Charles Wolgemuth

Summary

Affiliation: University of Connecticut Health Center
Country: USA

Publications

  1. pmc Crawling cells can close wounds without purse strings or signaling
    Pilhwa Lee
    Department of Cell Biology and Center for Cell Analysis and Modeling, University of Connecticut Health Center, Farmington, Connecticut, United States of America
    PLoS Comput Biol 7:e1002007. 2011
  2. pmc Redundant mechanisms for stable cell locomotion revealed by minimal models
    Charles W Wolgemuth
    Department of Cell Biology, University of Connecticut Health Center, Farmington, Connecticut, USA
    Biophys J 101:545-53. 2011
  3. ncbi request reprint The junctional pore complex and the propulsion of bacterial cells
    Charles W Wolgemuth
    University of Connecticut Health Center, Department of Physiology, Farmington, Connecticut 06030, USA
    J Mol Microbiol Biotechnol 7:72-7. 2004
  4. doi request reprint Plant biomechanics: using shape to steal motion
    Charles W Wolgemuth
    University of Connecticut Health Center, Department of Cell Biology and Center for Cell Analysis and Modeling, Farmington, CT 06030 3505, USA
    Curr Biol 19:R409-10. 2009
  5. pmc Collective swimming and the dynamics of bacterial turbulence
    Charles W Wolgemuth
    University of Connecticut Health Center, Department of Cell Biology and Center for Cell Analysis and Modeling, Farmington, Connecticut 06030 3505, USA
    Biophys J 95:1564-74. 2008
  6. ncbi request reprint The flagellar cytoskeleton of the spirochetes
    Charles W Wolgemuth
    Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030 3505, USA
    J Mol Microbiol Biotechnol 11:221-7. 2006
  7. pmc Force and flexibility of flailing myxobacteria
    Charles W Wolgemuth
    Department of Cell Biology, University of Connecticut Health Center, Farmington, USA
    Biophys J 89:945-50. 2005
  8. pmc Lamellipodial contractions during crawling and spreading
    Charles W Wolgemuth
    University of Connecticut Health Center, Department of Cell Biology, Farmington, Connecticut, USA
    Biophys J 89:1643-9. 2005
  9. pmc The shape and dynamics of the Leptospiraceae
    Wanxi Kan
    University of Connecticut Health Center, Department of Cell Biology, Farmington, Connecticut, USA
    Biophys J 93:54-61. 2007
  10. ncbi request reprint Advent of complex flows in epithelial tissues
    Pilhwa Lee
    Department of Cell Biology and Center for Cell Analysis and Modeling, University of Connecticut Health Center, Farmington, Connecticut 06030 6406, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 83:061920. 2011

Research Grants

Collaborators

Detail Information

Publications27

  1. pmc Crawling cells can close wounds without purse strings or signaling
    Pilhwa Lee
    Department of Cell Biology and Center for Cell Analysis and Modeling, University of Connecticut Health Center, Farmington, Connecticut, United States of America
    PLoS Comput Biol 7:e1002007. 2011
    ..These results suggest that wound healing is predominantly a mechanical process that is modified, but not produced, by cell-cell signaling...
  2. pmc Redundant mechanisms for stable cell locomotion revealed by minimal models
    Charles W Wolgemuth
    Department of Cell Biology, University of Connecticut Health Center, Farmington, Connecticut, USA
    Biophys J 101:545-53. 2011
    ..The models shed light on the roles of membrane-mediated area conservation and the coupling of mechanical and biochemical mechanisms in stabilizing motile cells...
  3. ncbi request reprint The junctional pore complex and the propulsion of bacterial cells
    Charles W Wolgemuth
    University of Connecticut Health Center, Department of Physiology, Farmington, Connecticut 06030, USA
    J Mol Microbiol Biotechnol 7:72-7. 2004
    ..This review discusses the role of slime extrusion and the junctional pore complex in the gliding motility of both cyanobacteria and myxobacteria...
  4. doi request reprint Plant biomechanics: using shape to steal motion
    Charles W Wolgemuth
    University of Connecticut Health Center, Department of Cell Biology and Center for Cell Analysis and Modeling, Farmington, CT 06030 3505, USA
    Curr Biol 19:R409-10. 2009
    ..Recent work using awns from Hordeum murinum in conjunction with mathematical modelling shows that awn shape leverages environmental oscillations in order to produce these directional translations...
  5. pmc Collective swimming and the dynamics of bacterial turbulence
    Charles W Wolgemuth
    University of Connecticut Health Center, Department of Cell Biology and Center for Cell Analysis and Modeling, Farmington, Connecticut 06030 3505, USA
    Biophys J 95:1564-74. 2008
    ..Dimensional analysis provides scaling relations for the dependence of the characteristic scales on the model parameters...
  6. ncbi request reprint The flagellar cytoskeleton of the spirochetes
    Charles W Wolgemuth
    Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030 3505, USA
    J Mol Microbiol Biotechnol 11:221-7. 2006
    ..Rotation of the flagella in the above species by a flagellar motor induces changes in the cell morphology that drives motility. Mutants that do not produce flagella have a markedly different shape than wild-type cells...
  7. pmc Force and flexibility of flailing myxobacteria
    Charles W Wolgemuth
    Department of Cell Biology, University of Connecticut Health Center, Farmington, USA
    Biophys J 89:945-50. 2005
    ..This force is comparable to that predicted by slime extrusion, and the bending modulus is 30-fold smaller than that measured in Bacillus subtilis. This model suggests experiments that can further quantify this process...
  8. pmc Lamellipodial contractions during crawling and spreading
    Charles W Wolgemuth
    University of Connecticut Health Center, Department of Cell Biology, Farmington, Connecticut, USA
    Biophys J 89:1643-9. 2005
    ....
  9. pmc The shape and dynamics of the Leptospiraceae
    Wanxi Kan
    University of Connecticut Health Center, Department of Cell Biology, Farmington, Connecticut, USA
    Biophys J 93:54-61. 2007
    ..We show that the transition between hook-shaped and spiral-shaped ends is purely a consequence of the change in direction of the flagellar motor and does not require flagellar polymorphism...
  10. ncbi request reprint Advent of complex flows in epithelial tissues
    Pilhwa Lee
    Department of Cell Biology and Center for Cell Analysis and Modeling, University of Connecticut Health Center, Farmington, Connecticut 06030 6406, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 83:061920. 2011
    ..We find that the tendency for cells to align is the dominant physical parameter that determines the stability of steady flows in the epithelium...
  11. pmc MSP dynamics drives nematode sperm locomotion
    Charles W Wolgemuth
    University of Connecticut Health Center, Department of Cell Biology, Farmington, Connecticut 06030 3505, USA
    Biophys J 88:2462-71. 2005
    ..This model explains the mechanism by which disassembly of the cytoskeleton generates the force necessary to pull the cell body forward and suggests further experiments that can test the validity of the models...
  12. ncbi request reprint Electron cryotomography reveals novel structures of a recently cultured termite gut spirochete
    Charles Wolgemuth
    Department of Cell Biology and Center for Cell Analysis and Modeling, University of Connecticut Health Center, Farmington, CT 06030 3505, USA
    Mol Microbiol 67:1181-3. 2008
    ..It also illustrates that newly cultured recalcitrant bacteria from complex environments are likely to possess novel structures not previously seen in other species...
  13. ncbi request reprint Measurement of normal and anomalous diffusion of dyes within protein structures fabricated via multiphoton excited cross-linking
    Swarna Basu
    University of Connecticut Health Center, Department of Cell Biology and Center for Cellular Analysis and Modelling, Farmington, Connecticut 06030, USA
    Biomacromolecules 5:2347-57. 2004
    ..Finally, the diffusion can be tuned within a multilayered protein matrix, and this in conjunction with slow diffusion also suggests the use of these structures in controlled release applications...
  14. pmc The motility of mollicutes
    Charles W Wolgemuth
    Department of Physiology, University of Connecticut Health Center, Farmington, Connecticut, USA
    Biophys J 85:828-42. 2003
    ..We demonstrate this possibility for two classes of wall-less bacteria called mollicutes: the swimming of helical-shaped Spiroplasma, and the gliding motility of Mycoplasma...
  15. ncbi request reprint How to make a spiral bacterium
    Charles W Wolgemuth
    Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030 3505, USA
    Phys Biol 2:189-99. 2005
    ..Any hydraulic cylinder can spiral by this mechanism if it is reinforced by stretch-resistant fibers wrapped helically in the same direction, or shortened by contractile elements. This might be useful in the design of man-made actuators...
  16. ncbi request reprint Kinematics of the swimming of Spiroplasma
    Jing Yang
    Center for Cell Analysis and Modeling, Department of Cell Biology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Phys Rev Lett 102:218102. 2009
    ..5 degrees and the optimal interkink length ratio is 0.338, values in good agreement with experimental observations...
  17. pmc Biochemical mechanisms for regulating protrusion by nematode major sperm protein
    Jelena Stajic
    Center for Cell Analysis and Modeling, University of Connecticut Health Center, Farmington, Connecticut, USA
    Biophys J 97:748-57. 2009
    ..In addition, our model predicts the force-velocity relation that is expected for in vitro protrusion assays...
  18. pmc Depolymerization-driven flow in nematode spermatozoa relates crawling speed to size and shape
    Mark Zajac
    Department of Cell Biology and Center for Cell Analysis and Modeling, University of Connecticut Health Center, Farmington, Connecticut, USA
    Biophys J 94:3810-23. 2008
    ..Our simulations also predict that speed should increase with cytoskeletal anisotropy and disassembly rate...
  19. ncbi request reprint The kinky propulsion of Spiroplasma
    Charles W Wolgemuth
    University of Connecticut Health Center, Department of Cell Biology, Farmington, Connecticut 06030, USA
    Cell 122:827-8. 2005
    ..They discover that Spiroplasma propels itself by generating two temporally distinct kinks that travel the length of the bacterium. These results point to the existence of a contractile apparatus that drives cell movement...
  20. ncbi request reprint Elasticity of alpha-helical coiled coils
    Charles W Wolgemuth
    Department of Cell Biology and Center for Cell Analysis and Modeling, University of Connecticut Health Center, Farmington, Connecticut 06030 3505, USA
    Phys Rev Lett 97:248101. 2006
    ....
  21. pmc Live imaging reveals a biphasic mode of dissemination of Borrelia burgdorferi within ticks
    Star M Dunham-Ems
    Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut, USA
    J Clin Invest 119:3652-65. 2009
    ....
  22. pmc Pattern formation by bacteria-driven flow
    N G Cogan
    Department of Mathematics, Tulane University, New Orleans, Louisiana 70118, USA
    Biophys J 88:2525-9. 2005
    ..Similar flow dynamics may also play a role in other biological systems such as encrusting bryozoan colonies...
  23. ncbi request reprint The hydration dynamics of polyelectrolyte gels with applications to cell motility and drug delivery
    Charles W Wolgemuth
    Departments of Molecular and Cellular Biology and ESPM, University of California, Berkeley, CA 94720 3112, USA
    Eur Biophys J 33:146-58. 2004
    ..Second, we use the model to describe the locomotion of nematode sperm cells. Finally, we describe the swelling dynamics of polyelectrolyte gels used for drug release...
  24. pmc Bacterial swimming and oxygen transport near contact lines
    Idan Tuval
    Institut Mediterrani d Estudis Avan├žats, Consejo Superior de Investigaciones Cientificas, Universitat de les Illes Balears, E 07071 Palma de Mallorca, Spain
    Proc Natl Acad Sci U S A 102:2277-82. 2005
    ..The vortex is shown to advectively enhance uptake of oxygen into the suspension, and the wedge geometry leads to a singularity in the chemotactic dynamics near the contact line...
  25. pmc Genetic analysis of spirochete flagellin proteins and their involvement in motility, filament assembly, and flagellar morphology
    Chunhao Li
    Department of Oral Biology, State University of New York at Buffalo, Buffalo, New York 14214, USA
    J Bacteriol 190:5607-15. 2008
    ..Finally, linear elasticity theory indicates that flagellar stiffness directly affects the spirochete's swimming speed...
  26. ncbi request reprint Theory of swimming filaments in viscoelastic media
    Henry C Fu
    Division of Engineering, Brown University, Providence, Rhode Island 02912, USA
    Phys Rev Lett 99:258101. 2007
    ..Viscoelasticity tends to decrease swimming speed, and changes in the beating patterns due to viscoelasticity can reverse swimming direction...
  27. pmc Z-ring force and cell shape during division in rod-like bacteria
    Ganhui Lan
    Department of Mechanical Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA
    Proc Natl Acad Sci U S A 104:16110-5. 2007
    ..With reasonable parameters, the model shows that a small force from the Z-ring (8 pN in Escherichia coli) is sufficient to accomplish division...

Research Grants5

  1. Biophysics of the morphology and motility of Borrelia burgdorferi in diverse envi
    Charles W Wolgemuth; Fiscal Year: 2010
    ....
  2. Elastic Model of Spirochete Morphology and Motility
    Charles Wolgemuth; Fiscal Year: 2004
    ..This grant will also support the experimental measurement of the bending moduli of the cell wall and the periplasmic flagella. ..
  3. An Elastic Model of Spirochete Morphology and Motility
    Charles Wolgemuth; Fiscal Year: 2005
    ..This grant will also support the experimental measurement of the bending moduli of the cell wall and the periplasmic flagella. ..
  4. An Elastic Model of Spirochete Morphology and Motility
    Charles Wolgemuth; Fiscal Year: 2006
    ..This grant will also support the experimental measurement of the bending moduli of the cell wall and the periplasmic flagella. ..
  5. An Elastic Model of Spirochete Morphology and Motility
    Charles Wolgemuth; Fiscal Year: 2007
    ..This grant will also support the experimental measurement of the bending moduli of the cell wall and the periplasmic flagella. ..