhaps more effortful frontal activity than their younger counterparts...
  38. pmc Vascular disease and dementias: paradigm shifts to drive research in new directions
    Mitchel A Kling
    Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Alzheimers Dement 9:76-92. 2013
    ..This strategy will require funding from multiple public and private sources to support collaborative and interdisciplinary research efforts to take full advantage of these opportunities and realize their societal benefits...
  39. pmc Cellular, synaptic, and biochemical features of resilient cognition in Alzheimer's disease
    Steven E Arnold
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neurobiol Aging 34:157-68. 2013
    ..These data characterize cellular and synaptic features and identify novel biochemical targets that may be associated with resilient cognitive brain aging in the setting of pathological AD...
  40. pmc Cognitive decline and reduced survival in C9orf72 expansion frontotemporal degeneration and amyotrophic lateral sclerosis
    David J Irwin
    Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Alzheimer s Disease Core Center, Institute on Aging, Philadelphia, Pennsylvania, USA
    J Neurol Neurosurg Psychiatry 84:163-9. 2013
    ..To clarify this issue, we compared a large C9P cohort with carefully matched non-expansion (C9N) cases with a known or highly-suspected underlying TAR DNA-binding protein 43 (TDP-43) proteinopathy...
  41. pmc Potential utility of resting-state magnetoencephalography as a biomarker of CNS abnormality in HIV disease
    James T Becker
    Department of Psychiatry, University of Pittsburgh, United States Department of Neurology, University of Pittsburgh, United States
    J Neurosci Methods 206:176-82. 2012
    ..The stability of the wide-band MEG frequency profiles over 24 weeks supports the utility of MEG as a biomarker. The links between the MEG profile, serostatus, and cognition suggest further research on its potential in HAND is needed...
  42. doi Temporally distinct neural coding of perceptual similarity and prototype bias
    David Alexander Kahn
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Vis 10:12. 2010
    ..These results suggest that the neural coding of perceptual similarity, in terms of both geometric and non-geometric representations, occurs rapidly and from relatively early in the perceptual processing stream...
  43. pmc Left posterior parietal cortex participates in both task preparation and episodic retrieval
    Jeffrey S Phillips
    Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Neuroimage 46:1209-21. 2009
    ..Such operations may be related to attentional control, monitoring of stimulus relevance, or retrieval...
  44. ncbi ERP correlates of recognition memory: effects of retention interval and false alarms
    David A Wolk
    Department of Neurology, University of Pittsburgh, Kaufmann Medical Building, PA 15213, USA
    Brain Res 1096:148-62. 2006
    ..This latter result is discussed with regard to the possibility of an overlapping posterior negativity...
  45. pmc Improved proper name recall in aging after electrical stimulation of the anterior temporal lobes
    Lars A Ross
    Olson Laboratory, Department of Psychology, Temple University Philadelphia, PA, USA
    Front Aging Neurosci 3:16. 2011
    ..The implications of these findings for the use of tDCS as tool for rehabilitation of age-related loss of name recall are discussed...
  46. doi Subjective memory complaints, cognitive performance, and psychological factors in healthy older adults
    Susanne I Steinberg
    1Department of Psychiatry, Crozer Chester Medical Center, One Medical Center Boulevard, Upland, PA, USA
    Am J Alzheimers Dis Other Demen 28:776-83. 2013
    ..To determine whether subjective memory complaints (SMCs) are associated with performance on objective cognitive measures and psychological factors in healthy, community-dwelling older adults...
  47. ncbi The role of sensory-motor information in object recognition: evidence from category-specific visual agnosia
    David A Wolk
    Department of Neurology, University of Pennsylvania, Hospital of the University of Pennsylvania 3400 Spruce Street Philadelphia, PA 19104, USA
    Brain Lang 94:131-46. 2005
    ..These data suggest that both information about object form computed in the ventral visual system as well as sensory-motor information specifying the manner of manipulation contribute to object recognition...
  48. ncbi Hemispheric mediation of spatial attention: pseudoneglect after callosal stroke
    David A Wolk
    Harvard Medical School, Department of Neurology, Brigham and Women s Hospital, Boston, MA 02120, USA
    Ann Neurol 56:434-6. 2004
    ..These results are consistent with the notion that each hemisphere supports spatial attention-intention toward contralateral space and that the corpus callosum is critical in the integration of such information...
  49. pmc Advancing Alzheimer's disease diagnosis, treatment, and care: recommendations from the Ware Invitational Summit
    Mary D Naylor
    Institute on Aging, University of Pennsylvania, Philadelphia, USA
    Alzheimers Dement 8:445-52. 2012
    ..The workgroups shared, discussed, and compiled an integrated set of priorities, recommendations, and action plans, which are presented in this article...
  50. ncbi Early impairment in consciousness predicts mortality after hemispheric ischemic stroke
    Brett L Cucchiara
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, USA
    Crit Care Med 32:241-5. 2004
    ..Early predictors of poor outcome after acute ischemic stroke may be useful in selecting patients for potentially beneficial but high-risk interventions...